Gene

KWMTBOMO04026

Pre Gene Modal

BGIBMGA010271

Annotation

PREDICTED:_katanin_p60_ATPase-containing_subunit_A-like_1_[Bombyx_mori]

Location

Bomo_Chr7(+):9126181-9174395      View in EpiBrowser

Full name

Katanin p60 ATPase-containing subunit A1      

Alternative Name

p60 katanin

Location in the cell

Nuclear   Reliability : 2.908

CDS

ATGGCTCGCGAGTATGAACAGCTGAAGGCGACGGTCGCGACGCTGCAGATGTTCCAGCACGAAGGCGAGAAAGCGATCACGCCGCTCACCGGAAATTACGAAGACCTTCCCACGAGAGACATGTGGGCGCCGGCTCCCCATGAACTGGATCCAGATATCTGGCCCCCGCCACCTGACAGAGATCCGAACGCGTGGCCACCTCCCACCAATGTTGAGCATAAAGGTCCGCCCGCCATGAAGTCGGCGCGAAACAACTCGCGCAACCCCCGCACTGACATCAAGAAGACAACGCCCGCCCCCAGGAACGCTACAACCTCGCAACGGAAGACCTCCGACGTCAGGAATCCTAGGATAGCCGCCAACAAGGCACATAGTGCTAAAACGAAAGACAATAGTAGTAACAAAGAGCATAGCTCTGGCAAGGAGAAGCAGGACAGAGACAATAACAATGGCGATACAGATGACGAGAAGCACAAGGACGAGGAACGGAAGTTTGAGCCTCCCAGTGCCGCAGATGGGGACTTAGTCGATATGTTGGAAAGAGATATAGTACAAAAGAATCCTAATATAAGATGGGACGACATAGCCGATTTAACGGAAGCGAAGCGACTGTTGGAAGAGGCGGTCGTGCTGCCAATGTGGATGCCGGATTTCTTTAAAGGCATCCGTCGGCCGTGGAAGGGAGTTCTGATGGTGGGTCCCCCCGGTACCGGCAAGACGATGCTAGCGAAGGCCGTCGCCACCGAATGCGGGACGACGTTTTTCAACGTCTCTTCCTCCACCCTGACCTCCAAGTACAGAGGGGAGTCTGAGAAGCTAGTCCGGTTGCTGTTTGAAATGGCGCGGTTCTACGCTCCGAGCACGATATTCATAGACGAGATAGACTCGTTGTGCTCGAGGCGCGGCTCGGACAGCGAACACGAGGCCTCGCGCCGCGTCAAGTCGGAGCTGCTCGTGCAAATGGACGGACTTGGGTCCGCCACTGATGAACCCGCCAAGGTAGTTATGGTGTTAGCAGCAACGAATTTCCCGTGGGACATAGACGAGGCGCTTAGAAGGAGATTGGAGAAGCGTATATACATCCCGCTGCCCACCCAGGAAGGAAGGGAAGCGTTACTGCATATAAACTTGAGAGAGGTCAAGGTGGACCCCGAGGTCGACCTGAGGGCCATAGCCAAGAAACTGGACGGCTACTCCGGTGCTGACATTACTAACGTTTGCAGGGACGCATCAATGATGTCGATGCGACGTAAAATCGCCGGATTGAAACCGGAGCAGATCAAACAACTTGCCAAAGAGGAGCTCGACCTGCCCGTCACCAAGCAAGACTTCCTCGAAGCCCTCGCCAAGTGCAACAAGTCTGTGTCGAAGGGAGACATACAGAAATACCTATCCTGGATGACGGAGTTCGGATCCTCCTGA

Protein

MAREYEQLKATVATLQMFQHEGEKAITPLTGNYEDLPTRDMWAPAPHELDPDIWPPPPDRDPNAWPPPTNVEHKGPPAMKSARNNSRNPRTDIKKTTPAPRNATTSQRKTSDVRNPRIAANKAHSAKTKDNSSNKEHSSGKEKQDRDNNNGDTDDEKHKDEERKFEPPSAADGDLVDMLERDIVQKNPNIRWDDIADLTEAKRLLEEAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPSTIFIDEIDSLCSRRGSDSEHEASRRVKSELLVQMDGLGSATDEPAKVVMVLAATNFPWDIDEALRRRLEKRIYIPLPTQEGREALLHINLREVKVDPEVDLRAIAKKLDGYSGADITNVCRDASMMSMRRKIAGLKPEQIKQLAKEELDLPVTKQDFLEALAKCNKSVSKGDIQKYLSWMTEFGSS

Description

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Catalytic Activity

n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.

Subunit

Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.

Similarity

Belongs to the AAA ATPase family.
Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Uniprot

A0A2H1W0U2   A0A2W1BW41   H9JL70   A0A212EUC8   A0A194PLR8   A0A194RL48   + More
A0A0P4W0L8   A0A182KMD9   A0A2M4BIM6   A0A182VRL3   A0A182QDV8   A0A182G6J7   A0A224XI20   A0A023F4Y5   A0A182LWZ3   A0A0V0GC00   A0A2M3ZIA2   U5EYR1   A0A182VLK2   A0A182TNB4   A0A182X2T4   Q7PY77   A0A2C9GQ17   A0A2M3Z979   A0A2M3Z968   A0A182RUD0   A0A182F999   A0A182KB37   A0A084WPC4   A0A182N4D6   Q171H9   A0A2M4AIB7   A0A182XV68   T1HMD1   W5JE97   A0A182P620   A0A154PQ55   A0A1B6JUQ1   A0A232FIN5   K7IQH5   A0A1B6EZ66   A0A0A9XV62   A0A0A9XZ59   A0A146LAA8   E0VC70   D6W745   A0A0A9VY23   A0A0A9XZ62   A0A0C9QQH2   A0A0A9Y584   A0A0A9Y580   A0A2A3E4E5   A0A087ZZZ8   A0A0A9XXM6   A0A0A9WRH1   A0A1B6DU61   A0A1B6C758   A0A195F8R1   A0A067QJX7   A0A0K2USM0   W8C6X5   W8BWI6   A0A1A9ZVN0   A0A1A9UX56   A0A1A9Y8G8   A0A1B0BMP8   E9ILS3   A0A1B0FIJ4   A0A195AY28   A0A158NP64   A0A195DYF2   A0A1Y1LJM6   E1ZVX4   A0A151WXB1   A0A195CH97   T1JGH2   A0A026W299   A0A3L8E347   A0A1I8M0N2   T1PBN2   A0A2H8TU21   A0A164VHQ4   A0A0P6BS32   A0A1A9WFU3   A0A0P5Q903   A0A0P5PGH5   A0A1I8NRY3   A0A0P5GPY9   A0A2S2NP14   E9FWN1   J9JLX1  

EC Number

5.6.1.1

Pubmed

28756777    19121390    22118469    26354079    27129103    20966253    + More
26483478    25474469    12364791    14747013    17210077    24438588    17510324    25244985    20920257    23761445    28648823    20075255    25401762    26823975    20566863    18362917    19820115    24845553    24495485    21282665    21347285    28004739    20798317    24508170    30249741    25315136    21292972   

EMBL

ODYU01005618    SOQ46647.1    KZ149942    PZC76876.1    BABH01011741    BABH01011742    + More
AGBW02012412    OWR45096.1    KQ459600    KPI94272.1    KQ459995    KPJ18558.1    GDKW01000178    JAI56417.1    GGFJ01003713    MBW52854.1    AXCN02000037    JXUM01045051    KQ561424    KXJ78628.1    GFTR01006968    JAW09458.1    GBBI01002614    JAC16098.1    AXCM01016628    GECL01000691    JAP05433.1    GGFM01007500    MBW28251.1    GANO01000128    JAB59743.1    AAAB01008987    EAA01173.5    APCN01005954    GGFM01004348    MBW25099.1    GGFM01004325    MBW25076.1    ATLV01025031    KE525368    KFB52068.1    CH477454    EAT40653.1    GGFK01007214    MBW40535.1    ACPB03001253    ADMH02001636    ETN61668.1    KQ435031    KZC14019.1    GECU01004772    JAT02935.1    NNAY01000172    OXU30329.1    GECZ01028435    GECZ01026856    GECZ01006491    JAS41334.1    JAS42913.1    JAS63278.1    GBHO01032563    GBHO01018932    GBRD01005260    GBRD01005256    JAG11041.1    JAG24672.1    JAG60561.1    GBHO01032565    GBHO01018933    JAG11039.1    JAG24671.1    GDHC01013361    JAQ05268.1    AAZO01000961    DS235048    EEB10976.1    KQ971307    EFA11410.2    GBHO01044526    GBHO01018931    GBRD01005258    GBRD01005257    JAF99077.1    JAG24673.1    JAG60563.1    GBHO01032564    GBHO01018928    JAG11040.1    JAG24676.1    GBYB01005959    JAG75726.1    GBHO01018930    GBHO01018929    JAG24674.1    JAG24675.1    GBHO01032560    GBHO01018934    JAG11044.1    JAG24670.1    KZ288379    PBC26633.1    GBHO01032561    GBHO01018925    JAG11043.1    JAG24679.1    GBHO01032562    GBHO01032559    JAG11042.1    JAG11045.1    GEDC01008082    JAS29216.1    GEDC01028203    JAS09095.1    KQ981727    KYN36828.1    KK853380    KDR08012.1    HACA01023496    CDW40857.1    GAMC01000872    JAC05684.1    GAMC01000870    JAC05686.1    JXJN01017018    GL764129    EFZ18426.1    CCAG010023805    KQ976703    KYM77153.1    ADTU01022253    KQ980066    KYN17940.1    GEZM01054074    GEZM01054073    JAV73859.1    GL434663    EFN74666.1    KQ982668    KYQ52542.1    KQ977791    KYM99806.1    JH432203    KK107468    EZA50215.1    QOIP01000001    RLU27066.1    KA645378    AFP60007.1    GFXV01004873    MBW16678.1    LRGB01001361    KZS12333.1    GDIP01010931    JAM92784.1    GDIQ01117542    JAL34184.1    GDIQ01128842    JAL22884.1    GDIQ01239405    JAK12320.1    GGMR01006314    MBY18933.1    GL732526    EFX87921.1    ABLF02037784   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000075882    UP000075920    + More
UP000075886    UP000069940    UP000249989    UP000075883    UP000075903    UP000075902    UP000076407    UP000007062    UP000075840    UP000075900    UP000069272    UP000075881    UP000030765    UP000075884    UP000008820    UP000076408    UP000015103    UP000000673    UP000075885    UP000076502    UP000215335    UP000002358    UP000009046    UP000007266    UP000242457    UP000005203    UP000078541    UP000027135    UP000092445    UP000078200    UP000092443    UP000092460    UP000092444    UP000078540    UP000005205    UP000078492    UP000000311    UP000075809    UP000078542    UP000053097    UP000279307    UP000095301    UP000076858    UP000091820    UP000095300    UP000000305    UP000007819   

PRIDE

H9JL70   

Pfam

PF00004   AAA        + More
PF09336   Vps4_C
PF17862   AAA_lid_3

Interpro

IPR041569   AAA_lid_3        + More
IPR003593   AAA+_ATPase       
IPR028596   KATNA1       
IPR003959   ATPase_AAA_core       
IPR015415   Vps4_C       
IPR003960   ATPase_AAA_CS       
IPR027417   P-loop_NTPase       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

A0A2H1W0U2   A0A2W1BW41   H9JL70   A0A212EUC8   A0A194PLR8   A0A194RL48   + More
A0A0P4W0L8   A0A182KMD9   A0A2M4BIM6   A0A182VRL3   A0A182QDV8   A0A182G6J7   A0A224XI20   A0A023F4Y5   A0A182LWZ3   A0A0V0GC00   A0A2M3ZIA2   U5EYR1   A0A182VLK2   A0A182TNB4   A0A182X2T4   Q7PY77   A0A2C9GQ17   A0A2M3Z979   A0A2M3Z968   A0A182RUD0   A0A182F999   A0A182KB37   A0A084WPC4   A0A182N4D6   Q171H9   A0A2M4AIB7   A0A182XV68   T1HMD1   W5JE97   A0A182P620   A0A154PQ55   A0A1B6JUQ1   A0A232FIN5   K7IQH5   A0A1B6EZ66   A0A0A9XV62   A0A0A9XZ59   A0A146LAA8   E0VC70   D6W745   A0A0A9VY23   A0A0A9XZ62   A0A0C9QQH2   A0A0A9Y584   A0A0A9Y580   A0A2A3E4E5   A0A087ZZZ8   A0A0A9XXM6   A0A0A9WRH1   A0A1B6DU61   A0A1B6C758   A0A195F8R1   A0A067QJX7   A0A0K2USM0   W8C6X5   W8BWI6   A0A1A9ZVN0   A0A1A9UX56   A0A1A9Y8G8   A0A1B0BMP8   E9ILS3   A0A1B0FIJ4   A0A195AY28   A0A158NP64   A0A195DYF2   A0A1Y1LJM6   E1ZVX4   A0A151WXB1   A0A195CH97   T1JGH2   A0A026W299   A0A3L8E347   A0A1I8M0N2   T1PBN2   A0A2H8TU21   A0A164VHQ4   A0A0P6BS32   A0A1A9WFU3   A0A0P5Q903   A0A0P5PGH5   A0A1I8NRY3   A0A0P5GPY9   A0A2S2NP14   E9FWN1   J9JLX1  

PDB

6B5C     E-value=3.19401e-134,     Score=1226

KEGG

101737410    K07767 katanin p60 ATPase-containing subunit A1 [EC:5.6.1.1] | (RefSeq) katanin p60 ATPase-containin

GO

GO:0008568   GO:0008017   GO:0005524   GO:0000922   GO:0016853   GO:0005737   GO:0005813   GO:0007049   GO:0051301   GO:0005874   GO:0016887   GO:0005634   GO:0031122   GO:0051013   GO:0007179   GO:0006811   GO:0006032   GO:0016021   GO:0004672   GO:0048384  

Subcellular location

Cytoplasm   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Cytoskeleton   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Microtubule organizing center   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Centrosome   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Spindle pole   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.
Spindle   Predominantly cytoplasmic. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.   With evidence from 1 publications.

Length:

473

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00202

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00719

outside

1  -  473

 

 

Pi

27.143548

Theta

166.811578

Tajima's D

2.252136

CLR

0.141865

CSRT

0.915704214789261

Interpretation

Uncertain