Gene

KWMTBOMO04005

Pre Gene Modal

BGIBMGA010261

Annotation

PREDICTED:_probable_DNA_mismatch_repair_protein_Msh6_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr7(+):8108941-8127684      View in EpiBrowser

Full name

DNA mismatch repair protein       + More
Probable DNA mismatch repair protein Msh6      

Location in the cell

Nuclear   Reliability : 2.872

CDS

ATGTCGAAACGAAACAGCACAGGGGCAGCCAATACTCTTTTCAACTATTTTACTAAAACACCGCCAACGAATAAAAAATTAAAAGCGGACGCTACTGAAGATACTGATTGTAATGGTTCCCCGAAAAGCAGTAAAAAAGGAATACATCTTGAAAACAAAAAACGCGAAAGGCAAATTACACCCTCACCGGAGCTTAAGAAGGCTTCGAGTGATGAAGAAGAAGTTATTTCATTGCCAACAAAAAGAAAAAGAATAAGACTAAATCCAGTCGATTCTGATGATTCTGATGTTGAAAATAAAGCAGACAATAAAATTGGAACAACTAAGAAGGAAGAAGATGAAGCAAAGAGTGAGAAAAAGAAAGAAAGTATAGTAGAAAAGAAACTTCAAGACAGTTTTAAATATGAACCAAATCAAACCTCAAAAAGTAACAAGAATACTAAAACTACAGCTGGATCAAAATCAAAAACAATATTACCTGAAGAAAACCCAAAGAGTCAGGAAGAAGAGTCATCAGATGGTAATTGGGTGCACTGCAAGTTAGACTGGTTGAAGCCAGACAAGATCAGAGATGCGATGAAGAGGAAACTGGACCATCCGGATTATAATCCGAGGACTCTGTATGTTCCACCGGATTTCTTAAAAAGTCAGACACCTGCTCATCAACAATGGTGGATAATGAAATCAACCAATTTTGATTGTGTATTGTTCTTCAAAGTTGGTAAATTCTATGAATTGTATCACATGGATGCTGCTGTTGGGGTCAATGAACTTGGATTCTCCTACATGAAAGGTGATTTCGCACATTCTGGCTTCCCTGAAAGCGCCTACGGACGTATGGCTTCGACTCTAGTATCGAAAGGTTACAAAATAGCACGCGTGGAACAAACCGAAACTCCTGAAATGACACAGGAAAGGTGTAGAAAAAGCGGACAGAGCAGTAAGCTGGACAAGGTGGTCCGGCGCGAGGTGTGCCAGGTGGCGGTGCGCGGCGCCGAGGGCTGCGGGCCCAACGACGCGCCGCGCGCCGCCGCACTCGCCGCCTACATGCTCGCGGTGGCTGAACAGGCACATAATGATTCAAGCACTTATGGGGTTTGTTTCATAGACACTTCAATAGGATTGTTCCACCTTGGACAGTTCGAAGACGACAAGCACTCATCGAGACTTCTCACCACACTGGCACACTACCCACCAGCCTTGATAATATACGACCGTAAAGCGACAACGGGCCGCACGAGCAAGCTGCTGTCCACGCACTGGCACGACGCGCGCAGGGAGCCCCGGACCCTGGGGGCTCCCGATGTCACGCTCAAAACCTTAGCCGAGAAGTACTACAGGACGAATGAGGACGGAGACTGGCCAGAAGGTATCAAGGAGTTCTTACATCAAGGTGATTCCCTGGGTCTGACACCGGCTCCCAACTGTGAACTCGCCATTAAAGCTCTCGGAGGATGCGTTTCTTATTTGACCGAGTGTTTATTGGACATACAAATACTAGGAATGTCGCAGTTCACATCGTACGCTCCACCCGATGTACTAAATAGGAAGTTATCGGAAAGGCATAAGGTCGATAATCTTTGGGAGGGCGGCAACACCTTGGTGCTGGACGCAATAACGCTGAGGAATTTACGGATAGTACAAGACGAAGGCTGTCTGTACGATAGATTGAATTTTTGTTCAACGGCTATGGGAAAAAGGTTGCTCTATCAATGGGTTTGTTCGCCGAGCGCTAATATAAACGTAATAAAAGAAAGGCAAGAAGCTGTCAAATGTTTGTTTGACAATCAGGAACTATGTCAAAATGCAAAGAACGTTTTGACATCATTACCCGATTTAGAACGTCTGTTAGCTAAAGTACACACCCTCGGAAACTTGAAGCGTTCAAAGCAGCATCCGGATTCTAGAGCAATATTCTACGAAGAGAAGACATATTCAAAGCGGAAGGTTCTAGAGTTCATCTCCGTGTTGAACGGCTTCACCTCAGCACTGACCCTTGCCGAGAGGTTCAGTGACGTAGACTCGGTGTTATTAAAAAGAATCACACAAGTCGAAGGTGGTAATTACCCGGATTACAGGGACACTTTGAAATTTTTTAAGGAAGCTTTCAATCAACAAGAGGCCGAGAAGGAAGGCTGCATCAAACCGGGCGCGGGCGTCGACAGAGAGTACGACGGAGCCCTGCAACGAATACACGAGATAGAGAGTGAGCTCAAAGAGTATTTAGCCGAGCAAGAGAAACACTTCCGCTGTAGATTGTCATATGTGGGTACGGACAAAAAGCGTTACCAGATCGAAGTGCCGCAGAGCGCTTGTACCCGCGCCGGCTCGGACTACCACATGGAGAGCGCTCGCAAAGGGTTCAAAAGGTTTTCTACCAGCGAGACGAAGGAGTTCCTGTCCCGCATGATGGCCGCCGAGGAACAAAAGACGAATGTGCTGAAGGACTTGAGCCGCAGAATGTACGAGAAGTTCTCGTCCCACTATGCGCAGTGGGAAGCGGCCGTGCACTGCCTCGCCAGCCTCGACGTGCTGCTGGCGTTCGCAGAGTTTGCACGACAACAGCACGGCGACATCTGTCTACCCGATGTCACTTTCGATACAGGGACAAAGCCCTACATAAACATCGTGGAGGGGCGCCACCCCTGCATATCGCTGGTGAACGAGTTCATACCGAACGACACGAGGCTGGGCGGCGCCGGGCCCGGCCTGCTGCTGCTCTCCGGGCCCAACATGGGCGGCAAGTCCACGCTCATGAGGCAGCTCGGCCTGCTCGCCGTCCTCGCGCACCTGGGTAGCTACGTGCCGGCGCGGGAGTGCGGCCTCAGCCTCGTGGACCGCGTGTTCACGCGCCTCGGAGCCTCCGACGACATCCTCGCCGGACAGTCCACGTTCCTGGTGGAGATGAACGAGACCGCAGCCATCGTCAGGCACGCCACCGTACATTCGCTGGTCTTGTTAGACGAATTGGGTCGAGGCACGTCCACGTACGACGGGACCGCCATAGCGTCTGGCGTGTGCGCGGCGCTGGCGGGGCGCGGCTGCCGGGCCGTGTTCTCGACACACTACCACTCGCTCGTGCGACATCTGGCGGCGCACGATGGACTCGTGCTCGGGCACATGGCGTGCATGGTAGAAACCGACGAATCGGTCCCCGATAGCGAAGATCACATACCGGAGGAGACTATCACGTTCCTATACAAGCTGAGTCCAGGTGCTTGTCCTAAGTCCTACGGTTTCAATGCGGCCCGCCTCGCTGGAATACCCAAAGAAATCACCCGCAGAGCTCACGAGATATCCAAGAAACTGGAAAAGGAGGCCATGTGCGCACGAGCCTTTAGGGATATCATGAAAATGGAAAACAATGCCGGTGGCGTTAGAGAGTTGCTGGCAACACTGACGATTTGA

Protein

MSKRNSTGAANTLFNYFTKTPPTNKKLKADATEDTDCNGSPKSSKKGIHLENKKRERQITPSPELKKASSDEEEVISLPTKRKRIRLNPVDSDDSDVENKADNKIGTTKKEEDEAKSEKKKESIVEKKLQDSFKYEPNQTSKSNKNTKTTAGSKSKTILPEENPKSQEEESSDGNWVHCKLDWLKPDKIRDAMKRKLDHPDYNPRTLYVPPDFLKSQTPAHQQWWIMKSTNFDCVLFFKVGKFYELYHMDAAVGVNELGFSYMKGDFAHSGFPESAYGRMASTLVSKGYKIARVEQTETPEMTQERCRKSGQSSKLDKVVRREVCQVAVRGAEGCGPNDAPRAAALAAYMLAVAEQAHNDSSTYGVCFIDTSIGLFHLGQFEDDKHSSRLLTTLAHYPPALIIYDRKATTGRTSKLLSTHWHDARREPRTLGAPDVTLKTLAEKYYRTNEDGDWPEGIKEFLHQGDSLGLTPAPNCELAIKALGGCVSYLTECLLDIQILGMSQFTSYAPPDVLNRKLSERHKVDNLWEGGNTLVLDAITLRNLRIVQDEGCLYDRLNFCSTAMGKRLLYQWVCSPSANINVIKERQEAVKCLFDNQELCQNAKNVLTSLPDLERLLAKVHTLGNLKRSKQHPDSRAIFYEEKTYSKRKVLEFISVLNGFTSALTLAERFSDVDSVLLKRITQVEGGNYPDYRDTLKFFKEAFNQQEAEKEGCIKPGAGVDREYDGALQRIHEIESELKEYLAEQEKHFRCRLSYVGTDKKRYQIEVPQSACTRAGSDYHMESARKGFKRFSTSETKEFLSRMMAAEEQKTNVLKDLSRRMYEKFSSHYAQWEAAVHCLASLDVLLAFAEFARQQHGDICLPDVTFDTGTKPYINIVEGRHPCISLVNEFIPNDTRLGGAGPGLLLLSGPNMGGKSTLMRQLGLLAVLAHLGSYVPARECGLSLVDRVFTRLGASDDILAGQSTFLVEMNETAAIVRHATVHSLVLLDELGRGTSTYDGTAIASGVCAALAGRGCRAVFSTHYHSLVRHLAAHDGLVLGHMACMVETDESVPDSEDHIPEETITFLYKLSPGACPKSYGFNAARLAGIPKEITRRAHEISKKLEKEAMCARAFRDIMKMENNAGGVRELLATLTI

Description

Component of the post-replicative DNA mismatch repair system (MMR).
Involved in post-replicative DNA-mismatch repair.

Subunit

Heterodimer of Msh2/Spel and Msh6.

Similarity

Belongs to the DNA mismatch repair MutS family.

Keywords

ATP-binding   Complete proteome   DNA damage   DNA repair   DNA-binding   Nucleotide-binding   Phosphoprotein   Reference proteome  

Feature

chain  Probable DNA mismatch repair protein Msh6

Uniprot

H9JL60   A0A2A4JUF0   A0A194PMN6   A0A2A4JUU1   A0A2H1VUW7   A0A1B0F0L9   + More
A0A182GA86   A0A1Q3EX21   Q16P35   A0A1S4FUJ8   A0A026WAP0   A0A0L7RGN9   A0A0M8ZP35   B0X103   A0A2J7QFE1   A0A2Z5U638   K7IYQ7   A0A151J421   A0A232FG60   A0A0J7KDX6   A0A088ADL1   A0A158NSK1   A0A291S6W8   A0A154NWM0   A0A2A3EPA1   E2ASE2   F4WMY7   A0A067RBU4   A0A151WIN7   A0A195FW72   A0A023F3N4   A0A0C9QQS6   A0A151HYG5   E2BJ16   A0A182M414   A0A084VAL0   A0A182K008   A0A182RC53   A0A182V9W5   A0A182LCD8   A0A182N517   A0A182VWN4   A0A1B0CTS5   A0A182XE48   A0A182IWK5   A0A182PT17   A0A034VS29   Q7QBF8   A0A182QD49   A0A182YHI8   E0VJY5   B4L131   A0A182HJ76   B4LGU7   B4N518   Q2M1A6   B4PCD8   A0A0K8U9X2   A0A1A9WE19   B4QKL0   A0A1W4VNP4   U4TVC4   B4HI59   A0A0K8VM51   A0A1B6HAN9   Q9VUM0   B3NI00   W8C538   A0A1I8M2R1   A0A1A9V465   B3M729   B4IZG1   A0A336MDM1   A0A182FKV2   A0A1B0FJM5   A0A1I8NUM9   A0A0M4EFF4   A0A3B0JY27   A0A2H8TG21   A0A1W4WFL5   J9K4M7   A0A0A9XJD4   A0A1B0B7Y9   A0A0T6BFQ8   A0A1J1HPQ5   A0A2S2R3P4   A0A0P6BWH5   A0A0P4VS63   A0A162NM85   A0A0P5W8Z4   A0A0N7ZZ83   A0A0P5NC62   A0A0P5J8D3   A0A0P5Q259   A0A0P5L389   A0A0P6IJX9   A0A0P5C3B5   A0A0P5HUA4   A0A0P6ESF2  

Pubmed

19121390    26354079    26483478    17510324    24508170    30249741    + More
26760975    20075255    28648823    21347285    28992199    20798317    21719571    24845553    25474469    24438588    20966253    25348373    12364791    25244985    20566863    17994087    15632085    17550304    22936249    23537049    10731132    12537572    17339220    18327897    24495485    25315136    25401762   

EMBL

BABH01011637    BABH01011638    BABH01011639    NWSH01000620    PCG75254.1    KQ459600    + More
KPI94258.1    PCG75253.1    ODYU01004590    SOQ44623.1    AJVK01007753    JXUM01008449    KQ560261    KXJ83487.1    GFDL01015192    JAV19853.1    CH477797    EAT36110.1    KK107295    QOIP01000003    EZA53100.1    RLU24967.1    KQ414596    KOC69993.1    KQ435944    KOX68230.1    DS232250    EDS38395.1    NEVH01015299    PNF27299.1    FX985841    BBA93728.1    KQ980211    KYN17186.1    NNAY01000292    OXU29419.1    LBMM01008759    KMQ88653.1    ADTU01024983    MF432999    ATL75350.1    KQ434773    KZC03981.1    KZ288206    PBC33082.1    GL442298    EFN63608.1    GL888223    EGI64457.1    KK852747    KDR17272.1    KQ983089    KYQ47660.1    KQ981261    KYN44089.1    GBBI01003218    JAC15494.1    GBYB01006084    JAG75851.1    KQ976720    KYM76714.1    GL448549    EFN84313.1    AXCM01004089    ATLV01004128    KE524190    KFB35004.1    AJWK01027946    GAKP01014589    JAC44363.1    AAAB01008879    EAA08481.5    AXCN02000179    DS235235    EEB13691.1    CH933809    EDW18188.1    APCN01002129    CH940647    EDW70562.1    CH964101    EDW79457.1    CH379069    EAL30669.1    CM000159    EDW94848.1    GDHF01028847    JAI23467.1    CM000363    CM002912    EDX10521.1    KMY99714.1    KB631623    ERL84752.1    CH480815    EDW41555.1    GDHF01012386    JAI39928.1    GECU01035996    JAS71710.1    AE014296    BT050543    CH954178    EDV52086.1    GAMC01001992    JAC04564.1    CH902618    EDV40894.1    CH916366    EDV97736.1    UFQT01000758    SSX27009.1    CCAG010020214    CP012525    ALC44671.1    OUUW01000002    SPP75998.1    GFXV01001251    MBW13056.1    ABLF02035342    GBHO01023853    JAG19751.1    JXJN01009745    LJIG01000768    KRT86172.1    CVRI01000015    CRK89947.1    GGMS01014759    MBY83962.1    GDIP01008522    JAM95193.1    GDRN01101618    JAI58342.1    LRGB01000568    KZS18116.1    GDIP01089725    JAM13990.1    GDIP01198073    JAJ25329.1    GDIQ01147306    JAL04420.1    GDIQ01228633    JAK23092.1    GDIQ01120175    JAL31551.1    GDIQ01182896    JAK68829.1    GDIQ01030311    JAN64426.1    GDIP01176162    JAJ47240.1    GDIQ01228632    JAK23093.1    GDIQ01072030    JAN22707.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000092462    UP000069940    UP000249989    + More
UP000008820    UP000053097    UP000279307    UP000053825    UP000053105    UP000002320    UP000235965    UP000002358    UP000078492    UP000215335    UP000036403    UP000005203    UP000005205    UP000076502    UP000242457    UP000000311    UP000007755    UP000027135    UP000075809    UP000078541    UP000078540    UP000008237    UP000075883    UP000030765    UP000075881    UP000075900    UP000075903    UP000075882    UP000075884    UP000075920    UP000092461    UP000076407    UP000075880    UP000075885    UP000007062    UP000075886    UP000076408    UP000009046    UP000009192    UP000075840    UP000008792    UP000007798    UP000001819    UP000002282    UP000091820    UP000000304    UP000192221    UP000030742    UP000001292    UP000000803    UP000008711    UP000095301    UP000078200    UP000007801    UP000001070    UP000069272    UP000092444    UP000095300    UP000092553    UP000268350    UP000192223    UP000007819    UP000092460    UP000183832    UP000076858   

PRIDE

H9JL60    Q9VUM0   

Pfam

PF05192   MutS_III        + More
PF00488   MutS_V
PF01624   MutS_I
PF05188   MutS_II
PF05190   MutS_IV
PF00855   PWWP

Interpro

IPR036187   DNA_mismatch_repair_MutS_sf        + More
IPR017261   DNA_mismatch_repair_MutS/MSH       
IPR007696   DNA_mismatch_repair_MutS_core       
IPR000432   DNA_mismatch_repair_MutS_C       
IPR036678   MutS_con_dom_sf       
IPR007861   DNA_mismatch_repair_MutS_clamp       
IPR007695   DNA_mismatch_repair_MutS-lik_N       
IPR016151   DNA_mismatch_repair_MutS_N       
IPR027417   P-loop_NTPase       
IPR007860   DNA_mmatch_repair_MutS_con_dom       
IPR000313   PWWP_dom       

SUPFAM

SSF55271   SSF55271        + More
SSF53150   SSF53150       
SSF52540   SSF52540       
SSF48334   SSF48334       

Gene 3D

3.30.420.110     3.40.1170.10    

ProteinModelPortal

H9JL60   A0A2A4JUF0   A0A194PMN6   A0A2A4JUU1   A0A2H1VUW7   A0A1B0F0L9   + More
A0A182GA86   A0A1Q3EX21   Q16P35   A0A1S4FUJ8   A0A026WAP0   A0A0L7RGN9   A0A0M8ZP35   B0X103   A0A2J7QFE1   A0A2Z5U638   K7IYQ7   A0A151J421   A0A232FG60   A0A0J7KDX6   A0A088ADL1   A0A158NSK1   A0A291S6W8   A0A154NWM0   A0A2A3EPA1   E2ASE2   F4WMY7   A0A067RBU4   A0A151WIN7   A0A195FW72   A0A023F3N4   A0A0C9QQS6   A0A151HYG5   E2BJ16   A0A182M414   A0A084VAL0   A0A182K008   A0A182RC53   A0A182V9W5   A0A182LCD8   A0A182N517   A0A182VWN4   A0A1B0CTS5   A0A182XE48   A0A182IWK5   A0A182PT17   A0A034VS29   Q7QBF8   A0A182QD49   A0A182YHI8   E0VJY5   B4L131   A0A182HJ76   B4LGU7   B4N518   Q2M1A6   B4PCD8   A0A0K8U9X2   A0A1A9WE19   B4QKL0   A0A1W4VNP4   U4TVC4   B4HI59   A0A0K8VM51   A0A1B6HAN9   Q9VUM0   B3NI00   W8C538   A0A1I8M2R1   A0A1A9V465   B3M729   B4IZG1   A0A336MDM1   A0A182FKV2   A0A1B0FJM5   A0A1I8NUM9   A0A0M4EFF4   A0A3B0JY27   A0A2H8TG21   A0A1W4WFL5   J9K4M7   A0A0A9XJD4   A0A1B0B7Y9   A0A0T6BFQ8   A0A1J1HPQ5   A0A2S2R3P4   A0A0P6BWH5   A0A0P4VS63   A0A162NM85   A0A0P5W8Z4   A0A0N7ZZ83   A0A0P5NC62   A0A0P5J8D3   A0A0P5Q259   A0A0P5L389   A0A0P6IJX9   A0A0P5C3B5   A0A0P5HUA4   A0A0P6ESF2  

PDB

2O8F     E-value=0,     Score=2076

KEGG

101744671    K08737 DNA mismatch repair protein MSH6 | (RefSeq) probable DNA mismatch repair protein Msh6

PATHWAY

03430    Mismatch repair - Bombyx mori (domestic silkworm)

GO

GO:0030983   GO:0006298   GO:0005524   GO:0032300   GO:0008094   GO:0032301   GO:0032876   GO:0036297   GO:0000710   GO:0045910   GO:0043570   GO:0000400   GO:0006290   GO:0008630   GO:0006281   GO:0016757   GO:0008270   GO:0008892   GO:0006811   GO:0006032   GO:0016021   GO:0004672   GO:0048384  

Length:

1135

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02983

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.00023

outside

1  -  1135

 

 

Pi

31.540222

Theta

31.267885

Tajima's D

0.115634

CLR

1.845731

CSRT

0.404729763511824

Interpretation

Uncertain