Gene

KWMTBOMO04000  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010258

Annotation

PREDICTED:_guanine_deaminase_[Amyelois_transitella]

Location

Bomo_Chr7(+):8037241-8042061      View in EpiBrowser

Full name

Guanine deaminase      

Alternative Name

Guanine aminohydrolase

Location in the cell

Cytoplasmic   Reliability : 2.697

CDS

ATGACCCGGAAACATACCTTTGTTGGTGCTTACGCTCATTCCGATAACAAAAGACAACTTTCTGTATGTTTCGGGTTTTTGACTATTGAAAATGGAAAGATAACACAAAAAGGATCAATTGAAGAGTTTGAAGAGCTTCTCAGTGCTGGTAAATTCAGTGAGCACATTGTAATAAATCTAAGTGATAGTCAATTAATAATTCCTGGATTTATTGACTGTCATATCCATGCTCCACAATTCCCCAACATTGGCCTCGGCTTAGACAGACCTTTACTTGAATGGCTGGACAAATATACATTCCCATTAGAAAAGAAGTACAGTGACACTGTATTTGCAAGTAAAGTCTATGATCAAGTTGTTCAAAGATTGTTAAAAAATGGCACAACCACAGCTTGCTACTTTGGATCATTACATTTGGATGGTACATTAGAGCTAGTGAAGAGTGTCCTCAAGTATCATCAAAGGGCATTTGTTGGAAAAGTCAGCATGAATTTACAGAATGATGCAGGATACTATAATTCCACAGAAAAGGAATTGCAAGACACTGAAGAGTTTGTACAGAAAGTACTAGACTACAAAAATGAGCTAATTCAACCAGTTGTCACACCAAGATTTGCTGTCAGTTGTGATCATCAACTGTTAAGTGGACTCGCAATGATCGCTAACAAATATGGTTGTAGTATGCAGAGTCATGTGTGTGAAAATTTAAAGGAAATAAATTATGTTTTGGAAATAAATCCACGCTGCAAAAGTTATTGTGAAGTTTATGACAAGAGTAAAATTTTGCATGAAAAGTGTATAATGGCACATGCTGTACATCTAACAGATGAAGAGATTGATTTACTGTCAAAGAAAGGAGTCTCCGTAGCCCACTGTCCTGCTTCGAACACTCGCCTAAAGTCAGGCCTCTGTCCTGTTAGGAAGCTTCTGGACAATAATATTGTCGTTGGTCTTGGAACAGACGTGTCCGGAGGCGACAGTGCGACAATACTTGACGCCGTGCGCAGAACGATGGATGTGTCTACGTGCTTGGAACTACAAGGTGCCGATAATTATTCACTCGATTGGAAAGAAGCGTTTTATCTTGCAACATTGGGTGGCGCTAAAGCTCTGAATTTGGATGATAAGATCGGAAATTTTGAAGTTGGCAAGGATTTCGACGCGCTACTAATAGACGCATACGCTCCCGGCGGTCCCATAGACGAGTACGAGTATACCGTAGACGAAAACAAGGAAGAACATGCCGTGAGCCTTCTCCAAAGGTTCATCTATTTGGGGGACGATAGAAATATCCTCCAAGTCTATGTTAAAGGAAAGAGCGTCAAAACTATTTAA

Protein

MTRKHTFVGAYAHSDNKRQLSVCFGFLTIENGKITQKGSIEEFEELLSAGKFSEHIVINLSDSQLIIPGFIDCHIHAPQFPNIGLGLDRPLLEWLDKYTFPLEKKYSDTVFASKVYDQVVQRLLKNGTTTACYFGSLHLDGTLELVKSVLKYHQRAFVGKVSMNLQNDAGYYNSTEKELQDTEEFVQKVLDYKNELIQPVVTPRFAVSCDHQLLSGLAMIANKYGCSMQSHVCENLKEINYVLEINPRCKSYCEVYDKSKILHEKCIMAHAVHLTDEEIDLLSKKGVSVAHCPASNTRLKSGLCPVRKLLDNNIVVGLGTDVSGGDSATILDAVRRTMDVSTCLELQGADNYSLDWKEAFYLATLGGAKALNLDDKIGNFEVGKDFDALLIDAYAPGGPIDEYEYTVDENKEEHAVSLLQRFIYLGDDRNILQVYVKGKSVKTI

Description

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

Catalytic Activity

guanine + H(+) + H2O = NH4(+) + xanthine

Cofactor

Zn(2+)

Similarity

Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.

Feature

chain  Guanine deaminase

Uniprot

H9JL57   A0A2W1BW91   A0A2A4IZ65   A0A3S2NEU3   A0A194PZH4   A0A212EIE8   + More
A0A194RKJ7   A0A2J7PWT9   A0A0C9Q8A2   A0A0C9RBD1   A0A0J7L2Z9   A0A3R7QD88   A0A2M4BMH4   A0A1B6C3K9   A0A2M4BMP5   A0A182FD09   A0A182H5Q2   Q17FY0   A0A182UCB7   A0A2P8YPE3   A0A182H4K2   A0A182ICY7   A0A2J7PX84   A0A151IMC0   A0A195DQS9   A0A3R7MFK8   Q7QI65   A0A182KVU9   A0A1B6CGQ5   A0A182K8C0   F4X8A9   A0A067RHG4   E2A4V0   A0A226EFQ2   A0A182WRY2   A0A182VDR1   A0A084VXK2   A0A224XP13   A0A182M2H0   A0A1D2NBP2   A0A195FCJ6   A0A182RQC4   T1HSY2   W8BMV4   R4FNH3   A0A182PQ74   A0A158NBS1   A0A182JHU3   A0A182WK56   A0A1Q3G4C1   A0A0P4VQX0   A0A151X9F5   G3P9D3   A0A3Q3S187   A0A1I8NCE7   A0A3Q3IWW0   A0A1W4W3D1   E2BID8   T1PA96   A0A2A3ES42   A0A3P8W7T7   A0A0Q3PK98   A0A2P2HZE1   A0A2I0UI06   A0A182QLR4   A0A147AAI8   A0A0L0BQC6   A0A023F7D2   A0A3Q2Z4A8   A0A2U9BTJ2   A0A0K8W9Z6   C3YDR7   A0A026W2T5   A0A3Q2FQQ5   A0A0K8W659   K7ISG1   A0A034WR69   A0A232FDZ2   U3K852   A0A3Q1EWM2   A0A3Q2ZY33   F7DIF8   A0A087ZWZ2   A0A0A1XMB5   A0A0L0G262   A0A195BG59   A0A154P6F6   A0A1V4KCV1   A0A3S2P7E4   A0A3B3YVA7   A0A182YP18   A0A069DTH7   A0A1I8NY97   A0A3B4V846   A0A3P9NI71   A0A3Q1BB31   A0A1L8EGS1   H2M5A1   A0A2I0MFY5   A0A2I4BJT9  

EC Number

3.5.4.3

Pubmed

19121390    28756777    26354079    22118469    26483478    17510324    + More
29403074    12364791    14747013    17210077    20966253    21719571    24845553    20798317    24438588    27289101    24495485    21347285    27129103    25315136    24487278    26108605    25474469    18563158    24508170    20075255    25348373    28648823    17495919    25830018    25244985    26334808    17554307    23371554   

EMBL

BABH01011629    BABH01011630    BABH01011631    BABH01011632    KZ149940    PZC76926.1    + More
NWSH01005147    PCG64403.1    RSAL01000155    RVE45654.1    KQ459582    KPI98732.1    AGBW02014660    OWR41262.1    KQ460075    KPJ17944.1    NEVH01020869    PNF20793.1    GBYB01010453    JAG80220.1    GBYB01010452    GBYB01010454    JAG80219.1    JAG80221.1    LBMM01000942    KMQ97177.1    QCYY01001815    ROT75048.1    GGFJ01005091    MBW54232.1    GEDC01029206    JAS08092.1    GGFJ01005092    MBW54233.1    JXUM01112253    KQ565576    KXJ70867.1    CH477267    EAT45494.1    PYGN01000453    PSN46074.1    JXUM01109795    KQ565354    KXJ71064.1    APCN01006072    NEVH01020861    PNF20939.1    KQ977059    KYN06027.1    KQ980581    KYN15270.1    ROT75045.1    AAAB01008810    EAA04787.4    GEDC01024687    JAS12611.1    GL888932    EGI57195.1    KK852470    KDR23222.1    GL436748    EFN71544.1    LNIX01000004    OXA56088.1    ATLV01018085    KE525212    KFB42696.1    GFTR01006124    JAW10302.1    AXCM01015211    LJIJ01000100    ODN02669.1    KQ981673    KYN38360.1    ACPB03015723    GAMC01006439    GAMC01006438    GAMC01006436    JAC00118.1    GAHY01001294    JAA76216.1    ADTU01011293    GFDL01000397    JAV34648.1    GDKW01001695    JAI54900.1    KQ982373    KYQ57007.1    GL448504    EFN84526.1    KA645614    AFP60243.1    KZ288189    PBC34613.1    LMAW01002370    KQK81427.1    IACF01001447    LAB67147.1    KZ505748    PKU45682.1    AXCN02001955    GCES01011101    JAR75222.1    JRES01001623    KNC21404.1    GBBI01001564    JAC17148.1    CP026251    AWP06866.1    GDHF01004301    JAI48013.1    GG666504    EEN61536.1    KK107459    EZA50395.1    GDHF01005762    JAI46552.1    GAKP01001818    JAC57134.1    NNAY01000364    OXU28872.1    AGTO01022003    GBXI01017136    GBXI01001828    JAC97155.1    JAD12464.1    KQ241941    KNC82283.1    KQ976500    KYM83189.1    KQ434827    KZC07509.1    LSYS01003700    OPJ82300.1    CM012445    RVE68395.1    GBGD01001531    JAC87358.1    GFDG01000867    JAV17932.1    AKCR02000015    PKK28566.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    + More
UP000235965    UP000036403    UP000283509    UP000069272    UP000069940    UP000249989    UP000008820    UP000075902    UP000245037    UP000075840    UP000078542    UP000078492    UP000007062    UP000075882    UP000075881    UP000007755    UP000027135    UP000000311    UP000198287    UP000076407    UP000075903    UP000030765    UP000075883    UP000094527    UP000078541    UP000075900    UP000015103    UP000075885    UP000005205    UP000075880    UP000075920    UP000075809    UP000007635    UP000261640    UP000095301    UP000261600    UP000192223    UP000008237    UP000242457    UP000265120    UP000051836    UP000075886    UP000265000    UP000037069    UP000264820    UP000246464    UP000001554    UP000053097    UP000265020    UP000002358    UP000215335    UP000016665    UP000257200    UP000264800    UP000002280    UP000005203    UP000054560    UP000078540    UP000076502    UP000190648    UP000261480    UP000076408    UP000095300    UP000261420    UP000242638    UP000257160    UP000001038    UP000053872    UP000192220   

PRIDE

H9JL57   

Pfam

PF13191   AAA_16        + More
PF00211   Guanylate_cyc
PF01979   Amidohydro_1

Interpro

IPR027417   P-loop_NTPase        + More
IPR041664   AAA_16       
IPR006680   Amidohydro-rel       
IPR029787   Nucleotide_cyclase       
IPR032466   Metal_Hydrolase       
IPR001054   A/G_cyclase       
IPR011059   Metal-dep_hydrolase_composite       
IPR014311   Guanine_deaminase       
IPR009057   Homeobox-like_sf       

SUPFAM

SSF51556   SSF51556        + More
SSF52540   SSF52540       
SSF55073   SSF55073       
SSF51338   SSF51338       
SSF46689   SSF46689       

Gene 3D

3.30.70.1230     2.30.40.10    

CDD

cd01303  GDEase

ProteinModelPortal

H9JL57   A0A2W1BW91   A0A2A4IZ65   A0A3S2NEU3   A0A194PZH4   A0A212EIE8   + More
A0A194RKJ7   A0A2J7PWT9   A0A0C9Q8A2   A0A0C9RBD1   A0A0J7L2Z9   A0A3R7QD88   A0A2M4BMH4   A0A1B6C3K9   A0A2M4BMP5   A0A182FD09   A0A182H5Q2   Q17FY0   A0A182UCB7   A0A2P8YPE3   A0A182H4K2   A0A182ICY7   A0A2J7PX84   A0A151IMC0   A0A195DQS9   A0A3R7MFK8   Q7QI65   A0A182KVU9   A0A1B6CGQ5   A0A182K8C0   F4X8A9   A0A067RHG4   E2A4V0   A0A226EFQ2   A0A182WRY2   A0A182VDR1   A0A084VXK2   A0A224XP13   A0A182M2H0   A0A1D2NBP2   A0A195FCJ6   A0A182RQC4   T1HSY2   W8BMV4   R4FNH3   A0A182PQ74   A0A158NBS1   A0A182JHU3   A0A182WK56   A0A1Q3G4C1   A0A0P4VQX0   A0A151X9F5   G3P9D3   A0A3Q3S187   A0A1I8NCE7   A0A3Q3IWW0   A0A1W4W3D1   E2BID8   T1PA96   A0A2A3ES42   A0A3P8W7T7   A0A0Q3PK98   A0A2P2HZE1   A0A2I0UI06   A0A182QLR4   A0A147AAI8   A0A0L0BQC6   A0A023F7D2   A0A3Q2Z4A8   A0A2U9BTJ2   A0A0K8W9Z6   C3YDR7   A0A026W2T5   A0A3Q2FQQ5   A0A0K8W659   K7ISG1   A0A034WR69   A0A232FDZ2   U3K852   A0A3Q1EWM2   A0A3Q2ZY33   F7DIF8   A0A087ZWZ2   A0A0A1XMB5   A0A0L0G262   A0A195BG59   A0A154P6F6   A0A1V4KCV1   A0A3S2P7E4   A0A3B3YVA7   A0A182YP18   A0A069DTH7   A0A1I8NY97   A0A3B4V846   A0A3P9NI71   A0A3Q1BB31   A0A1L8EGS1   H2M5A1   A0A2I0MFY5   A0A2I4BJT9  

PDB

4AQL     E-value=1.94305e-98,     Score=917

KEGG

101735528    K01487 guanine deaminase [EC:3.5.4.3] | (RefSeq) guanine deaminase

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016787   GO:0035556   GO:0009190   GO:0016849   GO:0006147   GO:0008270   GO:0008892   GO:0003677   GO:0046098   GO:0016810   GO:0006811   GO:0006032   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR11271:SF6  

Length:

444

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0069

Exp number, first 60 AAs:

0.00253

Total prob of N-in:

0.01273

outside

1  -  444

 

 

Pi

297.059165

Theta

191.307353

Tajima's D

1.453907

CLR

0.089438

CSRT

0.781560921953902

Interpretation

Uncertain