Silkworm Genome Informatics Database

Gene

KWMTBOMO03993

Pre Gene Modal

BGIBMGA010125

Annotation

NO-insensitive_guanylyl_cyclase_[Manduca_sexta]

Location

Bomo_Chr7(-):7824121-7863735 View in EpiBrowser

Full name

Guanylate cyclase

Location in the cell

Nuclear Reliability : 2.436

CDS

ATGTCCCTTGTTCCCCCTGGAGGCGCGGACTCTCCGAGTCCCCGGCGTGCTGTCAGCCCTTTACTGGAGATGCGAAGACCACACTGCACGTTGGCCTGCGACTATTGCGCGGCTATCTTGGAGGATAAGTTCAAACGCAGTTCTGAAACTAGGAACCGTGGCACTTCGCCATTATCAGCCTCCCCACGTCAATCTCTTACTGGAGAACCACCTTGGACCCTGCCAGATGACGATCGTCCCGATTTCTCAGCTTTGAAAGAAAATATACATAAGATCAACAAGGACTGTGAAACATCAACACGTTTGGATATGTTGCTCACTCAAGTGGAGCAATACGCCAACAATCTCGAAGCACTGGTCGAAGAAAGGACTTCAGATTACTTGGAGGAAAAACGGAAATGCGAAGAGCTTCTTTATCAGCTGCTACCCAAGTCTGTGGCATCTCAACTGATAATGGGACAACCAGTTATGGCTGAAACATACGATCAAGTTACAATCTACTTTAGTGACATCATTGGCTTCACTCAGCTCTCCGCGGAATCCACTCCTCTTGAAGTGGTGGATTTATTGAACGATTTGTACACGAATTTCGATTCCATCATTGAAAATTTTGATGTTTACAAGGTAGAAACAATAGGTGATGCGTATATGGTGGTCTCGGGTCTTCCGATGCGCAACGGTAACCGTCACGCTGCTGAGATCGCTCGCATGTCTCTGGCTCTCCTCGGAGCGGTGCGCGTGAAGACAGTTCCTCACAGACCAGGAGAACGGCTGCTCTTGAGAATCGGGATGCATACTGGTCCATGTGTGGCTGGTGTGGTTGGCTTAAAGATGCCAAGATACTGCCTCTTCGGCGATACAGTGAATACTGCTTCAAGAATGGAGTCACATGGCGAAGCCCTACGAATACACGTCAGTCCCAAAACCAAAGAAGTATTGGATTTATATGATTGTTTTGAACTGGAATGCAGAGGTCAGATTACAATGAAGGGTAAAGGCGAAATGACAACATACTGGCTAATCGGTGAAAAAACGCCACAAAACAAATACGTACCAACAGAAGAAGCTAATTTACAAAGCACCACCGTGACAAATCCTAGTATCACATTCCAGGGTCCGGATAGTCCTGCCGCGCATTCGCTCACCCAAAGTCACAGTCCAGAACAAATGGACGTTAAGGAAACCAGCAATCACCGGCCGCTTGAGATAATGAACGAAAGAGATCGTATCAAACACGAAATAGCGTCATTCGTGGCCAAAGATCTCATAAACAATATAGACAATGCTGTGAGAGAATTCAGAAAATCACAAAGCGCTAACTTCGCTAACTCAATGACGAACACAAAGCTATTGTGTAATGGCAATGAGAAAGGCCTAATTACACCGACATACGATAAAGAATTGGTCATCAGCAAAGGCAAAGTACGCGATGTCGTTAACAGATTCAACAGTTGCATTATAACTACGAATGATAATAATCTAAATAAAACACAAAAAATAAAGGCGACGAACGCTGAATAA

Protein

MSLVPPGGADSPSPRRAVSPLLEMRRPHCTLACDYCAAILEDKFKRSSETRNRGTSPLSASPRQSLTGEPPWTLPDDDRPDFSALKENIHKINKDCETSTRLDMLLTQVEQYANNLEALVEERTSDYLEEKRKCEELLYQLLPKSVASQLIMGQPVMAETYDQVTIYFSDIIGFTQLSAESTPLEVVDLLNDLYTNFDSIIENFDVYKVETIGDAYMVVSGLPMRNGNRHAAEIARMSLALLGAVRVKTVPHRPGERLLLRIGMHTGPCVAGVVGLKMPRYCLFGDTVNTASRMESHGEALRIHVSPKTKEVLDLYDCFELECRGQITMKGKGEMTTYWLIGEKTPQNKYVPTEEANLQSTTVTNPSITFQGPDSPAAHSLTQSHSPEQMDVKETSNHRPLEIMNERDRIKHEIASFVAKDLINNIDNAVREFRKSQSANFANSMTNTKLLCNGNEKGLITPTYDKELVISKGKVRDVVNRFNSCIITTNDNNLNKTQKIKATNAE

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Feature

chain Guanylate cyclase

Uniprot

O77149 A0A2H1WXY1 A0A2A4JZB0 A0A2W1BYS8 A0A194QYW0 A0A212EWA1 + More
A0A194QJ75 A0A0C9RFT0 A0A2J7RLU7 A0A2A3ECG2 A0A310S7E6 A0A2A3EEE4 A0A026WB13 A0A0P5AST5

EC Number

4.6.1.2

Pubmed

9933648 28756777 26354079 22118469 24508170

EMBL

AF073342 AAC62238.1 ODYU01011479 SOQ57234.1 NWSH01000377 PCG76843.1 + More
KZ149940 PZC76933.1 KQ460930 KPJ10723.1 AGBW02012068 OWR45737.1 KQ459167 KPJ03506.1 GBYB01005871 JAG75638.1 NEVH01002683 PNF41806.1 KZ288287 PBC29380.1 KQ777939 OAD52019.1 PBC29381.1 KK107293 EZA53250.1 GDIP01198510 JAJ24892.1

Proteomes

UP000218220 UP000053240 UP000007151 UP000053268 UP000235965 UP000242457 + More
UP000053097

Pfam

PF00211   Guanylate_cyc        + More
PF07701   HNOBA
PF01094   ANF_receptor
PF00069   Pkinase
PF07714   Pkinase_Tyr

Interpro

IPR018297   A/G_cyclase_CS        + More
IPR029787   Nucleotide_cyclase
IPR001054   A/G_cyclase
IPR011645   HNOB_dom_associated
IPR001828   ANF_lig-bd_rcpt
IPR001170   ANPR/GUC
IPR011009   Kinase-like_dom_sf
IPR028082   Peripla_BP_I
IPR000719   Prot_kinase_dom
IPR001245   Ser-Thr/Tyr_kinase_cat_dom

SUPFAM

SSF55073   SSF55073        + More
SSF56112   SSF56112
SSF53822   SSF53822

Gene 3D

3.30.70.1230

ProteinModelPortal

O77149 A0A2H1WXY1 A0A2A4JZB0 A0A2W1BYS8 A0A194QYW0 A0A212EWA1 + More
A0A194QJ75 A0A0C9RFT0 A0A2J7RLU7 A0A2A3ECG2 A0A310S7E6 A0A2A3EEE4 A0A026WB13 A0A0P5AST5

PDB

3ET6 E-value=2.78267e-43, Score=442

KEGG

101743950 K12323 atrial natriuretic peptide receptor A [EC:4.6.1.2] | (RefSeq) atrial natriuretic peptide rece

PATHWAY

00230 Purine metabolism - Bombyx mori (domestic silkworm)
01100 Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0035556 GO:0000166 GO:0016021 GO:0016849 GO:0009190 GO:0004383 GO:0004672 GO:0005524 GO:0006182 GO:0005216 GO:0006811 GO:0006032 GO:0048384

Length:

506

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05074

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00040

outside

1 - 506

Pi

230.734322

Theta

19.865609

Tajima's D

0.203809

CLR

1.666981

CSRT

0.432128393580321

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics