Gene

KWMTBOMO03990

Pre Gene Modal

BGIBMGA010254

Annotation

PREDICTED:_trypsin-7-like_[Amyelois_transitella]

Location

Bomo_Chr7(+):7713626-7714569      View in EpiBrowser

Full name

Transmembrane protease serine 3       + More
Alpha-fibrinogenase-like      
Snake venom serine protease ussurin      
Snake venom serine protease homolog 1      
Kallikrein 1-related peptidase b11      
Venom serine proteinase-like protein      

Alternative Name

Serine protease TADG-12
Tumor-associated differentially-expressed gene 12 protein
Snake venom serine protease
Glandular kallikrein K11
Tissue kallikrein-11
SP1
Snake venom serine protease homolog

Location in the cell

Extracellular   Reliability : 1.12

CDS

ATGAAGATAAATAGACGATGTAGCGGTTCTATTATTGATAAAAATTGGATAATAACAGCGGCCCATTGCGTCGTGGGACCGCTGAGAAGCGTTCGAGTTTACCACACGAGTGAATATTTTACAACCAAGCTTATTGCCAGAGTCGATCCTCAGAATGTGTTCAACAAGGACTTCGTGAAGGGTTCGAAAACCGTGAGTAATGAGGAAAATGATTTGGCGTTGTTGAAAACTCGTCGTCCGATTACCTTTAATGATAATATAGAACCAGTACTATTGGCTTCATACCCGATGGAGTTTGGACAAGTCGGAATCATTGCGGGTTACGGCAAGTCCGAGTCTAATGCATCCAAGCCGAGAGAAGGTGCAGTGCGAATAATTGACTGCAAATACACTATTGGTACTGATTTACTGTGTTCTGTTGGCGCAGTCAGGGCTGGGTCCGGAGATTCTGGGGGACCATTGATTTCAGAAGGTCGACTTCATGGCATAATAACACAGAGCTGTTCTGACGTAGAGATTAACAAGTTTTGTGTCACTATCTATGTTGATGTTGTCGTAAATTTGAATTGGATTCAGAACGTCATGGATTCGTCAATCAAGACTCAGGTTTTTTGA

Protein

MKINRRCSGSIIDKNWIITAAHCVVGPLRSVRVYHTSEYFTTKLIARVDPQNVFNKDFVKGSKTVSNEENDLALLKTRRPITFNDNIEPVLLASYPMEFGQVGIIAGYGKSESNASKPREGAVRIIDCKYTIGTDLLCSVGAVRAGSGDSGGPLISEGRLHGIITQSCSDVEINKFCVTIYVDVVVNLNWIQNVMDSSIKTQVF

Description

Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro).
Degrades alpha chain of fibrinogen (FGA), and has strong caseinolytic activity. Cleaves oxidized insulin B-chain at '40-Tyr-|-Leu-41', '48-Phe-|-Phe-49' and '49-Phe-|-Tyr-50', and glucagon at the bonds '62-Tyr-|-Ser-63', 66-Leu-|-Asp-67' and '78-Leu-|-Met-79' bonds.
Snake venom serine protease that may act in the hemostasis system of the prey.

Catalytic Activity

Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Subunit

Monomer.

Similarity

Belongs to the peptidase S1 family.
Belongs to the peptidase S1 family. Snake venom subfamily.
Belongs to the peptidase S1 family. Kallikrein subfamily.

Keywords

Alternative splicing   Autocatalytic cleavage   Complete proteome   Deafness   Disease mutation   Disulfide bond   Endoplasmic reticulum   Glycoprotein   Hydrolase   Membrane   Non-syndromic deafness   Polymorphism   Protease   Reference proteome   Serine protease   Signal-anchor   Transmembrane   Transmembrane helix   Zymogen   Fibrinogenolytic toxin   Hemostasis impairing toxin   Secreted   Signal   Toxin   Serine protease homolog  

Feature

chain  Transmembrane protease serine 3
splice variant  In isoform B.
sequence variant  In dbSNP:rs928302.
propeptide  Activation peptide

Uniprot

H9JL53   A0A2W1BPL2   A0A3B3UVR3   A0A336K3T8   A0A0M4F4W3   A0A1I7Z146   + More
B0VXU1   A0A1W4YHB1   A0A3B0K371   A0A0P7XUM9   A0A2W1BBX9   A0A2A4JNN7   A0A3Q2DDC1   A0A087QK60   A0A1A8AXS9   A0A3B5B6X6   A0A3B4TI40   K7FHL6   A0A3Q0G8J3   A0A3B4AAH6   A0A1A8S8U1   A0A3B5B708   A0A151NEI1   A0A2I7YS39   A0A1W4VHY9   A0A3B4CRW5   A0A146UZ51   A0A0K8W5B4   B4GYY5   Q29B86   A0A2I7YS93   A0A3Q0FPM8   W5L8F3   A0A091RXF0   Q98TH0   A0A151N948   A0A3B5BL60   D5KRX9   A0A3B4XPN0   K7F234   B4QIV7   A0A3B3IAQ9   T1DP67   A0A2I7YSB7   T1DE77   A0A1W7RB93   A0A093IXP4   A0A146UXL9   B4QIV5   A0A0K8RYM8   E7FDP9   P57727-2   A0A146UXA2   A0A3B4UG61   A0A3Q2XA31   A0A1A9Z6S9   A0A3Q3X1C1   Q6DIW2   A0A3Q2DGI8   T1DGZ7   A0A3Q3MTZ1   A0A3B4WG00   E5L0E3   H2Y5L9   T1PCU8   A0A3B4XPJ6   A0A0A1WVK7   A0A147AMU1   A0A1I7Z826   A0A383ZCH1   Q8UUJ2   A0A146UXJ5   A0A146UXG2   A0A1U7SF32   A0A3B5KLE7   A0A1I8M683   A0A0L0CBW3   Q8AY82   P57727   Q7ZZ80   A0A1I8Q3Z7   P57727-6   A0A286S0E4   A0A3B4T667   A0A1R3UDS6   P15946   A0A1I8PDH9   G5EMQ8   A0A0A1X4Q7   Q9GSM9   B4GYY3   A0A2I7YS75   A0A3Q3IL03   B6CGL8   Q9DF68   A0A383ZCI6   H2Y5M0   A0A3P8WH93   P57727-5  

EC Number

3.4.21.-
3.4.21.35

Pubmed

19121390    28756777    26392177    18096037    17381049    25463417    + More
22293439    29329419    17994087    15632085    25329095    14961394    17554307    26358130    25727380    23594743    11068177    11137999    15447792    12975309    14702039    10830953    15489334    12393794    11462234    11424922    11907649    16021470    23758969    21640745    25830018    21551351    25315136    26108605    28554670    28224083    3848399    3205728    3036794    11520682    24487278   

EMBL

BABH01011612    KZ149940    PZC76918.1    UFQS01000040    UFQT01000040    SSW98228.1    + More
SSX18614.1    CP012526    ALC46482.1    DQ464246    ABG26975.1    OUUW01000005    SPP80399.1    JARO02019797    KPP56634.1    KZ150183    PZC72478.1    NWSH01000974    PCG73328.1    KL225709    KFM01614.1    HADY01021497    SBP59982.1    AGCU01127025    HAEH01022436    SBS13959.1    AKHW03003238    KYO34935.1    MF974467    AUS82501.1    GCES01076476    JAR09847.1    GDHF01006008    JAI46306.1    CH479198    EDW28003.1    CM000070    EAL27110.2    MF974511    AUS82545.1    KK935312    KFQ46884.1    AB041929    BAB40329.1    AKHW03003697    KYO33350.1    GU592439    ADE45139.1    AGCU01044832    CM000363    EDX09382.1    GAKR01000009    JAA97976.1    MF974536    AUS82570.1    GAKQ01000010    JAA97959.1    GFHW01000055    JAV48393.1    KK601514    KFW06443.1    GCES01076472    JAR09851.1    EDX09380.1    GBKD01001542    GDBD01000088    JAG46076.1    JAS04810.1    CU062628    AF201380    AB038157    AB038158    AB038159    AB038160    AY633572    AY358458    AK172842    AP001623    CH471079    BC074846    BC074847    GCES01076473    JAR09850.1    BC075423    AAH75423.1    GAAZ01003083    GBKC01002452    GDBC01000056    JAA94860.1    JAG43618.1    JAS04748.1    HQ270464    KA645783    AFP60412.1    GBXI01011435    JAD02857.1    GCES01006405    JAR79918.1    AF444250    GCES01076470    JAR09853.1    GCES01076471    JAR09852.1    JRES01000728    KNC28934.1    AF545575    AL672083    CAD61105.1    KY129935    ASX97876.1    LT631588    SFW93235.1    X13215    X13216    X13217    X13218    BC013660    M18590    M18610    AB678427    BAL14139.1    GBXI01008547    JAD05745.1    AF302472    AAG30233.1    EDW28001.1    MF974492    AUS82526.1    EU163287    ABX89621.1    AF292110   

Proteomes

UP000005204    UP000261500    UP000092553    UP000095287    UP000192224    UP000268350    + More
UP000034805    UP000218220    UP000265020    UP000053286    UP000261400    UP000261420    UP000007267    UP000189705    UP000261520    UP000050525    UP000192221    UP000261440    UP000008744    UP000001819    UP000018467    UP000261360    UP000000304    UP000001038    UP000000437    UP000005640    UP000264820    UP000092445    UP000261620    UP000261640    UP000007875    UP000261681    UP000005226    UP000095301    UP000037069    UP000095300    UP000000589    UP000261600    UP000265120   

PRIDE

H9JL53    P57727    P15946   

Pfam

PF00089   Trypsin        + More
PF15494   SRCR_2
PF09272   Hepsin-SRCR
PF00057   Ldl_recept_a
PF00051   Kringle

Interpro

IPR001314   Peptidase_S1A        + More
IPR009003   Peptidase_S1_PA       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR001190   SRCR       
IPR036772   SRCR-like_dom_sf       
IPR017448   SRCR-like_dom       
IPR033116   TRYPSIN_SER       
IPR012224   Pept_S1A_FX       
IPR015352   Hepsin-SRCR_dom       
IPR002172   LDrepeatLR_classA_rpt       
IPR023415   LDLR_class-A_CS       
IPR036055   LDL_receptor-like_sf       
IPR018056   Kringle_CS       
IPR013806   Kringle-like       
IPR000001   Kringle       
IPR038178   Kringle_sf       

SUPFAM

SSF50494   SSF50494        + More
SSF56487   SSF56487       
SSF57424   SSF57424       
SSF57440   SSF57440       

Gene 3D

3.10.250.10     4.10.400.10     2.40.20.10    

CDD

cd00190  Tryp_SPc
cd00112  LDLa
cd00108  KR

ProteinModelPortal

H9JL53   A0A2W1BPL2   A0A3B3UVR3   A0A336K3T8   A0A0M4F4W3   A0A1I7Z146   + More
B0VXU1   A0A1W4YHB1   A0A3B0K371   A0A0P7XUM9   A0A2W1BBX9   A0A2A4JNN7   A0A3Q2DDC1   A0A087QK60   A0A1A8AXS9   A0A3B5B6X6   A0A3B4TI40   K7FHL6   A0A3Q0G8J3   A0A3B4AAH6   A0A1A8S8U1   A0A3B5B708   A0A151NEI1   A0A2I7YS39   A0A1W4VHY9   A0A3B4CRW5   A0A146UZ51   A0A0K8W5B4   B4GYY5   Q29B86   A0A2I7YS93   A0A3Q0FPM8   W5L8F3   A0A091RXF0   Q98TH0   A0A151N948   A0A3B5BL60   D5KRX9   A0A3B4XPN0   K7F234   B4QIV7   A0A3B3IAQ9   T1DP67   A0A2I7YSB7   T1DE77   A0A1W7RB93   A0A093IXP4   A0A146UXL9   B4QIV5   A0A0K8RYM8   E7FDP9   P57727-2   A0A146UXA2   A0A3B4UG61   A0A3Q2XA31   A0A1A9Z6S9   A0A3Q3X1C1   Q6DIW2   A0A3Q2DGI8   T1DGZ7   A0A3Q3MTZ1   A0A3B4WG00   E5L0E3   H2Y5L9   T1PCU8   A0A3B4XPJ6   A0A0A1WVK7   A0A147AMU1   A0A1I7Z826   A0A383ZCH1   Q8UUJ2   A0A146UXJ5   A0A146UXG2   A0A1U7SF32   A0A3B5KLE7   A0A1I8M683   A0A0L0CBW3   Q8AY82   P57727   Q7ZZ80   A0A1I8Q3Z7   P57727-6   A0A286S0E4   A0A3B4T667   A0A1R3UDS6   P15946   A0A1I8PDH9   G5EMQ8   A0A0A1X4Q7   Q9GSM9   B4GYY3   A0A2I7YS75   A0A3Q3IL03   B6CGL8   Q9DF68   A0A383ZCI6   H2Y5M0   A0A3P8WH93   P57727-5  

PDB

3W94     E-value=9.77168e-14,     Score=183

KEGG

101743799    no KO assigned | (RefSeq) alpha-fibrinogenase-like

GO

GO:0004252   GO:0016021   GO:0007596   GO:0005509   GO:0005044   GO:0008236   GO:0005737   GO:0016020   GO:0006508   GO:0005615   GO:0005783   GO:0007605   GO:0043025   GO:0005789   GO:0006883   GO:0017080   GO:0090729   GO:0005576   GO:0016811   GO:0031638   GO:0003073   GO:0004175   GO:0030141   GO:0032991   GO:0006281   GO:0008094   GO:0005216   GO:0006811   GO:0006032   GO:0004672   GO:0048384  

Subcellular location

Endoplasmic reticulum membrane  
Secreted  

Length:

204

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.21593

Exp number, first 60 AAs:

0.05284

Total prob of N-in:

0.32371

outside

1  -  204

 

 

Pi

290.817584

Theta

206.269672

Tajima's D

1.290351

CLR

0.673106

CSRT

0.736763161841908

Interpretation

Uncertain