Gene

KWMTBOMO03981  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010249

Annotation

PREDICTED:_regucalcin-like_[Bombyx_mori]

Location

Bomo_Chr7(+):7502741-7504058      View in EpiBrowser

Full name

Regucalcin      

Alternative Name

Gluconolactonase
Senescence marker protein 30

Location in the cell

Extracellular   Reliability : 0.916

CDS

ATGGATTTTTCTAGCAATGACTATGACGGAGCAATGCCTGACGGCATGACTATTGACAGTCAAGGACGGCTTTGGGTCGCTTTGTTATTCGGTGGAACAGTTTTACACATAGATCCGGACACAAGAAAAGTAATCTACACCTATAAGCTACCAGTTTCCAGGATCACCTCCGTATGCTGGGGAGGACCAAATCTTGACGAACTATTCGTCACTACAGCTCAGGAGAAAGCTGAACCCAAATCAGAACCACTTGGTGGTGCGATATTCACTATACGGGATACAGGATATCGAGGTCTGCCCCCTAACACCTTTCGATTCGATAATGCTGACAACTATTAA

Protein

MDFSSNDYDGAMPDGMTIDSQGRLWVALLFGGTVLHIDPDTRKVIYTYKLPVSRITSVCWGGPNLDELFVTTAQEKAEPKSEPLGGAIFTIRDTGYRGLPPNTFRFDNADNY

Description

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).

Catalytic Activity

D-glucono-1,5-lactone + H2O = D-gluconate + H(+)

Similarity

Belongs to the SMP-30/CGR1 family.

Keywords

Ascorbate biosynthesis   Calcium   Complete proteome   Cytoplasm   Hydrolase   Metal-binding   Reference proteome  

Feature

chain  Regucalcin

Uniprot

H9JL48   A0A2W1BPN9   A0A3S2LU12   A0A194R0G2   A0A194QD98   A0A0N1IC66   + More
A0A212EYC9   A0A2H1V3A7   A0A2A4JGT7   A0A3S2TF78   A0A2W1BUS9   H9JKT2   A0A2H1W032   A0A2P6KKY8   W5MN57   A0A2T7NRT4   K7J5D9   A0A194QZ50   A0A194QJ92   A0A2W1BVX6   A0A1W6EW18   A0A2L2XY40   A0A1B6BZ00   A0A131XYK8   A0A154PHW9   G1NPH8   A0A087SYW0   A0A1A8KUW7   M9NHL6   A0A1E1XII3   A0A1A8DWQ1   A0A1G2V704   H1A2E1   A0A2P6N266   A0A2P8Y3D2   A0A3P9J7P3   A0A2G9RWB5   A0A093GFD6   A0A093P5I8   A0A3B3HZ15   A0A3Q3NCF2   A0A3B3ILB1   G1KWI6   A0A3Q7N252   A0A091NFZ5   Q6DF62   A0A2I0ML43   A0A094LUN2   A0A3Q7MZ31   A0A0H4B944   A0A2T7NRT2   A0A3B4X9B4   A0A3M6UDB5   A0A1A8HL13   A0A1Y1KUS1   A0A1A8MXV4   A0A1A8CI06   A0A1A8IYK7   A0A1A8AP47   A0A1A8S7Q3   A0A1A8UWU3   A0A091F1S2   A0A3B4TJM6   A0A1A8FA96   A0A1A8PS65   G3MHQ9   B6RB14   H2ZTZ7   A0A091HFD7   V5HXG9   H0ZK44   A0A091VSY5   A0A3L8STE9   A0A091NGA9   U3JNE0   A0A3B4EE75   A0A1L8H8S4   A0A3B4D1Y8   B3RS39   A0A369S2P1   A0A023GBW8   A0A3B4EFQ2   A0A087R601   A0A2I0TKE3   G3ULN3   A0A093IQY6   A0A0P7U1V3   A0A3R7M6K0   B7ZQJ6   Q9I922   A0A099ZHM1   A0A224YNE9   A0A0A0ABM5   K7G2B2   A0A091IX64   A0A3S2MVP6   A0A1W4ZX49   I4DP01   A0A093JHF2  

Pubmed

19121390    28756777    26354079    22118469    20075255    26561354    + More
20838655    28503490    27774985    20360741    29378020    29403074    17554307    23371554    30382153    28004739    22216098    9215903    25765539    30282656    27762356    18719581    30042472    10891565    10727865    28797301    17381049    22651552   

EMBL

BABH01011590    BABH01011591    BABH01011592    KZ149940    PZC76948.1    RSAL01000202    + More
RVE44407.1    KQ460930    KPJ10735.1    KQ459167    KPJ03518.1    KQ458926    KPJ04556.1    AGBW02011577    OWR46467.1    ODYU01000453    SOQ35279.1    NWSH01001580    PCG70804.1    RVE44406.1    PZC76947.1    ODYU01005526    SOQ46459.1    MWRG01009688    PRD26954.1    AHAT01003387    PZQS01000010    PVD23868.1    AAZX01008996    KPJ10737.1    KPJ03521.1    PZC76950.1    KY563502    ARK19911.1    IAAA01006218    LAA00886.1    GEDC01030791    GEDC01000836    JAS06507.1    JAS36462.1    GEFM01003483    JAP72313.1    KQ434912    KZC11423.1    KK112598    KFM58049.1    HAEE01015948    SBR35998.1    JN036578    AFJ24877.1    GFAC01000292    JAT98896.1    HAEA01009882    SBQ38362.1    MHWZ01000021    OHB17417.1    ABQF01079663    MDYQ01000244    PRP78043.1    PYGN01000977    PSN38763.1    KV932667    PIO32197.1    KL216283    KFV68945.1    KL225453    KFW72238.1    KK846306    KFP87824.1    BC076881    AAH76881.1    AKCR02000007    PKK30401.1    KL279457    KFZ67234.1    CP011941    AKN61048.1    PVD23866.1    RCHS01001791    RMX51418.1    HAEC01015926    SBQ84147.1    GEZM01075834    GEZM01075833    JAV63930.1    HAEF01020180    SBR61339.1    HADZ01015408    SBP79349.1    HAED01015989    SBR02434.1    HADY01018324    SBP56809.1    HAEH01022234    SBS13618.1    HAEJ01011599    SBS52056.1    KK718333    KFO55830.1    HAEB01008527    SBQ55054.1    HAEI01003363    SBR84290.1    JO841410    AEO33027.1    EF103358    ABO26616.1    AFYH01211926    AFYH01211927    AFYH01211928    KL536517    KFO94591.1    GANP01005235    JAB79233.1    ABQF01013078    KL411326    KFR05618.1    QUSF01000007    RLW07822.1    KL383186    KFP88753.1    AGTO01020369    CM004469    OCT92514.1    DS985243    EDV26451.1    NOWV01000094    RDD40684.1    GBBM01005258    JAC30160.1    KL226137    KFM08905.1    KZ509255    PKU34287.1    KK565564    KFW04043.1    JARO02004669    KPP68102.1    QCYY01002660    ROT68491.1    BC169832    BC170119    CM004468    AAI69832.1    OCT95346.1    AB037936    AB033368    BAA90694.1    BAA93719.1    KL894601    KGL81884.1    GFPF01007982    MAA19128.1    KL871155    KGL90923.1    AGCU01170705    AGCU01170706    KL218306    KFP04211.1    CM012438    RVE75544.1    AK403222    BAM19641.1    KK609654    KFW11292.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000218220    + More
UP000018468    UP000245119    UP000002358    UP000076502    UP000001645    UP000054359    UP000007754    UP000241769    UP000245037    UP000265200    UP000053875    UP000054081    UP000001038    UP000261640    UP000001646    UP000286641    UP000008143    UP000053872    UP000036265    UP000261360    UP000275408    UP000052976    UP000261420    UP000008672    UP000053283    UP000276834    UP000016665    UP000261440    UP000186698    UP000009022    UP000253843    UP000053286    UP000007646    UP000034805    UP000283509    UP000053641    UP000053858    UP000007267    UP000054308    UP000192224   

PRIDE

H9JL48    H9JKT2    Q6DF62    V5HXG9    Q9I922   

Pfam

PF00249   Myb_DNA-binding        + More
PF08450   SGL
PF16498   SWIRM-assoc_3
PF16496   SWIRM-assoc_2
PF16495   SWIRM-assoc_1
PF04433   SWIRM
PF01825   GPS
PF07714   Pkinase_Tyr

Interpro

IPR013658   SGL        + More
IPR032450   SMARCC_N       
IPR032451   SMARCC_C       
IPR032448   SWIRM-assoc       
IPR001005   SANT/Myb       
IPR036388   WH-like_DNA-bd_sf       
IPR017884   SANT_dom       
IPR036420   BRCT_dom_sf       
IPR009057   Homeobox-like_sf       
IPR011042   6-blade_b-propeller_TolB-like       
IPR030087   BAF155       
IPR007526   SWIRM       
IPR005511   SMP-30       
IPR039096   SMP-30/CGR1       
IPR008367   Regucalcin       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR032675   LRR_dom_sf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR000203   GPS       

SUPFAM

SSF46689   SSF46689        + More
SSF52113   SSF52113       
SSF56112   SSF56112       

Gene 3D

1.10.10.10     2.120.10.30     3.80.10.10    

CDD

cd00167  SANT

ProteinModelPortal

H9JL48   A0A2W1BPN9   A0A3S2LU12   A0A194R0G2   A0A194QD98   A0A0N1IC66   + More
A0A212EYC9   A0A2H1V3A7   A0A2A4JGT7   A0A3S2TF78   A0A2W1BUS9   H9JKT2   A0A2H1W032   A0A2P6KKY8   W5MN57   A0A2T7NRT4   K7J5D9   A0A194QZ50   A0A194QJ92   A0A2W1BVX6   A0A1W6EW18   A0A2L2XY40   A0A1B6BZ00   A0A131XYK8   A0A154PHW9   G1NPH8   A0A087SYW0   A0A1A8KUW7   M9NHL6   A0A1E1XII3   A0A1A8DWQ1   A0A1G2V704   H1A2E1   A0A2P6N266   A0A2P8Y3D2   A0A3P9J7P3   A0A2G9RWB5   A0A093GFD6   A0A093P5I8   A0A3B3HZ15   A0A3Q3NCF2   A0A3B3ILB1   G1KWI6   A0A3Q7N252   A0A091NFZ5   Q6DF62   A0A2I0ML43   A0A094LUN2   A0A3Q7MZ31   A0A0H4B944   A0A2T7NRT2   A0A3B4X9B4   A0A3M6UDB5   A0A1A8HL13   A0A1Y1KUS1   A0A1A8MXV4   A0A1A8CI06   A0A1A8IYK7   A0A1A8AP47   A0A1A8S7Q3   A0A1A8UWU3   A0A091F1S2   A0A3B4TJM6   A0A1A8FA96   A0A1A8PS65   G3MHQ9   B6RB14   H2ZTZ7   A0A091HFD7   V5HXG9   H0ZK44   A0A091VSY5   A0A3L8STE9   A0A091NGA9   U3JNE0   A0A3B4EE75   A0A1L8H8S4   A0A3B4D1Y8   B3RS39   A0A369S2P1   A0A023GBW8   A0A3B4EFQ2   A0A087R601   A0A2I0TKE3   G3ULN3   A0A093IQY6   A0A0P7U1V3   A0A3R7M6K0   B7ZQJ6   Q9I922   A0A099ZHM1   A0A224YNE9   A0A0A0ABM5   K7G2B2   A0A091IX64   A0A3S2MVP6   A0A1W4ZX49   I4DP01   A0A093JHF2  

PDB

4GNC     E-value=8.14972e-19,     Score=223

KEGG

101743375    K01053 gluconolactonase [EC:3.1.1.17] | (RefSeq) regucalcin-like

PATHWAY

00030    Pentose phosphate pathway - Bombyx mori (domestic silkworm)
00053    Ascorbate and aldarate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0071564   GO:0016514   GO:0003677   GO:0071565   GO:0005509   GO:0030234   GO:0019853   GO:0004341   GO:0004672   GO:0016021   GO:0005524   GO:0050848   GO:0006874   GO:0032781   GO:0005634   GO:0005737   GO:0008270  

PANTHER

PTHR12802:SF9   PTHR10907  

Subcellular location

Nucleus  
Cytoplasm  

Length:

112

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

8.13809999999999

Exp number, first 60 AAs:

8.13495

Total prob of N-in:

0.11900

outside

1  -  112

 

 

Pi

294.609467

Theta

208.45948

Tajima's D

1.304617

CLR

0.207399

CSRT

0.741062946852657

Interpretation

Uncertain