Gene
KWMTBOMO03980
Pre Gene Modal
BGIBMGA010133
Annotation
PREDICTED:_regucalcin-like_isoform_X1_[Papilio_xuthus]
Full name
Regucalcin
Alternative Name
Gluconolactonase
Senescence marker protein 30
Senescence marker protein 30
Location in the cell
Cytoplasmic Reliability : 1.181
Sequence
CDS
ATGTATACCAAGGTTGTTTTGAAAAGAGGTCTCATTCTGATTGTGGTGTTTTTTTTTAAAATAACAGCTTTTAGATCATCGACACCGTTAATAAAAAATGTACACAGAGGCGGAATACATTACGAAGGACCACATTGGTCAACGTCAGAGAATGCTCTCTACTGGGTGGACATTCATGGACAGCAAATACTTAAATTGGACGCTGCATCAGGAAACGTAACCAGCAGGGCTATTGGCTACGGTCCCGTATCATTAGCGGTGACAGTCAAGGACAATCCCAAGCTTCTGTTGATTTCCGTAAGGTCAGAATTGTATTTGATGCCTTGGGACGCGCCGGCGGGAGACAGTGCTCTGAGGCTCCTAAGCGTTGTAGATTTAGGCTTGCCTGATAATAGATGCAACGATGGAAAAGTTGACGCAAACGGAAGACTTTGGTTCGGTACAATGGGCAAGGAGGTTGGAAATGATGTAGACAAAGATCAAGCAACACTTTATATGTTGGACGAAGGGAATTACTTGCATCCAAGCCACAAAGTTCGTCCAGTGTCTGTGTCCAATGGCATAGCTTGGACATCAGACAATACATTTATGTTCTACATAGACACACCTACCGGGAATATTGATGTGTTCAATTTTGATCTGGAGGAAGGAACTATTAGAAACCGAAGAACACTTTTTAGTTTTAAAGCAAATAATGTGACGGGCATGCCTGATGGAATGACTATTGATGATGAAGGCAACTTGTGGGTTGCATGTTTTAATGGTGGAAAGGTAATCAAAATAGATTCTCGAGCAGGAAAACTTTTGGAGCAACATAAGCTACCAGCCCAGAAAGTAACTTCAGTTATGTGGGGAGGTCATGACTTGTCCACCCTGTTTGTGACTACAAGTAGGGTTGGACTAACACCTGTGGAACAAGCTCAACAACCTGAGGCAGGCTCATTATTCGCCATTGAAGGAACAGGGTCAAAAGGCTTACCAGAAAATCAATTTGTCTTTACAGATGCTGCTAATTATTAA
Protein
MYTKVVLKRGLILIVVFFFKITAFRSSTPLIKNVHRGGIHYEGPHWSTSENALYWVDIHGQQILKLDAASGNVTSRAIGYGPVSLAVTVKDNPKLLLISVRSELYLMPWDAPAGDSALRLLSVVDLGLPDNRCNDGKVDANGRLWFGTMGKEVGNDVDKDQATLYMLDEGNYLHPSHKVRPVSVSNGIAWTSDNTFMFYIDTPTGNIDVFNFDLEEGTIRNRRTLFSFKANNVTGMPDGMTIDDEGNLWVACFNGGKVIKIDSRAGKLLEQHKLPAQKVTSVMWGGHDLSTLFVTTSRVGLTPVEQAQQPEAGSLFAIEGTGSKGLPENQFVFTDAANY
Summary
Description
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity).
Catalytic Activity
D-glucono-1,5-lactone + H2O = D-gluconate + H(+)
Subunit
Monomer.
Similarity
Belongs to the SMP-30/CGR1 family.
Keywords
Ascorbate biosynthesis
Calcium
Complete proteome
Cytoplasm
Hydrolase
Metal-binding
Reference proteome
Feature
chain Regucalcin
Uniprot
A0A2W1BVX6
A0A2H1W032
H9JKT2
A0A194QJ92
A0A194QZ50
A0A212EV56
+ More
A0A2W1BPN9 A0A194QD98 A0A194R0G2 A0A067QH68 K7J5D9 A0A2J7PX68 A0A1W6EW18 A0A224XUC0 A0A0J7KWI6 A0A2H1V3A7 A0A1B6LVI4 A0A3S2LU12 H9JL48 A0A1B6KMD5 A0A1W6EWA9 A0A212EYC9 A0A1B6E8A7 E2AGQ0 A0A195BA50 A0A3S2TF78 A0A158NKR2 A0A2A4JGT7 R4G322 T1HLA6 A0A151IV06 A0A154PHW9 E9IDS8 F4W8D2 A0A2W1BUS9 T1HLF0 A0A026WSS1 A0A3L8DAN9 D6X0J7 A0A0C9PVI0 A0A0C9REN7 A0A1D2NDD8 A0A195C416 A0A0L7RAD2 A0A2A3E1I8 V9IID5 D6X0J5 A0A0M8ZQU0 E0W247 A0A1W4XIB0 A0A2A3E259 A0A087ZSJ2 A0A154PHY1 A0A310SQM9 J3JZF0 V5GNF0 A0A0L7RA20 U4U594 U4U9P7 A0A2H8TR03 N6UBU7 E0XEM8 A0A2P8Z9M7 C4WUM8 A0A226DLD5 D6X0J6 A0A2J7PV34 A0A226F399 A0A1B6DWB3 J9JSL2 J9LYB7 A0A2S2NBF0 D6WJC7 J9JXU7 A0A226E3N3 E2B6Z8 A0A1Y1KUS1 U4TVX1 A0A1W4XLV1 J9K1Q8 A0A1Y1N1R6 A0A1Y1M4C3 C4WUN8 A0A2H8TP66 V5GXT7 F1RWY0 A0A2J7PV36 N6UEU4 Q06AA3 M9NHL6 A0A2S2R8U5 A0A139WHG8 A0A131XYK8 I4DP01 J3JXZ4 A0A2U3XL69 A0A195C220 A0A341B973 L8IC85
A0A2W1BPN9 A0A194QD98 A0A194R0G2 A0A067QH68 K7J5D9 A0A2J7PX68 A0A1W6EW18 A0A224XUC0 A0A0J7KWI6 A0A2H1V3A7 A0A1B6LVI4 A0A3S2LU12 H9JL48 A0A1B6KMD5 A0A1W6EWA9 A0A212EYC9 A0A1B6E8A7 E2AGQ0 A0A195BA50 A0A3S2TF78 A0A158NKR2 A0A2A4JGT7 R4G322 T1HLA6 A0A151IV06 A0A154PHW9 E9IDS8 F4W8D2 A0A2W1BUS9 T1HLF0 A0A026WSS1 A0A3L8DAN9 D6X0J7 A0A0C9PVI0 A0A0C9REN7 A0A1D2NDD8 A0A195C416 A0A0L7RAD2 A0A2A3E1I8 V9IID5 D6X0J5 A0A0M8ZQU0 E0W247 A0A1W4XIB0 A0A2A3E259 A0A087ZSJ2 A0A154PHY1 A0A310SQM9 J3JZF0 V5GNF0 A0A0L7RA20 U4U594 U4U9P7 A0A2H8TR03 N6UBU7 E0XEM8 A0A2P8Z9M7 C4WUM8 A0A226DLD5 D6X0J6 A0A2J7PV34 A0A226F399 A0A1B6DWB3 J9JSL2 J9LYB7 A0A2S2NBF0 D6WJC7 J9JXU7 A0A226E3N3 E2B6Z8 A0A1Y1KUS1 U4TVX1 A0A1W4XLV1 J9K1Q8 A0A1Y1N1R6 A0A1Y1M4C3 C4WUN8 A0A2H8TP66 V5GXT7 F1RWY0 A0A2J7PV36 N6UEU4 Q06AA3 M9NHL6 A0A2S2R8U5 A0A139WHG8 A0A131XYK8 I4DP01 J3JXZ4 A0A2U3XL69 A0A195C220 A0A341B973 L8IC85
Pubmed
EMBL
KZ149940
PZC76950.1
ODYU01005526
SOQ46459.1
BABH01011590
KQ459167
+ More
KPJ03521.1 KQ460930 KPJ10737.1 AGBW02012248 OWR45359.1 PZC76948.1 KPJ03518.1 KPJ10735.1 KK853729 KDQ89564.1 AAZX01008996 NEVH01020861 PNF20920.1 KY563502 ARK19911.1 GFTR01004857 JAW11569.1 LBMM01002383 KMQ94897.1 ODYU01000453 SOQ35279.1 GEBQ01012337 JAT27640.1 RSAL01000202 RVE44407.1 BABH01011591 BABH01011592 GEBQ01027358 JAT12619.1 KY563576 ARK19985.1 AGBW02011577 OWR46467.1 GEDC01003116 JAS34182.1 GL439383 EFN67386.1 KQ976537 KYM81413.1 RVE44406.1 ADTU01018655 NWSH01001580 PCG70804.1 GAHY01002071 JAA75439.1 ACPB03010982 KQ980926 KYN11376.1 KQ434912 KZC11423.1 GL762535 EFZ21282.1 GL887908 EGI69423.1 PZC76947.1 KK107133 EZA58119.1 QOIP01000011 RLU16988.1 KQ971371 EFA10097.2 GBYB01005453 JAG75220.1 GBYB01005451 JAG75218.1 LJIJ01000079 ODN03278.1 KQ978344 KYM94918.1 KQ414619 KOC67711.1 KZ288446 PBC25613.1 JR045777 AEY60054.1 EFA10016.2 KQ435903 KOX69067.1 DS235874 EEB19703.1 PBC25614.1 KZC11422.1 KQ760974 OAD58558.1 BT128631 AEE63588.1 GALX01002822 JAB65644.1 KOC67710.1 KB632136 ERL89059.1 ERL89058.1 GFXV01004227 MBW16032.1 APGK01029448 APGK01029449 APGK01029450 KB740735 ENN79130.1 GU013474 ADK55065.1 PYGN01000136 PSN53206.1 AK341136 BAH71598.1 LNIX01000015 OXA46355.1 EFA10015.2 NEVH01020989 PNF20197.1 LNIX01000001 OXA63830.1 GEDC01007379 JAS29919.1 ABLF02026045 ABLF02034011 GGMR01001925 MBY14544.1 KQ971343 EFA03135.1 ABLF02026048 LNIX01000007 OXA51634.1 GL446071 EFN88540.1 GEZM01075834 GEZM01075833 JAV63930.1 KB631643 ERL84922.1 ABLF02034387 GEZM01015209 GEZM01015208 JAV91851.1 GEZM01042396 JAV79888.1 AK341151 BAH71608.1 GFXV01003627 MBW15432.1 GALX01003288 JAB65178.1 AEMK02000113 PNF20199.1 ENN79131.1 DQ972961 JN036578 AFJ24877.1 GGMS01017161 MBY86364.1 KYB27438.1 GEFM01003483 JAP72313.1 AK403222 BAM19641.1 BT128116 AEE63077.1 KYM94919.1 JH881521 ELR53816.1
KPJ03521.1 KQ460930 KPJ10737.1 AGBW02012248 OWR45359.1 PZC76948.1 KPJ03518.1 KPJ10735.1 KK853729 KDQ89564.1 AAZX01008996 NEVH01020861 PNF20920.1 KY563502 ARK19911.1 GFTR01004857 JAW11569.1 LBMM01002383 KMQ94897.1 ODYU01000453 SOQ35279.1 GEBQ01012337 JAT27640.1 RSAL01000202 RVE44407.1 BABH01011591 BABH01011592 GEBQ01027358 JAT12619.1 KY563576 ARK19985.1 AGBW02011577 OWR46467.1 GEDC01003116 JAS34182.1 GL439383 EFN67386.1 KQ976537 KYM81413.1 RVE44406.1 ADTU01018655 NWSH01001580 PCG70804.1 GAHY01002071 JAA75439.1 ACPB03010982 KQ980926 KYN11376.1 KQ434912 KZC11423.1 GL762535 EFZ21282.1 GL887908 EGI69423.1 PZC76947.1 KK107133 EZA58119.1 QOIP01000011 RLU16988.1 KQ971371 EFA10097.2 GBYB01005453 JAG75220.1 GBYB01005451 JAG75218.1 LJIJ01000079 ODN03278.1 KQ978344 KYM94918.1 KQ414619 KOC67711.1 KZ288446 PBC25613.1 JR045777 AEY60054.1 EFA10016.2 KQ435903 KOX69067.1 DS235874 EEB19703.1 PBC25614.1 KZC11422.1 KQ760974 OAD58558.1 BT128631 AEE63588.1 GALX01002822 JAB65644.1 KOC67710.1 KB632136 ERL89059.1 ERL89058.1 GFXV01004227 MBW16032.1 APGK01029448 APGK01029449 APGK01029450 KB740735 ENN79130.1 GU013474 ADK55065.1 PYGN01000136 PSN53206.1 AK341136 BAH71598.1 LNIX01000015 OXA46355.1 EFA10015.2 NEVH01020989 PNF20197.1 LNIX01000001 OXA63830.1 GEDC01007379 JAS29919.1 ABLF02026045 ABLF02034011 GGMR01001925 MBY14544.1 KQ971343 EFA03135.1 ABLF02026048 LNIX01000007 OXA51634.1 GL446071 EFN88540.1 GEZM01075834 GEZM01075833 JAV63930.1 KB631643 ERL84922.1 ABLF02034387 GEZM01015209 GEZM01015208 JAV91851.1 GEZM01042396 JAV79888.1 AK341151 BAH71608.1 GFXV01003627 MBW15432.1 GALX01003288 JAB65178.1 AEMK02000113 PNF20199.1 ENN79131.1 DQ972961 JN036578 AFJ24877.1 GGMS01017161 MBY86364.1 KYB27438.1 GEFM01003483 JAP72313.1 AK403222 BAM19641.1 BT128116 AEE63077.1 KYM94919.1 JH881521 ELR53816.1
Proteomes
UP000005204
UP000053268
UP000053240
UP000007151
UP000027135
UP000002358
+ More
UP000235965 UP000036403 UP000283053 UP000000311 UP000078540 UP000005205 UP000218220 UP000015103 UP000078492 UP000076502 UP000007755 UP000053097 UP000279307 UP000007266 UP000094527 UP000078542 UP000053825 UP000242457 UP000053105 UP000009046 UP000192223 UP000005203 UP000030742 UP000019118 UP000245037 UP000198287 UP000007819 UP000008237 UP000008227 UP000245341 UP000252040
UP000235965 UP000036403 UP000283053 UP000000311 UP000078540 UP000005205 UP000218220 UP000015103 UP000078492 UP000076502 UP000007755 UP000053097 UP000279307 UP000007266 UP000094527 UP000078542 UP000053825 UP000242457 UP000053105 UP000009046 UP000192223 UP000005203 UP000030742 UP000019118 UP000245037 UP000198287 UP000007819 UP000008237 UP000008227 UP000245341 UP000252040
Pfam
Interpro
IPR005511
SMP-30
+ More
IPR013658 SGL
IPR011042 6-blade_b-propeller_TolB-like
IPR008367 Regucalcin
IPR039096 SMP-30/CGR1
IPR032450 SMARCC_N
IPR032451 SMARCC_C
IPR032448 SWIRM-assoc
IPR001005 SANT/Myb
IPR036388 WH-like_DNA-bd_sf
IPR017884 SANT_dom
IPR036420 BRCT_dom_sf
IPR009057 Homeobox-like_sf
IPR030087 BAF155
IPR007526 SWIRM
IPR000033 LDLR_classB_rpt
IPR013658 SGL
IPR011042 6-blade_b-propeller_TolB-like
IPR008367 Regucalcin
IPR039096 SMP-30/CGR1
IPR032450 SMARCC_N
IPR032451 SMARCC_C
IPR032448 SWIRM-assoc
IPR001005 SANT/Myb
IPR036388 WH-like_DNA-bd_sf
IPR017884 SANT_dom
IPR036420 BRCT_dom_sf
IPR009057 Homeobox-like_sf
IPR030087 BAF155
IPR007526 SWIRM
IPR000033 LDLR_classB_rpt
Gene 3D
CDD
ProteinModelPortal
A0A2W1BVX6
A0A2H1W032
H9JKT2
A0A194QJ92
A0A194QZ50
A0A212EV56
+ More
A0A2W1BPN9 A0A194QD98 A0A194R0G2 A0A067QH68 K7J5D9 A0A2J7PX68 A0A1W6EW18 A0A224XUC0 A0A0J7KWI6 A0A2H1V3A7 A0A1B6LVI4 A0A3S2LU12 H9JL48 A0A1B6KMD5 A0A1W6EWA9 A0A212EYC9 A0A1B6E8A7 E2AGQ0 A0A195BA50 A0A3S2TF78 A0A158NKR2 A0A2A4JGT7 R4G322 T1HLA6 A0A151IV06 A0A154PHW9 E9IDS8 F4W8D2 A0A2W1BUS9 T1HLF0 A0A026WSS1 A0A3L8DAN9 D6X0J7 A0A0C9PVI0 A0A0C9REN7 A0A1D2NDD8 A0A195C416 A0A0L7RAD2 A0A2A3E1I8 V9IID5 D6X0J5 A0A0M8ZQU0 E0W247 A0A1W4XIB0 A0A2A3E259 A0A087ZSJ2 A0A154PHY1 A0A310SQM9 J3JZF0 V5GNF0 A0A0L7RA20 U4U594 U4U9P7 A0A2H8TR03 N6UBU7 E0XEM8 A0A2P8Z9M7 C4WUM8 A0A226DLD5 D6X0J6 A0A2J7PV34 A0A226F399 A0A1B6DWB3 J9JSL2 J9LYB7 A0A2S2NBF0 D6WJC7 J9JXU7 A0A226E3N3 E2B6Z8 A0A1Y1KUS1 U4TVX1 A0A1W4XLV1 J9K1Q8 A0A1Y1N1R6 A0A1Y1M4C3 C4WUN8 A0A2H8TP66 V5GXT7 F1RWY0 A0A2J7PV36 N6UEU4 Q06AA3 M9NHL6 A0A2S2R8U5 A0A139WHG8 A0A131XYK8 I4DP01 J3JXZ4 A0A2U3XL69 A0A195C220 A0A341B973 L8IC85
A0A2W1BPN9 A0A194QD98 A0A194R0G2 A0A067QH68 K7J5D9 A0A2J7PX68 A0A1W6EW18 A0A224XUC0 A0A0J7KWI6 A0A2H1V3A7 A0A1B6LVI4 A0A3S2LU12 H9JL48 A0A1B6KMD5 A0A1W6EWA9 A0A212EYC9 A0A1B6E8A7 E2AGQ0 A0A195BA50 A0A3S2TF78 A0A158NKR2 A0A2A4JGT7 R4G322 T1HLA6 A0A151IV06 A0A154PHW9 E9IDS8 F4W8D2 A0A2W1BUS9 T1HLF0 A0A026WSS1 A0A3L8DAN9 D6X0J7 A0A0C9PVI0 A0A0C9REN7 A0A1D2NDD8 A0A195C416 A0A0L7RAD2 A0A2A3E1I8 V9IID5 D6X0J5 A0A0M8ZQU0 E0W247 A0A1W4XIB0 A0A2A3E259 A0A087ZSJ2 A0A154PHY1 A0A310SQM9 J3JZF0 V5GNF0 A0A0L7RA20 U4U594 U4U9P7 A0A2H8TR03 N6UBU7 E0XEM8 A0A2P8Z9M7 C4WUM8 A0A226DLD5 D6X0J6 A0A2J7PV34 A0A226F399 A0A1B6DWB3 J9JSL2 J9LYB7 A0A2S2NBF0 D6WJC7 J9JXU7 A0A226E3N3 E2B6Z8 A0A1Y1KUS1 U4TVX1 A0A1W4XLV1 J9K1Q8 A0A1Y1N1R6 A0A1Y1M4C3 C4WUN8 A0A2H8TP66 V5GXT7 F1RWY0 A0A2J7PV36 N6UEU4 Q06AA3 M9NHL6 A0A2S2R8U5 A0A139WHG8 A0A131XYK8 I4DP01 J3JXZ4 A0A2U3XL69 A0A195C220 A0A341B973 L8IC85
PDB
4GNA
E-value=1.42835e-47,
Score=477
Ontologies
PATHWAY
GO
PANTHER
Topology
Subcellular location
Nucleus
Cytoplasm
Cytoplasm
SignalP
Position: 1 - 23,
Likelihood: 0.616867
Length:
339
Number of predicted TMHs:
1
Exp number of AAs in TMHs:
18.0250399999999
Exp number, first 60 AAs:
18.01928
Total prob of N-in:
0.88127
POSSIBLE N-term signal
sequence
inside
1 - 4
TMhelix
5 - 24
outside
25 - 339
Population Genetic Test Statistics
Pi
268.381817
Theta
203.15664
Tajima's D
0.938456
CLR
0.160399
CSRT
0.639818009099545
Interpretation
Uncertain
