Gene

KWMTBOMO03976  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010135

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_glutamate_[NMDA]_receptor_subunit_1_[Bombyx_mori]

Location

Bomo_Chr7(-):7437546-7444660      View in EpiBrowser

Full name

Glutamate [NMDA] receptor subunit 1      

Location in the cell

PlasmaMembrane   Reliability : 4.116

CDS

ATGAGGTCCTACCAGTTCTTCCTCGTCCTGGTATTATGCTGTCAACTGGCTCATGCAGAGATTGACAGAAGAAGATTTTCCAACCCGACTTATTACAATGTTGGAGGTGTTCTTTCTAGCAACGAATCCATAGCTTTCTTCAAGGATACTATCTCGAATCTCAATTTTAAAGATCAATACGTACCGCGTGGCGTCACATATCATGATTATTCAATTCTAATGGACCCTAATCCGATAAAAACTGCCCTCAACGTTTGCAAAGATTTAATTGCTCATAGAGTTTACGCAGTAGTGGTTTCCCATCCGCTAACTGGAGATTTATCACCAGCTGCTGTTTCATATACCAGCGGGTTTTACCACATACCGGTCATAGGGATATCATCGCGCGACTCAGCGTTCTCCGACAAAAATATCCACGTTTCATTCCTGCGCACTGTGCCACCGTATTCGCATCAGGCTGACGTATGGGTTGATGTCCTCAAACACTTTAACTACATGAAAGTTATTGTCATTCATAGCTCGGATACCGACGGCAGAGCTATTTTGGGCAGGTTCCAGACAACATCTCAAAGTATAGACGAGGACGTTGATCGTAAAGTCGTAGTCGAACTGGTTATCGAATTCGAGCCTGGCCTTGATTCTTTCACAGAGAGCCTTATGGACGTAAAAAGTGCCCAAGCCAGAGTATTTCTCATGTATGCAAGTAAAACTGATGCTGAAATAATATTCCGTGATGCCACATACCTTAATATGACTACTGTTGGATACGTTTGGATGGTTACAGAGCAAGCGTTGGACGCTGCCAATGCACCGGAAGGCTTGTTAGGATTGCGTCTTGTAAACGCAACCAATGAACACGCACACATTCAGGACTCGATATACGTTTTGGCGTCAGCTATTCGCGACATGAACACTTCAGAAGAGATCCACGCGCCGCCGTCGGATTGCGACAATTCTGGATCCATTTGGACAACGGGAAGATTATTGTTTGATTACATAAGGAAGCAAAGTTTAGAGAATGGAGCGACTGGACACGTAGCGTTCGATGATCACGGAGATCGTGTGCATGCGGAATATGACATGGTGAACGTTAGGGCACAAGGCGAGCACGTCGCGGTGGGAAAGTACTTTTATTCGAAGGAAACACAAAAAATGCGTCTGGAATTGAAGGAACATGAGATAATTTGGATGGGTCGAAGTACTTCCAAACCTGAGGGCTTTATGATACCTACACATTTAAAGGTTTTAACAATTGAAGAAAAACCTTTTGTTTATACTCGACGTATTGACGACGGTAGCGAATGTTATCCGGAAGAAATACCTTGTCCTCACTACAATGCTAGCGACGAAACAGGTCAACTTTATTGCTGCAAAGGGTTTTGTATGGACCTCTTGAAATACCTTTCAAAGGCTATTAACTTTACGTATTCGGTGGCTCTTTCGCCAGACGGGCAGTTTGGTAATTACATAATACGTAATTTATCTGTTCCTGGATCTAAGAAAGAATGGACTGGCCTTATCGCTGAGCTAGTGTACGAACGGGCGGATATGATTGTCGCACCTCTAACCATCAATCCCGAAAGGGCAGAGTTCATCGAGTTCAGTAAGCCTTTTAAGTATCAAGGAATAACAATTCTTGAAAAAAAGCCTTCTCGATCGTCGACCTTAGTGTCCTTCTTACAACCATTTTCTAACACTCTCTGGATTTTGGTTATGGTGTCTGTACACGTTGTTGCTCTCGTGCTATATCTTTTGGACCGATTTTCTCCTTTCGGAAGATTTAAGCTCGCAAATATCGATGGAACCGAAGAAGATGCATTAAATCTATCGAGTGCTATTTGGTTTGCTTGGGGCGTCCTATTGAATAGTGGAATTGGCGAAGGCACACCGCGAAGCTTTTCAGCTCGAGTACTGGGTATGGTCTGGGCAGGCTTTGCAATGATCATTGTTGCTTCTTATACTGCTAATTTAGCCGCGTTCCTTGTACTTGAACGACCTAAAACAAAACTTACTGGAATCAACGATGCTAGATTACGAAACACAATGGAAAATTTAACTTGTGCGACTGTGAAAGGCTCGGCGGTGGACATGTACTTTAGAAGACAGGTGGAACTTTCAAATATGTATCGAACTATGGAGGCAAATAATTACGACAGCGCAGAGCAAGCTATTCAAGATGTAAAAGATGGAAAATTAATGGCTTTCATTTGGGATTCCTCGCGTCTGGAATTTGAAGCAGCTCAAGACTGTGAGTTGGTGACAGCAGGAGAATTATTTGGAAGATCAGGCTATGGCGTTGGATTACAGAAAGGATCACCTTGGGCAGACTTAGTAACGCTTGCAATATTGGATTTCCACGAGAGTGGTATAATGGAGTCACTCGATAATCAATGGATTCTGCGAAATAATATGTTGAATTGCGAAGAAAATGAAAAAACACCAAACACTTTAGGTTTGAAAAACATGGCTGGTGTCTTCATATTGGTGTTGGCTGGCATAATAGGGGGTATTGTACTTATCGTCATCGAGGTTGTCTATAAACGACATCAGATAAGAAAACAGAAGAGATTGGAAATAGCGAGACATGCAGCCGACAGGTGGCGCGGAGCCGTTGAGAAACGTAAGTCACTACGGGCTGCAATAATGCCAGCGCAGAGAAGAATCAAGTCGAATGGTGTGAAAGAAGCCGGGAGTATTAGTTTGGTCGTCGACAGAGGAGCGAGACGACGTGACGAGCCTCGAGTACCGAGATATCTTCCGGCTTACACTCCGGATGTCTCGCACCTAGTAGTTTAG

Protein

MRSYQFFLVLVLCCQLAHAEIDRRRFSNPTYYNVGGVLSSNESIAFFKDTISNLNFKDQYVPRGVTYHDYSILMDPNPIKTALNVCKDLIAHRVYAVVVSHPLTGDLSPAAVSYTSGFYHIPVIGISSRDSAFSDKNIHVSFLRTVPPYSHQADVWVDVLKHFNYMKVIVIHSSDTDGRAILGRFQTTSQSIDEDVDRKVVVELVIEFEPGLDSFTESLMDVKSAQARVFLMYASKTDAEIIFRDATYLNMTTVGYVWMVTEQALDAANAPEGLLGLRLVNATNEHAHIQDSIYVLASAIRDMNTSEEIHAPPSDCDNSGSIWTTGRLLFDYIRKQSLENGATGHVAFDDHGDRVHAEYDMVNVRAQGEHVAVGKYFYSKETQKMRLELKEHEIIWMGRSTSKPEGFMIPTHLKVLTIEEKPFVYTRRIDDGSECYPEEIPCPHYNASDETGQLYCCKGFCMDLLKYLSKAINFTYSVALSPDGQFGNYIIRNLSVPGSKKEWTGLIAELVYERADMIVAPLTINPERAEFIEFSKPFKYQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLANIDGTEEDALNLSSAIWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAMIIVASYTANLAAFLVLERPKTKLTGINDARLRNTMENLTCATVKGSAVDMYFRRQVELSNMYRTMEANNYDSAEQAIQDVKDGKLMAFIWDSSRLEFEAAQDCELVTAGELFGRSGYGVGLQKGSPWADLVTLAILDFHESGIMESLDNQWILRNNMLNCEENEKTPNTLGLKNMAGVFILVLAGIIGGIVLIVIEVVYKRHQIRKQKRLEIARHAADRWRGAVEKRKSLRAAIMPAQRRIKSNGVKEAGSISLVVDRGARRRDEPRVPRYLPAYTPDVSHLVV

Description

NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation (By similarity).
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. Plays a role in associative learning and in long-term memory consolidation.

Subunit

Forms a heteromeric NMDA channel with Nmdar2.

Similarity

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.

Keywords

Calcium   Cell junction   Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Ion channel   Ion transport   Ligand-gated ion channel   Magnesium   Membrane   Phosphoprotein   Postsynaptic cell membrane   Receptor   Reference proteome   Signal   Synapse   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Glutamate [NMDA] receptor subunit 1

Uniprot

A0A0B4ZYK4   A0A075T320   A0A2W1BTK1   A0A2H1V2L0   A0A194Q1F2   A0A212FKH1   + More
H9A5R9   A0A0L7L2M9   D6WZF1   A0A1Y1LBL2   A0A1B1FKH6   A0A0L7R8Q3   A0A0M8ZPY3   Q4QYY7   Q7YXK7   T1H8F5   A0A154PKB3   A0A2J7PII3   S4VUM3   A0A067RRP7   A0A088A6E0   A0A0M4JNQ3   A0A0C9R0T5   A0A026WP69   A0A1B6JZE7   A0A075Q430   E1ZZB3   A0A158NEC2   E0VD56   F4WJ93   A0A1W4W870   U4U439   A0A195CAI0   A0A1B6E0C7   A0A151J6J7   A0A151WSI7   A0A1B6M8R4   A0A195FL41   A0A0A9ZDF8   A0A146L6Z0   E9J1H1   E2B3J8   V9I876   A0A2A3E4F9   A0A0J7NMU9   A0A195BX39   J9JNJ5   A0A182FRS7   A0A182QJG9   A0A182N9Z4   Q7PXM3   A0A182YBA3   A0A182XA20   A0A182HKZ9   A0A182VHR5   A0A182ISB1   A0A182PH08   A0A182M9C1   A0A0P8YKM4   B3LZ39   A0A182R517   A0A0M3QXW7   B4GF83   A0A3B0JQA1   A0A182VWC9   Q296F7   B3P2E5   W5JAC1   B4JHV0   B4QWW7   B4I414   A0A0Q9WU59   B4LZB5   A0A0R1E083   B4PVB0   B4KD90   Q24418   A0A1J1HVN7   A0A1W4UJH2   A0A140CQB5   A0A0A1XK08   A0A0K8VCG5   A0A336MEH8   A0A0K8UUU4   U3M5E9   Q16YE2   W8AGY7   B4MU83   A0A1I8NT09   A0A0L0CL67   A0A1Q3G593   A0A1I8MF01   A0A1B0G3U0   A0A1S4EJ85   A0A1A9Z8G8   A0A1Q3G548   A0A1B0AXH5   A0A2H4ZBE5   A0A1A9VB43   A0A1A9YIQ1  

Pubmed

25027790    28756777    26354079    22118469    22363688    27006164    + More
26227816    18362917    19820115    28004739    16480817    24845553    26265180    24508170    30249741    25657209    20798317    21347285    20566863    21719571    23537049    25401762    26823975    21282665    12364791    14747013    17210077    25244985    17994087    15632085    20920257    23761445    17550304    8508917    11773617    10731132    12537572    12537569    15823532    17893096    26752702    25830018    17510324    24495485    26108605    25315136    29133804   

EMBL

KJ542732    AJD81616.1    KF768734    AIG51928.1    KZ149940    PZC76954.1    + More
ODYU01000204    SOQ34592.1    KQ459579    KPI99381.1    AGBW02008070    OWR54190.1    JN836719    AFC91759.2    JTDY01003320    KOB69748.1    KQ971372    EFA09715.1    GEZM01060349    JAV71052.1    KT268302    ANQ46496.1    KQ414632    KOC67208.1    KQ435922    KOX68537.1    AM040211    CAJ09700.1    AY331183    AAP94623.1    ACPB03001345    KQ434936    KZC11904.1    NEVH01025127    PNF16119.1    KC814695    KZ288405    AGO81729.1    PBC26173.1    KK852463    KDR23335.1    KP843218    ALD51354.1    GBYB01009754    JAG79521.1    KK107154    QOIP01000001    EZA56894.1    RLU26208.1    GECU01003139    JAT04568.1    KJ747198    AIG13068.1    GL435311    EFN73528.1    ADTU01013244    ADTU01013245    DS235072    EEB11312.1    GL888182    EGI65671.1    KB632092    ERL88669.1    KQ978023    KYM97879.1    GEDC01005928    JAS31370.1    KQ979851    KYN18839.1    KQ982769    KYQ50814.1    GEBQ01007668    JAT32309.1    KQ981490    KYN41066.1    GBHO01001668    JAG41936.1    GDHC01014411    JAQ04218.1    GL767671    EFZ13311.1    GL445346    EFN89750.1    JR036626    AEY57270.1    PBC26172.1    LBMM01003188    KMQ93835.1    KQ976401    KYM92533.1    ABLF02034268    ABLF02034274    AXCN02001521    AAAB01008987    EAA00817.3    APCN01000876    AXCM01006945    CH902617    KPU79430.1    EDV41913.1    CP012526    ALC46643.1    CH479182    EDW34268.1    OUUW01000008    SPP84374.1    CM000070    EAL28500.1    CH954181    EDV47895.1    ADMH02001846    ETN60916.1    CH916369    EDV92858.1    CM000364    EDX11729.1    CH480821    EDW54957.1    CH940650    KRF83701.1    EDW68150.1    CM000160    KRK02717.1    KRK02718.1    EDW95779.1    CH933806    EDW14872.1    X71790    AE014297    AY070577    AAF52016.1    AAL48048.1    CAA50675.1    CVRI01000021    CRK91618.1    KR998357    AMH85976.1    GBXI01003072    JAD11220.1    GDHF01015670    JAI36644.1    UFQS01001064    UFQT01001064    SSX08793.1    SSX28705.1    GDHF01021872    JAI30442.1    JX987094    AGS58420.1    CH477518    EAT39625.1    GAMC01018879    GAMC01018878    GAMC01018877    GAMC01018876    GAMC01018875    JAB87680.1    CH963852    EDW75672.1    JRES01000249    KNC32986.1    GFDL01000109    JAV34936.1    CCAG010022403    GFDL01000114    JAV34931.1    JXJN01005266    JXJN01005267    MF975500    MF975512    AUF73076.1   

Proteomes

UP000053268    UP000007151    UP000037510    UP000007266    UP000053825    UP000053105    + More
UP000015103    UP000076502    UP000235965    UP000242457    UP000027135    UP000005203    UP000053097    UP000279307    UP000000311    UP000005205    UP000009046    UP000007755    UP000192223    UP000030742    UP000078542    UP000078492    UP000075809    UP000078541    UP000008237    UP000036403    UP000078540    UP000007819    UP000069272    UP000075886    UP000075884    UP000007062    UP000076408    UP000076407    UP000075840    UP000075903    UP000075880    UP000075885    UP000075883    UP000007801    UP000075900    UP000092553    UP000008744    UP000268350    UP000075920    UP000001819    UP000008711    UP000000673    UP000001070    UP000000304    UP000001292    UP000008792    UP000002282    UP000009192    UP000000803    UP000183832    UP000192221    UP000008820    UP000007798    UP000095300    UP000037069    UP000095301    UP000092444    UP000079169    UP000092445    UP000092460    UP000078200    UP000092443   

PRIDE

B3LZ39    B4GF83    Q296F7    B3P2E5    B4JHV0    B4I414    + More
B4LZB5    B4PVB0    Q24418    B4MU83   

Pfam

PF01094   ANF_receptor        + More
PF10562   CaM_bdg_C0
PF00060   Lig_chan
PF10613   Lig_chan-Glu_bd
PF00412   LIM
PF15949   DUF4757
PF03099   BPL_LplA_LipB

Interpro

IPR001508   Iono_rcpt_met        + More
IPR028082   Peripla_BP_I       
IPR019594   Glu/Gly-bd       
IPR001828   ANF_lig-bd_rcpt       
IPR001320   Iontro_rcpt       
IPR018882   CaM-bd_C0_NMDA_rcpt_NR1       
IPR001781   Znf_LIM       
IPR031865   DUF4757       
IPR004143   BPL_LPL_catalytic       

SUPFAM

SSF53822   SSF53822       

ProteinModelPortal

A0A0B4ZYK4   A0A075T320   A0A2W1BTK1   A0A2H1V2L0   A0A194Q1F2   A0A212FKH1   + More
H9A5R9   A0A0L7L2M9   D6WZF1   A0A1Y1LBL2   A0A1B1FKH6   A0A0L7R8Q3   A0A0M8ZPY3   Q4QYY7   Q7YXK7   T1H8F5   A0A154PKB3   A0A2J7PII3   S4VUM3   A0A067RRP7   A0A088A6E0   A0A0M4JNQ3   A0A0C9R0T5   A0A026WP69   A0A1B6JZE7   A0A075Q430   E1ZZB3   A0A158NEC2   E0VD56   F4WJ93   A0A1W4W870   U4U439   A0A195CAI0   A0A1B6E0C7   A0A151J6J7   A0A151WSI7   A0A1B6M8R4   A0A195FL41   A0A0A9ZDF8   A0A146L6Z0   E9J1H1   E2B3J8   V9I876   A0A2A3E4F9   A0A0J7NMU9   A0A195BX39   J9JNJ5   A0A182FRS7   A0A182QJG9   A0A182N9Z4   Q7PXM3   A0A182YBA3   A0A182XA20   A0A182HKZ9   A0A182VHR5   A0A182ISB1   A0A182PH08   A0A182M9C1   A0A0P8YKM4   B3LZ39   A0A182R517   A0A0M3QXW7   B4GF83   A0A3B0JQA1   A0A182VWC9   Q296F7   B3P2E5   W5JAC1   B4JHV0   B4QWW7   B4I414   A0A0Q9WU59   B4LZB5   A0A0R1E083   B4PVB0   B4KD90   Q24418   A0A1J1HVN7   A0A1W4UJH2   A0A140CQB5   A0A0A1XK08   A0A0K8VCG5   A0A336MEH8   A0A0K8UUU4   U3M5E9   Q16YE2   W8AGY7   B4MU83   A0A1I8NT09   A0A0L0CL67   A0A1Q3G593   A0A1I8MF01   A0A1B0G3U0   A0A1S4EJ85   A0A1A9Z8G8   A0A1Q3G548   A0A1B0AXH5   A0A2H4ZBE5   A0A1A9VB43   A0A1A9YIQ1  

PDB

6MMX     E-value=0,     Score=1940

KEGG

101743090    K05208 glutamate receptor ionotropic, NMDA 1 | (RefSeq) glutamate [NMDA] receptor subunit 1

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0004970   GO:0045211   GO:0030054   GO:0005886   GO:0004972   GO:0017146   GO:0046872   GO:0035235   GO:0007616   GO:0055074   GO:0008355   GO:0014069   GO:0042391   GO:0007268   GO:0006464   GO:0050975   GO:0042331   GO:0048149   GO:0072375   GO:0008306   GO:0008328   GO:0005234   GO:0016020   GO:0004872   GO:0005216   GO:0006811   GO:0006032   GO:0004672   GO:0048384  

Subcellular location

  
Cell membrane  
Cell junction  
Synapse  
Postsynaptic cell membrane  
Postsynaptic density  

SignalP

Position:   1 - 19,         Likelihood:  0.999529

 

 

Length:

931

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

75.25792

Exp number, first 60 AAs:

0.04156

Total prob of N-in:

0.00293

outside

1  -  565

TMhelix

566  -  585

inside

586  -  640

TMhelix

641  -  663

outside

664  -  823

TMhelix

824  -  846

inside

847  -  931

 

 

Pi

228.659539

Theta

172.641281

Tajima's D

0.959734

CLR

0.025893

CSRT

0.651767411629419

Interpretation

Uncertain