Gene

KWMTBOMO03973  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010245

Annotation

HSP90_cochaperone_CDC37_homologue_[Bombyx_mori]

Location

Bomo_Chr7(+):7413561-7417645      View in EpiBrowser

Full name

Hsp90 co-chaperone Cdc37      

Alternative Name

Hsp90 chaperone protein kinase-targeting subunit
Protein enhancer of sevenless 3B

Location in the cell

Nuclear   Reliability : 3.502

CDS

ATGGTCGACTACAGCAAATGGAAAGATATCGAAATTTCCGACGATGAAGACGAGACCCATCCAAACATTGATACCCCATCATTGTTTCGATGGCGGCACCAGGCCCGTGTGGAACGCATGGAAGAGCGACGCCGCGAGAAAGAGGAACTGGAGCAAAGAAAGAAAGAAAACCAACGACGTCTAACCGAGACCAGGAAAAAAATATCGGAAGCTGATGCAGACAGCCCTAATCTAAATTCATTAAAAAAGACGCTAGCTGAGCTTGAGAATGATGAAAAAAAATTACTGAAAAAGGATGAAGAACTCAGGAAAAAAGACAAGCATACGCCATGGAATGTAGATACCATTAGTGAGCCGGGTTTCAATAAAACAGTGATTAATACAAAAGCATTAAGACCCAGCAATGAAAACCTCACTGAAGAGGAAAAAGAAGCTAAAATGAAGAAATTTATCAAAGAGAATGAGAAATTTTTGAAGCAATTTGGATTGCTCCGTAAATATGAGGACTCCACTAAATTTTTGCTGGACCATTACCAGTTAGTCTGTGAAGAAACTGCCAATTACCTTGTCATCTGGTGTATTAATTTAGAAATGGAGGAGAAACATGATCTAATGTCCCATGTGGCCCACCAGACTATTTGCATGCAGTACATATTGGAACTGTCCAGACAATTGGATGTGGATCCAAGAGCTTGTGTTGGCTCTTTCTTTTCAAAAATACAAACTGCAGAACAAGCTTATAAAGATGCTTTCGAAGATGAGTTAAAGCAATTTAAAATTAGAATCAAGAAGCGTGCTGCAGAAAAAATTCAGGAAGCCATAAAAGAGGCAGAGGAAGAAGAAAGAAAGGCCAGGCTGGGACCTGGAGGATTGGATCCTGTAGAAGTTTATGAGGAGCTGCCTGATGAATTGAAAAAGTGCTTTGATGCCCAAGATGTTCCAATGCTGCAAGCTACCATTGCCAAAATTCCTCAAGAAGAAGCAATTTATTACATGAACAGATGTATAGCTTCCGGGCTCTGGGTACCTGGCAAAAATGATGAGGAACCCACCATGAAGGATTCCAAAACTGAAAAGCATTCAGGGGAAACTTCTACCAATGCTAATGATGTTGACTGA

Protein

MVDYSKWKDIEISDDEDETHPNIDTPSLFRWRHQARVERMEERRREKEELEQRKKENQRRLTETRKKISEADADSPNLNSLKKTLAELENDEKKLLKKDEELRKKDKHTPWNVDTISEPGFNKTVINTKALRPSNENLTEEEKEAKMKKFIKENEKFLKQFGLLRKYEDSTKFLLDHYQLVCEETANYLVIWCINLEMEEKHDLMSHVAHQTICMQYILELSRQLDVDPRACVGSFFSKIQTAEQAYKDAFEDELKQFKIRIKKRAAEKIQEAIKEAEEEERKARLGPGGLDPVEVYEELPDELKKCFDAQDVPMLQATIAKIPQEEAIYYMNRCIASGLWVPGKNDEEPTMKDSKTEKHSGETSTNANDVD

Description

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Required for cytokinesis and chromosome segregation in mitosis and male meiosis.

Subunit

Forms a complex with Hsp90. Interacts with a number of kinases such as CDC2 and Sevenless (By similarity).
Forms a complex with Hsp90. Interacts with a number of kinases such as Cdk1, Sevenless and ial.

Similarity

Belongs to the CDC37 family.

Keywords

Chaperone   Complete proteome   Cytoplasm   Reference proteome   Cell cycle   Cell division   Chromosome partition   Developmental protein   Meiosis   Mitosis   Phosphoprotein  

Feature

chain  Hsp90 co-chaperone Cdc37

Uniprot

H9JL44   Q5CCL4   A0A212FKC1   A0A2H1VGX5   A0A2W1BUT9   A0A1E1W8F8   + More
A0A2A4JA61   A0A194QZN3   A0A194Q218   A0A067RU34   V5GUQ3   A0A0J7L1K1   A0A2P8XL58   A0A2J7PIG5   A0A026W6N5   E2AAF7   E2BBM8   A0A158N919   D6WNW9   A0A0A9YDS2   B4GS14   A0A0A1WXT4   Q2M071   D6QYT8   B3NEV6   A0A232F3J5   W8C674   D6QYU2   A0A0K8WJQ0   K7IS17   B2ZI58   B4QML0   B0FE24   B2ZIB8   B2ZI57   A0A1W4X3F0   B0FE26   A0A3B0KGP1   A0A0L0CIA3   B2ZI59   Q24740   A0A034WK21   B4KY90   A0A1W4W6C8   B4PDU3   B2ZI56   A0A1B6BYC6   A0A2H8TDP1   A0A0V0G560   A0A1L8DWR3   A0A0R1DV60   A0A0M4EJL2   B3M7A2   A0A1S3DTB1   C4IY07   Q24276   Q86NM8   A0A2P0ZDT0   A0A023F8S1   A0A0P4VUJ1   J9K0Q2   J3JVU7   R4G3V8   A0A151IBI6   T1P815   A0A151WNP2   A0A069DT94   A0A224XQ01   A0A182JHH2   F4WHI5   B4N596   A0A195FVQ4   A0A195BU05   A0A151J846   A0A1Q3FDT5   A0A087UA67   A0A0L7QRM0   A0A182FQJ0   A0A182VQZ6   A0A182Q8H0   A0A154P902   A0A310SAV1   A0A182N5Z2   A0A0K8RJJ5   B7QFI7   A0A0P5J2Q1   B4IZW8   A0A0N8EJD6   A0A1A9WCW4   T1HRN0   A0A182K0E8   A0A131XYZ1   A0A2M3Z962   Q16U07   W5J684   A0A2M4BQV7   E9GZK7   A0A2M4BR52   A0A2M4AIT8   A0A084VRZ1  

Pubmed

19121390    22118469    28756777    26354079    24845553    29403074    + More
24508170    30249741    20798317    21347285    18362917    19820115    25401762    26823975    17994087    25830018    15632085    20351054    28648823    24495485    20075255    18560591    22936249    18288436    26108605    8020093    14738738    25348373    18057021    17550304    10731132    12537572    12374737    17372656    18327897    26453233    25474469    27129103    22516182    23537049    25315136    26334808    21719571    17510324    20920257    23761445    21292972    24438588   

EMBL

BABH01011586    AB206401    BAD90847.1    AGBW02008070    OWR54194.1    ODYU01002510    + More
SOQ40100.1    KZ149940    PZC76957.1    GDQN01007810    JAT83244.1    NWSH01002417    PCG68330.1    KQ460930    KPJ10744.1    KQ459579    KPI99378.1    KK852463    KDR23354.1    GALX01003069    JAB65397.1    LBMM01001346    KMQ96473.1    PYGN01001801    PSN32738.1    NEVH01025127    PNF16121.1    KK107372    QOIP01000004    EZA51720.1    RLU23407.1    GL438125    EFN69558.1    GL447128    EFN86905.1    ADTU01009036    KQ971343    EFA03198.1    GBHO01014351    GBHO01014350    GBHO01014349    GBHO01014348    GBRD01012407    GDHC01021869    GDHC01015579    JAG29253.1    JAG29254.1    JAG29255.1    JAG29256.1    JAG53417.1    JAP96759.1    JAQ03050.1    CH479188    EDW40549.1    GBXI01010821    JAD03471.1    CH379069    EAL31065.1    HM017757    HM017758    HM017759    HM017760    HM017762    HM017763    HM017764    HM017765    HM017766    ADG65108.1    ADG65109.1    ADG65110.1    ADG65111.1    ADG65113.1    ADG65114.1    ADG65115.1    ADG65116.1    ADG65117.1    CH954178    EDV50229.1    NNAY01001030    OXU25416.1    GAMC01004444    JAC02112.1    HM017761    ADG65112.1    GDHF01001219    JAI51095.1    EU670449    ACD56248.1    CM000363    CM002912    EDX08867.1    KMY96951.1    EU310312    EU310313    EU310315    EU310316    ABY55420.1    ABY55421.1    ABY55423.1    ABY55424.1    EU670509    CH480817    ACD56250.1    EDW50120.1    EU670448    ACD56247.1    EU310314    ABY55422.1    OUUW01000009    SPP84906.1    JRES01000364    KNC31927.1    EU670450    ACD56249.1    L37055    CH940647    AY849340    GAKP01004472    JAC54480.1    CH933809    EDW17669.1    KRG05685.1    CM000159    EDW92908.2    EU670447    ACD56246.1    GEDC01031279    JAS06019.1    GFXV01000390    MBW12195.1    GECL01002921    JAP03203.1    GFDF01003194    JAV10890.1    KRK00799.1    CP012525    ALC43197.1    CH902618    EDV38763.1    BT083438    ACQ99843.1    L32839    AE014296    BT004828    AAO45184.1    KY780369    AVH78509.1    GBBI01000920    JAC17792.1    GDKW01002089    JAI54506.1    ABLF02030859    APGK01037114    BT127365    KB740948    AEE62327.1    ENN77232.1    GAHY01001880    JAA75630.1    KQ978095    KYM97010.1    KA644707    AFP59336.1    KQ982907    KYQ49463.1    GBGD01001719    JAC87170.1    GFTR01005774    JAW10652.1    GL888161    EGI66339.1    CH964101    EDW79535.1    KQ981268    KYN43939.1    KQ976405    KYM91887.1    KQ979640    KYN20027.1    GFDL01009321    JAV25724.1    KK118950    KFM74256.1    KQ414775    KOC61272.1    AXCN02000191    KQ434827    KZC07630.1    KQ762190    OAD56153.1    GADI01002542    JAA71266.1    ABJB010058502    ABJB010457476    ABJB010491297    DS926118    EEC17609.1    GDIQ01203968    JAK47757.1    CH916366    EDV96740.1    GDIQ01020980    JAN73757.1    ACPB03020538    GEFM01004860    JAP70936.1    GGFM01004291    MBW25042.1    CH477635    EAT38011.1    ADMH02002134    ETN58370.1    GGFJ01006261    MBW55402.1    GL732578    EFX75013.1    GGFJ01006260    MBW55401.1    GGFK01007375    MBW40696.1    ATLV01015787    KE525036    KFB40735.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000053240    UP000053268    UP000027135    + More
UP000036403    UP000245037    UP000235965    UP000053097    UP000279307    UP000000311    UP000008237    UP000005205    UP000007266    UP000008744    UP000001819    UP000008711    UP000215335    UP000002358    UP000000304    UP000001292    UP000192223    UP000268350    UP000037069    UP000008792    UP000009192    UP000192221    UP000002282    UP000092553    UP000007801    UP000079169    UP000000803    UP000007819    UP000019118    UP000078542    UP000095301    UP000075809    UP000075880    UP000007755    UP000007798    UP000078541    UP000078540    UP000078492    UP000054359    UP000053825    UP000069272    UP000075920    UP000075886    UP000076502    UP000075884    UP000001555    UP000001070    UP000091820    UP000015103    UP000075881    UP000008820    UP000000673    UP000000305    UP000030765   

PRIDE

H9JL44    Q5CCL4    Q24740    C4IY07    Q24276    Q86NM8    + More

Pfam

PF08564   CDC37_C        + More
PF08565   CDC37_M
PF03234   CDC37_N

Interpro

IPR013855   Cdc37_N_dom        + More
IPR013874   Cdc37_Hsp90-bd       
IPR038189   Cdc37_Hsp90-bd_sf       
IPR013873   Cdc37_C       
IPR004918   Cdc37       

Gene 3D

1.20.58.610    

ProteinModelPortal

H9JL44   Q5CCL4   A0A212FKC1   A0A2H1VGX5   A0A2W1BUT9   A0A1E1W8F8   + More
A0A2A4JA61   A0A194QZN3   A0A194Q218   A0A067RU34   V5GUQ3   A0A0J7L1K1   A0A2P8XL58   A0A2J7PIG5   A0A026W6N5   E2AAF7   E2BBM8   A0A158N919   D6WNW9   A0A0A9YDS2   B4GS14   A0A0A1WXT4   Q2M071   D6QYT8   B3NEV6   A0A232F3J5   W8C674   D6QYU2   A0A0K8WJQ0   K7IS17   B2ZI58   B4QML0   B0FE24   B2ZIB8   B2ZI57   A0A1W4X3F0   B0FE26   A0A3B0KGP1   A0A0L0CIA3   B2ZI59   Q24740   A0A034WK21   B4KY90   A0A1W4W6C8   B4PDU3   B2ZI56   A0A1B6BYC6   A0A2H8TDP1   A0A0V0G560   A0A1L8DWR3   A0A0R1DV60   A0A0M4EJL2   B3M7A2   A0A1S3DTB1   C4IY07   Q24276   Q86NM8   A0A2P0ZDT0   A0A023F8S1   A0A0P4VUJ1   J9K0Q2   J3JVU7   R4G3V8   A0A151IBI6   T1P815   A0A151WNP2   A0A069DT94   A0A224XQ01   A0A182JHH2   F4WHI5   B4N596   A0A195FVQ4   A0A195BU05   A0A151J846   A0A1Q3FDT5   A0A087UA67   A0A0L7QRM0   A0A182FQJ0   A0A182VQZ6   A0A182Q8H0   A0A154P902   A0A310SAV1   A0A182N5Z2   A0A0K8RJJ5   B7QFI7   A0A0P5J2Q1   B4IZW8   A0A0N8EJD6   A0A1A9WCW4   T1HRN0   A0A182K0E8   A0A131XYZ1   A0A2M3Z962   Q16U07   W5J684   A0A2M4BQV7   E9GZK7   A0A2M4BR52   A0A2M4AIT8   A0A084VRZ1  

PDB

5FWP     E-value=1.39065e-75,     Score=719

KEGG

692540    K09554 cell division cycle protein 37 | (RefSeq) Cdc37; HSP90 cochaperone CDC37 homologue

GO

GO:0019901   GO:0051082   GO:0050821   GO:0006457   GO:0031072   GO:0051087   GO:0005737   GO:0051301   GO:0035556   GO:0070374   GO:0051321   GO:0007059   GO:0030296   GO:0007275   GO:0050909   GO:0016021   GO:0008061   GO:0004553   GO:0004568   GO:0006032   GO:0004672   GO:0048384  

PANTHER

PTHR12800  

Subcellular location

Cytoplasm  

Length:

372

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00064

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03479

outside

1  -  372

 

 

Pi

198.972165

Theta

162.417526

Tajima's D

0.71121

CLR

0.270905

CSRT

0.576171191440428

Interpretation

Uncertain