Gene

KWMTBOMO03970

Pre Gene Modal

BGIBMGA010241

Annotation

PREDICTED:_dopamine_receptor_2_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr7(+):7281701-7318422      View in EpiBrowser

Full name

Dopamine receptor 2      

Alternative Name

Dopamine 1-like receptor 2

Location in the cell

PlasmaMembrane   Reliability : 4.918

CDS

ATGAATGCCACCGAACCGGATATAGTAGTGGCAAGAGGCCAACTGGACTCATCGTATAGAAGCCCAGAGTACACACTGGAGTTCACGGGTGCCGCCTACAACAATGCCATAGAATTCAACCTCACCTTCGATAACATCAGCGCCTACAATATCTCCAGCGAACCAGAAGGTCTTTGGAATGACTACATCAAGCTTCTTCATGACAGAGCGTTGCTCGTGTCGTTTCTGCTATTATTCTCCTTGACGACAGTCTTTGGAAACATGCTAGTTATATTGGCCGTAGTACGCGAACGATACTTGCACACCTCAACGAATTACTTCGTGACTTCCCTTGCAGTGGCCGATTGTCTCGTCGGACTTGTGGTTATGCCTTTTTCGGCCCTATACGAAGTTTTAGAACATACTTGGTTCTTCGGTGTCGATTGGTGTGATGTGTGGCGTTCGTTAGATGTTTTATTCAGTACCGCTTCCATTTTGAACTTGTGCGTGATCTCACTGGACCGTTACTGGGCTATCACGGACCCGATAACATATCCTATGCGAATGAGCGGACGCAAGGCAGCTTTCCTAATAGCCGCCGTGTGGGTGTGTTCCGGTGCGATATCGTTCCCCGCGATCGCGTGGTGGCGCGCTGTTCGCACTGAAGAAGTTCCCGATTACAAGTGCCCGTTCACGGAAAACTTGGAGTACATTATATTCTCGTCGACAATATCGTTTTATTTGCCGCTTTTCGTGATGGTGTTCACTTATTATAGAATATATAGGGCGGCAACAATACAAACGAGGTCACTTAAAATCGGCACTAAACAAGTGATGAGACCGAGTGGTGAATTGGAGTTGACGCTGCGGATCCACAGGGGCGGGACGATGCGTCAGCGAAACGACGTTTGCCACGGAGTATGCACGCCCGAAGAAGCTGATCAAGAACCACTAACAGCACTCCAGAACAATGGTCTATCGCGATCTTCTACGCGTCTAACAAACGTGACTCACGGCAAGCATTTGCCGAAAAACTTTTCGCTGTCCCGTAAACTAGCCAAATTCGCGAAAGAGAAGAAAGCGGCCAAGACTTTAGGTATAGTTATGGGTGTGTTCATAGTGTGCTGGTTACCGTTCTTTGTGGTGAACTTGTTATCGGGAATTTGTTCGGCGTGCATAGCGCACGAGGAGATCGTTAACGTGGTCGTAACGTGGCTGGGTTGGGTGAACTCTTCCATGAATCCTGTTATATACGCCTGTTGGAGCAGAGATTTTAGAAGGGCTTTCCTAAGAATACTATGCGTGTGCTGCCCAAGGAAACTAAGGAGAAAATACCAGCCACAGTTAAGATTCAAACAGTCACAGTTGCGTACGACTCGACGTTATTACTCATCGAGCGAACTGATGGGCATACAGCAGATCAGGCAAAATTCCTGCGAACAAACTTATATATAG

Protein

MNATEPDIVVARGQLDSSYRSPEYTLEFTGAAYNNAIEFNLTFDNISAYNISSEPEGLWNDYIKLLHDRALLVSFLLLFSLTTVFGNMLVILAVVRERYLHTSTNYFVTSLAVADCLVGLVVMPFSALYEVLEHTWFFGVDWCDVWRSLDVLFSTASILNLCVISLDRYWAITDPITYPMRMSGRKAAFLIAAVWVCSGAISFPAIAWWRAVRTEEVPDYKCPFTENLEYIIFSSTISFYLPLFVMVFTYYRIYRAATIQTRSLKIGTKQVMRPSGELELTLRIHRGGTMRQRNDVCHGVCTPEEADQEPLTALQNNGLSRSSTRLTNVTHGKHLPKNFSLSRKLAKFAKEKKAAKTLGIVMGVFIVCWLPFFVVNLLSGICSACIAHEEIVNVVVTWLGWVNSSMNPVIYACWSRDFRRAFLRILCVCCPRKLRRKYQPQLRFKQSQLRTTRRYYSSSELMGIQQIRQNSCEQTYI

Description

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Lipoprotein   Membrane   Palmitate   Phosphoprotein   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Dopamine receptor 2
splice variant  In isoform B.

Uniprot

A9ZLX7   G9FIE4   Q5TLF1   H9JL40   A0A0K0QVX8   A0A2A4JFN1   + More
A0A2W1B7T1   A0A194Q7J3   A0A2H1VE94   A0A0L7KUZ2   A0A194QZN9   A0A212F1V0   Q178M5   H6D5H2   A0A0B5H0X6   N1NVE9   D6W9I7   A0A1B0FHK3   Q0QBJ0   A0A1A9VYA4   Q24563   A0A1I8PYB9   A0A1B0BU21   A0A1A9XTH8   A0A158NUA3   B4M5N1   A0A0H4A731   A0A182X7G0   A0A1W5KQ45   A0A182I9X9   A0A182VG80   B4NBI6   Q0QBI9   B3MTF8   Q29BV5   A0A0B4KI18   A0A1I8M930   A0A3B0JKN0   Q8T0Y4   A0A0L0CEE5   B4JGU2   S4VUD0   A0A0R1E4P1   A0A195BAM5   A0A0M3QXN7   A0A1W4URU8   A0A151IGM3   Q24563-2   A0A1I8PYD4   V6DNI7   A0A1I8PYA3   A0A158NUA2   A0A1B0AGI2   A0A1J1J694   A0A182MPY4   A0A3L8DIJ1   A0A182RIK6   I2FKF0   Q7PRQ0   Q0QBI8   E2BIP6   A0A2P8YN31   A0A182W609   E9JC84   A0A195FKE1   N6T3W6   A0A1B0DCA4   A0A067RIW6   A0A151ITH2   E2AB47   B0X368   F4WR97   A0A182SYI0   A0A0J7KS03   V6DRG4   A0A026X5D3   A0A154PKS5   A0A336LR61   A0A2J7PZF0   A0A310SI83   B4HZB5   A0A0M8ZYP7   A0A0A9Y8Q3   A0A0L7QYI1   E0VYM7   A0A1A9WB44   A0A232EVA9   A0A0U1ZXN5   A0A3Q0INR4   A0A182LDM9   A0A2R7VUE6   K7J7W5   T1GCK5   J9K8J5   A0A2S2PJ60   Q2V625   A0A1B3P983   A0A2P6KNY7   A0A2R5L879  

Pubmed

18353107    15544938    19121390    26179416    28756777    26354079    + More
26227816    22118469    17510324    22292096    25793586    18054377    18025266    18316733    20068045    21843505    23604020    18362917    19820115    17027841    8656286    8663989    10731132    12537572    21347285    17994087    27048546    15632085    12537568    12537573    12537574    16110336    17569856    17569867    25315136    9535160    12717701    26108605    17550304    30249741    12364791    14747013    17210077    20798317    29403074    21282665    23537049    24845553    21719571    24508170    25401762    20566863    28648823    25873872    20966253    20075255    16426885   

EMBL

AB162716    BAF98648.1    JN117929    AEU17118.1    AB182634    BAD72870.1    + More
BABH01011569    BABH01011570    KP784318    AKR18179.1    NWSH01001759    PCG70233.1    KZ150300    PZC71538.1    KQ459579    KPI99375.1    ODYU01002088    SOQ39153.1    JTDY01005552    KOB66891.1    KQ460930    KPJ10749.1    AGBW02010788    OWR47710.1    CH477361    EAT42665.2    JN043503    AFB73767.1    KM262648    AJF34871.1    BK005860    DAA64497.1    KQ971312    EEZ99218.2    CCAG010002977    DQ459405    ABF01005.1    U34383    U61264    AE014297    BT010212    JXJN01020451    JXJN01020452    ADTU01026364    ADTU01026365    ADTU01026366    CH940652    EDW58957.2    KP711748    AKN44273.1    KU948225    AMX74031.1    APCN01001073    CH964232    EDW81150.2    DQ459406    ABF01006.1    CH902623    EDV30548.2    CM000070    EAL26891.3    AGB96452.1    OUUW01000007    SPP82887.1    AF498306    AAM19330.1    JRES01000501    KNC30621.1    CH916369    EDV92696.1    KC814691    KZ288185    AGO81726.1    PBC34886.1    CM000160    KRK04188.1    KQ976532    KYM81601.1    CP012526    ALC46189.1    KQ977739    KYN00213.1    HG794355    CDK37789.1    CVRI01000070    CRL07292.1    AXCM01006973    AXCM01006974    QOIP01000007    RLU20254.1    AB720740    BAM15635.1    AAAB01008847    EAA06824.5    DQ459407    ABF01007.1    GL448520    EFN84440.1    PYGN01000479    PSN45646.1    GL771752    EFZ09569.1    KQ981512    KYN40826.1    APGK01053225    KB741223    KB632273    ENN72323.1    ERL91077.1    AJVK01013962    KK852446    KDR23742.1    KQ981017    KYN10267.1    GL438234    EFN69323.1    DS232309    EDS39570.1    GL888284    EGI63314.1    LBMM01003766    KMQ93162.1    HG794356    CDK37790.1    KK107019    EZA62624.1    KQ434948    KZC12456.1    UFQT01000123    SSX20450.1    NEVH01020335    PNF21714.1    KQ765222    OAD54080.1    CH480819    EDW53372.1    KQ435821    KOX72313.1    GBHO01016126    JAG27478.1    KQ414688    KOC63658.1    DS235845    EEB18483.1    NNAY01002023    OXU22280.1    KP780183    AKD41293.1    KK854091    PTY11103.1    AAZX01000049    AAZX01000050    AAZX01000051    CAQQ02082058    ABLF02029456    ABLF02029459    ABLF02029460    ABLF02029461    GGMR01016826    MBY29445.1    DQ295790    ABB87182.1    KU710377    AOG14373.1    MWRG01007814    PRD28048.1    GGLE01001577    MBY05703.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000037510    UP000053240    UP000007151    + More
UP000008820    UP000007266    UP000092444    UP000078200    UP000000803    UP000095300    UP000092460    UP000092443    UP000005205    UP000008792    UP000076407    UP000075840    UP000075903    UP000007798    UP000007801    UP000001819    UP000095301    UP000268350    UP000037069    UP000001070    UP000242457    UP000002282    UP000078540    UP000092553    UP000192221    UP000078542    UP000092445    UP000183832    UP000075883    UP000279307    UP000075900    UP000007062    UP000008237    UP000245037    UP000075920    UP000078541    UP000019118    UP000030742    UP000092462    UP000027135    UP000078492    UP000000311    UP000002320    UP000007755    UP000075901    UP000036403    UP000053097    UP000076502    UP000235965    UP000001292    UP000053105    UP000053825    UP000009046    UP000091820    UP000215335    UP000079169    UP000075882    UP000002358    UP000015102    UP000007819   

PRIDE

A9ZLX7    H9JL40    Q24563   

Pfam

PF00001   7tm_1

Interpro

IPR017452   GPCR_Rhodpsn_7TM        + More
IPR000276   GPCR_Rhodpsn       
IPR002233   ADR_fam       

ProteinModelPortal

A9ZLX7   G9FIE4   Q5TLF1   H9JL40   A0A0K0QVX8   A0A2A4JFN1   + More
A0A2W1B7T1   A0A194Q7J3   A0A2H1VE94   A0A0L7KUZ2   A0A194QZN9   A0A212F1V0   Q178M5   H6D5H2   A0A0B5H0X6   N1NVE9   D6W9I7   A0A1B0FHK3   Q0QBJ0   A0A1A9VYA4   Q24563   A0A1I8PYB9   A0A1B0BU21   A0A1A9XTH8   A0A158NUA3   B4M5N1   A0A0H4A731   A0A182X7G0   A0A1W5KQ45   A0A182I9X9   A0A182VG80   B4NBI6   Q0QBI9   B3MTF8   Q29BV5   A0A0B4KI18   A0A1I8M930   A0A3B0JKN0   Q8T0Y4   A0A0L0CEE5   B4JGU2   S4VUD0   A0A0R1E4P1   A0A195BAM5   A0A0M3QXN7   A0A1W4URU8   A0A151IGM3   Q24563-2   A0A1I8PYD4   V6DNI7   A0A1I8PYA3   A0A158NUA2   A0A1B0AGI2   A0A1J1J694   A0A182MPY4   A0A3L8DIJ1   A0A182RIK6   I2FKF0   Q7PRQ0   Q0QBI8   E2BIP6   A0A2P8YN31   A0A182W609   E9JC84   A0A195FKE1   N6T3W6   A0A1B0DCA4   A0A067RIW6   A0A151ITH2   E2AB47   B0X368   F4WR97   A0A182SYI0   A0A0J7KS03   V6DRG4   A0A026X5D3   A0A154PKS5   A0A336LR61   A0A2J7PZF0   A0A310SI83   B4HZB5   A0A0M8ZYP7   A0A0A9Y8Q3   A0A0L7QYI1   E0VYM7   A0A1A9WB44   A0A232EVA9   A0A0U1ZXN5   A0A3Q0INR4   A0A182LDM9   A0A2R7VUE6   K7J7W5   T1GCK5   J9K8J5   A0A2S2PJ60   Q2V625   A0A1B3P983   A0A2P6KNY7   A0A2R5L879  

PDB

3SN6     E-value=1.61226e-55,     Score=548

KEGG

100141430    K04148 dopamine receptor D1-like | (RefSeq) Dopr2; dopamine receptor 2

PATHWAY

04080    Neuroactive ligand-receptor interaction - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0004930   GO:0005886   GO:0004935   GO:0071880   GO:0007188   GO:0005887   GO:1903223   GO:0001588   GO:0099509   GO:0008226   GO:0007191   GO:1990834   GO:0007212   GO:0001306   GO:0007186   GO:0008227   GO:0042321   GO:1903351   GO:0030285   GO:0004952   GO:0004715   GO:0008061   GO:0004553   GO:0004568   GO:0006032   GO:0004672   GO:0048384  

Subcellular location

Cell membrane  

Length:

477

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

152.97742

Exp number, first 60 AAs:

0.01805

Total prob of N-in:

0.02566

outside

1  -  71

TMhelix

72  -  94

inside

95  -  106

TMhelix

107  -  129

outside

130  -  143

TMhelix

144  -  166

inside

167  -  186

TMhelix

187  -  209

outside

210  -  228

TMhelix

229  -  251

inside

252  -  358

TMhelix

359  -  381

outside

382  -  390

TMhelix

391  -  413

inside

414  -  477

 

 

Pi

210.222154

Theta

182.304147

Tajima's D

0.375447

CLR

0.433929

CSRT

0.475726213689316

Interpretation

Uncertain