Gene

KWMTBOMO03966  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010240

Annotation

chitinase_precursor_[Bombyx_mori]

Location

Bomo_Chr7(+):7138254-7154253      View in EpiBrowser

Full name

Endochitinase      

Location in the cell

Extracellular   Reliability : 2.385

CDS

ATGCGAGCGATATTTGCGACGTTGGCTGTCCTGGCGAGTTGCGCCGCATTAGTTCAGTCGGACAGCAGAGCGCGCATCGTTTGTTACTTCAGTAATTGGGCGGTGTACCGACCCGGCGTTGGACGTTATGGCATCGAAGACATCCCCGTGGATTTGTGTACCCACTTGATTTATTCCTTTATTGGCGTCACCGAGAAATCAAGCGAAGTTCTCATTATCGATCCTGAGTTGGACGTAGATAAGAGTGGTTTCCGTAACTTCACATCCCTCCGCTCCAAACACCCCGATGTCAAGTTCATGGTCGCGGTTGGCGGTTGGGCTGAAGGCGGCTCCAAGTACTCACACATGGTGGCCCAGAAGAGCACTAGGATGTCCTTCATCAGAAGCGTTGTCGACTTCTTGAAGAAATATGACTTCGACGGTTTGGATCTGGACTGGGAGTATCCCGGTGCCGCTGACCGGGGTGGCTCCTTCTCCGATAAAGACAAGTTCTTGTATTTCGTCCAAGAGTTAAAGAGGGCGTTCATCAGAGCCGGTAGAGGATGGGAGCTGACTGCTGCCGTACCGCTTGCTAATTTCAGGCTGATGGAGGGATATCATGTACCAGAGCTGTGTCAGGAACTGGACGCTATCCACGTGATGTCGTATGATCTGCGCGGTAATTGGGCCGGTTTCGCCGATGTGCATTCGCCTTTATACAAACGCCCTCACGACCAATGGGCCTACGAGAAACTTAACGTGAATGATGGTCTTAATTTATGGGAAGAGAAGGGTTGCCCTACCAATAAACTAGTGGTCGGTATTCCGTTCTATGGACGTTCATTCACTTTATCTGCTGGAAACAACAACTATGGCCTTGGAACTTACATCAACAAAGAGGCTGGTGGTGGAGACCCTGCTCCCTATACAAACGCAACTGGATTCTGGGCTTATTATGAAATTTGCACAGAAGTAGATGCAGATGGATCAGGATGGACTAAGAAATGGGACGAGTTCGGGAAATGCCCCTACGCATACAAGGGAACTCAATGGGTGGGCTACGAAGATCCTCGTAGTGTGGAGATCAAGATGAACTGGATCAAGGAGAAGGGCTACCTCGGGGCTATGACATGGGCTATAGATATGGACGATTTTAAGGGACTATGCGGCGAGGAAAATCCCTTGATCAAGCTTCTGCATAAGCATATGAGCACTTACACAGTACCGCCTGCGCGCACTGGACACACAACTCCTACTCCGGAATGGGCGCGTCCACCTTCAACTCCATCAGACCCATCTGAGGGTGATCCGATTCCTACCACAACCACCACCACCGTGAAACCGACGACAACAAGAACCACCGCGAGGCCAACTACTACCACAACGAAAGTACCCCATGGCACCACTGAAGAAGACTTTGACATTAACGTGAGACCGGAAGTCGAGGAACTACCCACGGAAAACGAAGTCGACAATGCGGATGTGTGTAACTCTGAGGACGACTACGTACCAGACAAGAAAGAGTGTAGCAAGTATTGGCGATGTGTGAACGGCGAGGGAGTTCAGTTCTCGTGTCAACCGGGGACAATCTTCAACGTGAAACTTAACGTTTGCGATTGGCCTGAAAATACAGACAGACCGGAATGTTCGTAA

Protein

MRAIFATLAVLASCAALVQSDSRARIVCYFSNWAVYRPGVGRYGIEDIPVDLCTHLIYSFIGVTEKSSEVLIIDPELDVDKSGFRNFTSLRSKHPDVKFMVAVGGWAEGGSKYSHMVAQKSTRMSFIRSVVDFLKKYDFDGLDLDWEYPGAADRGGSFSDKDKFLYFVQELKRAFIRAGRGWELTAAVPLANFRLMEGYHVPELCQELDAIHVMSYDLRGNWAGFADVHSPLYKRPHDQWAYEKLNVNDGLNLWEEKGCPTNKLVVGIPFYGRSFTLSAGNNNYGLGTYINKEAGGGDPAPYTNATGFWAYYEICTEVDADGSGWTKKWDEFGKCPYAYKGTQWVGYEDPRSVEIKMNWIKEKGYLGAMTWAIDMDDFKGLCGEENPLIKLLHKHMSTYTVPPARTGHTTPTPEWARPPSTPSDPSEGDPIPTTTTTTVKPTTTRTTARPTTTTTKVPHGTTEEDFDINVRPEVEELPTENEVDNADVCNSEDDYVPDKKECSKYWRCVNGEGVQFSCQPGTIFNVKLNVCDWPENTDRPECS

Catalytic Activity

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Similarity

Belongs to the glycosyl hydrolase 18 family.
Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

Keywords

Carbohydrate metabolism   Chitin degradation   Chitin-binding   Disulfide bond   Glycoprotein   Glycosidase   Hydrolase   Polysaccharide degradation   Secreted   Signal  

Feature

chain  Endochitinase

Uniprot

H9JL39   Q9GV05   Q9GR93   P90710   Q8WR52   Q9GQC4   + More
Q9GPG9   A0A2H1W9V9   G9I1Y8   Q0VIL7   D7PF25   Q9GV44   B0LF75   A0A0U4B8E0   Q6EHZ5   A0A2A4JCK6   A0A0F6PN38   C4P7I5   Q6QSW1   Q2TPT7   A0A097PUR2   Q6VUB9   W8NYT3   G9I1Y7   G5DAD1   B8XSK6   Q2TPA6   A0A0H3WBS6   Q704Y2   Q2TU94   A0A2W1BUR3   P36362   P91731   A0A212FGP4   Q2V6H4   Q8MTK0   Q06GI9   A0A221LFZ7   A0A194Q2Z5   A0A076JNR7   I4DLY6   A0A194R0H7   D2DNL8   A0A182VXC7   A0A182RA00   A0A182PAD7   T1PI84   A0A1I8M3L0   A0A182UNL2   A0A0L0BN03   A0A182XWX9   A0A182LF53   A0A182XI23   A0A182MC90   D6W8E2   A0A2Y9D129   A0A232F6Q5   A0A182JS87   A0A1I8PWN5   A0ND35   K7J396   Q5QE61   A0A182NFJ2   A0A2P0P9F2   U5EV15   A0A182SUB7   A0A084WRG7   A0A1W4WRE8   A0A182ITQ4   A0A182QUJ8   F6KNX7   A0A2D0WXJ9   A0A1B0A7Q8   A0A1A9WEG0   A0A1B0FE85   A0A1A9UNW6   N6UL94   A0A1A9Y093   A0A1B0AKM8   A0A2I6Q765   A0A1Q3FQF9   Q299Y8   A0A0A1XJW1   A0A0K8VQB0   A0A1Y1LBM0   A0A0G2RLU0   Q17GK4   O17411   A0A034VJR8   A0A0C9QZA9   A0A2Z2Z001   W8BTF2   T1I7M4   B4G3H9   B4MBM4   A0A1J1HKY8   A0A1W4URV0   A0A0A9W6L0  

EC Number

3.2.1.14

Pubmed

19121390    11222960    12045191    9654739    10984482    22124732    + More
11267891    16203206    14511669    25846407    15475298    28756777    8353525    9061927    22118469    24699639    24828498    12429133    26354079    22651552    25315136    26108605    25244985    20966253    18362917    19820115    28648823    12364791    14747013    17210077    20075255    18342250    24438588    21611131    23537049    29236932    15632085    17994087    25830018    28004739    17510324    9662472    25348373    24495485    25401762    27192063   

EMBL

BABH01011561    AB048355    BAB13481.1    AB052914    BAB20017.1    U86876    + More
AAB47538.1    AF455139    AAL51080.1    AF273695    AAG37105.1    AF326596    AAG48700.1    ODYU01007129    SOQ49632.1    JN558351    AEV22117.1    AY678531    AAV91784.1    GU371868    ADI24346.1    AB032107    BAB12678.1    EU035316    ABW03227.1    KT894380    ALY11060.1    AY325497    AY326456    AAQ91787.1    AAQ94194.1    NWSH01001914    PCG69691.1    KP641331    AJW87647.1    FJ899540    ACQ73745.1    AY527414    AAS18266.1    AY705930    KT899316    AAW30162.1    ALO79342.1    KM259868    AIU56908.1    AY325496    AY326455    AAQ94193.1    KF932280    AHL21606.1    JN558350    AEV22116.1    JN607321    AEP25533.1    FJ436415    ACL30984.1    AY726548    AAW50396.1    KP337328    AKL59780.1    AJ620505    CAF05663.1    AY508698    AAS92245.1    KZ149930    PZC77374.1    U02270    L49234    U86877    AAB47539.1    AGBW02008627    OWR52897.1    DQ294305    ABB97081.2    AY098731    AAM43792.1    DQ887770    ABI81757.1    KX668137    ASM94206.1    KQ459579    KPI99374.1    KF897513    AII78788.1    AK402304    BAM18926.1    KQ460930    KPJ10750.1    FJ613480    ACU42267.1    KA647628    AFP62257.1    JRES01001623    KNC21401.1    AXCM01008603    KQ971307    EFA10939.1    APCN01000396    NNAY01000863    OXU26160.1    AAAB01008859    EAU77120.3    AY675073    AAV74190.1    KU739366    ARA90543.1    GANO01002081    JAB57790.1    ATLV01026054    KE525405    KFB52811.1    AXCN02000212    HQ456129    AEE44123.1    KX954127    ARU08055.1    CCAG010019310    APGK01028620    APGK01028621    KB740694    ENN79462.1    JXJN01026309    KY274431    AUM84816.1    GFDL01005194    JAV29851.1    CM000070    EAL27563.2    GBXI01003504    JAD10788.1    GDHF01011276    JAI41038.1    GEZM01065502    JAV68457.1    KP000850    AJG44545.1    CH477258    EAT45796.1    AF026491    AAB81849.1    GAKP01017169    JAC41783.1    GBYB01006052    JAG75819.1    KY681041    AUP42568.1    GAMC01010054    JAB96501.1    ACPB03020017    ACPB03020018    ACPB03020019    CH479179    EDW24987.1    CH940656    EDW58495.1    CVRI01000010    CRK88728.1    KT717326    GBHO01040160    GBRD01009115    ANC95000.1    JAG03444.1    JAG56706.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000075920    + More
UP000075900    UP000075885    UP000095301    UP000075903    UP000037069    UP000076408    UP000075882    UP000076407    UP000075883    UP000007266    UP000075840    UP000215335    UP000075881    UP000095300    UP000007062    UP000002358    UP000075884    UP000075901    UP000030765    UP000192223    UP000075880    UP000075886    UP000092445    UP000091820    UP000092444    UP000078200    UP000019118    UP000092443    UP000092460    UP000001819    UP000008820    UP000015103    UP000008744    UP000008792    UP000183832    UP000192221   

PRIDE

H9JL39    Q9GV05    Q9GR93    P90710    Q8WR52    Q9GQC4    + More
P36362    P91731   

Pfam

PF00704   Glyco_hydro_18        + More
PF01607   CBM_14
PF16880   EHD_N
PF00232   Glyco_hydro_1

Interpro

IPR001223   Glyco_hydro18_cat        + More
IPR029070   Chitinase_insertion_sf       
IPR002557   Chitin-bd_dom       
IPR001579   Glyco_hydro_18_chit_AS       
IPR017853   Glycoside_hydrolase_SF       
IPR011583   Chitinase_II       
IPR036508   Chitin-bd_dom_sf       
IPR027417   P-loop_NTPase       
IPR031692   EHD_N       
IPR030381   G_DYNAMIN_dom       
IPR001360   Glyco_hydro_1       

SUPFAM

SSF51445   SSF51445        + More
SSF57625   SSF57625       
SSF54556   SSF54556       
SSF52540   SSF52540       

Gene 3D

3.10.50.10    

ProteinModelPortal

H9JL39   Q9GV05   Q9GR93   P90710   Q8WR52   Q9GQC4   + More
Q9GPG9   A0A2H1W9V9   G9I1Y8   Q0VIL7   D7PF25   Q9GV44   B0LF75   A0A0U4B8E0   Q6EHZ5   A0A2A4JCK6   A0A0F6PN38   C4P7I5   Q6QSW1   Q2TPT7   A0A097PUR2   Q6VUB9   W8NYT3   G9I1Y7   G5DAD1   B8XSK6   Q2TPA6   A0A0H3WBS6   Q704Y2   Q2TU94   A0A2W1BUR3   P36362   P91731   A0A212FGP4   Q2V6H4   Q8MTK0   Q06GI9   A0A221LFZ7   A0A194Q2Z5   A0A076JNR7   I4DLY6   A0A194R0H7   D2DNL8   A0A182VXC7   A0A182RA00   A0A182PAD7   T1PI84   A0A1I8M3L0   A0A182UNL2   A0A0L0BN03   A0A182XWX9   A0A182LF53   A0A182XI23   A0A182MC90   D6W8E2   A0A2Y9D129   A0A232F6Q5   A0A182JS87   A0A1I8PWN5   A0ND35   K7J396   Q5QE61   A0A182NFJ2   A0A2P0P9F2   U5EV15   A0A182SUB7   A0A084WRG7   A0A1W4WRE8   A0A182ITQ4   A0A182QUJ8   F6KNX7   A0A2D0WXJ9   A0A1B0A7Q8   A0A1A9WEG0   A0A1B0FE85   A0A1A9UNW6   N6UL94   A0A1A9Y093   A0A1B0AKM8   A0A2I6Q765   A0A1Q3FQF9   Q299Y8   A0A0A1XJW1   A0A0K8VQB0   A0A1Y1LBM0   A0A0G2RLU0   Q17GK4   O17411   A0A034VJR8   A0A0C9QZA9   A0A2Z2Z001   W8BTF2   T1I7M4   B4G3H9   B4MBM4   A0A1J1HKY8   A0A1W4URV0   A0A0A9W6L0  

PDB

3W4R     E-value=0,     Score=2333

KEGG

693039    K01183 chitinase [EC:3.2.1.14] | (RefSeq) Chi, chiB, chiB4; chitinase

PATHWAY

00520    Amino sugar and nucleotide sugar metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006030   GO:0008061   GO:0004553   GO:0005576   GO:0005975   GO:0004568   GO:0006032   GO:0000272   GO:0016021   GO:0005525   GO:0030246   GO:0005615   GO:0042060   GO:0040003   GO:0018990   GO:0004672   GO:0048384  

Subcellular location

Secreted  

SignalP

Position:   1 - 20,         Likelihood:  0.998257

 

 

Length:

543

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.17445

Exp number, first 60 AAs:

0.17225

Total prob of N-in:

0.01031

outside

1  -  543

 

 

Pi

261.690083

Theta

173.880253

Tajima's D

1.159655

CLR

0.028898

CSRT

0.703214839258037

Interpretation

Uncertain