Gene

KWMTBOMO03962  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002350

Annotation

PREDICTED:_aurora_kinase_B_[Amyelois_transitella]

Location

Bomo_Chr7(-):7040225-7043853      View in EpiBrowser

Full name

Aurora kinase B       + More
Oxysterol-binding protein      

Alternative Name

IPL1/Aurora-like protein kinase
Serine/threonine-protein kinase Ial
Serine/threonine-protein kinase aurora-B

Location in the cell

Cytoplasmic   Reliability : 2.477

CDS

ATGAAGAGCGAAGTGCTCGAACTTGAAACAAAAATAATAAACCATGATGCCTACGGATCTTCGTACAAGTGGTCTCCAAGAGATTTTGAGCTCGGATCTTCACTAGGCCAAGGCAAATTCGGACATGTTCACGTAGCTAGAGAGAAAAAAACTGGATTCCTTGTTGCCATTAAGACTTTGTTCAAATCTCAAATCGTGAAATCGAAATGTGAACGACAAGTTATGCGAGAAATTGAAATTCAGTCACATTTGAAACACTCAAACATACTTCGACTGCTGACGTGGTTTCATGATGAGAGACGCATATATCTGGTTGTAGAATTTGCAGCTGGTGGAGAACTGTACAAACATCTCACAAATTCACCCCAAGGACGTTTTCCAGAAAGTAAAGCAGCAAGATACATATACCAGGTAGCTGATGCTGTTGAATACTGTCACCAACATCATGTAATACATCGTGACATAAAACCAGAAAATATTCTGGTGGCTTTTAGTGGAGATCTTAAACTTGCTGACTTTGGTTGGTCAGTCCATGCTCCATCTGAAAGACGTAAAACGATGTGTGGAACCCTTGATTATCTGCCACCAGAAATGATAAAACGCGAAGTATATGATGTGTCTGTTGACCACTGGTGCATAGGGGTGTTGCTTTATGAGTTTCTAGTGGGAAAGCCTCCATTTGAAACTGAAGGTGAAGACAAGACATATGCAAGAATATTGAGTCTCGATATTGTATACCCAAGTCATATACCTGATGGAGCCAAGGATTTGATCTCAAAGCTTTTAAGACACTCGAGTAAAGATAGATTGTCCCTTGAAGGAGTAAAAAAACATTATTGGGTCCAACAATTTCAGACAGTATAG

Protein

MKSEVLELETKIINHDAYGSSYKWSPRDFELGSSLGQGKFGHVHVAREKKTGFLVAIKTLFKSQIVKSKCERQVMREIEIQSHLKHSNILRLLTWFHDERRIYLVVEFAAGGELYKHLTNSPQGRFPESKAARYIYQVADAVEYCHQHHVIHRDIKPENILVAFSGDLKLADFGWSVHAPSERRKTMCGTLDYLPPEMIKREVYDVSVDHWCIGVLLYEFLVGKPPFETEGEDKTYARILSLDIVYPSHIPDGAKDLISKLLRHSSKDRLSLEGVKKHYWVQQFQTV

Description

Serine/threonine-protein kinase which mediates both meiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates mei-S332 within residues 124-126 and stabilizes its association with centromeres during meiosis.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Subunit

Interacts with Incenp and Cdc37.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Belongs to the OSBP family.

Keywords

ATP-binding   Cell cycle   Cell division   Chromatin regulator   Chromosome   Chromosome partition   Complete proteome   Cytoplasm   Cytoskeleton   Kinase   Magnesium   Meiosis   Metal-binding   Mitosis   Nucleotide-binding   Reference proteome   Transferase  

Feature

chain  Aurora kinase B

Uniprot

L8B3S6   A0A2A4J9P7   A0A212EJG1   S4PTA4   A0A194QYZ1   A0A194Q1E1   + More
H9IYL6   A0A336L5P6   A0A0K8W1X4   A0A034WDS3   W8BXG8   A0A232FLQ2   K7INW3   A0A1W4XRU6   A0A084W3Q3   A0A182W9W9   A0A182GUP7   A0A0A1XP02   Q175B8   A0A182SU91   A0A182L2B7   A0A1S4GWG8   A0A182V3I8   A0A182UKX7   A0A182WTG2   A0A182IEM6   A0A182M4P0   Q7Q3F8   A0A182NLK7   A0A182YPM7   A0A1B0CQ81   E2BXF8   A0A088A1Z6   A0A182R393   A0A1Q3EW20   A0A182IJW2   B4LS72   A0A182R099   W5JR20   A0A0M4EPD2   A0A154PRE7   A0A0L7QUL4   A0A3L8DGR3   B0XL95   A0A182F681   A0A0J7KM67   T1GK03   A0A1B6BZW6   A0A1B0DJA7   B4P132   B4HWX2   B4Q9V4   Q9VKN7   N6UL49   B4KKM4   B4NLN3   Q29PJ0   B4G6W9   A0A0K8V3M6   B3N518   B4JPU6   B3MJX5   A0A3B0JH60   F4X4U4   A0A1B0FH58   A0A1B6FAH1   D6X165   A0A1W4W495   A0A151X625   B4KKM5   A0A2A3ELE1   A0A158NQG8   A0A151IC22   A0A067RI07   A0A1A9UQY8   A0A1B6IYX2   A0A1A9XVS1   A0A1B0ANV9   A0A1Y1L784   A0A1I8PAY1   A0A0C9PH86   A0A2J7QMS1   A0A1I8NFU6   A0A0L0C1S3   A0A1A9WUY1   A0A1I8MLG7   A0A1B6LIQ3   I2B3M3   A0A1J1I9E6   A0A1J1I5M0   R7TMJ4   A7SLH0   A0A0M9AA88   B5THM9   E2AED8   A0A0P5M4A1   A0A0P6FR25   A0A023FWI0   A0A0P5Y7J5  

EC Number

2.7.11.1

Pubmed

27836666    22118469    23622113    26354079    19121390    25348373    + More
24495485    28648823    20075255    24438588    26483478    25830018    17510324    20966253    12364791    25244985    20798317    17994087    20920257    23761445    30249741    17550304    22936249    10433558    10231582    10731132    12537572    12537569    11266459    11352945    12374737    16824953    23537049    15632085    21719571    18362917    19820115    21347285    24845553    28004739    25315136    26108605    22427657    23254933    17615350   

EMBL

KX420635    AB777868    AQQ11601.1    BAM76581.1    NWSH01002306    PCG68569.1    + More
AGBW02014474    OWR41624.1    GAIX01012383    JAA80177.1    KQ460930    KPJ10753.1    KQ459579    KPI99371.1    BABH01042651    UFQS01001093    UFQT01001093    SSX08970.1    SSX28881.1    GDHF01007156    JAI45158.1    GAKP01007014    GAKP01007011    GAKP01007009    GAKP01007000    JAC51943.1    GAMC01002593    JAC03963.1    NNAY01000039    OXU31664.1    ATLV01020099    KE525294    KFB44847.1    JXUM01089600    JXUM01089601    JXUM01089602    KQ563783    KXJ73311.1    GBXI01001620    JAD12672.1    CH477403    EAT41669.1    AAAB01008964    APCN01005210    AXCM01005979    EAA12168.3    AJWK01023212    GL451254    EFN79606.1    GFDL01015540    JAV19505.1    CH940649    EDW64758.1    AXCN02002185    ADMH02000676    ETN65350.1    CP012523    ALC38687.1    KQ435078    KZC14479.1    KQ414735    KOC62259.1    QOIP01000009    RLU19058.1    DS234366    EDS33747.1    LBMM01005480    KMQ91478.1    CAQQ02019963    GEDC01030492    GEDC01014096    GEDC01013796    JAS06806.1    JAS23202.1    JAS23502.1    AJVK01006302    CM000157    EDW88007.1    CH480818    EDW52517.1    CM000361    CM002910    EDX04621.1    KMY89639.1    AF121358    AF121361    AE014134    AY118562    APGK01019217    KB740096    KB630363    KB631141    KB631630    ENN81411.1    ERL83560.1    ERL84130.1    ERL84863.1    CH933807    EDW12688.1    CH964274    EDW85272.1    CH379058    EAL34303.1    CH479180    EDW28288.1    GDHF01034051    GDHF01032835    GDHF01023976    GDHF01019129    GDHF01006830    GDHF01000903    JAI18263.1    JAI19479.1    JAI28338.1    JAI33185.1    JAI45484.1    JAI51411.1    CH954177    EDV58963.1    CH916372    EDV98926.1    CH902620    EDV32430.1    OUUW01000006    SPP81734.1    GL888679    EGI58517.1    CCAG010021908    GECZ01022567    JAS47202.1    KQ971368    EFA10666.1    KQ982491    KYQ55759.1    EDW12689.2    KZ288215    PBC32623.1    ADTU01023318    KQ978069    KYM97356.1    KK852498    KDR22618.1    GECU01015594    GECU01006637    JAS92112.1    JAT01070.1    JXJN01001068    GEZM01062681    JAV69543.1    GBYB01000213    JAG69980.1    NEVH01013204    PNF29868.1    JRES01001119    KNC25364.1    GEBQ01016412    JAT23565.1    JN021276    AFJ45029.1    CVRI01000042    CRK95590.1    CRK95589.1    AMQN01002464    KB309292    ELT94849.1    DS469698    EDO35437.1    KQ435716    KOX79039.1    EU939755    ACH73237.1    GL438828    EFN68190.1    GDIQ01160836    JAK90889.1    GDIP01063462    GDIQ01046633    GDIQ01046632    JAM40253.1    JAN48104.1    GBBL01001461    JAC25859.1    GDIP01063461    GDIQ01048184    LRGB01001005    JAM40254.1    JAN46553.1    KZS13905.1   

Proteomes

UP000218220    UP000007151    UP000053240    UP000053268    UP000005204    UP000215335    + More
UP000002358    UP000192223    UP000030765    UP000075920    UP000069940    UP000249989    UP000008820    UP000075901    UP000075882    UP000075903    UP000075902    UP000076407    UP000075840    UP000075883    UP000007062    UP000075884    UP000076408    UP000092461    UP000008237    UP000005203    UP000075900    UP000075880    UP000008792    UP000075886    UP000000673    UP000092553    UP000076502    UP000053825    UP000279307    UP000002320    UP000069272    UP000036403    UP000015102    UP000092462    UP000002282    UP000001292    UP000000304    UP000000803    UP000019118    UP000030742    UP000009192    UP000007798    UP000001819    UP000008744    UP000008711    UP000001070    UP000007801    UP000268350    UP000007755    UP000092444    UP000007266    UP000192221    UP000075809    UP000242457    UP000005205    UP000078542    UP000027135    UP000078200    UP000092443    UP000092460    UP000095300    UP000235965    UP000095301    UP000037069    UP000091820    UP000183832    UP000014760    UP000001593    UP000053105    UP000000311    UP000076858   

PRIDE

L8B3S6    H9IYL6    Q9VKN7   

Pfam

PF00069   Pkinase        + More
PF01237   Oxysterol_BP
PF00169   PH

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR028772   AURKB       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR030616   Aur       
IPR001849   PH_domain       
IPR018494   Oxysterol-bd_CS       
IPR000648   Oxysterol-bd       
IPR037239   OSBP_sf       
IPR011993   PH-like_dom_sf       

SUPFAM

SSF56112   SSF56112        + More
SSF144000   SSF144000       

Gene 3D

2.30.29.30    

ProteinModelPortal

L8B3S6   A0A2A4J9P7   A0A212EJG1   S4PTA4   A0A194QYZ1   A0A194Q1E1   + More
H9IYL6   A0A336L5P6   A0A0K8W1X4   A0A034WDS3   W8BXG8   A0A232FLQ2   K7INW3   A0A1W4XRU6   A0A084W3Q3   A0A182W9W9   A0A182GUP7   A0A0A1XP02   Q175B8   A0A182SU91   A0A182L2B7   A0A1S4GWG8   A0A182V3I8   A0A182UKX7   A0A182WTG2   A0A182IEM6   A0A182M4P0   Q7Q3F8   A0A182NLK7   A0A182YPM7   A0A1B0CQ81   E2BXF8   A0A088A1Z6   A0A182R393   A0A1Q3EW20   A0A182IJW2   B4LS72   A0A182R099   W5JR20   A0A0M4EPD2   A0A154PRE7   A0A0L7QUL4   A0A3L8DGR3   B0XL95   A0A182F681   A0A0J7KM67   T1GK03   A0A1B6BZW6   A0A1B0DJA7   B4P132   B4HWX2   B4Q9V4   Q9VKN7   N6UL49   B4KKM4   B4NLN3   Q29PJ0   B4G6W9   A0A0K8V3M6   B3N518   B4JPU6   B3MJX5   A0A3B0JH60   F4X4U4   A0A1B0FH58   A0A1B6FAH1   D6X165   A0A1W4W495   A0A151X625   B4KKM5   A0A2A3ELE1   A0A158NQG8   A0A151IC22   A0A067RI07   A0A1A9UQY8   A0A1B6IYX2   A0A1A9XVS1   A0A1B0ANV9   A0A1Y1L784   A0A1I8PAY1   A0A0C9PH86   A0A2J7QMS1   A0A1I8NFU6   A0A0L0C1S3   A0A1A9WUY1   A0A1I8MLG7   A0A1B6LIQ3   I2B3M3   A0A1J1I9E6   A0A1J1I5M0   R7TMJ4   A7SLH0   A0A0M9AA88   B5THM9   E2AED8   A0A0P5M4A1   A0A0P6FR25   A0A023FWI0   A0A0P5Y7J5  

PDB

4C2V     E-value=9.17419e-87,     Score=815

KEGG

101735672    K11479 aurora kinase B [EC:2.7.11.1] | (RefSeq) Aurora-B; aurora kinase B-like

GO

GO:0007094   GO:0043988   GO:0004674   GO:0032133   GO:0005524   GO:0032467   GO:0032465   GO:0000780   GO:0051233   GO:0035174   GO:0031616   GO:0005876   GO:0007052   GO:0000776   GO:0048132   GO:0004712   GO:0061952   GO:0030496   GO:0007076   GO:1990385   GO:0006325   GO:0000775   GO:0051321   GO:0046872   GO:0005737   GO:0005819   GO:0006468   GO:0000281   GO:0000070   GO:0030261   GO:0016572   GO:0016021   GO:0004672   GO:0006869   GO:0005634   GO:0005665   GO:0043565   GO:0048384  

PANTHER

PTHR24350   PTHR24350:SF24   PTHR10972  

Subcellular location

Chromosome  
Cytoplasm  
Cytoskeleton  
Midbody  

Length:

287

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00208

Exp number, first 60 AAs:

0.0001

Total prob of N-in:

0.01511

outside

1  -  287

 

 

Pi

235.815548

Theta

197.632801

Tajima's D

0.702549

CLR

0

CSRT

0.577471126443678

Interpretation

Uncertain