Gene

KWMTBOMO03958  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010238

Annotation

PREDICTED:_pseudouridine-5'-phosphatase_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr7(+):6961964-6967074      View in EpiBrowser

Full name

Pseudouridine-5'-phosphatase      

Alternative Name

Haloacid dehalogenase-like hydrolase domain-containing protein 1
Haloacid dehalogenase-like hydrolase domain-containing protein 1A
Protein GS1
Pseudouridine-5'-monophosphatase

Location in the cell

Cytoplasmic   Reliability : 3.438

CDS

ATGGACGGATTACTATTGAATACTGAGGATTTATACACGGTCGGGTTTCAAAAAGTGGCCTCGCGCTACGGCAAAAAGTTCACGTTCGAATTAAAAAGTCGGATAATGGGACAGCAGACGAGAGAGTTTGCCGGGAACATAATAAAATATCTCGATTTGCCTCTTACAATCGAAGATTTTGTATCAGAGACACGTCAAATCTTCGAAGAGCTTTTCCCTCAGAGCGAAATACTGCCTGGTGTAAAGAAACTCATTTATCATCTAAATCAACACAACATTCCAATGGGTTTAGCAACGAGCAGTAGTAAGGAGTCGTACGAATTGAAAACGCTCAAGCATCAAGATTTGTTTGACTTATTTTCACATAAAACTTTAGGCTCTTCAGATCCAGACGTGAAGAGAGGGAAGCCACACCCCGATATATTTATTGTTGCCGCCAATAAGTTTCTCGATAAACCGGATTTAGAAAAGTGTCTCGTTTTCGAAGATTCGATTAATGGCGTGAAGGCGGCGCGCGCTGCTGGCATGCAGGTCGTGATGGTCCCGGACCCGAGACTAGATCGGAGTCACGCCACCGAAGCTACACTTATCCTCGACTCAATGGAGGAATTTAAACCAGAACTGTTCGGTTTACCGCCCTACGAATTCTGA

Protein

MDGLLLNTEDLYTVGFQKVASRYGKKFTFELKSRIMGQQTREFAGNIIKYLDLPLTIEDFVSETRQIFEELFPQSEILPGVKKLIYHLNQHNIPMGLATSSSKESYELKTLKHQDLFDLFSHKTLGSSDPDVKRGKPHPDIFIVAANKFLDKPDLEKCLVFEDSINGVKAARAAGMQVVMVPDPRLDRSHATEATLILDSMEEFKPELFGLPPYEF

Description

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.

Catalytic Activity

H2O + psi-UMP = phosphate + pseudouridine

Cofactor

Mg(2+)

Biophysicochemical Properties

0.38 uM for 5'-PsiMP
1.5 mM for 3'-AMP
5.9 mM for Fructose-6-P
9.4 mM for 5'-UMP

Similarity

Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.

Keywords

3D-structure   Alternative splicing   Complete proteome   Hydrolase   Magnesium   Metal-binding   Nucleotide metabolism   Polymorphism   Reference proteome  

Feature

chain  Pseudouridine-5'-phosphatase
splice variant  In isoform 4.
sequence variant  In dbSNP:rs1131197.

Uniprot

H9JL37   A0A2A4JAX9   A0A2W1BQK6   A0A194Q1A8   A0A194QYZ7   A0A194Q1D5   + More
A0A194QZP8   A0A212FKC6   S4PLG4   H9JL36   A0A2H1WMW9   A0A2W1BX41   A0A151IEQ1   A0A195DNI0   A0A0N0BIR5   A0A2A3E2K7   F4W6C9   A0A195FI83   A0A195AVH3   A0A158P248   A0A151X0K1   E2B275   A0A0J7L6L0   C1C3S8   E9IV40   Q28I61   C1BLF5   A0A088ASD2   A0A0P5R2D3   Q5M7R5   E9IZ63   A0A3Q2III5   A0A023GGR8   A0A2Y9KJL4   A0A3Q1FE28   E2ATA8   A0A195CY64   A0A3Q7MXY1   I3LS97   A0A2K6FCK5   A0A3P8RMI9   A0A151XCE6   A0A3Q7TE77   A0A151NWK4   A0A0L7L3Q9   A0A3Q1IGB7   A0A250YCW0   A0A2U3WYU6   H2PUV1   A0A1E1XRC3   A0A3P8W2D3   U6DWX9   Q3KPS1   A0A1D5Q5D5   G7NKM5   E2BE28   A0A2K5UEI5   G3SH27   A0A131YQD2   A0A3B4ZR48   A0A2K6DQT0   A0A2K5WQD7   W5JCB8   G9K3Y8   A0A3B4ZR65   A0A212EJH8   A0A0D9RSF7   A0T4G2   Q503F9   A0A3R7NW74   A0A1Z5KWT6   A0A2K5E6I3   A0A2Y9GEU3   A0A162CH04   A0A1L8HDA0   A0A0M4EEI1   A0A3B4ED79   K7BK11   A0A1U7TUB8   A0A195E6Q3   A0A0P5K3D5   A0A3B1IUN1   A0A158NLD8   A0A131Z0D8   A0A2M4ALP7   A0A0P6EIH3   A0A1W4XYU9   A0A2D4I690   B5XA20   A0A2M4BY45   A0A2D4ND14   A0A1A8GZV4   A0A1W7RGW9   A0A2K6RYU9   F1RE99   A0A2I3MTZ8   A0A2K5N317   Q08623   F7FYJ0   A0A3P9CVH0  

EC Number

3.1.3.96

Pubmed

19121390    28756777    26354079    22118469    23622113    21719571    + More
21347285    20798317    21282665    20431018    19892987    30723633    22293439    26227816    28087693    29209593    24487278    17431167    22002653    22398555    26830274    20920257    23761445    23236062    12364791    14747013    17210077    28528879    27762356    16136131    25329095    20433749    26358130    23594743    14702039    15772651    15489334    1284467    20722631    21269460    17495919    25186727   

EMBL

BABH01011545    NWSH01002306    PCG68580.1    KZ149930    PZC77379.1    KQ459579    + More
KPI99367.1    KQ460930    KPJ10758.1    KPI99366.1    KPJ10759.1    AGBW02008070    OWR54191.1    GAIX01004040    JAA88520.1    ODYU01009402    SOQ53804.1    PZC77380.1    KQ977858    KYM99286.1    KQ980724    KYN14054.1    KQ435726    KOX78131.1    KZ288425    PBC25930.1    GL887707    EGI70264.1    KQ981523    KYN40385.1    KQ976731    KYM76233.1    ADTU01006978    KQ982625    KYQ53466.1    GL445067    EFN60201.1    LBMM01000494    KMQ98213.1    BT081507    ACO51638.1    GL766116    EFZ15560.1    AAMC01087056    AAMC01087057    AAMC01087058    AAMC01087059    AAMC01087060    AAMC01087061    AAMC01087062    AAMC01087063    AAMC01087064    AAMC01087065    CR760575    CAJ81276.1    BT075434    ACO09858.1    GDIQ01106461    JAL45265.1    BC088493    AAH88493.1    GL767119    EFZ14132.1    GBBM01002339    JAC33079.1    GL442545    EFN63353.1    KQ977115    KYN05610.1    AEMK02000112    DQIR01274589    HDC30067.1    KQ982314    KYQ58023.1    AKHW03001669    KYO41113.1    JTDY01003218    KOB69929.1    GFFW01003331    JAV41457.1    ABGA01388421    ABGA01388422    ABGA01388423    NDHI03003531    PNJ26873.1    GFAA01001621    JAU01814.1    HAAF01014750    CCP86572.1    BC106588    AAI06589.1    JSUE03019506    CM001270    EHH29273.1    GL447755    EFN86015.1    AQIA01032450    CABD030122626    CABD030122627    GEDV01007867    JAP80690.1    AQIA01083301    AQIA01083302    AQIA01083303    ADMH02001839    ETN60968.1    JP011015    AER99612.1    AGBW02014474    OWR41621.1    AQIB01143676    AQIB01143677    AQIB01143678    AQIB01143679    AQIB01143680    AQIB01143681    AQIB01143682    AQIB01143683    AQIB01143684    AQIB01143685    AAAB01008904    EAA44497.5    BC095345    BC165028    AAH95345.1    AAI65028.1    QCYY01002667    ROT68424.1    GFJQ02007377    JAV99592.1    LRGB01000868    KZS15742.1    CM004468    OCT94079.1    CP012523    ALC38555.1    AACZ04029441    AACZ04029442    AACZ04029443    GABC01001085    GABF01009795    GABE01009361    NBAG03000502    JAA10253.1    JAA12350.1    JAA35378.1    PNI19155.1    KQ979568    KYN20771.1    GDIQ01215870    JAK35855.1    ADTU01019320    GEDV01004362    JAP84195.1    GGFK01008394    MBW41715.1    GDIQ01076017    JAN18720.1    IACK01081428    LAA79715.1    BT047889    ACI67690.1    GGFJ01008792    MBW57933.1    IACM01171143    LAB42876.1    HAEB01003233    HAEC01009210    SBQ77426.1    GDAY02001035    JAV50392.1    CR925879    AHZZ02036370    AHZZ02036371    AK300985    AK313155    AK223405    AK300740    AC073583    CH471074    BC012494    DR156836    M86934   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000078542    + More
UP000078492    UP000053105    UP000242457    UP000007755    UP000078541    UP000078540    UP000005205    UP000075809    UP000000311    UP000036403    UP000008143    UP000005203    UP000002281    UP000248482    UP000257200    UP000286641    UP000008227    UP000233160    UP000265080    UP000286642    UP000050525    UP000037510    UP000265040    UP000245340    UP000001595    UP000265120    UP000006718    UP000008237    UP000233100    UP000001519    UP000261400    UP000233120    UP000000673    UP000029965    UP000007062    UP000283509    UP000233020    UP000248481    UP000076858    UP000186698    UP000092553    UP000261440    UP000002277    UP000189704    UP000018467    UP000192224    UP000087266    UP000233220    UP000000437    UP000028761    UP000233060    UP000005640    UP000002280    UP000265160   

PRIDE

H9JL37    H9JL36    I3LS97    Q08623   

Pfam

PF13419   HAD_2

Interpro

IPR006439   HAD-SF_hydro_IA        + More
IPR023198   PGP-like_dom2       
IPR041492   HAD_2       
IPR036412   HAD-like_sf       
IPR023214   HAD_sf       

SUPFAM

SSF56784   SSF56784       

Gene 3D

1.10.150.240     3.40.50.1000    

ProteinModelPortal

H9JL37   A0A2A4JAX9   A0A2W1BQK6   A0A194Q1A8   A0A194QYZ7   A0A194Q1D5   + More
A0A194QZP8   A0A212FKC6   S4PLG4   H9JL36   A0A2H1WMW9   A0A2W1BX41   A0A151IEQ1   A0A195DNI0   A0A0N0BIR5   A0A2A3E2K7   F4W6C9   A0A195FI83   A0A195AVH3   A0A158P248   A0A151X0K1   E2B275   A0A0J7L6L0   C1C3S8   E9IV40   Q28I61   C1BLF5   A0A088ASD2   A0A0P5R2D3   Q5M7R5   E9IZ63   A0A3Q2III5   A0A023GGR8   A0A2Y9KJL4   A0A3Q1FE28   E2ATA8   A0A195CY64   A0A3Q7MXY1   I3LS97   A0A2K6FCK5   A0A3P8RMI9   A0A151XCE6   A0A3Q7TE77   A0A151NWK4   A0A0L7L3Q9   A0A3Q1IGB7   A0A250YCW0   A0A2U3WYU6   H2PUV1   A0A1E1XRC3   A0A3P8W2D3   U6DWX9   Q3KPS1   A0A1D5Q5D5   G7NKM5   E2BE28   A0A2K5UEI5   G3SH27   A0A131YQD2   A0A3B4ZR48   A0A2K6DQT0   A0A2K5WQD7   W5JCB8   G9K3Y8   A0A3B4ZR65   A0A212EJH8   A0A0D9RSF7   A0T4G2   Q503F9   A0A3R7NW74   A0A1Z5KWT6   A0A2K5E6I3   A0A2Y9GEU3   A0A162CH04   A0A1L8HDA0   A0A0M4EEI1   A0A3B4ED79   K7BK11   A0A1U7TUB8   A0A195E6Q3   A0A0P5K3D5   A0A3B1IUN1   A0A158NLD8   A0A131Z0D8   A0A2M4ALP7   A0A0P6EIH3   A0A1W4XYU9   A0A2D4I690   B5XA20   A0A2M4BY45   A0A2D4ND14   A0A1A8GZV4   A0A1W7RGW9   A0A2K6RYU9   F1RE99   A0A2I3MTZ8   A0A2K5N317   Q08623   F7FYJ0   A0A3P9CVH0  

PDB

3L5K     E-value=2.19351e-61,     Score=594

KEGG

101744719    K17623 pseudouridine 5'-phosphatase [EC:3.1.3.96] | (RefSeq) pseudouridine-5'-phosphatase

GO

GO:0016787   GO:0000287   GO:0043097   GO:1990738   GO:0005829   GO:0009117   GO:0008152   GO:0006351   GO:0005634   GO:0005665   GO:0043565   GO:0016021   GO:0004672   GO:0048384  

Length:

216

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00031

Exp number, first 60 AAs:

0.0003

Total prob of N-in:

0.01886

outside

1  -  216

 

 

Pi

252.280616

Theta

164.0222

Tajima's D

1.395321

CLR

0.200876

CSRT

0.764361781910904

Interpretation

Uncertain