Gene

KWMTBOMO03955  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010236

Annotation

Aminomethyltransferase_[Operophtera_brumata]

Location

Bomo_Chr7(+):6936538-6937346      View in EpiBrowser

Full name

Aminomethyltransferase      

Alternative Name

Glycine cleavage system T protein

Location in the cell

Cytoplasmic   Reliability : 1.142 Mitochondrial   Reliability : 1.472

CDS

ATGCTAGAAACTTCGGAATTGTTCAAGAAAAGAGGTAATGACGTGAATGTCAGCTTCTGGGATGTGAACGACAGAGCACTTCTAGCACTACAGGGGCCGAAAGCAGCCAAATTATTGCAAACATTGACTGATTTTTCTTTAGATGATCTAGTATTTATGACATCACGTGAGGGTCGTGTCGCCAATGTTGGTTGCAGAGTGACGCGCTGCGGATATACAGGCGAAGATGGTGTAGAACTCTCTATTCCGGCAGATAAAGCAATCGCTGTTGCAGAAGCATTGATGGAATCGAGTGATGTGAAATTAGCAGGACTCGGGGCTAGAGATTCATTGCGTTTAGAGGCAGGCCTTTGTCTTTACGGTAACGATATAGACGAAACGGTAACTCCTGTTGAAGCTAATTTGACCTGGCTAATAGCGAAACGTAGGCGACAGGAATCCAACTTTCCCGGAGCTAACATTATAATGAAACAGATTAAAGAAGGAGTATTAAAACGAAGAGTTGGTATTAGATTAGAGTCTGGACCTCCTGCTAGAAAAGATGCAATTTTAAAGGACCCAATCAATAATAAAGAAATAGGTAAAGTGACAAGTGGATGCCCAACGCCCTCACTTGGCGGTAGCATAGCAATGGGATATGTTTCCGAAGCATTCAAAAAAGTAGGTACTAATCTTTTGGTGAACATTCGTGGTAAAGACGTTCCGTGTTCTGTGGCTAAAATGCCTTTTGTGCCGTCTAAATACTACATTAAAAAATAA

Protein

MLETSELFKKRGNDVNVSFWDVNDRALLALQGPKAAKLLQTLTDFSLDDLVFMTSREGRVANVGCRVTRCGYTGEDGVELSIPADKAIAVAEALMESSDVKLAGLGARDSLRLEAGLCLYGNDIDETVTPVEANLTWLIAKRRRQESNFPGANIIMKQIKEGVLKRRVGIRLESGPPARKDAILKDPINNKEIGKVTSGCPTPSLGGSIAMGYVSEAFKKVGTNLLVNIRGKDVPCSVAKMPFVPSKYYIKK

Description

The glycine cleavage system catalyzes the degradation of glycine.

Catalytic Activity

(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)

Subunit

The glycine cleavage system is composed of four proteins: P, T, L and H.

Similarity

Belongs to the GcvT family.

Uniprot

H9JL35   A0A2W1BQK3   A0A2A4JA83   A0A2H1WFZ6   A0A0L7LMJ4   A0A212EJF6   + More
A0A194PLJ0   A0A194R4H5   A0A1B0D587   A0A336LTL8   E0V924   A0A1J1HSW0   A0A1L8E2U3   A0A2P8YRA9   A0A2M3Z8V0   A0A3S3RMY6   A0A2M3Z8R5   A0A2M4AG71   A0A2M4CZI8   A0A2M4AFQ0   A0A2M4AFV4   A0A067RHU6   A0A2M4CN70   A0A182FRY6   A0A2M4BPA8   U4UI28   A0A182PR60   N6U7K5   W5J5A8   A0A1W4WI20   A0A1W0WTQ7   Q7PWZ1   A0A1B6CL61   A0A2M4BPC1   A0A1S4FQ28   A0A182GE74   Q16TD5   A0A182XNY3   A0A2J7RE92   A0A3Q3X7N5   K7ING3   A0A182L8A0   A0A182HK29   E1ZYN2   A0A1B6E951   A0A232EPR6   A0A1A9X525   A0A182V677   A0A182NR11   A0A182U9G4   A0A0B7AVP6   A0A137NZ17   A0A1B6JQM4   A0A310SFN7   D3TLX4   A0A195CD38   A0A1A9Y9I1   A0A1B0B9E3   A0A3B4Z508   A0A182RG19   A0A1A9Z3I6   D2A5E0   A0A182GEG9   E9IIN7   A0A1Q3F4G5   A0A3Q0SKP2   Q4T171   A0A154P2R3   A0A3P8QIR5   A0A182YNA7   A0A0F8CC69   A0A182VW90   A9C3Q7   A0A182Q1N0   H3CHM0   A0A3Q4M1G3   I3J039   A0A2U9C151   A0A3Q3BPF1   A0A3P8QI89   A0A3P9BLR3   A0A026WVF9   A0A195DPC3   A0A372QQ01   A0A3B4FTP5   A0A182JRQ9   A0A0M9A9S2   B0X8W0   A0A0J7KJT8   Q5XJA4   A0A084W080   H2TCG8   A0A195EZE9   A0A2N1NLT5   A0A2I1ENA7   U9T4P7   A0A2I1GCC5   A0A015IP81   A0A2N0PPI1   A0A158P324  

EC Number

2.1.2.10

Pubmed

19121390    28756777    26227816    22118469    26354079    20566863    + More
29403074    24845553    23537049    20920257    23761445    12364791    14747013    17210077    26483478    17510324    20075255    20966253    20798317    28648823    25977457    20353571    18362917    19820115    21282665    15496914    25244985    25835551    23594743    25186727    24508170    24438588    21551351    24277808    29355972    21347285   

EMBL

BABH01011545    KZ149930    PZC77382.1    NWSH01002306    PCG68578.1    ODYU01008384    + More
SOQ51937.1    JTDY01000583    KOB76579.1    AGBW02014474    OWR41619.1    KQ459600    KPI94192.1    KQ460930    KPJ10761.1    AJVK01003416    AJVK01003417    UFQT01000102    SSX20013.1    DS234988    EEB09880.1    CVRI01000019    CRK90468.1    GFDF01001192    JAV12892.1    PYGN01000417    PSN46754.1    GGFM01004174    MBW24925.1    NCKU01006569    RWS03370.1    GGFM01004162    MBW24913.1    GGFK01006297    MBW39618.1    GGFL01006090    MBW70268.1    GGFK01006282    MBW39603.1    GGFK01006296    MBW39617.1    KK852626    KDR19910.1    GGFL01002555    MBW66733.1    GGFJ01005779    MBW54920.1    KB632225    ERL90266.1    APGK01036687    KB740941    ENN77640.1    ADMH02002129    ETN58593.1    MTYJ01000048    OQV18581.1    AAAB01008987    EAA01036.3    GEDC01023091    JAS14207.1    GGFJ01005778    MBW54919.1    JXUM01057734    KQ561969    KXJ77032.1    CH477652    EAT37761.1    NEVH01005277    PNF39147.1    APCN01000815    GL435237    EFN73696.1    GEDC01002914    JAS34384.1    NNAY01002914    OXU20331.1    HACG01038048    CEK84913.1    KQ964607    KXN67891.1    GECU01006216    JAT01491.1    KQ764883    OAD54280.1    CCAG010016065    EZ422426    ADD18702.1    KQ977935    KYM98630.1    JXJN01010369    KQ971345    EFA05357.1    JXUM01057960    KQ561980    KXJ76993.1    GL763494    EFZ19584.1    GFDL01012593    JAV22452.1    CAAE01010703    CAF93361.1    KQ434796    KZC05634.1    KQ041207    KKF29273.1    CR450777    CR847503    AXCN02001483    AERX01012482    CP026253    AWP09389.1    KK107087    EZA59968.1    KQ980713    KYN14334.1    QKKE01000367    RGB30273.1    KQ435711    KOX79396.1    DS232507    EDS42716.1    LBMM01006325    KMQ90693.1    BC083400    BC164008    DQ104411    AAH83400.1    AAI64008.1    AAZ08415.1    ATLV01019094    KE525262    KFB43624.1    KQ981905    KYN33506.1    LLXL01000281    PKK74828.1    LLXK01000635    PKY23607.1    KI295788    AUPC02000274    ESA02352.1    POG63197.1    LLXI01000312    PKY44282.1    JEMT01026548    EXX59022.1    LLXJ01000519    PKC08734.1    ADTU01007681   

Proteomes

UP000005204    UP000218220    UP000037510    UP000007151    UP000053268    UP000053240    + More
UP000092462    UP000009046    UP000183832    UP000245037    UP000285301    UP000027135    UP000069272    UP000030742    UP000075885    UP000019118    UP000000673    UP000192223    UP000007062    UP000069940    UP000249989    UP000008820    UP000076407    UP000235965    UP000261620    UP000002358    UP000075882    UP000075840    UP000000311    UP000215335    UP000091820    UP000075903    UP000075884    UP000075902    UP000070444    UP000092444    UP000078542    UP000092443    UP000092460    UP000261400    UP000075900    UP000092445    UP000007266    UP000261340    UP000076502    UP000265100    UP000076408    UP000075920    UP000000437    UP000075886    UP000007303    UP000261580    UP000005207    UP000246464    UP000264840    UP000265160    UP000053097    UP000078492    UP000263633    UP000261460    UP000075881    UP000053105    UP000002320    UP000036403    UP000030765    UP000005226    UP000078541    UP000233469    UP000018888    UP000234323    UP000022910    UP000232722    UP000005205   

PRIDE

H9JL35    U9T4P7   

Pfam

PF01571   GCV_T        + More
PF08669   GCV_T_C
PF01597   GCV_H
PF03188   Cytochrom_B561

Interpro

IPR029043   GcvT/YgfZ_C        + More
IPR006222   GCV_T_N       
IPR027266   TrmE/GcvT_dom1       
IPR006223   GCS_T       
IPR013977   GCV_T_C       
IPR011053   Single_hybrid_motif       
IPR028896   GCST/YgfZ/DmdA       
IPR033753   GCV_H/Fam206       
IPR006593   Cyt_b561/ferric_Rdtase_TM       

SUPFAM

SSF51230   SSF51230        + More
SSF101790   SSF101790       

Gene 3D

3.30.1360.120    

ProteinModelPortal

H9JL35   A0A2W1BQK3   A0A2A4JA83   A0A2H1WFZ6   A0A0L7LMJ4   A0A212EJF6   + More
A0A194PLJ0   A0A194R4H5   A0A1B0D587   A0A336LTL8   E0V924   A0A1J1HSW0   A0A1L8E2U3   A0A2P8YRA9   A0A2M3Z8V0   A0A3S3RMY6   A0A2M3Z8R5   A0A2M4AG71   A0A2M4CZI8   A0A2M4AFQ0   A0A2M4AFV4   A0A067RHU6   A0A2M4CN70   A0A182FRY6   A0A2M4BPA8   U4UI28   A0A182PR60   N6U7K5   W5J5A8   A0A1W4WI20   A0A1W0WTQ7   Q7PWZ1   A0A1B6CL61   A0A2M4BPC1   A0A1S4FQ28   A0A182GE74   Q16TD5   A0A182XNY3   A0A2J7RE92   A0A3Q3X7N5   K7ING3   A0A182L8A0   A0A182HK29   E1ZYN2   A0A1B6E951   A0A232EPR6   A0A1A9X525   A0A182V677   A0A182NR11   A0A182U9G4   A0A0B7AVP6   A0A137NZ17   A0A1B6JQM4   A0A310SFN7   D3TLX4   A0A195CD38   A0A1A9Y9I1   A0A1B0B9E3   A0A3B4Z508   A0A182RG19   A0A1A9Z3I6   D2A5E0   A0A182GEG9   E9IIN7   A0A1Q3F4G5   A0A3Q0SKP2   Q4T171   A0A154P2R3   A0A3P8QIR5   A0A182YNA7   A0A0F8CC69   A0A182VW90   A9C3Q7   A0A182Q1N0   H3CHM0   A0A3Q4M1G3   I3J039   A0A2U9C151   A0A3Q3BPF1   A0A3P8QI89   A0A3P9BLR3   A0A026WVF9   A0A195DPC3   A0A372QQ01   A0A3B4FTP5   A0A182JRQ9   A0A0M9A9S2   B0X8W0   A0A0J7KJT8   Q5XJA4   A0A084W080   H2TCG8   A0A195EZE9   A0A2N1NLT5   A0A2I1ENA7   U9T4P7   A0A2I1GCC5   A0A015IP81   A0A2N0PPI1   A0A158P324  

PDB

1WSV     E-value=3.19289e-65,     Score=628

KEGG

101744428    K00605 aminomethyltransferase [EC:2.1.2.10] | (RefSeq) aminomethyltransferase, mitochondrial

PATHWAY

00260    Glycine, serine and threonine metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
00670    One carbon pool by folate - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004047   GO:0006546   GO:0005739   GO:0008483   GO:0008168   GO:0055114   GO:0016021   GO:0019464   GO:0006730   GO:0004375   GO:0005515   GO:0003899   GO:0006351   GO:0005634   GO:0005665   GO:0043565   GO:0004672   GO:0048384  

Subcellular location

Mitochondrion  

Length:

252

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00523

Exp number, first 60 AAs:

0

Total prob of N-in:

0.03924

outside

1  -  252

 

 

Pi

137.712227

Theta

233.659283

Tajima's D

-1.228794

CLR

1071.43501

CSRT

0.0996450177491125

Interpretation

Uncertain