Gene

KWMTBOMO03933  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010230

Annotation

PREDICTED:_histone_acetyltransferase_type_B_catalytic_subunit_[Papilio_polytes]

Location

Bomo_Chr7(+):6764605-6770166      View in EpiBrowser

Full name

Histone acetyltransferase type B catalytic subunit      

Location in the cell

Cytoplasmic   Reliability : 1.578 Nuclear   Reliability : 1.884

CDS

ATGACTGATGCTTTGTGCCACTTAGTTGTTGATGGGAACGACGTTTTGGAATTCAAACTAGTGAGGTCGGTAGATGATCTCGAAAATGAAGAGACAAGCTTTGGTCCCGACATGTGTCACCAGGTATTTGGAGAGAATGAGAATATATTTGGATATACAGATCTACACATTAAATTATATTACAGTGCAGGAAGTCTTCAAACATATCTAGGAATTGATTACACTGATAAGATCGAACCAAGTAAGTCAGAAGGAATGAAAGCAGATGATGTTGAGGGTGCTCTGACTAAAGTTATAGCACCAGGGTATATCACTAATTTGGATCACTTTGTGTCACAATTAAAGAAAGATGAGTCATTCACACCACATGGAAAAATGCTGCATGCATTCAATGTAACCCCTTTTGATGGAGAGAGCAGATCATTTGAAGTATATTATTGTGAGACTTCAACTCAAGGTTTTCTAGAATACCATCAACGTTTACAAACATTTCTCCTGTGGTATGTAGATGCAGCATCATTCATAGATGTTGATGATGATCAGTGGACATTCTTCACAGTTTTTGAGAAATATCAAACGAGTGAAGGCAGTGTTCGATACGCTACAGCTGCCTATGCAACTGTATACAGATATTATGCCTATCCAAACCATCAACGTCCACGAATCTCACAAGTTCTTACATTACCGCCCTTCAGAAAACTCGGAATTTGTGCACAAATGTTACAGGCCGTATACTCTCACTTTATAATAATACCTGAAGTGATAGATCTCACAGTTGAAGACCCCTCACCTGACTTTCAAAGGGTTAGAGATTATGTTGATGCTAAGAACTGTGAAAGATTACCGGCATTTCAGCCAGCTGCCTTATACTTAGGGTTCTCAGCTGAAATGGCGATCCAGGCGCGAAATAAATTTAAAATAAACAAAAAACAAGCAAGGAGAATTTATGAAATATTGCGTTTGAAGAATACAAATACTTCTGATAAGACTGCATATTTGAATTATAGATTAGATGTTAAGAACAGACTGAATGCTCCATTTCAGAAAAAGAAGCTAGAAATGAAAAAGCTTCAGAAGGTATTGAAACCTGAAGAGTTTGTAGCCACTGTGACAGTTACTGGTGCTAATGAGACACAGGCGAGACTCTCCAGTCAATACCACTCGCTCGAGATCGAGTACCGCCGCGTCATACATCGGATGGAACAAGACTAA

Protein

MTDALCHLVVDGNDVLEFKLVRSVDDLENEETSFGPDMCHQVFGENENIFGYTDLHIKLYYSAGSLQTYLGIDYTDKIEPSKSEGMKADDVEGALTKVIAPGYITNLDHFVSQLKKDESFTPHGKMLHAFNVTPFDGESRSFEVYYCETSTQGFLEYHQRLQTFLLWYVDAASFIDVDDDQWTFFTVFEKYQTSEGSVRYATAAYATVYRYYAYPNHQRPRISQVLTLPPFRKLGICAQMLQAVYSHFIIIPEVIDLTVEDPSPDFQRVRDYVDAKNCERLPAFQPAALYLGFSAEMAIQARNKFKINKKQARRIYEILRLKNTNTSDKTAYLNYRLDVKNRLNAPFQKKKLEMKKLQKVLKPEEFVATVTVTGANETQARLSSQYHSLEIEYRRVIHRMEQD

Description

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.

Catalytic Activity

acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]

Subunit

Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.

Similarity

Belongs to the HAT1 family.

Feature

chain  Histone acetyltransferase type B catalytic subunit

Uniprot

H9JL29   A0A2W1BQV4   A0A2A4K126   A0A3S2LC78   A0A194PSW4   S4PLD9   + More
A0A212FAG7   A0A2H1VZU6   A0A0M9A5V6   A0A0L7QM96   A0A088A604   A0A154P5T0   A0A194R4K0   A0A2A3ECN5   A0A310SIZ0   A0A0P5TQ39   A0A0P5PND8   A0A0P5N7V6   E9GXH7   A0A067QM69   A0A0P5QGF0   A0A0N8AHA4   A0A0N8DFS3   A0A0P6I305   A0A232F5C9   A0A0P6B491   E2C3Z7   A0A2R5LCJ8   A0A2J7PXD5   A0A1E1XLF1   A0A2P8XZQ5   A0A293N3Y2   A0A1Z5LCI0   A0A1E1XC66   B7PSE2   A0A0K8RN34   A0A0P5YME8   A0A0P5RGH6   A0A0P5P3X6   T1IZF3   A0A131Z7M8   A0A131XD21   A0A151IMD9   A0A0P4Z597   C3YL13   A0A1S3IAS7   A0A195FDR8   A0A0P6CSJ9   A0A195DQY3   A0A158NBR1   A0A210PHA4   A0A151X9E9   A0A1Q1M8W1   F4X877   E9IFJ4   A0A1Q1M8Z4   A0A026W9L0   A0A1Q1M8Z5   A0A1Q1M902   L7M374   L7LRS0   A0A0P5ABG8   A0A1Q1M8X1   A0A1B6D2L5   V4AGL7   A0A1B6HEP4   A0A1B6GEC1   E1ZVD4   A0A023GJC0   G3MRZ9   A0A1B6MIW2   A0A1B6M3C7   A0A224YPL1   A0A2G8JI07   A0A2T7PV17   A0A0P4VLM5   T1FM44   A0A1B6KWX0   A0A060VQR9   A0A1B6MCB4   R4FKM3   A0A1B0DLX2   A0A1S3PM63   A0A0B6YTN1   G1DGD8   W4XPC8   A0A250YHY3   F1P5A3   A0A1B0CUG1   A0A3P8Z229   Q58DR1   W5NUK5   L8J278   A0A1S3AN79   Q0P580   A0A384BSY4   A0A341AHI7   A0A2U3V404   A0A340XFL3  

EC Number

2.3.1.48

Pubmed

19121390    28756777    26354079    23622113    22118469    21292972    + More
24845553    28648823    20798317    29209593    29403074    28528879    28503490    26830274    28049606    18563158    21347285    28812685    28126515    21719571    21282665    24508170    30249741    25576852    23254933    22216098    28797301    29023486    27129103    24755649    28087693    15592404    25069045    12140684    16305752    19393038    20809919    22751099    24813606   

EMBL

BABH01011536    KZ149930    PZC77408.1    NWSH01000258    PCG77947.1    RSAL01000049    + More
RVE50425.1    KQ459600    KPI94220.1    GAIX01004075    JAA88485.1    AGBW02009472    OWR50736.1    ODYU01005440    SOQ46303.1    KQ435736    KOX77096.1    KQ414894    KOC59768.1    KQ434809    KZC06490.1    KQ460930    KPJ10786.1    KZ288305    PBC28781.1    KQ760706    OAD59327.1    GDIP01126205    LRGB01001036    JAL77509.1    KZS13677.1    GDIQ01131644    JAL20082.1    GDIQ01157229    JAK94496.1    GL732573    EFX75805.1    KK853254    KDR09285.1    GDIQ01124287    JAL27439.1    GDIP01147505    JAJ75897.1    GDIP01038063    JAM65652.1    GDIQ01017878    JAN76859.1    NNAY01000904    OXU26001.1    GDIP01021520    JAM82195.1    GL452364    EFN77383.1    GGLE01002951    MBY07077.1    NEVH01020859    PNF20992.1    GFAA01003390    JAU00045.1    PYGN01001114    PSN37476.1    GFWV01022759    MAA47486.1    GFJQ02001854    JAW05116.1    GFAC01002389    JAT96799.1    ABJB010203113    ABJB010291202    ABJB010406542    ABJB010738830    ABJB011089772    ABJB011118347    DS778096    EEC09514.1    GADI01001281    JAA72527.1    GDIP01056610    JAM47105.1    GDIQ01102954    JAL48772.1    GDIQ01154832    JAK96893.1    JH431714    GEDV01001260    JAP87297.1    GEFH01003047    JAP65534.1    KQ977059    KYN06040.1    GDIP01218388    JAJ05014.1    GG666525    EEN59004.1    KQ981673    KYN38347.1    GDIQ01087864    JAN06873.1    KQ980581    KYN15283.1    ADTU01011290    NEDP02076701    OWF35869.1    KQ982373    KYQ56992.1    KY295852    AQM32547.1    GL888932    EGI57208.1    GL762841    EFZ20669.1    KY295851    AQM32546.1    KK107372    QOIP01000004    EZA51704.1    RLU23741.1    KY295853    AQM32548.1    KY295846    AQM32541.1    GACK01006712    JAA58322.1    GACK01010333    JAA54701.1    GDIP01201437    JAJ21965.1    KY295850    AQM32545.1    GEDC01017371    JAS19927.1    KB201847    ESO94305.1    GECU01034594    JAS73112.1    GECZ01009009    JAS60760.1    GL434492    EFN74844.1    GBBM01001452    JAC33966.1    JO844650    AEO36267.1    GEBQ01004077    JAT35900.1    GEBQ01009583    JAT30394.1    GFPF01008392    MAA19538.1    MRZV01001917    PIK35373.1    PZQS01000002    PVD37263.1    GDKW01003017    JAI53578.1    AMQM01000370    KB095811    ESO13193.1    GEBQ01024057    JAT15920.1    FR904281    CDQ57176.1    GEBQ01006420    JAT33557.1    GAHY01001783    JAA75727.1    AJVK01016583    HACG01011990    CEK58855.1    JI861854    AEJ84342.1    AAGJ04007319    GFFW01001649    JAV43139.1    AADN05000350    AJWK01029153    BT021536    AAX46383.1    AMGL01052690    JH880354    ELR62328.1    BC120387    AAI20388.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053105    + More
UP000053825    UP000005203    UP000076502    UP000053240    UP000242457    UP000076858    UP000000305    UP000027135    UP000215335    UP000008237    UP000235965    UP000245037    UP000001555    UP000078542    UP000001554    UP000085678    UP000078541    UP000078492    UP000005205    UP000242188    UP000075809    UP000007755    UP000053097    UP000279307    UP000030746    UP000000311    UP000230750    UP000245119    UP000015101    UP000193380    UP000092462    UP000087266    UP000007110    UP000000539    UP000092461    UP000265140    UP000009136    UP000002356    UP000079721    UP000261680    UP000291021    UP000252040    UP000245320    UP000265300   

PRIDE

H9JL29   

Pfam

PF10394   Hat1_N        + More
PF00583   Acetyltransf_1

Interpro

IPR013523   Hist_AcTrfase_HAT1_C        + More
IPR037113   Hat1_N_sf       
IPR019467   Hat1_N       
IPR016181   Acyl_CoA_acyltransferase       
IPR017380   Hist_AcTrfase_B-typ_cat-su       
IPR000182   GNAT_dom       

SUPFAM

SSF55729   SSF55729       

Gene 3D

1.10.10.390     3.90.360.10    

ProteinModelPortal

H9JL29   A0A2W1BQV4   A0A2A4K126   A0A3S2LC78   A0A194PSW4   S4PLD9   + More
A0A212FAG7   A0A2H1VZU6   A0A0M9A5V6   A0A0L7QM96   A0A088A604   A0A154P5T0   A0A194R4K0   A0A2A3ECN5   A0A310SIZ0   A0A0P5TQ39   A0A0P5PND8   A0A0P5N7V6   E9GXH7   A0A067QM69   A0A0P5QGF0   A0A0N8AHA4   A0A0N8DFS3   A0A0P6I305   A0A232F5C9   A0A0P6B491   E2C3Z7   A0A2R5LCJ8   A0A2J7PXD5   A0A1E1XLF1   A0A2P8XZQ5   A0A293N3Y2   A0A1Z5LCI0   A0A1E1XC66   B7PSE2   A0A0K8RN34   A0A0P5YME8   A0A0P5RGH6   A0A0P5P3X6   T1IZF3   A0A131Z7M8   A0A131XD21   A0A151IMD9   A0A0P4Z597   C3YL13   A0A1S3IAS7   A0A195FDR8   A0A0P6CSJ9   A0A195DQY3   A0A158NBR1   A0A210PHA4   A0A151X9E9   A0A1Q1M8W1   F4X877   E9IFJ4   A0A1Q1M8Z4   A0A026W9L0   A0A1Q1M8Z5   A0A1Q1M902   L7M374   L7LRS0   A0A0P5ABG8   A0A1Q1M8X1   A0A1B6D2L5   V4AGL7   A0A1B6HEP4   A0A1B6GEC1   E1ZVD4   A0A023GJC0   G3MRZ9   A0A1B6MIW2   A0A1B6M3C7   A0A224YPL1   A0A2G8JI07   A0A2T7PV17   A0A0P4VLM5   T1FM44   A0A1B6KWX0   A0A060VQR9   A0A1B6MCB4   R4FKM3   A0A1B0DLX2   A0A1S3PM63   A0A0B6YTN1   G1DGD8   W4XPC8   A0A250YHY3   F1P5A3   A0A1B0CUG1   A0A3P8Z229   Q58DR1   W5NUK5   L8J278   A0A1S3AN79   Q0P580   A0A384BSY4   A0A341AHI7   A0A2U3V404   A0A340XFL3  

PDB

2P0W     E-value=3.95079e-75,     Score=716

KEGG

101743374    K11303 histone acetyltransferase 1 [EC:2.3.1.48] | (RefSeq) histone acetyltransferase type B catalyt

GO

GO:0042393   GO:0005634   GO:0004402   GO:0000781   GO:0006348   GO:0010485   GO:0043967   GO:0000790   GO:0008483   GO:0032991   GO:0005654   GO:0006336   GO:0006335   GO:0016573   GO:0006325   GO:0043565   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR12046  

Length:

403

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.04907

Exp number, first 60 AAs:

0.00035

Total prob of N-in:

0.00655

outside

1  -  403

 

 

Pi

253.915654

Theta

211.162362

Tajima's D

0.104682

CLR

0.795121

CSRT

0.397430128493575

Interpretation

Uncertain