Gene

KWMTBOMO03925

Pre Gene Modal

BGIBMGA010226

Annotation

PREDICTED:_glycoprotein_3-alpha-L-fucosyltransferase_A_[Bombyx_mori]

Location

Bomo_Chr7(+):6680145-6701550      View in EpiBrowser

Full name

Glycoprotein 3-alpha-L-fucosyltransferase A      

Alternative Name

Core alpha-(1,3)-fucosyltransferase

Location in the cell

Mitochondrial   Reliability : 1.01

CDS

ATGCGGGTGAGGGCGGCTCGGGCCCTGCGTGCTTTAAGACGCGTGGCACTCTTGTTTCCGCTAGTATTGACTGCGCTGGCGCTAATCCTGCTGCCGCGCCCGGGACCTCTCACACCCCTTGCACAGAATCCTACCATTGCCGCACAGATCCACTCGCTCAAAGACGACCAGCATATTCAAGATCGTTCCAATGAACTTCAAGAAGAGGTGCTGCACGAGGAAGGTGACACCGTATCCCGTCGCCACTGGTTCATGCGCGGAGGTGAACAACGGCCTTGGAAACACGATCCTAGTGCACAAATATTCCCTGAGGATGCCCCTGGGGATGACAGAATCGTTCAACAGCTATCATACATATTACCGAACGACGAGGAGGCGCCTATTAAAAAAATACTACTTGCCAATGGCCTCGGGGCGTGGGGCGTAACCGGTGGTCGTACAGAATTCCTCCGAAACAAGTGCCCCATAGACCGGTGTCATCTTACGGCGGACTCGAGGGATGCCGCCTCTGCAGACGCTATACTCTTCAAAGATCACCATACGCCTTTTAACGTCAAAAGATCTCCTAATCAGATTTGGATTCTCTACTACTTGGAATGTCCTTACCACACGGCTTCCTTGCGGTCTTCATCCTTCGACGTATTTAACTGGACTGCAACTTACCGCAGAGACTCTGATATAGTAGCACCTTACGAAAGATGGGTGTATTATGATAATTTGATTCCTGAAAAAGATATAGAAAGGAACTATGCAGCTAATAAAACAAAGAAGGTAGCGTGGTTTGTATCAAACTGCCACGCTCGCAACCGTCGGCTCCAGTACGCGCGGCAACTCAGCAAATTCATCCAAGTGGACATATACGGCGCGTGCGGCTCTCATCACTGCCCACGAACCGACCCCAACTGCTTGGAAATGTTGGACAAAGAATACAAGTTTTATCTGGCTTTTGAAAATTCAAACTGTCGGGATTACATAACGGAAAAATTCTTCGTCAATGGATTACAACACAACGTTTTACCGATCGTGATGGGAGCCCGGCCATCGGAGTATGCAGCAGTGGCTCCACGTAATTCGTACATTCATGTAGAAGAGTTTGCCGGTCCTGAAGAACTCGCTGCGTACTTACATCGCCTTGATGAAGACCAAGATCTATACAACTCTTACTTTAAATGGAAGGGAACAGGAGAATTCATTAACACATATTTCTTTTGCCGCGTATGTGCGATGATTCACGCGAACGAAAGACGGCAAAGGAATACTCACTACAGCGACGTGCAGGCATGGTGGCGGGACTCCACGTGCACGCGAGGCGAATGGCGAGCCATGGAATCTGATACTAAAGATAATGGATAA

Protein

MRVRAARALRALRRVALLFPLVLTALALILLPRPGPLTPLAQNPTIAAQIHSLKDDQHIQDRSNELQEEVLHEEGDTVSRRHWFMRGGEQRPWKHDPSAQIFPEDAPGDDRIVQQLSYILPNDEEAPIKKILLANGLGAWGVTGGRTEFLRNKCPIDRCHLTADSRDAASADAILFKDHHTPFNVKRSPNQIWILYYLECPYHTASLRSSSFDVFNWTATYRRDSDIVAPYERWVYYDNLIPEKDIERNYAANKTKKVAWFVSNCHARNRRLQYARQLSKFIQVDIYGACGSHHCPRTDPNCLEMLDKEYKFYLAFENSNCRDYITEKFFVNGLQHNVLPIVMGARPSEYAAVAPRNSYIHVEEFAGPEELAAYLHRLDEDQDLYNSYFKWKGTGEFINTYFFCRVCAMIHANERRQRNTHYSDVQAWWRDSTCTRGEWRAMESDTKDNG

Description

Catalyzes alpha-1,3 glycosidic linkages of N-glycans (PubMed:11382750). Plays a role in neuronal development by promoting ventral nerve cord formation, possibly by promoting interactions between migrating cells and the extracellular matrix or by promoting neural activity (PubMed:21203496).

Catalytic Activity

GDP-beta-L-fucose + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] = GDP + H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[(1->4)-alpha-L-Fuc]-beta-D-GlcNAc}-L-asparaginyl-[protein]

Cofactor

Mn(2+)

Similarity

Belongs to the glycosyltransferase 10 family.

Keywords

Complete proteome   Glycoprotein   Glycosyltransferase   Golgi apparatus   Membrane   Reference proteome   Signal-anchor   Transferase   Transmembrane   Transmembrane helix  

Feature

chain  Glycoprotein 3-alpha-L-fucosyltransferase A

Uniprot

H9JL25   A0A2A4J8S2   A0A2H1WI51   A0A212FJJ1   A0A194PSX4   A0A2W1BTB4   + More
A0A194R0M1   A0A2J7QGF8   D6WLF9   A0A0L0C0I7   A0A2P8Y5U4   A0A1A9ZKF2   A0A1I8P4T8   A0A0K8UAX6   A0A0T6BCI2   A0A1B0G4N4   A0A1A9UG39   A0A182T609   A0A1I8MBY4   A0A336MXS3   A0A067R3U8   A0A336LTI5   Q7QBF7   B4IZG2   Q333S7   A0A151J5M2   A0A0K2TXU3   A0A182LCF3   A0A1B0AQT3   A0A158P3S6   Q16P34   A0A182PT18   A0A182K009   A0A182UH12   A0A1A9YIJ0   A0A1B6E207   A0A195FJ96   A0A1S4FUB7   B4L130   A0A195BCP2   A0A151WF38   A0A1B6D299   A0A182URK3   Q333S5   A0A1L8E299   A0A182RC52   A0A182GA87   Q333S0   A0A182YHI7   A0A182VWN3   Q333R8   F4X1Z4   K7S1N1   A0A182N516   A0A182MQ85   E2AJ83   Q333S3   A0A084VAK9   A0A182QES5   A0A151IHC1   A0A1Q3FQ13   Q333R9   Q333S6   A0A026WBS0   I0DHK8   Q9VUL9   E2BFR5   A0A3L8DQJ2   A0A182IXD5   A0A1B0CTS6   A0A1B6KZF6   Q333S2   A0A1B6H0S2   B4QKK9   Q333S1   B0X104   A0A1A9WE13   W5JG97   B4LGU6   A0A1W4XKA8   A0A1B6GM23   A0A182FKV1   B4N519   A0A1J1IGV5   B4GUE1   Q2M1A5   A0A1W4VBB6   A0A182XE47   A0A1Y1MT53   Q05GU3   A0A3B0JQR6   A0A087ZVV0   Q333S4   E0VWX1   A0A0L7QL71   A0A0C9PJM7   E9IK34   A0A0C9QJ70   K7J241   J3JTR8  

EC Number

2.4.1.214

Pubmed

19121390    22118469    26354079    28756777    18362917    19820115    + More
26108605    29403074    25315136    24845553    12364791    17994087    18057021    20966253    21347285    17510324    26483478    25244985    17550304    21719571    20798317    24438588    24508170    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    11382750    12537569    21203496    30249741    22936249    20920257    23761445    15632085    23185243    28004739    17029591    20566863    21282665    20075255    22516182    23537049   

EMBL

BABH01011524    BABH01011525    AB551654    AB551655    BAU20373.1    NWSH01002496    + More
PCG68166.1    ODYU01008814    SOQ52745.1    AGBW02008256    OWR53905.1    KQ459600    KPI94230.1    KZ149942    PZC76884.1    KQ460930    KPJ10795.1    NEVH01014371    PNF27672.1    KQ971343    EFA04106.1    JRES01001072    KNC25771.1    PYGN01000894    PSN39630.1    GDHF01028804    GDHF01021571    JAI23510.1    JAI30743.1    LJIG01001910    KRT85030.1    CCAG010020613    CCAG010020614    UFQS01003686    UFQT01003686    SSX15858.1    SSX35202.1    KK852777    KDR16752.1    UFQS01000185    UFQT01000185    SSX00880.1    SSX21260.1    AAAB01008879    EAA08406.5    CH916366    EDV97737.1    AM113990    CH902618    CAJ42046.1    EDV40895.1    KPU78831.1    KPU78832.1    KQ979970    KYN18400.1    HACA01013447    CDW30808.1    JXJN01002026    JXJN01002027    ADTU01008400    CH477797    EAT36111.1    GEDC01026997    GEDC01005330    JAS10301.1    JAS31968.1    KQ981523    KYN40478.1    CH933809    EDW18187.1    KQ976524    KYM81987.1    KQ983227    KYQ46421.1    GEDC01017565    GEDC01000368    JAS19733.1    JAS36930.1    AM113992    CAJ42048.1    GFDF01001449    JAV12635.1    JXUM01008449    JXUM01008450    JXUM01008451    JXUM01008452    KQ560261    KXJ83488.1    AM113997    CAJ42053.1    AM113999    CM000159    CAJ42055.1    EDW94847.1    GL888558    EGI59530.1    JX566883    AFV92754.1    AXCM01004089    GL439967    EFN66523.1    AM113994    CAJ42050.1    ATLV01004128    KE524190    KFB35003.1    AXCN02000179    KQ977625    KYN01221.1    GFDL01005482    JAV29563.1    AM113998    CAJ42054.1    AM113991    CH954178    CAJ42047.1    EDV52085.1    KK107293    EZA53413.1    BT133453    AE014296    AFH89826.1    AGB94565.1    AJ302045    AY071324    GL448039    EFN85453.1    QOIP01000005    RLU22705.1    AJWK01027946    GEBQ01023149    JAT16828.1    AM113995    CAJ42051.1    GECZ01001496    JAS68273.1    CM000363    CM002912    EDX10520.1    KMY99712.1    AM113996    CAJ42052.1    DS232250    EDS38396.1    ADMH02001488    ETN62363.1    CH940647    EDW70561.1    KRF84994.1    KRF84996.1    GECZ01006318    JAS63451.1    CH964101    EDW79458.1    CVRI01000048    CRK99002.1    CH479191    EDW26224.1    CH379069    EAL30670.2    KRT07513.1    KRT07514.1    KRT07515.1    GEZM01024998    JAV87650.1    AM279411    CAK50252.1    OUUW01000002    SPP75999.1    AM113993    CAJ42049.1    DS235824    EEB17877.1    KQ414933    KOC59368.1    GBYB01001157    GBYB01001158    JAG70924.1    JAG70925.1    GL763924    EFZ19014.1    GBYB01014778    JAG84545.1    BT126627    KB631879    AEE61590.1    ERL86899.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000235965    + More
UP000007266    UP000037069    UP000245037    UP000092445    UP000095300    UP000092444    UP000078200    UP000075901    UP000095301    UP000027135    UP000007062    UP000001070    UP000007801    UP000078492    UP000075882    UP000092460    UP000005205    UP000008820    UP000075885    UP000075881    UP000075902    UP000092443    UP000078541    UP000009192    UP000078540    UP000075809    UP000075903    UP000075900    UP000069940    UP000249989    UP000076408    UP000075920    UP000002282    UP000007755    UP000075884    UP000075883    UP000000311    UP000030765    UP000075886    UP000078542    UP000008711    UP000053097    UP000000803    UP000008237    UP000279307    UP000075880    UP000092461    UP000000304    UP000002320    UP000091820    UP000000673    UP000008792    UP000192223    UP000069272    UP000007798    UP000183832    UP000008744    UP000001819    UP000192221    UP000076407    UP000268350    UP000005203    UP000009046    UP000053825    UP000002358    UP000030742   

PRIDE

H9JL25    I0DHK8    Q9VUL9   

Pfam

PF17039   Glyco_tran_10_N        + More
PF00852   Glyco_transf_10
PF16087   DUF4817

Interpro

IPR031481   Glyco_tran_10_N        + More
IPR038577   GT10-like_sf       
IPR001503   Glyco_trans_10       
IPR032135   DUF4817       

Gene 3D

3.40.50.11660    

ProteinModelPortal

H9JL25   A0A2A4J8S2   A0A2H1WI51   A0A212FJJ1   A0A194PSX4   A0A2W1BTB4   + More
A0A194R0M1   A0A2J7QGF8   D6WLF9   A0A0L0C0I7   A0A2P8Y5U4   A0A1A9ZKF2   A0A1I8P4T8   A0A0K8UAX6   A0A0T6BCI2   A0A1B0G4N4   A0A1A9UG39   A0A182T609   A0A1I8MBY4   A0A336MXS3   A0A067R3U8   A0A336LTI5   Q7QBF7   B4IZG2   Q333S7   A0A151J5M2   A0A0K2TXU3   A0A182LCF3   A0A1B0AQT3   A0A158P3S6   Q16P34   A0A182PT18   A0A182K009   A0A182UH12   A0A1A9YIJ0   A0A1B6E207   A0A195FJ96   A0A1S4FUB7   B4L130   A0A195BCP2   A0A151WF38   A0A1B6D299   A0A182URK3   Q333S5   A0A1L8E299   A0A182RC52   A0A182GA87   Q333S0   A0A182YHI7   A0A182VWN3   Q333R8   F4X1Z4   K7S1N1   A0A182N516   A0A182MQ85   E2AJ83   Q333S3   A0A084VAK9   A0A182QES5   A0A151IHC1   A0A1Q3FQ13   Q333R9   Q333S6   A0A026WBS0   I0DHK8   Q9VUL9   E2BFR5   A0A3L8DQJ2   A0A182IXD5   A0A1B0CTS6   A0A1B6KZF6   Q333S2   A0A1B6H0S2   B4QKK9   Q333S1   B0X104   A0A1A9WE13   W5JG97   B4LGU6   A0A1W4XKA8   A0A1B6GM23   A0A182FKV1   B4N519   A0A1J1IGV5   B4GUE1   Q2M1A5   A0A1W4VBB6   A0A182XE47   A0A1Y1MT53   Q05GU3   A0A3B0JQR6   A0A087ZVV0   Q333S4   E0VWX1   A0A0L7QL71   A0A0C9PJM7   E9IK34   A0A0C9QJ70   K7J241   J3JTR8  

PDB

2NZY     E-value=0.0452303,     Score=86

KEGG

101742412    K00753 glycoprotein 3-alpha-L-fucosyltransferase [EC:2.4.1.214] | (RefSeq) glycoprotein 3-alpha-L-fu

PATHWAY

01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0032580   GO:0006486   GO:0016021   GO:0008417   GO:0036065   GO:0046920   GO:0005797   GO:0036071   GO:0007399   GO:0033932   GO:0018392   GO:0016757   GO:0016020   GO:0006355   GO:0008270   GO:0043565   GO:0004672   GO:0048384  

PANTHER

PTHR11929  

Subcellular location

  

Length:

450

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.08717

Exp number, first 60 AAs:

20.06055

Total prob of N-in:

0.99506

POSSIBLE N-term signal

sequence

inside

1  -  11

TMhelix

12  -  31

outside

32  -  450

 

 

Pi

207.500303

Theta

186.827171

Tajima's D

0.676656

CLR

0.361008

CSRT

0.571771411429429

Interpretation

Uncertain