Gene

KWMTBOMO03917

Pre Gene Modal

BGIBMGA010155

Annotation

PREDICTED:_RNA_exonuclease_1_homolog_[Bombyx_mori]

Location

Bomo_Chr7(-):6540964-6542854      View in EpiBrowser

Full name

Ubiquinone biosynthesis O-methyltransferase, mitochondrial      

Alternative Name

3-demethylubiquinol 3-O-methyltransferase
Polyprenyldihydroxybenzoate methyltransferase

Location in the cell

Nuclear   Reliability : 4.58

CDS

ATGGAGCCTGATGAAGAGACTATAGCGATGGAATGCAAGAAGATTTTTGATGAATATGTTCCAATCAGAAAGATAGTTGCAGAGGAAAATGAACCTACTATAGAAGAAACACAAGATGAGGAATATGTGCCCACAAAGAAGAGAGTATCACGTGCTGTAGATGTTAAAGTTGTAACAAAACGACAAATAAAACCAGATTACAAGATTAGTGCTGCCCAAGCAATGGCAGAAAGATTGGCTAAGGTTAGAGAGTTTCATAGCACAAAAGTTAATAATTCTCTGCAAAATGAAAGTAAAGGTGAGGACAATACAAATATAACAAAAAGGGAACTTCAGAAATCCATATTTAGTACAGTAAACTCTAGTAATTTGAAAATTCGTATTGCTCATGTACCATATGCCTCAACATTGATAAATGCCAAAAGAAATATTTCAACTAGCCAAGACATTGCAAAAAACAGTTTGCCCGCCGGCTCTAATTCATCTACTACTGTCCAAACCATAAAGAAAGGAGCACTGAGGGTAGCACACATGCCTAGTGAGAAATTTATAGATCGCCCAGGTGTTTTAGAGCCTTTGGCTTCAAAAATACCAGCAAATATTAGATCTACTTATTTAAATCTTATGATAGATGAATGCTTGAAACTTTACCTTTCCGCAACTGATGCGTATTCTAGAGCTCAACATGAAGAACTAGCTACGAGCAAGAAATGTAATACGGTTTCTATTTATAAAAACTCTGCAGTATTAACAGTCAACCGACTAAGAAAGGAATTACAGGAAAATAATGGTGAGAAAAAATCAAGTTCTGATTCAAGTAGAAAAGTAGATGCTAGGAATACAGGTTCATGGAGCATAGAGAATAGAAATAAAAAAAGTGATGAGATATCTAAAGAATTAACAGGTGCTAAATTTTATAACAATATTGAAAAATGGATATTAACTGAAGAGCAGCTTCAAGAAAATGGATTTCCTAGAACACACATAAGTGGAGAAAAAGGCAGAGCTTCAATTTATGTGCAACAAAAACAAAAACAAAAACCCCCTAAAGGCTCTATAAGAACATGTTGTAGATGTAAAAAAGATTATACTGTGGACAAAAAAGGTTTTCCAGCTGTAAAAGAGGAATGCATTTATCATCCTAATAATAAATACAGAATACGAGGTGAAGCTCGATATCAATGTTGTAGTCAGGATGGATCATCTGATGGATGTTGTATAGCACCTACCCATGTCTATGAATATGTAGACTATGATAATTTGAGAGGGTTTGTAAAAACATTACCTCCAGATAATAAGTGTGAAGATTATGGAGTGTATGCATTAGATTGTGAGATGTGTTATACTACCCATGGGTTAGACTTGACTAGGGTGACTATAATTAATGCAGAATGTAAAGTCGTTTATGAAACTCTTATAAAACCATTGCACCCTATAATTGACTATAATACTAGATTTTCAGGAATAACTGAAGAACAAATGGCTGAAGTAAAGACAACTCTTTTAGATGTTCAGGCCACTCTTCTAACAATGTTCAATAGTAAGACAATATTGATAGGTCACAGCTTAGAATCAGATTTTAAAGCTTTAAAACTTATTCATGATACAGTCGTAGATACAAGTGTTTTATTCCCTCATAAGATGGGTCCACCATATAAAAGAGCTTTAAGAAACCTATCTTCTGAATATTTAAAGAAGATAATACAAAATTCTGTAGATGGGCACAACAGTGCAGAAGATGCACTCGTGTGTATGGAATTAATTCATTACAAATTAAAAGAGTATTTGAAAACAAGATGA

Protein

MEPDEETIAMECKKIFDEYVPIRKIVAEENEPTIEETQDEEYVPTKKRVSRAVDVKVVTKRQIKPDYKISAAQAMAERLAKVREFHSTKVNNSLQNESKGEDNTNITKRELQKSIFSTVNSSNLKIRIAHVPYASTLINAKRNISTSQDIAKNSLPAGSNSSTTVQTIKKGALRVAHMPSEKFIDRPGVLEPLASKIPANIRSTYLNLMIDECLKLYLSATDAYSRAQHEELATSKKCNTVSIYKNSAVLTVNRLRKELQENNGEKKSSSDSSRKVDARNTGSWSIENRNKKSDEISKELTGAKFYNNIEKWILTEEQLQENGFPRTHISGEKGRASIYVQQKQKQKPPKGSIRTCCRCKKDYTVDKKGFPAVKEECIYHPNNKYRIRGEARYQCCSQDGSSDGCCIAPTHVYEYVDYDNLRGFVKTLPPDNKCEDYGVYALDCEMCYTTHGLDLTRVTIINAECKVVYETLIKPLHPIIDYNTRFSGITEEQMAEVKTTLLDVQATLLTMFNSKTILIGHSLESDFKALKLIHDTVVDTSVLFPHKMGPPYKRALRNLSSEYLKKIIQNSVDGHNSAEDALVCMELIHYKLKEYLKTR

Description

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Catalytic Activity

3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

Uniprot

A0A2H1WEP5   A0A2W1BTC5   A0A3S2P649   A0A0L7L3S8   A0A2A4JST1   A0A194QZU2   + More
A0A194PML8   A0A212EJM2   E2ABA9   A0A3L8D7C7   A0A154PKX9   A0A026W1R3   A0A0N0U5F2   A0A088AUV7   E2BPL4   A0A195DCB6   A0A0C9R580   F4WMA4   A0A151X0Q8   E9IL07   A0A151IA86   A0A158P2J1   A0A195BBV4   A0A195F331   A0A232EZU9   A0A2A3E184   A0A0L7QL72   D6WGM7   A0A1W4WA75   A0A0C9R8I6   U4UFS9   N6U4L3   T1JBB2   A0A2J7PSX5   A0A2J7PSX4   A0A1Y1K9N4   A0A067QSS5   A0A0T6B1H8   A0A147BP91   A0A182PBA0   A0A0N8CH03   E9G4N6   A0A0P4Z3J5   B7PS66   W5J469   A0A0N8CXU6   A0A0P5AXI2   A0A182F9B4   A0A0P6INF8   A0A182W160   A0A2I0TDV2   A0A182Q5S3   A0A182JWP7   A0A182MBX0   A0A182LAK0   A0A182NFX9   A0A182USS9   A0A182RX82   A0A1U7RPX9   U3KH32   H0YPQ6   A0A087TEV7   A0A182XX37   A0A091FP14   A0A2T7NR94   H0YPR0   A0A091WF27   A0A182I8P2   A0A2P8XQE5   U3IWV5   A0A182UIG5   R0LDF6   A0A1S3K3L0   A0A091PRZ7   G1MTT5   A0A1S3K4C9   A0A091N3N0   Q7QFU0   A0A182WV17   A0A093J531   A0A226NUB4   A0A093BYR2   A0A1Q3F1A5   A0A1Q3F199   K1QWF6   A0A091SGC2   A0A091R602   A0A210QF48   A0A091UUI5   A0A093BJ94   A0A182IN61   A0A091GNY0   A0A084VEF6   F7FLP1   A0A093EX76   A0A182H778   A0A1D5PKF6   A0A093KH03  

Pubmed

28756777    26227816    26354079    22118469    20798317    30249741    + More
24508170    21719571    21282665    21347285    28648823    18362917    19820115    23537049    28004739    24845553    29652888    21292972    20920257    23761445    20966253    20360741    25244985    29403074    23749191    20838655    12364791    14747013    17210077    24621616    22992520    28812685    24438588    17495919    26483478    15592404   

EMBL

ODYU01008168    SOQ51543.1    KZ149942    PZC76894.1    RSAL01000013    RVE53346.1    + More
JTDY01003207    KOB69949.1    NWSH01000744    PCG74452.1    KQ460930    KPJ10804.1    KQ459600    KPI94238.1    AGBW02014441    OWR41675.1    GL438234    EFN69385.1    QOIP01000012    RLU15983.1    KQ434954    KZC12516.1    KK107488    EZA49968.1    KQ435794    KOX74132.1    GL449633    EFN82418.1    KQ980989    KYN10531.1    GBYB01003110    JAG72877.1    GL888217    EGI64748.1    KQ982620    KYQ53750.1    GL764026    EFZ18764.1    KQ978271    KYM95804.1    ADTU01001201    KQ976522    KYM82046.1    KQ981855    KYN34791.1    NNAY01001458    OXU23905.1    KZ288455    PBC25513.1    KQ414934    KOC59362.1    KQ971321    EFA00159.1    GBYB01003111    JAG72878.1    KB632169    ERL89441.1    APGK01049539    KB741156    ENN73522.1    JH432010    NEVH01021922    PNF19437.1    PNF19438.1    GEZM01091347    JAV56890.1    KK853326    KDR08483.1    LJIG01016330    KRT80926.1    GEGO01003102    JAR92302.1    GDIP01132623    JAL71091.1    GL732532    EFX85526.1    GDIP01218964    GDIP01101178    LRGB01000568    JAJ04438.1    KZS17806.1    ABJB010074323    ABJB010176374    ABJB010317023    ABJB010518913    ABJB010740315    ABJB010969191    DS777384    EEC09439.1    ADMH02002099    ETN59207.1    GDIP01088279    JAM15436.1    GDIP01206963    JAJ16439.1    GDIQ01001479    JAN93258.1    KZ511983    PKU31983.1    AXCN02001147    AXCM01001896    AGTO01001290    ABQF01047567    ABQF01047568    ABQF01047569    ABQF01047570    ABQF01047571    ABQF01047572    KK114896    KFM63646.1    KL447206    KFO70889.1    PZQS01000010    PVD23678.1    KK735318    KFR13740.1    APCN01003098    PYGN01001536    PSN34218.1    ADON01087869    ADON01087870    KB743311    EOA99539.1    KK664088    KFQ10091.1    KK841069    KFP83524.1    AAAB01008844    EAA05997.5    KL205758    KFV74099.1    AWGT02000876    OXB70902.1    KL230111    KFV05092.1    GFDL01013709    JAV21336.1    GFDL01013736    JAV21309.1    JH816011    EKC41217.1    KK471558    KFQ57682.1    KK810636    KFQ35248.1    NEDP02003918    OWF47383.1    KL410128    KFQ94346.1    KN126613    KFU91209.1    KL506041    KFO84889.1    ATLV01012275    KE524778    KFB36350.1    KK377299    KFV46611.1    JXUM01115795    KQ565915    KXJ70539.1    AADN05000490    KK586047    KFV97080.1   

Proteomes

UP000283053    UP000037510    UP000218220    UP000053240    UP000053268    UP000007151    + More
UP000000311    UP000279307    UP000076502    UP000053097    UP000053105    UP000005203    UP000008237    UP000078492    UP000007755    UP000075809    UP000078542    UP000005205    UP000078540    UP000078541    UP000215335    UP000242457    UP000053825    UP000007266    UP000192223    UP000030742    UP000019118    UP000235965    UP000027135    UP000075885    UP000000305    UP000076858    UP000001555    UP000000673    UP000069272    UP000075920    UP000075886    UP000075881    UP000075883    UP000075882    UP000075884    UP000075903    UP000075900    UP000189705    UP000016665    UP000007754    UP000054359    UP000076408    UP000053760    UP000245119    UP000053605    UP000075840    UP000245037    UP000016666    UP000075902    UP000085678    UP000001645    UP000007062    UP000076407    UP000053584    UP000198419    UP000005408    UP000242188    UP000053283    UP000075880    UP000030765    UP000002280    UP000069940    UP000249989    UP000000539   

PRIDE

B7PS66   

Pfam

PF15870   EloA-BP1        + More
PF00929   RNase_T

Interpro

IPR012337   RNaseH-like_sf        + More
IPR034922   REX1-like_exo       
IPR031736   EloA-BP1       
IPR036397   RNaseH_sf       
IPR013520   Exonuclease_RNaseT/DNA_pol3       
IPR000571   Znf_CCCH       
IPR010233   UbiG_MeTrfase       
IPR029063   SAM-dependent_MTases       

SUPFAM

SSF53098   SSF53098        + More
SSF53335   SSF53335       

Gene 3D

3.30.420.10    

CDD

cd06145  REX1_like

ProteinModelPortal

A0A2H1WEP5   A0A2W1BTC5   A0A3S2P649   A0A0L7L3S8   A0A2A4JST1   A0A194QZU2   + More
A0A194PML8   A0A212EJM2   E2ABA9   A0A3L8D7C7   A0A154PKX9   A0A026W1R3   A0A0N0U5F2   A0A088AUV7   E2BPL4   A0A195DCB6   A0A0C9R580   F4WMA4   A0A151X0Q8   E9IL07   A0A151IA86   A0A158P2J1   A0A195BBV4   A0A195F331   A0A232EZU9   A0A2A3E184   A0A0L7QL72   D6WGM7   A0A1W4WA75   A0A0C9R8I6   U4UFS9   N6U4L3   T1JBB2   A0A2J7PSX5   A0A2J7PSX4   A0A1Y1K9N4   A0A067QSS5   A0A0T6B1H8   A0A147BP91   A0A182PBA0   A0A0N8CH03   E9G4N6   A0A0P4Z3J5   B7PS66   W5J469   A0A0N8CXU6   A0A0P5AXI2   A0A182F9B4   A0A0P6INF8   A0A182W160   A0A2I0TDV2   A0A182Q5S3   A0A182JWP7   A0A182MBX0   A0A182LAK0   A0A182NFX9   A0A182USS9   A0A182RX82   A0A1U7RPX9   U3KH32   H0YPQ6   A0A087TEV7   A0A182XX37   A0A091FP14   A0A2T7NR94   H0YPR0   A0A091WF27   A0A182I8P2   A0A2P8XQE5   U3IWV5   A0A182UIG5   R0LDF6   A0A1S3K3L0   A0A091PRZ7   G1MTT5   A0A1S3K4C9   A0A091N3N0   Q7QFU0   A0A182WV17   A0A093J531   A0A226NUB4   A0A093BYR2   A0A1Q3F1A5   A0A1Q3F199   K1QWF6   A0A091SGC2   A0A091R602   A0A210QF48   A0A091UUI5   A0A093BJ94   A0A182IN61   A0A091GNY0   A0A084VEF6   F7FLP1   A0A093EX76   A0A182H778   A0A1D5PKF6   A0A093KH03  

PDB

5Z9X     E-value=2.43913e-18,     Score=228

KEGG

101742366    K14570 RNA exonuclease 1 [EC:3.1.-.-] | (RefSeq) RNA exonuclease 1 homolog

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0003676   GO:0046872   GO:0003746   GO:0004527   GO:0031314   GO:0008689   GO:0008425   GO:0006744   GO:1990886   GO:0004395   GO:0005634   GO:0008859   GO:0016021   GO:0016604   GO:0005515   GO:0003700   GO:0006355   GO:0008270   GO:0043565   GO:0004672   GO:0048384  

Subcellular location

Mitochondrion inner membrane  

Length:

599

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00322

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00067

outside

1  -  599

 

 

Pi

125.68148

Theta

133.451561

Tajima's D

-0.184304

CLR

26.842141

CSRT

0.31938403079846

Interpretation

Uncertain