Silkworm Genome Informatics Database

Gene

KWMTBOMO03916 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010222

Annotation

ubiquitin-conjugating_enzyme_E2-17_kDa_[Papilio_polytes]

Location

Bomo_Chr7(+):6533625-6536446 View in EpiBrowser

Full name

Ubiquitin-conjugating enzyme E2-17 kDa

Alternative Name

E2 ubiquitin-conjugating enzyme 6
Ubiquitin carrier protein
Ubiquitin-protein ligase

Location in the cell

Nuclear Reliability : 4.067

CDS

ATGTCAACTCCAGCAAGAAGACGCCTGATGAGGGATTTTAAACGCTTACAAGAGGATCCACCTACAGGTGTGTCAGGAGCTCCAACTGATAACAATATTATGATCTGGAATGCTGTGATATTTGGCCCTCATGATACTCCATTTGAAGATGGAACATTCAAACTCACAATAGAATTTACAGAAGAATATCCAAATAAACCCCCAACAGTACGATTTGTATCAAAAATGTTTCATCCAAATGTTTACGCCGATGGTGGAATCTGCCTAGATATCCTGCAAAACAGATGGAGTCCTACTTATGATGTTTCAGCTATACTTACTTCTATACAGTCATTATTAAGTGATCCCAACCCAAACTCTCCAGCAAATTCGATGGCCGCACAGCTTTACAAGGAGAATCGACGAGAATACGAAAAGAGAGTGAAAGCGTGTGTAGAACAATCATTTATTGATTAG

Protein

MSTPARRRLMRDFKRLQEDPPTGVSGAPTDNNIMIWNAVIFGPHDTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGGICLDILQNRWSPTYDVSAILTSIQSLLSDPNPNSPANSMAAQLYKENRREYEKRVKACVEQSFID

Description

Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA (PubMed:1902572). Involved in the negative regulation of the Ras/MAPK signaling pathway in the wing by acting with the putative E3 ligases poe, Kcmf1 and Ufd4 to mediate the ubiquitination and proteasomal degradation of rl/MAPK (PubMed:27552662).

Catalytic Activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.

Similarity

Belongs to the ubiquitin-conjugating enzyme family.

Keywords

ATP-binding Complete proteome DNA damage DNA repair Nucleotide-binding Nucleus Reference proteome Transferase Ubl conjugation pathway

Feature

chain Ubiquitin-conjugating enzyme E2-17 kDa

Uniprot

A0A1L8DSL5 A0A023EFB4 I4DR69 A0A194QZ39 T1E363 A0A1Q3FUV3 + More
U5EVB6 A0A1E1WHY3 A0A2H1WF97 A0A1B0DKX1 A0A194PLN3 H9JL21 A0A2M3Z687 S4PPK1 A0A2M4AJG9 A0A182MVC4 A0A182QYR7 A0A182UY58 W5J2Y2 A0A336L164 A0A182W145 Q17J88 A0A182LAI0 A0A182WV02 A0A182JLF0 Q7QFT1 A0A182FSU8 A0A182RRU5 A0A182I8M7 A0A224Y018 A0A0P4VYM8 K7J131 A0A067R4Z3 A0A158NSK4 E2A2Q3 A0A1B6E8Q0 A0A069DPD4 R4G531 A0A0C9QEM2 A0A0A9ZEV6 A0A212EJL6 A0A1W4X672 D6X3V2 A0A1Y1KT80 J3JVA7 A0A1B6MJQ3 A0A1B6FB11 A0A1B6HHF3 A0A2H8TKY9 A0A2S2NY19 C4WVF3 V9IID6 A0A088ADQ8 A0A2R7VTD0 A0A0V0G6S5 A0A023FB74 E9JCV2 A0A232FN48 A0A1W4UJY5 B4M545 B4QW67 D3TPS5 A0A1I8MZB9 B4KDC5 A0A1A9XQ02 A0A3B0JQY8 A0A0K8UB41 A0A1A9V8H9 A0A1B0C344 Q295Z5 B4GFH3 A0A034VNX7 B4PUJ1 A0A0M4ES55 A0A1I8PS77 B3M150 B4NL66 A0A0L0CIH5 B4I3U8 B4JUQ2 B3P283 A0A1B0A9J5 A0A0K8TQ18 A0A0A1XRA3 W8BZW3 A0A0B4K5Z5 P25153 E9FRE8 A0A0P5XPT3 A0A162RZZ3 A0A2H8TUF9 J9K586 A0A1D2MWE2 A0A226E7I7 A0A3Q0IPI6 T1IZG4 E0W2X7 A0A0C9RKF3 A0A3L8DYT7 A0A0N0BC13

EC Number

2.3.2.23

Pubmed

24945155 22651552 26354079 24330624 19121390 23622113 + More
20920257 23761445 17510324 20966253 12364791 14747013 17210077 27129103 20075255 24845553 21347285 20798317 26334808 25401762 26823975 22118469 18362917 19820115 28004739 22516182 23537049 25474469 21282665 28648823 17994087 20353571 25315136 15632085 25348373 17550304 26108605 26369729 25830018 24495485 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 1902572 27552662 21292972 27289101 20566863 30249741

EMBL

GFDF01004621 JAV09463.1 GAPW01005500 JAC08098.1 AK404971 BAM20409.1 + More
KQ460930 KPJ10803.1 GALA01000655 JAA94197.1 GFDL01003727 JAV31318.1 GANO01001106 JAB58765.1 GDQN01004455 JAT86599.1 ODYU01008168 SOQ51542.1 AJVK01006517 KQ459600 KPI94237.1 BABH01011503 GGFM01003285 MBW24036.1 GAIX01000202 JAA92358.1 GGFK01007614 MBW40935.1 AXCM01000394 AXCN02000343 ADMH02002125 GGFL01004231 ETN58677.1 MBW68409.1 UFQS01001323 UFQT01001323 SSX10339.1 SSX30027.1 CH477234 EAT46718.1 AXCP01001761 AAAB01008844 EAA06004.5 APCN01003089 GFTR01002533 JAW13893.1 GDKW01000873 JAI55722.1 KK852747 KDR17265.1 ADTU01024994 ADTU01024995 GL436195 EFN72291.1 GEDC01002986 JAS34312.1 GBGD01003343 JAC85546.1 ACPB03008564 GAHY01000845 JAA76665.1 GBYB01007340 GBYB01012948 JAG77107.1 JAG82715.1 GBHO01001687 GBHO01001686 GBRD01000168 GBRD01000167 GDHC01014872 JAG41917.1 JAG41918.1 JAG65653.1 JAQ03757.1 AGBW02014441 OWR41676.1 KQ971326 EEZ97366.1 GEZM01074327 GEZM01074326 JAV64593.1 BT127174 KB632402 AEE62136.1 ERL94965.1 GEBQ01003811 JAT36166.1 GECZ01022362 JAS47407.1 GECU01033589 JAS74117.1 GFXV01002999 MBW14804.1 GGMR01009490 MBY22109.1 ABLF02032256 AK341491 BAH71873.1 JR049231 AEY60903.1 KK854035 PTY09930.1 GECL01002467 JAP03657.1 GBBI01000539 JAC18173.1 GL771866 EFZ09206.1 NNAY01000009 OXU32075.1 CH940652 EDW59756.1 CM000364 EDX11666.1 EZ423427 ADD19703.1 CH933806 EDW15934.1 OUUW01000008 SPP84587.1 GDHF01028744 JAI23570.1 JXJN01024780 CM000070 EAL28563.1 CH479182 EDW34358.1 GAKP01015140 JAC43812.1 CM000160 EDW95713.1 CP012526 ALC45392.1 CH902617 EDV44320.1 CH964272 EDW84269.1 JRES01000345 KNC32046.1 CH480821 EDW54891.1 CH916374 EDV91222.1 CH954181 EDV47833.1 GDAI01001608 JAI15995.1 GBXI01004454 GBXI01000877 JAD09838.1 JAD13415.1 GAMC01004298 GAMC01004297 JAC02259.1 AE014297 KX531446 AFH06235.1 ANY27256.1 M63792 M64435 M63791 BT003481 GL732523 EFX90151.1 GDIP01069022 GDIQ01037290 JAM34693.1 JAN57447.1 LRGB01000086 KZS20915.1 GFXV01005774 MBW17579.1 ABLF02031760 LJIJ01000448 ODM97380.1 LNIX01000006 OXA52851.1 JH431715 DS235881 EEB19983.1 GBYB01007341 JAG77108.1 QOIP01000003 RLU24968.1 KQ435944 KOX68238.1

Proteomes

UP000053240 UP000092462 UP000053268 UP000005204 UP000075883 UP000075886 + More
UP000075903 UP000000673 UP000075920 UP000008820 UP000075882 UP000076407 UP000075880 UP000007062 UP000069272 UP000075900 UP000075840 UP000002358 UP000027135 UP000005205 UP000000311 UP000015103 UP000007151 UP000192223 UP000007266 UP000030742 UP000007819 UP000005203 UP000215335 UP000192221 UP000008792 UP000000304 UP000095301 UP000009192 UP000092443 UP000268350 UP000078200 UP000092460 UP000001819 UP000008744 UP000002282 UP000092553 UP000095300 UP000007801 UP000007798 UP000037069 UP000001292 UP000001070 UP000008711 UP000092445 UP000000803 UP000000305 UP000076858 UP000094527 UP000198287 UP000079169 UP000009046 UP000279307 UP000053105

PRIDE

H9JL21 P25153

Pfam

PF00179 UQ_con

Interpro

IPR023313   UBQ-conjugating_AS        + More
IPR000608   UBQ-conjugat_E2
IPR016135   UBQ-conjugating_enzyme/RWD

SUPFAM

SSF54495 SSF54495

Gene 3D

3.10.110.10

CDD

cd00195 UBCc

ProteinModelPortal

A0A1L8DSL5 A0A023EFB4 I4DR69 A0A194QZ39 T1E363 A0A1Q3FUV3 + More
U5EVB6 A0A1E1WHY3 A0A2H1WF97 A0A1B0DKX1 A0A194PLN3 H9JL21 A0A2M3Z687 S4PPK1 A0A2M4AJG9 A0A182MVC4 A0A182QYR7 A0A182UY58 W5J2Y2 A0A336L164 A0A182W145 Q17J88 A0A182LAI0 A0A182WV02 A0A182JLF0 Q7QFT1 A0A182FSU8 A0A182RRU5 A0A182I8M7 A0A224Y018 A0A0P4VYM8 K7J131 A0A067R4Z3 A0A158NSK4 E2A2Q3 A0A1B6E8Q0 A0A069DPD4 R4G531 A0A0C9QEM2 A0A0A9ZEV6 A0A212EJL6 A0A1W4X672 D6X3V2 A0A1Y1KT80 J3JVA7 A0A1B6MJQ3 A0A1B6FB11 A0A1B6HHF3 A0A2H8TKY9 A0A2S2NY19 C4WVF3 V9IID6 A0A088ADQ8 A0A2R7VTD0 A0A0V0G6S5 A0A023FB74 E9JCV2 A0A232FN48 A0A1W4UJY5 B4M545 B4QW67 D3TPS5 A0A1I8MZB9 B4KDC5 A0A1A9XQ02 A0A3B0JQY8 A0A0K8UB41 A0A1A9V8H9 A0A1B0C344 Q295Z5 B4GFH3 A0A034VNX7 B4PUJ1 A0A0M4ES55 A0A1I8PS77 B3M150 B4NL66 A0A0L0CIH5 B4I3U8 B4JUQ2 B3P283 A0A1B0A9J5 A0A0K8TQ18 A0A0A1XRA3 W8BZW3 A0A0B4K5Z5 P25153 E9FRE8 A0A0P5XPT3 A0A162RZZ3 A0A2H8TUF9 J9K586 A0A1D2MWE2 A0A226E7I7 A0A3Q0IPI6 T1IZG4 E0W2X7 A0A0C9RKF3 A0A3L8DYT7 A0A0N0BC13

PDB

6CYO E-value=3.70012e-72, Score=684

KEGG

101741122 K10573 ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] | (RefSeq) ubiquitin-conjugating enzyme E2-17

PATHWAY

04120 Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0005524 GO:0016740 GO:0016874 GO:0033503 GO:0006281 GO:0000790 GO:0061631 GO:0043161 GO:0000209 GO:0002039 GO:0032436 GO:1902166 GO:0043518 GO:0000422 GO:0051299 GO:0032456 GO:0005737 GO:0019904 GO:0005634 GO:0006511 GO:0007098 GO:0004842 GO:0043066

Subcellular location

Nucleus

Length:

151

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00805

Exp number, first 60 AAs:

0.0069

Total prob of N-in:

0.29543

outside

1 - 151

Pi

25.709646

Theta

226.504481

Tajima's D

-1.042099

CLR

2.257763

CSRT

0.136193190340483

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics