Silkworm Genome Informatics Database

Gene

KWMTBOMO03914 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010221

Annotation

PREDICTED:_histone-lysine_N-methyltransferase_trithorax-like_[Bombyx_mori]

Location

Bomo_Chr7(+):6494875-6517136 View in EpiBrowser

Full name

Histone-lysine N-methyltransferase trithorax

Alternative Name

Lysine N-methyltransferase 2A

Location in the cell

Nuclear Reliability : 3.962

CDS

ATGGGAAGGTCGAGATTCCCTGGAAAGCCACTCAAATTTCAAAACAGAAAGCGTATCAGTGTTTTATCTGGGACTGTTTATCATGAAACTGCTGCAGAGGGCCCGCCAGCCCGCAGCGTTGCTGCTAATGATTTTGCTGGGGAACAAGAGGAAGAAGAAAAGAAAGAAGCAAACAATGAAGTCAAAAATGAAATTGAAGCCACTGAAAACGAATTAAGTCAACCAAACAAAAAACAAGACTCTAAAAGTATCCATACATCAAAGTCTCCTGTGCGTACCCGGTCGCAAAATAAAATGGAGGCCACAAAAGCTGATAAACCTGTAAAGAAAACAGTAACCTTTGGTACTGTTGAAAGCTGTGAAGATATATTTTTTCCCCTAAAAAAGCTTCCTTCAAAACATCATGCTCCTCTTGTCCCTATTATAAAGAAAAAATCTTTATTGAAACAAACTGAATATTCAACATTCAACAGTATACTTAAACCCGCGAAACTTACTGATTTGAGCTCTAAGTCTTCATCAGAACATCAAGAAGGGTATTTAAGAAAAAATTTGAATCCTTTGTCAAAACCTATGAATAAATTTTCACAGCTGAGTGAGAACCGTTGTATTTCACCACCACCAAGAAATTCATCACCTGTTGAAAGAGATAATAATGGAACAACAACAAAATTTGTATTGCCTGTTAGAAGTGCCCATTCATCTCGTGTTATTAAACCCAATAAAAGGTTTATAGATGGTGAGGAGCCAACAGCAATAACAAGTATAATATCTTCAGGAAAGGTTCTTAAGAAACCAAAGCTAAAGAGATTGGTTTTCAATAATATACATAATGACGATGATGAAACTCCAGATGAAGATGAACTCAATAAAATTATTGAAGCAGAAAAAAATAAGGAAAAATCTGTTCTTAAAACTTCTAGTTTATTCAAAGACAAAACAACAAACTCCTTTTTATCTCTTAATAGTGGTTCACGAAAAGGAGTTCATGATCTATTTTCTTATGATAAGGAACGCGAACATCAAGATGAGAATTCCAATGTAGAATGTTCAGAAAAGGTGAAAACAACTGAATCAGCCAAGGATGACAGGTCCGGGCATGCTATGAGAAAATTAATGGACATATCTGATGCAAGTAGCTCAAGCAGCACCAGTAGTGGTTCTGAATCTGAAGAGAGTTGGGAGAGTGATAGTGCTGAGGGAAGTGGAGAAGAATTAGATAAACCAATTTTACCAAGTCCAGATAAAGACAAATCAGCTTCTCAGTTACTAAGTGGAAAAGTTATAATAAGGGAGGCTAGATTACAACTTAATTCTCCCGCTCAAACAACTTCTGGATTAGATGGTCCTTTCTCGATGCTCACATCAGCCTCATCAAACAATCCACCAACAACTGTAACTTGTGGAGTTTGTGGAGCTGTGAGGTTTTACAGATTTGTGAAACAAGCCAGAAAATTTGGAATTTATTCATGTGAATCTTGTCGCAAATTTATCACAAAACTCTTGAAAAGAGATAAAATGGCTCATAGAATGGGTCCTGTCTCAATGCACTGCCTAAAAGGAGAAGGAAATTGTCATGTACCACCAATAGTTAGATCACAACAGTGGAAGTTATTACGATGTACAAATAAAACTAGATGTCCTGCGTGCTGGCTGAAAATGTGCTTAAAGGCTTTTCAAGTACCACCCAGCATTAGAGCTAGCCTTACTGCTATGTTGCCACCTAACATGAGGCCAAGTGTTAAGCCTACTCCTTTATCACCAGCGAATCCGCTAAGAGTGCCTACTACAAACGCTGCTGTAACCAGTCAGCCTGTTTTTGGGTTAAGTGTGAATGACAATGAAACAAACATATTTGGTAGTTTGACGTCAACCAAGAAAACAGTAGAGGAGCCAGAAAAAGTTGAGGAGAAGGTTTCAAAGGAACAATCAAATACAGAAGAAAACAATGAAGATTTTTGTGCCAGTAGGAAGCGCCAATTAACAAGGATAAAAGTTAGGAAAAAAGATAAATCAGAGGCCAAACAAATTGAAGACCCTAAGAGGCAAAAAATGGAACTCAAAGGTCCAAGAGTTAAGCATGTCTGTCGAAGTGCATCCATTGTATTGGGACAACCTATTGCTACTTTTCCTACTATGGAAGAAAAAGACAAACATGACAAAGTTATATCTGAAGAAGATAACACTGTCTCTACCATTGATAAAGATATTGAAGCACCTGATTTATCAAGTGAAGAATCTGAGGTAGATCTGGAGAATAAAGTACCACAGATAATTCTTGAAGCGGTTTCAGTAAAGGATGTAGAGGAATCCCCTGTAGAACCAAAGAAAAGAAAAGTTGATCCATTGCTGGCTAAACAGGGTAAAGCAGAATCAAGTGAGGATGAAACTGTAATGGACCTCATACCCAAGAAAACTATACAGAAACCTTTATCCAACATCACTAATGTCCGCGGGCGCACACAGAAATGTGGACAAAATCGACCAGAATTAATATGTGTCGATTTTTGGGAGAGTTACGACCCTGATGAAGTATGCAATTCTGGATTTGGTCTCATCGGCACTTTACCATTCACTGTTGCCAAATTGTGTTTCTTATGCGGAAGTGCTGGCCAAGAAAAACAGATGGTAGTGTGCTCGAGCTGTTGCGAGTGGTACCACACGTGGTGCGCGGAGGACGCGAGCGGCGGGCGCGGCTGGCGGTGCGCGCGCTGTGCGTGCTGTGCCGTGTGCGAGCGCGCCGCCGCCCGTTTACGATGTCGTCTGTGCGCTGCGCCACATCATGCAATTTGTCTGCCCGCTGCACCTCCGGACCATCGTAGTGACTGGCCACAGATCTGCAGTGCGTGTCTGAAATGTAAAAGCTGCGAAAGTACTCGCGTGAGCAAGTTTGTTGGTAGTTTACCTTTTTGTGGTCCATGCTTTAAACTTAGACAAAAAGGAAATTATTGTCCGCTCTGTCAAGCGTGTTACAGAGATAATGATTTTGATAGCAAGATGATGGAATGTGGTTGGTGTGGCCGCTGGGTACATGCAAGCTGTGAAGGTTTATCTGGAGAGGAGTACCAACTTCTTTCCGCACTTCCGCCCTCGATCGAGTATATTTGTTGTAAATGCATGCCTCATGATCCCCCTTGGAGGAAAATGCTTACTGAACATTTAAAAGGACGACTTTTACATCTACTCAAACTACTTGCCAAGAGTAAAAAAGCTTGTGCATTACTAAAATTGACACCACACAAAAATACGCCGATCGCTAACAAACCGTACCGCATTACATCACCACAGGCTATCAGAAAACTACACTTTGAATCCGAAGATGATTCTTTGAAAACAACTGAAACTAAAGTCTACAGAAACAGCTCTAGAGGAAAACGTAATAATGCACAAACCAAAGATGATACAACCGAGTCGCAAGTATGGCGTTGTTCATCGCTGTTAGCTGATGTCGATATGGAAAAGGAAGACATTCCACATACTTCTCATAAAGTTGTAAATCTTCAGGAACCCTTGATGCAGAATAAAGAGGTCTGCTTTTCAACAGGTCTTTATGGTACCAAGACAGAGTTTGATGCCCCTTGTGTTGAAGTACACGAAAATTACCCTTCTCAGAAACAAAACGACAAAGCAACAACAATGCTACCAGCATCTCCTAATGTTGAAAAATATTGTGATGATGAGACAGTGAGGAGCTTCCCACAAGCTCGAAGTGAACAAGACTTGAGCCCAGCCATTGTAAGAATTAATGATACAATAGTTGCTGAAATGACTGAAAATAATAAGATGGTGTCACCATCTTTACTAGACATAAAGAAAAGAGTCAATAATGATGAATATGTTTCTTTAAAAGATTTTAATCATGATATGAAGGAAGTTATTACCAGGACAGTAAATGACGACTTGAAGAAAATTTACAAAGATTTATTCTCAGAAACATTTCCCTGGTTTGATTGTGAAAACAATTGTCTTCAACCAAATTTGGAAGTTGAGGGTGAACTGGAAGATAGTGAATCCTTAAAAGATGATGACATGTCTGATAATAAAGGGCTTAAAGCTTCTGCACAATCAATCGAAAGACCCCAAGATCAGATAGTTCCAAAAATTGAAAACGATGAAAATAAAATAGAAGAAGATTTGATAGACTTTTATCCAGTTTTTGATTCTAGAACTTGTGTCTTGTGCAAAGTGGTCGGTGACGCTACTCCGTCAATGGAAGGACGCTTGCTTTATTGTGGTCAGAATGATTGGATTCATGCTAATTGTGCTTTATGGTCAGCAGAAGTGTTTGAAGAAATAGATGGATCTTTGCAAAATGTACATTCAGCAATATCCAGAGGAAAAATGATTAAATGTGCTGCATGTGAAACAAAAGGTGCAAGTGTCGGTTGTTGCGCTAAAAATTGTAGTGAGACCTACCACTATGCCTGTGCAAGAAAACAAACTTGTGCCTTTATGGATGATAAAAGAGTGTTTTGCCCTACACATGGGAAAGATGTACCTAAGAAAAGTTTACAAAAAGACACAGATTTTGAACTAACAAGACCTGTTTATGTTGAGCTTGACAAGAAAAAGAAAAGGTATGGTGAAATTAATAAAGTTCAATTTATACTTGGATCACTAACAGTAAATACTTTGGGAAAAATTGTACCTTCAGTATCAGATTATGAAGAATTCTTAATCCCTGTTGATTTTTCTTGTACCCGATTATTTTGGTCTTGTAAAAAACCTACGAAAATAGTGAGATACACAATCAAAACCAAATTGATACTAGCAGAACCTTTGCCTGGTTTTGACTTTGGAGTTAATATAACCGTAGATCATAATTTGGAAACTCATGCAGTTGACAGAATGATGGCTGAAATTGGATCATGGCATGAAAGTTTGCAGAATGGGTCCAGTAAATCTGCACTCATGTTATCCAACGATAAGTCTCCAACAAAACAAGGGAATTCTGTTACCTTAGAGGATTTAGCAGTACAGCAAGTGGTTGAACATTTATTAGATAATGTTTGCAAACAAGAACAACAGGATGATGAAGAACCTCAAAATACTGCCGACTTATTACCTCCTGAAGTAAAAGATGCTATTTTCGAAGATTTGAACCATGATTTACTGGATGGTATATCCATGCAAGATATATTTCAAGACTTGAGACATGAATTTTACGGTATAGTTGTACAATCCGAAGACAAAAGTAATGATAAATCAGATTTGCGTCCTACTGATATCATTGACGAATTACTTAATGCAAGATTTGAATCAGGAAGCAAAGAATTGAAAAGAAGTAAATCTGAGATGCTGCTTCAAACTCATGGCCTCAAAAATTTGACAACTGGTCGTGGTCAACAAAGATCAAGCAGTTGGAACAATAAATTTGATACAAGTTTATTGTCATCTACTATAAAACGATGTAAAATTGGAAAAGCATCTACAGTAACAGAAAAACTTAATCCTGCCCAAAGAGGAGGAATAGTAGTTGAAAACCAAACTGTAGCAACAAAGGAAGCCGAAAGTACTAATTCGAGGTCGGAAGAAAAAAAAGCGAAAGTAGATCGTTGCTCCAATAATGTATGCGATGAAGTGCCTCACACGTCTGGTGTAAACTACCGTGAAACTAAAGAAAAAGAAGAATCTACGGCAGTAAAAAATGATAAAACCGAAGGGTACTTTGCAGATGTAATAGACTTCTATACAAAGATACAGTGTAGTCCCATAGCACAACTAGATGGTACTGAAGATTGGTCAGGATCTGAGAGTTCCTGTGGTTCACGTCCAAGCAGCCCCCGAGAAAATGATTTTTCTCCTATTCAGCAACTAGATGGCGCAGAAGATAATATTCCAGGTGATACACAGAGAAGTCAAACAAATCAATTTATGTATAGAGCCAGTGGGACAGAGAGTTACACAGTCACATTTGCTGGGAATTCGGTTAATGGGCAATCAGAGCTTGTTATGAGATCGTTTGAAGATCCTTCAGGGACGATAAATCAAATGGAACAACCCGTGCGATGTGATAGATGTCAATGCACTTATAGAAATAAAGATTCTTATGACAGACATGTGCCATCTTGCGACATGGTGTCAACTAGTGAAAGTGAGAGTGAAAATCCTAAATCGCCAGAAAATCGAACATTAACAACCCTTCAAAATGCTTTTCAAGGTGCTTTTGCACAACCAATGATTATTCATGCAGGAGTTGTCAGTGGCTCAGAAAACACTGTAAAAGCTGAAAGCATATCAGCCAGAAGAACATCTATCAATACGAGGCAAATTACCATTAATGGAACAATTGTGGAAACACCATCTCCGGGACCTTCAAACGAAATGACTATGACAATTACAGAGCAAATGAAATCTGGAACTGTAATATTTGATCAAAGTAAGACTACTAACGTTCAAGTGTCCACTAATCAGCAAATGATGCCATCGCCACAAATCGTTGTTACTCCTCAAATGCTGCTGCCCAACAAATCGAATTCTGGGGCAGGAAAAATGATGACACCTCAAATAATTACACAGCCCGGAATTTTACCATACAATATTTGTGTTAAACAAGGAAACACTAACATACAACAAATTCAAGGAAGTACAGATATGACTCAACTTTTATCTGGATCAGGGGGTATACAAGTTATATCATCGAATTCCAACCAAGTACTTACAATACCTTCAAATCAACAGGGTAATATTACTCCCATTATCCAGGGTAAAAATCAAGTGGCAAATTTCCCAAACATGGCCAGTGCTTCGTCAATAGCTTTACCTGTTAATTCAATACAAGGAATGCCAAATTCTTCTATTATTCAAAATATCCAACCAATGATACGACCATCTAATCCAACCATTGTTGTACCTGCAGTGTCGGCACAAAGACTAGCTTCACCAAACACACACAAGCAACAGATTTTAATGCCTGGAACCCAAAAATCTCCAAAGAAACAACCGACTCCCGTTCAGCCTAAACCCATTTTTCAAACAACGAATAGGCCAAGAGGTCGACCGATACCCAAACCCGCTTCAGTAAAACGACACACTAAACTAGAAAAAACTTTCACGACAATCAATCAGACACCCATCGGCCCCGGAAATACAGTGATTCAATTACAAACTAACAATCAAACAGGTCAGCCTTCAATAATTGTGCAACCTGTAGCCAACCAGAACATTATGTCGGCCTATGTTGAAGCACTATCTCAACAACAAAATCAAAATATGCAATATATCGCCACAATTGCACCTCAGGGAGATTTTAAGACAGGACCGACACAGTTTATATCACAAGGTGGTCTTGTACCTCAAACGTTCCAAATACAACAGACTGAATCTGGAGGATTAGTTGCTGTGCCTAGTGGGGGAATACCAGTATTACTGCCCCAAGGAAACGTCGGAATCTTGCCACAAACTATTCAGCAGGGAGCTACCATCTTACCCCAAGGAGCAATACAGACACAAGGAATAATTTCGCAGGGACCAAATGGACCTACAATTTTACCTCAAACGATTCACACCCAAAATGGTGCAACATTAATACCACAAGGTACACTACAAGGTTTGGCCCCTGGGAATATTACAACGCAAACCGCAACGCTGCTCCCAAATAATACATTGCAGACGGCAGGTGCTACTGTCGTACCACAGAGTGGAATTGGGAATGGTCAAACCACTATAATACCTAATGCGTTACAAACACAAGGTAATACTTTGACAGGTGCAACTATTCTACCACAAGGTACGCTTCTGCCTCAGTTCTGCAACGATCAAGTTTTGCTCGGATCGACACCAACACTGGAAATGGTGACGGATTCATCTGGATGCATGTATTTAACTACGACGCAACCTGTCTATTATGGCTTAGAAACGATTGTGCAGAATACAGTAATGTCATCTCAACAATTTGTCTCGACTGCTATGCAAGGAGTGCTCGCACAAAACAGTAGTTTTTCCGCAACAACTACACAAGTGTTCCAAGCCAGTAAGATTGAACCTATTGTAGAAGTACCAACAGGCTATGTTGTTGTGAACAATGTCGGAGATAATGTTTCATCGTCGACGCCTAACGTTGTAACGGCACAATCGGTTCAGTCTTCTCCGGCTTCCATGAAGGCAGTTAAAACTAGCGTTCCCAATCTTACACTGCAACCATTAACCGAGAAAGCTTTAAATAATAGCATCCGTCAAACACCCAAAGTAATCCATATGAGTTCTTCACCTTTAACAATGGGATCGCAGTCGTGCCCTAACTCAATAATGACTGGGAGACAGACAATAAATCCGATAACGTCGCAGATTCACAGTATGACGTTGTCAAACGCTTCGCATAATATTCACCGAGCCGCCAATGTGACTAAACAAAACGTTTCGATGTCTCCTGTCACTCTAGTTTCTTCCACTGGACAGCCCGTTCTGGCAATATCTCAATCGACTCCAAACTCTACGACAACATTTTCAATGCAACCTATACCGCTGTCACAGCCTATAGTCACAAGCTCTATAGCACCATCTTTAAATAAGAACAATGTTAAAACAGAAAACTCCCATGTCATTGAAATTAGTGGCAATTTGCAAGACAATACGAATTCGTCCAATGTACCGACTATAAGTGTGGCACAGAGTATTAAATCACCAACACCTTGGAGACAAATAAGTACGTTAACCAATAATGCTCATACCGAAAACAAGATAGAAATGCAAGGAACAGGAAAAACGAATATTATTACACCATCAATGACCATACAAAGCAATAATATGCCAGGAAGGTCACATTTACACAATGAACATGATAAAATAAATCAAAGTTGTCTTATGACAATGTCAAATAATGGTAATGGTTTATCAAATGTCAATACACACTCTCATCAGTATGAGCCTAATCTCAATGTGAGCCACCATCAGTCCCATTCTTCGAACAATGTTATACATATAGCAGCGGGAAACATATATCCACCTGTATCAGGTATGAGCACTTTTGATGCTGACACGACATTGAAATTGAGTAAGATAAATGCTCTTTCGAAAACTGAAGGAGGTCATCTGAATTTCTCACAAGAAATAATGGCTTCACACTCGCAACATAATGCTAATAATGAAAAATCTTTTCAAAATTTGGGAACAAATGACAACAAACATAATATGGATTGCATGTCGGGTCAAATGAATATACACAAATTAAACAGTTGCCAGATGGCTGGCAGCATGAACAATGCTCCTGCCATTAGTATTATACCTCACAATGTCATGCGTCCACCATCACAAAGTACTCAAAACAATCTACCTTCCAACAATCAAAACCAAATGTGTTCGATTTCAACAAGTTCTTCTCACGGACAAGTGCAGCTATTGAACTCTGGAAACAACTCTATTCAAAATATAAACTTATCTTGTCAGGAAGCTGTAAACAGTAGAATGAATATTGTTTCATCCAATGATAACATGCAATTGAATCATGAAATCACAAATACATCTAATATGCCTCATGGAAATATGCAAATAGTTTCTCATGAAAATAATCAAATGTCATCATCCAATCAGATTCACATCATGAATGGACAAATTCAACACAATCGTCAAATTGATACTAATAATCAACTACAACAGCAAATTAGTCAAAACAGCTCTGGAAGATCTTTCCATGAAAATATGATGAGCTCCCAGCAAAATCACAACCAAACCATGATGTCCATCCGTAACACTCCTGACAGTAATGACCTTATAAATCAGTCTATGAATATGCACAATTTAGGCAGCAATGCACATCCCAACAGATCGGAAATAAATGATCACAATCATATGCAAATGCAGCAAGCAATGTCAAATATGCAAAATAATAGAATATTAATGGATAATATGCAACCTCACAATTTGAATAACCATAACCACACCATACATTCCAATCGAGGGATGGACAACATGCATAATACACAATTGCAAAACATGCAACAAATAAACCATCATATGAATAGCAACAGTCGTTCTTTGATGGAAAATAATATGCATGTAAACCAGCAGATGAATATGCAACAAAACAGACAAATCGACAATTCAGGCATGCATCATCAACATCAAATGCCCAATGTCATGCAAATGCAAAATAATCGCCAACACAATGAGAGCAATATGATAAATTTGCATCAACATGTAAATCAAATGCATAATAGACAACAAATTGAAACTTCTATGCATATGCATCATATGCCAGCAAATACAACAAATATGAATTTAAATCAGATGGATAATTCTGGCTCACTACCATACATACACGGGAACAGAAATGACAACAATGCAATGGCAATGCAAGGGATGAATGTAATGAATCAAATTCAAAACAATAGATGTGCAATGGATCATTCATCAATCATGCAACACCAAATGAATAATATGAGTTCTATGAATAACATGAACATGCACAATAATCTAAGTAATGCAATGCAAATGAATAACGTAAATCATCAATCTATGAATACTTCATTGATGCACGTTCCTAACATTCCGGATATTAAAACAGAACTTCAAAATTCATGCAGTGGAAGTTGTTCTAGCAATAGTTCTCTCTTCTCTGCAAATCAGAATTCAATGGAAATCTGTTCCAACATGAACGCTCCCAATATGACAATGGGTTCGAGTACGATGTTGCATGGTATGAATGCAAATAATCCAAATATGTCTTCTAGTAATATGATGTTGAATAATATAAATAACAGCAACAATATGTTTGCAACGGGCGCTCAAAACAATATAAATAGCCACGATATGTTGATGAATTGCACCAACGCCGCCGATCATAGTGTCGCTGGCCTGTTGTCTGGAACACCTAATCATAGTATGATGATGAACAGCCCTCAAACTCATGCAACAAATAATGCAAGCCAATCGTTAAATACCCAAATTAGTAACAATTCCCAAGTGAACCTGAATAATTGTAGTATGGCTGCTAATAATGCGCAAAACCCAAATGTACCAAATATGGAGGGTCAATTAAACAGAAACAATTTACCGGTAGAACCACCTAAATTCACCCAGGAACCACTAAGAGGCAAGAATATGATGAGCTCTGCAACAAATAATAATATCTCCATTCCTAATATTCCTAACAATGATTGTGCTAAAGTTAATATCGTCAATAACGACAAGCCGAATCACAACATTTCCGTAAATAATCAAATCGGATATATGCAGATGAATTCACAAAACAACAGAATTATAAATTTACCAGAGAGAAACAACAGACTAAACAATACAAGTATAGACAGCAATATTTCGCAACATGTCCAACAACAGCACAATATACGTGTGGTTACAAATAACAGCAACGGTAATGTAAGCGGAATTGCAAACGATCCGATATCATTCCAGCAGAAGAATGAAAGTTCTGGAACCACAATAAACGTACCTTTTCAAGCTATTCCAAACAGTGCCCCGATGAACATCAACGTGAATTCTAGTAACAACACTGTTAATATAACCGTACAGAATAACCTTGTCGACCCTAAAATAGCTTCAAAAGGTGCTGCGGATATCAGTTTTCCATTGCAAAACAATGCGAATATTTTGCCAAACCAAAATTCCACAAACAATATGATTTGCATTCCAGTACAGAATAATACTATAAATTTACCAACACAGAACAGTTCCAGTATCACTTTACCTAAAGCACCGCCAACTCAACAATCCGGTATACCGACAAATGTTGTGAATCCAATGTCCATGCGACCCATGAACAGAGTATTGCCACTACACAGGGACTGTCAAAGCAAATCGGCTACGAAATCGTCACCTTCGACAAAAACTTTACCAGTGCCAAAACAAAGACCAGTTAGTCATGATATGCCAGATCTAAATATAAAAGACGAAACAATTGACAGTGACCTCGAAAAAGCCATTGAAGAATCCAAGCGAATGATGGAACTTGAAAGGGCTAATAGAGAAAAAGAAGAAAGAGACGCCACTCAAGCTATGCAGCTATCAACTGAACTGAACAGAGCGAACACGAGCTCCGCTTCAGATAACGAGACTATCAGAATAAATGCTCCAGCTGAAATTAAATCTAAGGAATCTTCACTACCAAGCTTAGATGCAGAGATGATCGAAGTTCAACCACCAAGAATATTGATAGAAAAGGACAGAAATAAAGCGCCTGCACCGGCTAAATTATCGACCGCTACAACAAAGCTGTTGAAAAGACCTATACACCACACGGATAAGAAAAATGAAAATGAAACAGTGACGAAGAAGCCCAGCAAGCTTTCTAAGGAAAATAAACCTACTCTGTCCAAGCCGGGTCCGGATATTCCAAAAGATGATGGGCCCAAATTGATTTATGAAGTCTCTTCAGAGGATGGATTTAATTATACATCATCATCATTGAATGATCTTTGGGCAAAAGTAATTGAAGCTGTACAAAATGCAAGAAAACAGTCGGGACTACCACTTATACAATATAATTTACCACCTAGCACATCCGGAACCCATCTTTTGGGACTCAACAACAATGCGCTAAGATATCTTGTTGAACAACTGCCTGGGGCAAGCCGTTGCATCAAATACAAAACACGACAGGGGCGACAATTGAATAGCTTGGATACGGATTTAGACCTTAGTGAAGGATTCAAAGAGAGCCCCTGGGGAAGCGCTAGAACAGGGCCCATAGCGAGGAAACCTAATCACGACATGTTCAGCTGGATGGCCTCACCTTTCAGAGAGGAACCGCCTCCGTTTGGTGGTCAAGAGACTGAGAGCTCGATTTCTAGACGTTTAGCGACTTTACCGCCGGCGATGAGATTCAGACAACTGAAAGAAACTTCTAAGATATCAGTCGGCGTCTACAGGTCGCACATTCACGGACGTGGCTTATTCTGCAAACGTGATATCGAAGAAGGTGATATGGTGATCGAGTACGCGGGAGAAGTGATCCGCGCCGTGCTGGCGGACCAGCGCGAGAAGCGTTACGAGGCGATGAGCGGGCGGCGCGGCGTCGGCGGCTGCTACATGTTCCGCATCGACGACAACCTCGTGGTCGACGCCACGCTCAAGGGAAACGCAGCGAGATTTATCAACCACTCCTGTGACCCGAACTGTTATTCGCGGGTAGTTGACATCCACGGTCACAAACACATTCTGATCTTCGCTCTGCGTCGCATCACCGTGGGAGAGGAACTCACCTACGACTACAAGTTTCCTTTCGAGGAAGTGAAGATTCCATGCACTTGTGGCGCAAAGAAATGCCGCAAATATCTCAATTGA

Protein

MGRSRFPGKPLKFQNRKRISVLSGTVYHETAAEGPPARSVAANDFAGEQEEEEKKEANNEVKNEIEATENELSQPNKKQDSKSIHTSKSPVRTRSQNKMEATKADKPVKKTVTFGTVESCEDIFFPLKKLPSKHHAPLVPIIKKKSLLKQTEYSTFNSILKPAKLTDLSSKSSSEHQEGYLRKNLNPLSKPMNKFSQLSENRCISPPPRNSSPVERDNNGTTTKFVLPVRSAHSSRVIKPNKRFIDGEEPTAITSIISSGKVLKKPKLKRLVFNNIHNDDDETPDEDELNKIIEAEKNKEKSVLKTSSLFKDKTTNSFLSLNSGSRKGVHDLFSYDKEREHQDENSNVECSEKVKTTESAKDDRSGHAMRKLMDISDASSSSSTSSGSESEESWESDSAEGSGEELDKPILPSPDKDKSASQLLSGKVIIREARLQLNSPAQTTSGLDGPFSMLTSASSNNPPTTVTCGVCGAVRFYRFVKQARKFGIYSCESCRKFITKLLKRDKMAHRMGPVSMHCLKGEGNCHVPPIVRSQQWKLLRCTNKTRCPACWLKMCLKAFQVPPSIRASLTAMLPPNMRPSVKPTPLSPANPLRVPTTNAAVTSQPVFGLSVNDNETNIFGSLTSTKKTVEEPEKVEEKVSKEQSNTEENNEDFCASRKRQLTRIKVRKKDKSEAKQIEDPKRQKMELKGPRVKHVCRSASIVLGQPIATFPTMEEKDKHDKVISEEDNTVSTIDKDIEAPDLSSEESEVDLENKVPQIILEAVSVKDVEESPVEPKKRKVDPLLAKQGKAESSEDETVMDLIPKKTIQKPLSNITNVRGRTQKCGQNRPELICVDFWESYDPDEVCNSGFGLIGTLPFTVAKLCFLCGSAGQEKQMVVCSSCCEWYHTWCAEDASGGRGWRCARCACCAVCERAAARLRCRLCAAPHHAICLPAAPPDHRSDWPQICSACLKCKSCESTRVSKFVGSLPFCGPCFKLRQKGNYCPLCQACYRDNDFDSKMMECGWCGRWVHASCEGLSGEEYQLLSALPPSIEYICCKCMPHDPPWRKMLTEHLKGRLLHLLKLLAKSKKACALLKLTPHKNTPIANKPYRITSPQAIRKLHFESEDDSLKTTETKVYRNSSRGKRNNAQTKDDTTESQVWRCSSLLADVDMEKEDIPHTSHKVVNLQEPLMQNKEVCFSTGLYGTKTEFDAPCVEVHENYPSQKQNDKATTMLPASPNVEKYCDDETVRSFPQARSEQDLSPAIVRINDTIVAEMTENNKMVSPSLLDIKKRVNNDEYVSLKDFNHDMKEVITRTVNDDLKKIYKDLFSETFPWFDCENNCLQPNLEVEGELEDSESLKDDDMSDNKGLKASAQSIERPQDQIVPKIENDENKIEEDLIDFYPVFDSRTCVLCKVVGDATPSMEGRLLYCGQNDWIHANCALWSAEVFEEIDGSLQNVHSAISRGKMIKCAACETKGASVGCCAKNCSETYHYACARKQTCAFMDDKRVFCPTHGKDVPKKSLQKDTDFELTRPVYVELDKKKKRYGEINKVQFILGSLTVNTLGKIVPSVSDYEEFLIPVDFSCTRLFWSCKKPTKIVRYTIKTKLILAEPLPGFDFGVNITVDHNLETHAVDRMMAEIGSWHESLQNGSSKSALMLSNDKSPTKQGNSVTLEDLAVQQVVEHLLDNVCKQEQQDDEEPQNTADLLPPEVKDAIFEDLNHDLLDGISMQDIFQDLRHEFYGIVVQSEDKSNDKSDLRPTDIIDELLNARFESGSKELKRSKSEMLLQTHGLKNLTTGRGQQRSSSWNNKFDTSLLSSTIKRCKIGKASTVTEKLNPAQRGGIVVENQTVATKEAESTNSRSEEKKAKVDRCSNNVCDEVPHTSGVNYRETKEKEESTAVKNDKTEGYFADVIDFYTKIQCSPIAQLDGTEDWSGSESSCGSRPSSPRENDFSPIQQLDGAEDNIPGDTQRSQTNQFMYRASGTESYTVTFAGNSVNGQSELVMRSFEDPSGTINQMEQPVRCDRCQCTYRNKDSYDRHVPSCDMVSTSESESENPKSPENRTLTTLQNAFQGAFAQPMIIHAGVVSGSENTVKAESISARRTSINTRQITINGTIVETPSPGPSNEMTMTITEQMKSGTVIFDQSKTTNVQVSTNQQMMPSPQIVVTPQMLLPNKSNSGAGKMMTPQIITQPGILPYNICVKQGNTNIQQIQGSTDMTQLLSGSGGIQVISSNSNQVLTIPSNQQGNITPIIQGKNQVANFPNMASASSIALPVNSIQGMPNSSIIQNIQPMIRPSNPTIVVPAVSAQRLASPNTHKQQILMPGTQKSPKKQPTPVQPKPIFQTTNRPRGRPIPKPASVKRHTKLEKTFTTINQTPIGPGNTVIQLQTNNQTGQPSIIVQPVANQNIMSAYVEALSQQQNQNMQYIATIAPQGDFKTGPTQFISQGGLVPQTFQIQQTESGGLVAVPSGGIPVLLPQGNVGILPQTIQQGATILPQGAIQTQGIISQGPNGPTILPQTIHTQNGATLIPQGTLQGLAPGNITTQTATLLPNNTLQTAGATVVPQSGIGNGQTTIIPNALQTQGNTLTGATILPQGTLLPQFCNDQVLLGSTPTLEMVTDSSGCMYLTTTQPVYYGLETIVQNTVMSSQQFVSTAMQGVLAQNSSFSATTTQVFQASKIEPIVEVPTGYVVVNNVGDNVSSSTPNVVTAQSVQSSPASMKAVKTSVPNLTLQPLTEKALNNSIRQTPKVIHMSSSPLTMGSQSCPNSIMTGRQTINPITSQIHSMTLSNASHNIHRAANVTKQNVSMSPVTLVSSTGQPVLAISQSTPNSTTTFSMQPIPLSQPIVTSSIAPSLNKNNVKTENSHVIEISGNLQDNTNSSNVPTISVAQSIKSPTPWRQISTLTNNAHTENKIEMQGTGKTNIITPSMTIQSNNMPGRSHLHNEHDKINQSCLMTMSNNGNGLSNVNTHSHQYEPNLNVSHHQSHSSNNVIHIAAGNIYPPVSGMSTFDADTTLKLSKINALSKTEGGHLNFSQEIMASHSQHNANNEKSFQNLGTNDNKHNMDCMSGQMNIHKLNSCQMAGSMNNAPAISIIPHNVMRPPSQSTQNNLPSNNQNQMCSISTSSSHGQVQLLNSGNNSIQNINLSCQEAVNSRMNIVSSNDNMQLNHEITNTSNMPHGNMQIVSHENNQMSSSNQIHIMNGQIQHNRQIDTNNQLQQQISQNSSGRSFHENMMSSQQNHNQTMMSIRNTPDSNDLINQSMNMHNLGSNAHPNRSEINDHNHMQMQQAMSNMQNNRILMDNMQPHNLNNHNHTIHSNRGMDNMHNTQLQNMQQINHHMNSNSRSLMENNMHVNQQMNMQQNRQIDNSGMHHQHQMPNVMQMQNNRQHNESNMINLHQHVNQMHNRQQIETSMHMHHMPANTTNMNLNQMDNSGSLPYIHGNRNDNNAMAMQGMNVMNQIQNNRCAMDHSSIMQHQMNNMSSMNNMNMHNNLSNAMQMNNVNHQSMNTSLMHVPNIPDIKTELQNSCSGSCSSNSSLFSANQNSMEICSNMNAPNMTMGSSTMLHGMNANNPNMSSSNMMLNNINNSNNMFATGAQNNINSHDMLMNCTNAADHSVAGLLSGTPNHSMMMNSPQTHATNNASQSLNTQISNNSQVNLNNCSMAANNAQNPNVPNMEGQLNRNNLPVEPPKFTQEPLRGKNMMSSATNNNISIPNIPNNDCAKVNIVNNDKPNHNISVNNQIGYMQMNSQNNRIINLPERNNRLNNTSIDSNISQHVQQQHNIRVVTNNSNGNVSGIANDPISFQQKNESSGTTINVPFQAIPNSAPMNINVNSSNNTVNITVQNNLVDPKIASKGAADISFPLQNNANILPNQNSTNNMICIPVQNNTINLPTQNSSSITLPKAPPTQQSGIPTNVVNPMSMRPMNRVLPLHRDCQSKSATKSSPSTKTLPVPKQRPVSHDMPDLNIKDETIDSDLEKAIEESKRMMELERANREKEERDATQAMQLSTELNRANTSSASDNETIRINAPAEIKSKESSLPSLDAEMIEVQPPRILIEKDRNKAPAPAKLSTATTKLLKRPIHHTDKKNENETVTKKPSKLSKENKPTLSKPGPDIPKDDGPKLIYEVSSEDGFNYTSSSLNDLWAKVIEAVQNARKQSGLPLIQYNLPPSTSGTHLLGLNNNALRYLVEQLPGASRCIKYKTRQGRQLNSLDTDLDLSEGFKESPWGSARTGPIARKPNHDMFSWMASPFREEPPPFGGQETESSISRRLATLPPAMRFRQLKETSKISVGVYRSHIHGRGLFCKRDIEEGDMVIEYAGEVIRAVLADQREKRYEAMSGRRGVGGCYMFRIDDNLVVDATLKGNAARFINHSCDPNCYSRVVDIHGHKHILIFALRRITVGEELTYDYKFPFEEVKIPCTCGAKKCRKYLN

Description

Histone methyltransferase that methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12408863). Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes (PubMed:2107543, PubMed:7958911). Acts as an activator of BX-C (PubMed:7924996). Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo (PubMed:7924996, PubMed:25310983).

Catalytic Activity

L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Subunit

Interacts (via SET domain) with ash1 (via SET domain) (PubMed:10454589, PubMed:10656681). Interacts with Nup98 (PubMed:25310983).

Similarity

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.

Keywords

Activator Alternative splicing Chromatin regulator Chromosome Complete proteome Developmental protein DNA-binding Metal-binding Methyltransferase Nucleus Reference proteome Repeat S-adenosyl-L-methionine Transcription Transcription regulation Transferase Zinc Zinc-finger

Feature

chain Histone-lysine N-methyltransferase trithorax
splice variant In isoform B.

Uniprot

P20659.4

EC Number

2.1.1.43

Pubmed

2107543 7924996 8555104 10731132 12537572 12537569 + More
10454589 10656681 7958911 12408863 25310983

EMBL

M31617 Z50152 Z31725 AE014297 AY051904

Proteomes

UP000000803

PRIDE

P20659

Pfam

PF05964   FYRN        + More
PF05965   FYRC
PF00628   PHD
PF00856   SET

Interpro

IPR034732   EPHD        + More
IPR001841   Znf_RING
IPR016569   MeTrfase_trithorax
IPR003888   FYrich_N
IPR001214   SET_dom
IPR001965   Znf_PHD
IPR013083   Znf_RING/FYVE/PHD
IPR019787   Znf_PHD-finger
IPR003616   Post-SET_dom
IPR001628   Znf_hrmn_rcpt
IPR011011   Znf_FYVE_PHD
IPR003889   FYrich_C

SUPFAM

SSF57903 SSF57903

Gene 3D

3.30.40.10

ProteinModelPortal

P20659.4

PDB

5F6L E-value=7.75066e-64, Score=628

KEGG

101742231 K09186 histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43] | (RefSeq) histone-lysine N-methyltrans

PATHWAY

00310 Lysine degradation - Bombyx mori (domestic silkworm)

GO

GO:0035097 GO:0044665 GO:0000123 GO:0042800 GO:0005634 GO:0032968 GO:0008354 GO:0005704 GO:0045893 GO:0007482 GO:0016573 GO:0043565 GO:0001654 GO:0016571 GO:0051568 GO:0003700 GO:0008023 GO:0008270 GO:0043966 GO:0042802 GO:0007411 GO:0003682 GO:0005700 GO:0008157 GO:0045944 GO:0042803 GO:0005515 GO:0006355 GO:0016021 GO:0004672 GO:0048384

Subcellular location

Nucleus
Chromosome

Length:

4411

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00036

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.00002

outside

1 - 4411

Pi

233.158392

Theta

213.289923

Tajima's D

0.160939

CLR

174.224912

CSRT

0.411429428528574

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics