Gene

KWMTBOMO03893

Pre Gene Modal

BGIBMGA010210

Annotation

PREDICTED:_putative_glutathione-specific_gamma-glutamylcyclotransferase_2_[Amyelois_transitella]

Location

Bomo_Chr7(+):5968775-5970533      View in EpiBrowser

Full name

Gamma-glutamylcyclotransferase       + More
Putative glutathione-specific gamma-glutamylcyclotransferase 2      

Alternative Name

Cation transport regulator-like protein 2

Location in the cell

Cytoplasmic   Reliability : 2.066

CDS

ATGTGGGTTTTTGGGTATGGTTCCTTAATTTGGAAAGCGGACTTCAAGTATGAGACTAAGCTAGTAGGCTATATTTTAGGCTATAAAAGAAGATTTTATCAACATAGTGTCGATCACAGAGGTGTCCCCGAAAAACCTGGTAGAGTAGTTACTTTAATACCCAGCAAGTTTCCTAATAGCACTGTGTGGGGTGTAGCATACAGGATTAGAGCAGAAGATATAGATGAAGTAACCAAACATTTAGATTTTAGAGAAAAGAATGGTTATTCTAAGAAAACTGTCACATTCCATCCAAATAATAGCGAATATTTACCATTTCCATTGACTTTGTATGTTGCAGTAGAGGAGAACGAATCTTATGCTGGGCCAGCAGCAATAGAAGACATAGCACAACAAGTTGTTACATCTTTCGGTCCTAGTGGTTCAAACAAAGAATATGTGTACAACTTGGCTGAAGCAATGAGACAGTTGGCACCAAATGCAGAAGATGAACACTTATTTGCTTTGGAAAAGGCGGTGAAAGAGATAGATCCAGATTTAAAGAACCTAAAAAAATAG

Protein

MWVFGYGSLIWKADFKYETKLVGYILGYKRRFYQHSVDHRGVPEKPGRVVTLIPSKFPNSTVWGVAYRIRAEDIDEVTKHLDFREKNGYSKKTVTFHPNNSEYLPFPLTLYVAVEENESYAGPAAIEDIAQQVVTSFGPSGSNKEYVYNLAEAMRQLAPNAEDEHLFALEKAVKEIDPDLKNLKK

Description

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide (PubMed:27913623). Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity).

Catalytic Activity

glutathione = 5-oxo-L-proline + L-cysteinylglycine

Biophysicochemical Properties

3 mM for glutathione

Subunit

Monomer.

Similarity

Belongs to the gamma-glutamylcyclotransferase family.
Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.

Keywords

Complete proteome   Cytoplasm   Lyase   Reference proteome   Alternative splicing  

Feature

chain  Putative glutathione-specific gamma-glutamylcyclotransferase 2
splice variant  In isoform 2.

Uniprot

H9JL09   A0A194Q0B1   S4P2C5   A0A212ES29   A0A2H1WMW0   A0A0T6B3H5   + More
A0A2A4K0D7   A0A151JSQ0   A0A2P8Y6P9   E0VLY2   A0A0B6YS24   U4TXW1   A0A067QTU1   N6UNR7   E2AVE7   E2BQG7   V5GU94   D2CSM0   D6W720   B7PC44   A0A1B6GLW2   A0A154PA02   A0A151I6V5   A0A210PPI8   A0A2R7W3B1   T1JB24   A0A2R5L6J9   A0A1B6LMI0   A0A0K8RFR1   A0A224YPS1   A0A1W4X631   A0A2J7Q4R7   A0A2A3E302   A0A088ARU3   K1PMH4   A0A131YVV1   A0A131YCA1   L7LXB0   A0A2C9JXZ1   A0A2G8LBA5   A0A131XEY1   K7J9W9   A0A384CUB2   A0A3Q7UP80   L8HVB7   C3Y083   A0A2G8KP25   G3WPZ6   A0A151MGD7   A0A1W5BFL8   A0A2P4SPA3   F1NE73   D2GY90   A0A2K5JH24   A0A2R8MQ85   A0A3Q7NTH9   A0A2U3W6D5   A0A2U3X869   H2XPV5   A0A1U7UTI4   K7FVK6   A0A0N0BF07   A0A287B4W3   A0A341B812   W5P231   A0A340XW04   A0A2Y9Q5X7   A0A2Y9FJ24   A0A2Y9D8U6   A0A2K5C536   F7DH59   A0A384ASI2   A0A1S3A1T2   A0A2K6E5C4   G7PM72   F7BCW7   F0J9B5   H9F1I3   Q641Z5   A0A2K5RAQ7   A0A2K6U5X6   A0A1V4IGH0   A0A3Q7RSD9   Q9CQG1   M3X427   S7NR43   A0A1E1XIG9   A0A3P4M8I3   M3YH44   A0A1L8G1G5   Q5PPV4   A0A2Y9JG26   A0A2U4BYB8   M1EJP5   A0A226P3W4   A0A2K6L6W5   A0A2K6RL23   V9L484   K9IGX7   A0A232F116  

EC Number

4.3.2.-
4.3.2.7

Pubmed

19121390    26354079    23622113    22118469    29403074    20566863    + More
23537049    24845553    20798317    18362917    19820115    28812685    28797301    22992520    26830274    25576852    15562597    29023486    28049606    20075255    24813606    22751099    18563158    21709235    22293439    15592404    20010809    12481130    15114417    17381049    20809919    19892987    22002653    17431167    21362191    25319552    15489334    16141072    19468303    21183079    27913623    17975172    28503490    27762356    23236062    24621616    25362486    24402279    28648823   

EMBL

BABH01011458    KQ459582    KPI98738.1    GAIX01012090    JAA80470.1    AGBW02012891    + More
OWR44269.1    ODYU01009759    SOQ54405.1    LJIG01016029    KRT81828.1    NWSH01000329    PCG77364.1    KQ982014    KYN30634.1    PYGN01000863    PSN39926.1    DS235283    EEB14388.1    HACG01012204    CEK59069.1    KB631815    ERL86444.1    KK853280    KDR09038.1    APGK01024615    KB740555    ENN80377.1    GL443090    EFN62581.1    GL449769    EFN82025.1    GALX01000727    JAB67739.1    EU713234    EU713235    EU713236    EU713237    EU713238    ACI00225.1    KQ971307    EFA11426.1    ABJB010017770    ABJB010835893    ABJB011004675    DS681555    EEC04166.1    GECZ01006362    JAS63407.1    KQ434856    KZC08725.1    KQ978456    KYM93896.1    NEDP02005568    OWF38401.1    KK854273    PTY14069.1    JH432008    GGLE01000992    MBY05118.1    GEBQ01015032    JAT24945.1    GADI01003828    JAA69980.1    GFPF01006593    MAA17739.1    NEVH01018377    PNF23577.1    KZ288427    PBC25854.1    JH816701    EKC25202.1    GEDV01005799    JAP82758.1    GEDV01012455    JAP76102.1    GACK01008589    JAA56445.1    MRZV01000140    PIK57495.1    GEFH01003669    JAP64912.1    AAZX01008749    AAZX01020483    JH883230    ELR47007.1    GG666478    EEN66156.1    MRZV01000448    PIK49764.1    AEFK01031425    AKHW03006178    KYO23585.1    PPHD01031249    POI25952.1    AADN05000009    GL192376    EFB28565.1    EAAA01000761    AGCU01079349    AGCU01079350    KQ435814    KOX72668.1    AEMK02000021    AMGL01077445    AQIA01018071    AQIA01018072    CM001288    EHH55567.1    JSUE03010883    CM001265    EHH22118.1    BK007466    DAA34409.1    JU324736    AFE68492.1    BC082031    LSYS01009753    OPJ58950.1    AK010914    AK021391    AK078993    AL662891    BC025100    AANG04002548    KE164608    EPQ19180.1    GFAC01000185    JAT99003.1    CYRY02007889    VCW76773.1    AEYP01087353    CM004475    OCT77696.1    BC087482    JP007561    AER96158.1    AWGT02000182    OXB74302.1    JW873422    AFP05939.1    GABZ01008157    JAA45368.1    NNAY01001351    OXU24272.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000218220    UP000078541    UP000245037    + More
UP000009046    UP000030742    UP000027135    UP000019118    UP000000311    UP000008237    UP000007266    UP000001555    UP000076502    UP000078542    UP000242188    UP000192223    UP000235965    UP000242457    UP000005203    UP000005408    UP000076420    UP000230750    UP000002358    UP000261680    UP000291021    UP000286642    UP000001554    UP000007648    UP000050525    UP000000539    UP000233080    UP000008225    UP000286641    UP000245340    UP000245341    UP000008144    UP000189704    UP000007267    UP000053105    UP000008227    UP000252040    UP000002356    UP000265300    UP000248483    UP000248484    UP000248480    UP000233020    UP000002281    UP000261681    UP000079721    UP000233120    UP000009130    UP000233100    UP000006718    UP000002494    UP000233040    UP000233220    UP000190648    UP000286640    UP000000589    UP000011712    UP000000715    UP000186698    UP000248482    UP000245320    UP000198419    UP000233180    UP000233200    UP000215335   

PRIDE

H9JL09    Q641Z5    Q9CQG1   

Pfam

PF04752   ChaC

Interpro

IPR006840   ChaC        + More
IPR013024   GGCT-like       
IPR036568   GGCT-like_sf       

SUPFAM

SSF110857   SSF110857       

CDD

cd06661  GGCT_like

ProteinModelPortal

H9JL09   A0A194Q0B1   S4P2C5   A0A212ES29   A0A2H1WMW0   A0A0T6B3H5   + More
A0A2A4K0D7   A0A151JSQ0   A0A2P8Y6P9   E0VLY2   A0A0B6YS24   U4TXW1   A0A067QTU1   N6UNR7   E2AVE7   E2BQG7   V5GU94   D2CSM0   D6W720   B7PC44   A0A1B6GLW2   A0A154PA02   A0A151I6V5   A0A210PPI8   A0A2R7W3B1   T1JB24   A0A2R5L6J9   A0A1B6LMI0   A0A0K8RFR1   A0A224YPS1   A0A1W4X631   A0A2J7Q4R7   A0A2A3E302   A0A088ARU3   K1PMH4   A0A131YVV1   A0A131YCA1   L7LXB0   A0A2C9JXZ1   A0A2G8LBA5   A0A131XEY1   K7J9W9   A0A384CUB2   A0A3Q7UP80   L8HVB7   C3Y083   A0A2G8KP25   G3WPZ6   A0A151MGD7   A0A1W5BFL8   A0A2P4SPA3   F1NE73   D2GY90   A0A2K5JH24   A0A2R8MQ85   A0A3Q7NTH9   A0A2U3W6D5   A0A2U3X869   H2XPV5   A0A1U7UTI4   K7FVK6   A0A0N0BF07   A0A287B4W3   A0A341B812   W5P231   A0A340XW04   A0A2Y9Q5X7   A0A2Y9FJ24   A0A2Y9D8U6   A0A2K5C536   F7DH59   A0A384ASI2   A0A1S3A1T2   A0A2K6E5C4   G7PM72   F7BCW7   F0J9B5   H9F1I3   Q641Z5   A0A2K5RAQ7   A0A2K6U5X6   A0A1V4IGH0   A0A3Q7RSD9   Q9CQG1   M3X427   S7NR43   A0A1E1XIG9   A0A3P4M8I3   M3YH44   A0A1L8G1G5   Q5PPV4   A0A2Y9JG26   A0A2U4BYB8   M1EJP5   A0A226P3W4   A0A2K6L6W5   A0A2K6RL23   V9L484   K9IGX7   A0A232F116  

PDB

5HWK     E-value=6.22378e-24,     Score=270

KEGG

101738946    K07232 glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7] | (RefSeq) putative glutathi

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0061928   GO:0006751   GO:0003839   GO:0016740   GO:0005737   GO:0005829   GO:0016021   GO:0031515   GO:0006412   GO:0007219   GO:0007275   GO:0004672   GO:0048384  

PANTHER

PTHR12192  

Subcellular location

  

Length:

185

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00619999999999999

Exp number, first 60 AAs:

0.00534

Total prob of N-in:

0.02714

outside

1  -  185

 

 

Pi

270.173473

Theta

221.63048

Tajima's D

0.765298

CLR

0.063884

CSRT

0.587670616469177

Interpretation

Uncertain