Gene

KWMTBOMO03884  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010207

Annotation

tRNA_methyltransferase_[Danaus_plexippus]

Location

Bomo_Chr7(+):5814985-5853095      View in EpiBrowser

Full name

tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A      

Location in the cell

Cytoplasmic   Reliability : 2.593

CDS

ATGAGTTTTAGAAATTATAAGGATAAAGTAGATGAAGGAGATACAGTGATCTTATACCTTAGTAACAATTTATATGCAATAGATGTTAAGACTGAAGTTAAAAATAAGAAAGGTGAAACGATTGAGAATGTCTTCCAAACACCTTTCGGTGCTTTAAAAGTAAGGAACTTAATTGGTATACAGTATGGAAGTCGGATAGAACTATCAAAGGGCTGGGGACACATACTACAGCCAACCCCTGAGATGTGGTCCCTAACATTGCCTCACCGCACTCAAATTATATACACGCCTGACATAAGCATGATCCTGTTCCAATTGGACTTAGTTCCTGGCTGTGTTGTCATCGAAGCTGGTACAGGTAGTGGCTCCTTAACTCATGCACTCATACGTCGCGTGCGGCCAGAAGGGCATGTTTACACTTTTGATTTTCATGAGCACAGATCCAAAATTGCTAGAGAAGAGTTTGAGGCTCATGATGTTGCCGACTTTGTTACTGCGCAACACAGAGACATCATACGAGACGGCTTTTCTGAAGAATTGAATGGGAAAGCGGATGCCGTGTTTTTGGATTTACCCAGTCCTTGGCTTGGAATTTCTCATGCAGTAAAAGCCATCAAAGAACAAGGCGGAAGATTCTGTTCGTTCTCTCCTTGCATCGAACAAGTACAAAGGACATGTCTAGTTCTTCAAGAGAATGGCTTCCAGGACATCAACACTATGGAGATATTGCAGAGGGAGCTTAAAGTCACTAAAAGAACGATACCCGTGAGGGACTTATCATTTCTGAAACACAAAATCTCTTAG

Protein

MSFRNYKDKVDEGDTVILYLSNNLYAIDVKTEVKNKKGETIENVFQTPFGALKVRNLIGIQYGSRIELSKGWGHILQPTPEMWSLTLPHRTQIIYTPDISMILFQLDLVPGCVVIEAGTGSGSLTHALIRRVRPEGHVYTFDFHEHRSKIAREEFEAHDVADFVTAQHRDIIRDGFSEELNGKADAVFLDLPSPWLGISHAVKAIKEQGGRFCSFSPCIEQVQRTCLVLQENGFQDINTMEILQRELKVTKRTIPVRDLSFLKHKIS

Description

Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.

Catalytic Activity

adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.

Uniprot

A0A212ES41   A0A2A4JXF9   A0A2W1BZ81   H9JL06   A0A3S2M7R5   A0A2H1WYW7   + More
A0A0L0C3C8   W8BQM5   A0A0K8VKE8   R4FND9   A0A0P4VVB4   A0A224XTM2   A0A023F8C2   A0A1I8PCD6   A0A1I8MBH5   A0A1B6FJX9   N6UJJ4   A0A1Q3EXW5   B0WJB3   Q16ZN4   U4UIK8   A0A182H750   A0A2P8Z6H3   D6WA21   A0A1L8DGP9   K7J3Z8   A0A336LJD7   A0A1B6CPE4   A0A1Y1M862   A0A0C9QQW2   A0A1A9WF52   A0A0M3QXZ4   A0A194Q178   A0A026WXM3   A0A1W4V7K6   B3M2U0   B4LYT4   B4NK44   B3P698   Q9VBH7   B4JGK1   B4K6E2   B4QW28   A0A1B3PDB5   A0A0L7R9V6   B4ICJ3   B4PSW4   A0A151X951   A0A182XXM9   E2ALA4   Q296Z9   B4GEF2   A0A1J1HHM2   A0A1A9XEX3   A0A1B0BEV8   A0A195FBW0   Q7Q294   A0A1A9VDZ9   A0A154P0A2   A0A158NKQ3   A0A195DG69   A0A2M4CTN8   A0A195CKY4   A0A182JCP4   V9IIE3   A0A232EVS8   A0A310SNV1   A0A0A9Y1D5   T1DPM6   F4X3G2   A0A088AD89   A0A3B0K611   A0A0M8ZYV7   A0A1B3PDJ1   A0A0P4Y650   A0A2S2PZ83   A0A0P5TII0   E0W403   A0A3L8D9N4   A0A0P6EWY4   A0A1B0GF17   A0A2A3ECL0   A0A2S2NYU5   A0A2H8TFL0   A0A0P6D1T9   A0A182QCC9   E2C811   A0A195BLV4   E9GX16   A0A0P4WSQ9   A0A2J7QT15   A0A1B0DQK6   A0A0P5UAJ4   A0A1S3H9R5   A0A0P5BIN1   T1HIF1   A0A067RDJ5   A0A131XWK8   T1J699   A0A1S3H7W8  

EC Number

2.1.1.220

Pubmed

22118469    28756777    19121390    26108605    24495485    27129103    + More
25474469    25315136    23537049    17510324    26483478    29403074    18362917    19820115    20075255    28004739    26354079    24508170    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    25244985    20798317    15632085    12364791    14747013    17210077    21347285    28648823    25401762    26823975    21719571    20566863    30249741    21292972    24845553   

EMBL

AGBW02012891    OWR44271.1    NWSH01000396    PCG76705.1    KZ149914    PZC77996.1    + More
BABH01011443    RSAL01000013    RVE53392.1    ODYU01012082    SOQ58192.1    JRES01000953    KNC26838.1    GAMC01005193    JAC01363.1    GDHF01012953    JAI39361.1    GAHY01001334    JAA76176.1    GDKW01000610    JAI55985.1    GFTR01004973    JAW11453.1    GBBI01001172    JAC17540.1    GECZ01019288    JAS50481.1    APGK01031799    APGK01031800    KB740824    ENN78837.1    GFDL01014915    JAV20130.1    DS231958    EDS29048.1    CH477487    EAT40124.1    KB632314    ERL92238.1    JXUM01028000    KQ560807    KXJ80807.1    PYGN01000174    PSN52092.1    KQ971312    EEZ98075.1    GFDF01008452    JAV05632.1    AAZX01000987    UFQT01000022    SSX18016.1    GEDC01021988    JAS15310.1    GEZM01041321    GEZM01041320    JAV80515.1    GBYB01006119    JAG75886.1    CP012526    ALC46729.1    KQ459582    KPI98744.1    KK107078    EZA60491.1    CH902617    EDV43470.1    CH940650    EDW67011.1    CH964272    EDW85086.1    CH954182    EDV53568.1    AE014297    AY119248    AAF56565.1    AAM51108.1    ALI30641.1    CH916369    EDV93698.1    CH933806    EDW15215.1    CM000364    EDX14527.1    KU659911    AOG17710.1    KQ414620    KOC67652.1    CH480828    EDW45089.1    CM000160    EDW98651.1    KQ982409    KYQ56818.1    GL440570    EFN65783.1    CM000070    EAL28307.1    CH479182    EDW33987.1    CVRI01000004    CRK87527.1    JXJN01013032    KQ981693    KYN37871.1    AAAB01008978    EAA13617.4    KQ434787    KZC05345.1    ADTU01018960    KQ980886    KYN11837.1    GGFL01004536    MBW68714.1    KQ977649    KYN00739.1    JR045824    AEY60064.1    NNAY01001960    OXU22446.1    KQ760551    OAD59820.1    GBHO01018153    GDHC01016527    GDHC01013376    JAG25451.1    JAQ02102.1    JAQ05253.1    GAMD01003219    JAA98371.1    GL888613    EGI58990.1    OUUW01000023    SPP89565.1    KQ435811    KOX72896.1    KU659988    AOG17786.1    GDIP01235789    JAI87612.1    GGMS01001633    MBY70836.1    GDIP01127358    JAL76356.1    AAZO01007496    DS235885    EEB20359.1    QOIP01000011    RLU17220.1    GDIQ01056923    JAN37814.1    CCAG010012732    KZ288285    PBC29475.1    GGMR01009519    MBY22138.1    GFXV01001046    MBW12851.1    GDIQ01086408    JAN08329.1    AXCN02000286    GL453506    EFN75929.1    KQ976439    KYM86709.1    GL732571    EFX75994.1    GDRN01029702    GDRN01029701    JAI67589.1    NEVH01011202    PNF31726.1    AJVK01019160    GDIP01115761    JAL87953.1    GDIP01188298    JAJ35104.1    ACPB03009370    KK852771    KDR16889.1    GEFM01005188    JAP70608.1    JH431874   

Proteomes

UP000007151    UP000218220    UP000005204    UP000283053    UP000037069    UP000095300    + More
UP000095301    UP000019118    UP000002320    UP000008820    UP000030742    UP000069940    UP000249989    UP000245037    UP000007266    UP000002358    UP000091820    UP000092553    UP000053268    UP000053097    UP000192221    UP000007801    UP000008792    UP000007798    UP000008711    UP000000803    UP000001070    UP000009192    UP000000304    UP000053825    UP000001292    UP000002282    UP000075809    UP000076408    UP000000311    UP000001819    UP000008744    UP000183832    UP000092443    UP000092460    UP000078541    UP000007062    UP000078200    UP000076502    UP000005205    UP000078492    UP000078542    UP000075880    UP000215335    UP000007755    UP000005203    UP000268350    UP000053105    UP000009046    UP000279307    UP000092444    UP000242457    UP000075886    UP000008237    UP000078540    UP000000305    UP000235965    UP000092462    UP000085678    UP000015103    UP000027135   

PRIDE

H9JL06    Q9VBH7   

Pfam

PF08704   GCD14        + More
PF05502   Dynactin_p62
PF12937   F-box-like

Interpro

IPR014816   tRNA_MeTrfase_Gcd14        + More
IPR029063   SAM-dependent_MTases       
IPR008603   DCTN4       
IPR001810   F-box_dom       
IPR036047   F-box-like_dom_sf       
IPR032675   LRR_dom_sf       

SUPFAM

SSF53335   SSF53335        + More
SSF81383   SSF81383       

Gene 3D

3.80.10.10    

ProteinModelPortal

A0A212ES41   A0A2A4JXF9   A0A2W1BZ81   H9JL06   A0A3S2M7R5   A0A2H1WYW7   + More
A0A0L0C3C8   W8BQM5   A0A0K8VKE8   R4FND9   A0A0P4VVB4   A0A224XTM2   A0A023F8C2   A0A1I8PCD6   A0A1I8MBH5   A0A1B6FJX9   N6UJJ4   A0A1Q3EXW5   B0WJB3   Q16ZN4   U4UIK8   A0A182H750   A0A2P8Z6H3   D6WA21   A0A1L8DGP9   K7J3Z8   A0A336LJD7   A0A1B6CPE4   A0A1Y1M862   A0A0C9QQW2   A0A1A9WF52   A0A0M3QXZ4   A0A194Q178   A0A026WXM3   A0A1W4V7K6   B3M2U0   B4LYT4   B4NK44   B3P698   Q9VBH7   B4JGK1   B4K6E2   B4QW28   A0A1B3PDB5   A0A0L7R9V6   B4ICJ3   B4PSW4   A0A151X951   A0A182XXM9   E2ALA4   Q296Z9   B4GEF2   A0A1J1HHM2   A0A1A9XEX3   A0A1B0BEV8   A0A195FBW0   Q7Q294   A0A1A9VDZ9   A0A154P0A2   A0A158NKQ3   A0A195DG69   A0A2M4CTN8   A0A195CKY4   A0A182JCP4   V9IIE3   A0A232EVS8   A0A310SNV1   A0A0A9Y1D5   T1DPM6   F4X3G2   A0A088AD89   A0A3B0K611   A0A0M8ZYV7   A0A1B3PDJ1   A0A0P4Y650   A0A2S2PZ83   A0A0P5TII0   E0W403   A0A3L8D9N4   A0A0P6EWY4   A0A1B0GF17   A0A2A3ECL0   A0A2S2NYU5   A0A2H8TFL0   A0A0P6D1T9   A0A182QCC9   E2C811   A0A195BLV4   E9GX16   A0A0P4WSQ9   A0A2J7QT15   A0A1B0DQK6   A0A0P5UAJ4   A0A1S3H9R5   A0A0P5BIN1   T1HIF1   A0A067RDJ5   A0A131XWK8   T1J699   A0A1S3H7W8  

PDB

5CD1     E-value=2.13422e-65,     Score=630

KEGG

101738675    K07442 tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]

GO

GO:0016429   GO:0031515   GO:0005634   GO:0005869   GO:0030488   GO:0006412   GO:0007219   GO:0007275   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR12133  

Subcellular location

Nucleus  

Length:

267

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.21331

Exp number, first 60 AAs:

0.00429

Total prob of N-in:

0.16649

outside

1  -  267

 

 

Pi

26.004821

Theta

193.416738

Tajima's D

0.842629

CLR

0.159218

CSRT

0.615369231538423

Interpretation

Uncertain