Silkworm Genome Informatics Database

Gene

KWMTBOMO03883

Pre Gene Modal

BGIBMGA010166

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_mediator_of_RNA_polymerase_II_transcription_subunit_24_[Bombyx_mori]

Location

Bomo_Chr7(-):5806081-5809104 View in EpiBrowser

Full name

Mediator of RNA polymerase II transcription subunit 24

Alternative Name

Mediator complex subunit 24
dMED24
dTRAP100

Location in the cell

PlasmaMembrane Reliability : 2.01

CDS

ATGGATGCTTCCAAAATAACGAGTAAAACTAGTTCACTAAAAGCTTTAATTTTAAAAGCTTGGAAAGAACGATGGACTGATATTCAATGGGGCATCAACATCAAAACTATACTGCCGAGGGGCGTCAGTGGTGACCTATATAATCTGGCTGATTGTATTCTTCAACAAGCCATGGTAGGCTGTGGGGCCAATCAGTTAGTGATATCGTATTTGAAACATTCACTTGCGTGTCATTTGGTCTCTTTCGCGGCTGTGTTACAACGAATCGCAAAATTTGATGCTTTTCACAAACCTCATTGTATAATAAGCTTGTTGGAGTTCCTTGAAACCTTTTTGGAGAGTATTACATGCAGAGGCAAGTTAGAAGAAGAAGTTTTAGCTTATGCTGTATCATCTATAATATTGTGGCTTTTACAAGTATTTCACTATTCATTAACCAAGTATCCAGCTTCAAGTTCTGTTCAAAGTCAGGAATTATTGGAGAAATCATCAGTTTTACTGAACTCTATTGTTAATACAGATTTTCTGATTGCAATGTTCTATTTGGCCAAGCAGAATGATCCTGATGAGTATAACGAAGTGACAAAGAAATGTCAAGAGATAACAGCATTTATGATGATGAACACTCAATTCAAACCTCCGATGACCATACATGTCACTTTACACAAAATCTGCAATATGGAATTGGATAAAATAGCACCCTTAAACAATAAACCAGAAGCTGTAACCTATTGTCTGCAGGCTTTAATAGCTATAAATGTGTTCTCAAACCCTAGTGCAGGCATGCAACAGATCTCCAGCCAACTACTAATGGTTCAGAAAATAAAAGGCTATTCATTGTCACGTCTCTACTGTGAACTTATTAGAGCTTGTTTCATTTCACTAAATGATTCTAGTAATGATGCATCGAAGCAATCATTGTGGGCTGCATTCACTTTTCTAAAAGTTCCACAAGTGATAAATCACCTCCATAATATGTGTGGGACAACAAATAAGGAAAGTGAATATTCTACTGAGGTTGTGGAAGCTTTTGAAATGTTATTACAATCAGCTCCACTCCTGGATATTGTTGATACGAAGAATTCTTGTAATAGTGTTATTTCACTTATAGAGCCATTAGTTAAACTTAATGTTCTGTCAGATAATACTTTGACATATTTTAAACAAAAACGTGAGACTATTGATCATCCTTTACAAAAATTTGAGCCAATAGGATTACAAGGCTCAGTCCCATTATTTATAACTCGTGTTGAACCTACATTGGCAGAGATTTTAAAAGCATTGAGTGGTGAATTTCACAAAACTCAAGAGTCGCTCTATATCATGCTATGCCAAATAGTTGGTCGAACTACATTGGATACCATCCTGGCCGTTGCAACTGTGGAAGGAAAACTAAAAATGTTTGTGTCAAGACTCATTAAGTTTAATGAATTTGCATTGTTTGCTGCAAGTGAAAAAGGTGCACCACAATCAAAAGTATATATATTTGACATTTCATTTTTGCTTTTATGTTGGATAGTCCAAGATTATGGAGCTGATGTTGTTCTAGAAGAAAATGGTGATTCATTTTTTGAGAAATGGGTAAGGGATTGTATGGTACATAAAGGAAATTATAAATCTTCAGATCAGATACTTCAGAAATGTGATCATGTTGTTGATGTTATCATTCACCATTTGAGTGCTCCTGACTTTGATTTCAAAAATACTAATGTCAAACCTCATGATCTTTGTATGAATATCACTGGTGCAGTCAAAGAGGTTCTTTTTGCTTGGGAACAAGGTCTACTTTCGGCAACAGATGTTAAAAGAATGTTGGATTCTATAAGACAAAAAATGGCTTCCTTGGCAGTGTGTGCATCAGTATGGCTTTGTTCATACATCAATGTTGTCCATCAAGATGCATCAATAAAACCCATGAATATGGTTCAGCAATTTTTAACATCACCTACTGAATTAGAATTAACTCAAATAGACAATTTTCAAGAAAGAGCAATTTTGATGTGTCAGATAATAAGAAAATTACTGTTTAAAATTCATCCTACCTCAATGCCAAAATCAAAAGAGCAGCAGTTGCCATACAGTATCACCTCTCGCAAGCCAATATTAGAGCAACTACAAAGCATTTGGGAAAATATAAAGTCTAGAGGATACCTTCATATTGATGCTACCCATCTCGTTGAGAATCTTTTGAACACAACTGGCCCAATATGGTTTGTGACGAACTTAGTGAAAGAGACATTAAAATTTCGGTACCAAGTAGATCTCGATAGATCTGTTGATATTGTGTTGGCGATGTTCCATTTGGACATAGAAAAGTGCACAGGAGCACTTTTATTACATGTTCTACCACAATACCTGTATAATTCTAAGTTGTCTGAAGAGCTAGTTGAACCCCAGTCTTCTGTATTAGCCAAGCTAGCAGTGTATTGCATATATGCTGCCTTAGATTACAGCAACACTAAAAAGTCGCATTTTTCGAGGAAGCGTCGTCATGACGAAGTTGAGGATTTGGATGCGATGTCGTCTAGTAAAATGCGGAAACTCAACGACAATACATCCGATGGAAGTGGTGTTTATTATTGTAAGGGACAAGGATATGAAATATCATTAAAAGAACCATTGTTGTCAGCTTTAGAAACGCTGTATGCGTCCTTTTCACAACTAGCTGGCAAGGACGGAAATATCACACCCCAAACACATTTTATACTTCAGTTCTTGATTTATGTGGTTCAATGTGGCCAAGATAGGGCCCAGTTAGTATTACAGAAAATGCCTAGTGAACTCGTACCAACTTTAATTAAAGCTCTACCTGACAATTTTAACATTGGTCTGATTTTACGCTTATATAATTTGAATACTGCTTACGGAAGAAAAGACACCGCGAGAGATCTATGCCTTTTACGAAATATGAGGTTAAGGCCAGAATAA

Protein

MDASKITSKTSSLKALILKAWKERWTDIQWGINIKTILPRGVSGDLYNLADCILQQAMVGCGANQLVISYLKHSLACHLVSFAAVLQRIAKFDAFHKPHCIISLLEFLETFLESITCRGKLEEEVLAYAVSSIILWLLQVFHYSLTKYPASSSVQSQELLEKSSVLLNSIVNTDFLIAMFYLAKQNDPDEYNEVTKKCQEITAFMMMNTQFKPPMTIHVTLHKICNMELDKIAPLNNKPEAVTYCLQALIAINVFSNPSAGMQQISSQLLMVQKIKGYSLSRLYCELIRACFISLNDSSNDASKQSLWAAFTFLKVPQVINHLHNMCGTTNKESEYSTEVVEAFEMLLQSAPLLDIVDTKNSCNSVISLIEPLVKLNVLSDNTLTYFKQKRETIDHPLQKFEPIGLQGSVPLFITRVEPTLAEILKALSGEFHKTQESLYIMLCQIVGRTTLDTILAVATVEGKLKMFVSRLIKFNEFALFAASEKGAPQSKVYIFDISFLLLCWIVQDYGADVVLEENGDSFFEKWVRDCMVHKGNYKSSDQILQKCDHVVDVIIHHLSAPDFDFKNTNVKPHDLCMNITGAVKEVLFAWEQGLLSATDVKRMLDSIRQKMASLAVCASVWLCSYINVVHQDASIKPMNMVQQFLTSPTELELTQIDNFQERAILMCQIIRKLLFKIHPTSMPKSKEQQLPYSITSRKPILEQLQSIWENIKSRGYLHIDATHLVENLLNTTGPIWFVTNLVKETLKFRYQVDLDRSVDIVLAMFHLDIEKCTGALLLHVLPQYLYNSKLSEELVEPQSSVLAKLAVYCIYAALDYSNTKKSHFSRKRRHDEVEDLDAMSSSKMRKLNDNTSDGSGVYYCKGQGYEISLKEPLLSALETLYASFSQLAGKDGNITPQTHFILQFLIYVVQCGQDRAQLVLQKMPSELVPTLIKALPDNFNIGLILRLYNLNTAYGRKDTARDLCLLRNMRLRPE

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.

Subunit

Component of the Mediator complex.
Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.

Similarity

Belongs to the Mediator complex subunit 24 family.

Keywords

Activator Complete proteome Nucleus Reference proteome Repeat Transcription Transcription regulation Nucleotide-binding Phosphoprotein

Feature

chain Mediator of RNA polymerase II transcription subunit 24

Uniprot

A0A2A4JYJ0 A0A2W1BXN8 A0A2H1WYQ2 A0A1E1WI64 A0A194RKS2 A0A194Q5R9 + More
A0A0L7K4C6 A0A2J7RQD5 A0A026WEZ6 A0A3L8DLG5 A0A2J7RQD1 E2AUW9 A0A0M9AA91 A0A0L7RC11 A0A2A3EC37 E2AUX0 A0A088AR93 E2BLG6 A0A195FKN7 A0A195BEC1 A0A158NRB7 A0A154PA05 F4WAZ0 A0A151JBX2 A0A151XFF2 A0A1B6DIW1 E9IS14 A0A151IFR0 A0A232EX53 A0A0J7NRN9 K7IVF6 A0A310SM26 A0A1B6MRZ1 A0A1B6GZP4 A0A151IFT7 A0A023F129 A0A224XJ24 A0A0K8S8C5 A0A0A9ZHE8 T1HXZ9 A0A1B0GML2 A0A0C9RQM8 Q16X15 J9JL65 A0A1Q3FCU6 A0A1B6JPJ0 A0A182M134 A0A182WK08 Q7Q6D9 A0A1I8JTV3 A0A182V4T0 A0A2M4CZU1 Q16HQ2 A0A182QMT0 A0A1A9WLL4 B0XB70 A0A084W2M8 E0V968 A0A182FD56 A0A0L0CAB5 A0A182RF13 A0A182Y2W0 A0A1W4WYV4 W5JQ24 A0A182TZF7 A0A182J7K6 A0A1B0GF77 A0A1A9UKR1 A0A1A9ZDX3 A0A182P6E2 A0A1I8NQE2 A0A1I8N1J8 A0A182X6W8 A0A0A1XTD7 A0A182NLN9 A0A182JVK1 A0A0K8U401 D6WF89 W8BVH2 A0A1Y1L3D3 A0A1I8NQF1 A0A0T6ATC7 A0A1A9XJV7 A0A1B0C6P9 A0A1W4UTT5 B4HJD9 T1JEP9 B3NFW4 B3M9M7 B4QLJ5 Q29FJ5 B4N4C9 A0A0M4ER78 Q9VSF2 B4LCB6

Pubmed

28756777 26354079 26227816 24508170 30249741 20798317 + More
21347285 21719571 21282665 28648823 20075255 25474469 25401762 26823975 17510324 12364791 24438588 20566863 26108605 25244985 20920257 23761445 25315136 25830018 18362917 19820115 24495485 28004739 17994087 22936249 15632085 10731132 12537572 12537569 12021283 16751183 18327897

EMBL

NWSH01000396 PCG76704.1 KZ149914 PZC77997.1 ODYU01012082 SOQ58193.1 + More
GDQN01004406 JAT86648.1 KQ460075 KPJ17930.1 KQ459582 KPI98745.1 JTDY01011353 KOB56813.1 NEVH01001341 PNF43044.1 KK107238 EZA54680.1 QOIP01000007 RLU20678.1 PNF43040.1 GL442898 EFN62777.1 KQ435711 KOX79676.1 KQ414615 KOC68522.1 KZ288289 PBC29250.1 EFN62778.1 GL449017 EFN83518.1 KQ981522 KYN40559.1 KQ976504 KYM82918.1 ADTU01023848 KQ434853 KZC08657.1 GL888056 EGI68610.1 KQ979122 KYN22528.1 KQ982205 KYQ58998.1 GEDC01011664 JAS25634.1 GL765283 EFZ16671.1 KQ977771 KYM99981.1 NNAY01001775 OXU22954.1 LBMM01002234 KMQ95095.1 KQ763581 OAD54966.1 GEBQ01001283 JAT38694.1 GECZ01001887 JAS67882.1 KYN00014.1 GBBI01003490 JAC15222.1 GFTR01008395 JAW08031.1 GBRD01016299 JAG49527.1 GBHO01001959 GDHC01021519 GDHC01015819 JAG41645.1 JAP97109.1 JAQ02810.1 ACPB03017387 ACPB03017388 AJVK01012175 AJVK01012176 AJVK01012177 AJVK01012178 GBYB01009541 JAG79308.1 CH477548 ABLF02033416 GFDL01009624 JAV25421.1 GECU01006651 JAT01056.1 AXCM01004559 AAAB01008960 APCN01000104 GGFL01006664 MBW70842.1 CH478149 EAT33788.1 AXCN02002338 DS232615 EDS44123.1 ATLV01019640 ATLV01019641 KE525275 KFB44472.1 DS234989 EEB09924.1 JRES01000681 KNC29192.1 ADMH02000844 ETN64864.1 CCAG010012769 GBXI01000384 JAD13908.1 GDHF01030872 JAI21442.1 KQ971319 EFA00473.1 GAMC01003363 JAC03193.1 GEZM01071059 JAV66096.1 LJIG01022852 KRT78383.1 JXJN01026846 CH480815 EDW40663.1 JH432127 CH954178 EDV50726.1 CH902618 EDV39033.1 CM000363 CM002912 EDX09655.1 KMY98309.1 CH379067 EAL31259.2 CH964095 EDW79003.1 CP012525 ALC44930.1 AF289998 AE014296 AY122223 BT025232 CH940647 EDW68761.1

Proteomes

UP000218220 UP000053240 UP000053268 UP000037510 UP000235965 UP000053097 + More
UP000279307 UP000000311 UP000053105 UP000053825 UP000242457 UP000005203 UP000008237 UP000078541 UP000078540 UP000005205 UP000076502 UP000007755 UP000078492 UP000075809 UP000078542 UP000215335 UP000036403 UP000002358 UP000015103 UP000092462 UP000008820 UP000007819 UP000075883 UP000075920 UP000007062 UP000075840 UP000075903 UP000075886 UP000091820 UP000002320 UP000030765 UP000009046 UP000069272 UP000037069 UP000076408 UP000192223 UP000000673 UP000075902 UP000075880 UP000092444 UP000078200 UP000092445 UP000075885 UP000095300 UP000095301 UP000075884 UP000075881 UP000007266 UP000092443 UP000092460 UP000192221 UP000001292 UP000008711 UP000007801 UP000000304 UP000001819 UP000007798 UP000092553 UP000000803 UP000008792

PRIDE

Q16X15 Q7Q6D9 Q9VSF2

Pfam

PF11277   Med24_N        + More
PF01103   Bac_surface_Ag
PF07159   DUF1394
PF00501   AMP-binding
PF10232   Med8
PF13193   AMP-binding_C

Interpro

IPR021429   Mediator_Med24        + More
IPR000184   Bac_surfAg_D15
IPR009828   DUF1394
IPR042099   AMP-dep_Synthh-like_sf
IPR000873   AMP-dep_Synth/Lig
IPR019364   Mediatior_Med8_fun/met
IPR020845   AMP-binding_CS
IPR025110   AMP-bd_C

Gene 3D

3.40.50.12780

ProteinModelPortal

A0A2A4JYJ0 A0A2W1BXN8 A0A2H1WYQ2 A0A1E1WI64 A0A194RKS2 A0A194Q5R9 + More
A0A0L7K4C6 A0A2J7RQD5 A0A026WEZ6 A0A3L8DLG5 A0A2J7RQD1 E2AUW9 A0A0M9AA91 A0A0L7RC11 A0A2A3EC37 E2AUX0 A0A088AR93 E2BLG6 A0A195FKN7 A0A195BEC1 A0A158NRB7 A0A154PA05 F4WAZ0 A0A151JBX2 A0A151XFF2 A0A1B6DIW1 E9IS14 A0A151IFR0 A0A232EX53 A0A0J7NRN9 K7IVF6 A0A310SM26 A0A1B6MRZ1 A0A1B6GZP4 A0A151IFT7 A0A023F129 A0A224XJ24 A0A0K8S8C5 A0A0A9ZHE8 T1HXZ9 A0A1B0GML2 A0A0C9RQM8 Q16X15 J9JL65 A0A1Q3FCU6 A0A1B6JPJ0 A0A182M134 A0A182WK08 Q7Q6D9 A0A1I8JTV3 A0A182V4T0 A0A2M4CZU1 Q16HQ2 A0A182QMT0 A0A1A9WLL4 B0XB70 A0A084W2M8 E0V968 A0A182FD56 A0A0L0CAB5 A0A182RF13 A0A182Y2W0 A0A1W4WYV4 W5JQ24 A0A182TZF7 A0A182J7K6 A0A1B0GF77 A0A1A9UKR1 A0A1A9ZDX3 A0A182P6E2 A0A1I8NQE2 A0A1I8N1J8 A0A182X6W8 A0A0A1XTD7 A0A182NLN9 A0A182JVK1 A0A0K8U401 D6WF89 W8BVH2 A0A1Y1L3D3 A0A1I8NQF1 A0A0T6ATC7 A0A1A9XJV7 A0A1B0C6P9 A0A1W4UTT5 B4HJD9 T1JEP9 B3NFW4 B3M9M7 B4QLJ5 Q29FJ5 B4N4C9 A0A0M4ER78 Q9VSF2 B4LCB6

PDB

6F5J E-value=0.034409, Score=91

KEGG

101741503 K15167 mediator of RNA polymerase II transcription subunit 24 | (RefSeq) mediator of RNA polymerase

GO

GO:0016592 GO:0019867 GO:0000166 GO:0003712 GO:0006357 GO:0003824 GO:0035209 GO:0006919 GO:0035072 GO:0043067 GO:0043068 GO:0005634 GO:0035070 GO:0006367

PANTHER

PTHR12898

Subcellular location

Nucleus

Length:

975

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.15092999999995

Exp number, first 60 AAs:

0.01073

Total prob of N-in:

0.31999

outside

1 - 975

Pi

126.791864

Theta

163.599352

Tajima's D

-0.76182

CLR

255.867461

CSRT

0.187590620468977

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics