Gene

KWMTBOMO03859

Pre Gene Modal

BGIBMGA010195

Annotation

delta_precursor_[Bombyx_mori]

Location

Bomo_Chr7(+):4920816-4956151      View in EpiBrowser

Full name

Delta-like protein       + More
Neurogenic locus protein delta      

Location in the cell

Extracellular   Reliability : 3.836

CDS

ATGCGCGCCTCCGCGGTGCTCTTGGCCCTGCTAGGGTTTCTGCCCCAGGTGCTGACGTCTGGTTTTTTTGAACTTAGGATAAAAAGTTTTACGAACTCCTTGGGTAGGTTAAGTAGTGGCCAGTGCTGTGATGGTTCCTCAAAAAGTGATGCGCCGTGTTTGGCGCCGTGCAGGACTAAGTTCCGAGTGTGTCTCAAGATTTATCAAGCCAACATCGACACGACGTCGCCGTGCACCTTCGGCGACATCACGACACCGGTATTGGGCGGGAACTCATTGGACGTGCCCAACCTCAACGTGGAAGGATTCAGCAATCCGATCGTGTTCCCCTTCGACTTCACGTGGCCGGGCACATTCTCGCTTATAGTGGAAGCGTGGCACGACAACAACGACACATCCAGAACTGACGATGCGTTAATCGGCCGAATGACGAAGCAAAGTGTGGCCGATGTCGGAGGTCCGTGGATAGAGGAGGAGCAGCGTTGGGGAGGTCCGTCCGAAGCCCACTTAAGGGTTTCGTTCCGAGTCACCTGCGCTCCCCATTACTACGGTGCCGGCTGCGCTGTGCTGTGCCGGCCCCGGGACGACAGCTTCGGCCACTACACCTGCTCGTCTGCCGGGGAAATCGTGTGCCAGGATGGATGGACCGGAGACTATTGTAGCAAACCAAAATGCCTGGCCGGCTGCGACTCCGAGCACGGTTACTGCACCAAGCCCGACGAATGCATATGTCACTCGGGGTGGGTGGGCAAACGCTGCGATAAGTGCGAGCCGCATCCGGGATGCGTCCACGGAACCTGCTCGAGGCCCTGGGATTGCATCTGCAAAGAAGGTTGGGGTGGACTTTTCTGCAACCAAGATCTGAACTACTGCACCAATCACCGACCGTGCAGAAATGGAGGCACTTGTCTTAACACCGGTCAAGGCAGTTATACTTGCGTGTGTCCACCTGAGTATACGGGATCGGACTGCGAGAAGTCTCTACACTCATGCGCCGTACGCCCTTGTCTCAATGGAGGCCTTTGCGTACCAGATGAAGGTGGCGAACTTTCCTGTACTTGTCCCCAAGGATACGAAGGAGCGCGCTGTGAGACGCGGCGACTTACCTGCTTTGATCGACCTTGTCACAACGGAGGAACCTGTGAACCGAAATCCTCCGGCTACGTGTGTGTATGTCCGGTAGGGTTCGCGGGCACGGACTGCGCCCTCGAAGCCGACCCATGCGCCGCCAACCCCTGCCGCAACGGAGCCACCTGCTCCCGAGCAGGCAACGGCTTCAAATGCACGTGCAGAACAGGCTTTAGAGGCAACCGATGCGAGATTGACATAGACGACTGCGCCGGCATCTTGTGCGAACACGGCGGGACCTGCGTCGACCTTGTTAACGGACAGAAATGTCAGTGTGCTCCCGGATTCCTCGGCCCCCGCTGTGAAACTCGAGTAGACATGTGCTTGACAAAACCGTGCGCAAACGGCGGCGAGTGTCTAGTTCTAGACAACGACTACGGGTGCCGGTGCCGGCCTGGCTTCACCGGCAAGGATTGCAGCATCGACATCGACGAATGCGCCTCTTCGCCGTGCCGGAACGGAGGAACGTGTCGCGACCGAGTGGACGGGTACAGATGCGTGTGTCCGCACGGATGGGGAGGGCGCTCTTGTACCGTGTCGCTGTCGGAGTTGGCAGCGAAACAGGCAGGCGGACACTTGCCGCGCGTAGGTGATTCCGACGAAGAGGAGCGGCTGTCGGCGCAGCAGGTGGCGTGGATAGCGGCGCTGGGCGCTCTGGTGCCGGCGGGTGCAGGTGCGGCTGCGCTGGCCGTGGTTTGCGTCCGGCGCCGGAGAGCGCGGGCGGCCGCCGCTGCCGACGCGGAGGCGCGCGCCCAGAACGCGGCCAACGCGGGCGGCGGTCACGTGATCCGCAACACGTGGGGCAAGTGCGACGCGCCGCCCCCTGAGTGTCAGAACGCGCACAACGCTGCCGCCGAGGAGTGCAAGCGCAAGACGCTCAACACCGAGAGCGCGCGCCTGCTCGCCGCGCTTGATCCCCGACTCTCCAGGCTCTCCGCAGACTCGGCGTATTGCGCGAATAGCGATACGTCGTTAGTGAAGCGGGCGCTGGAGGGCGGGGGGGTGTACGTGCTGGACGACCACTGCTTGCCGCCGACGTTCGCCACGCAAGTGTAG

Protein

MRASAVLLALLGFLPQVLTSGFFELRIKSFTNSLGRLSSGQCCDGSSKSDAPCLAPCRTKFRVCLKIYQANIDTTSPCTFGDITTPVLGGNSLDVPNLNVEGFSNPIVFPFDFTWPGTFSLIVEAWHDNNDTSRTDDALIGRMTKQSVADVGGPWIEEEQRWGGPSEAHLRVSFRVTCAPHYYGAGCAVLCRPRDDSFGHYTCSSAGEIVCQDGWTGDYCSKPKCLAGCDSEHGYCTKPDECICHSGWVGKRCDKCEPHPGCVHGTCSRPWDCICKEGWGGLFCNQDLNYCTNHRPCRNGGTCLNTGQGSYTCVCPPEYTGSDCEKSLHSCAVRPCLNGGLCVPDEGGELSCTCPQGYEGARCETRRLTCFDRPCHNGGTCEPKSSGYVCVCPVGFAGTDCALEADPCAANPCRNGATCSRAGNGFKCTCRTGFRGNRCEIDIDDCAGILCEHGGTCVDLVNGQKCQCAPGFLGPRCETRVDMCLTKPCANGGECLVLDNDYGCRCRPGFTGKDCSIDIDECASSPCRNGGTCRDRVDGYRCVCPHGWGGRSCTVSLSELAAKQAGGHLPRVGDSDEEERLSAQQVAWIAALGALVPAGAGAAALAVVCVRRRRARAAAAADAEARAQNAANAGGGHVIRNTWGKCDAPPPECQNAHNAAAEECKRKTLNTESARLLAALDPRLSRLSADSAYCANSDTSLVKRALEGGGVYVLDDHCLPPTFATQV

Description

Putative Notch ligand involved in the mediation of Notch signaling.
Acts as a ligand for Notch (N) receptor. Essential for proper differentiation of ectoderm. Dl is required for the correct separation of neural and epidermal cell lineages. Fringe (fng) acts in the Golgi to determine the type of O-linked fucose on the EGF modules in N, altering the ability of N to bind with Delta (Dl). O-fut1 also has a role in modulating the interaction.

Subunit

Interacts with N via the EGF repeats and the N EGF repeats.

Miscellaneous

Separation of neuroblasts from the ectoderm into the inner part of embryo is one of the first steps of CNS development in insects, this process is under control of the neurogenic genes.
Notch and Serrate may interact at the protein level, it is conceivable that the Serrate and Delta proteins may compete for binding with the Notch protein.

Keywords

3D-structure   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Glycoprotein   Membrane   Neurogenesis   Notch signaling pathway   Phosphoprotein   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix   Ubl conjugation  

Feature

chain  Delta-like protein

Uniprot

C5NS65   A0A212F7S7   A0A3S2TRS3   H9JKZ4   A0A2A4JVJ9   S4P9W0   + More
A0A2H1W753   A0A194RJ98   A0A0L7KQA8   B6EBG2   X5J6H3   A0A067QK07   A0A1B6IU85   A0A1B6IV84   A0A1B6DHS9   U5EUD2   A0A3L8DFJ2   D6W6S0   A0A0L7R5K2   A0A1Q3G0E2   A0A2Z6BDU2   A0A154P0V1   B4KD59   A0A151XA34   A0A195DCJ0   A0A023F2F3   A0A195C622   A0A195FUA0   B4LZ18   B4JZ07   A0A195BC72   A0A0L0CIP5   A0A146LSY1   A0A088A1A9   A0A1W4XDD9   A0A1I8NEK0   B4PMU6   A0A1A9ZXT9   A0A1A9X1K6   A0A1A9XZ44   B3P352   W8BLF4   A0A0R1E101   A0A1I8P4M6   A0A0K8VRR9   A0A0A1WL33   B4IHW6   A4V346   P10041   A0A1W4W8A8   B3M2E0   A0A1Y1KDN6   A0A0C9RG58   A0A0T6BEM2   B4QTE8   Q293P0   B4NIU4   A0A3B0K6S8   A0A0M3QY36   A0A2M4CHQ4   A0A0A9YEE2   A0A2M4CIK6   A0A1S4H3H3   A0A2M3ZEQ0   A0A2M4AHW4   C3ZMU2   A0A084W5K9   A0A182F488   A0A224XNL1   A0A3F2Z217   A0A2M4AKZ5   T1IPW5   A0A1J1IE25   A0A182KJW8   V9P4G1   A0A2M4AJ44   A0A0U5JEA9   A0A182YN00   A0ZVQ7   A0A087TDV5   A0A2R7X495   N6UDS0   A0A0P6B6P4   A0A182QLK7   A0A0P5D3T0   E9HI96   A0A0N8BY81   A0A0P4ZAQ6   A0A0P5PDR8   A0A0P6EZF7   Q7Q0M5   A0A0P5P9B1   A0A0P6FMW7   A0A0P5MZA8   A0A0N8BK19   A0A0P5SIL6   A0A0P5NYC9   A0A0P5ILE6  

Pubmed

22118469    19121390    23622113    26354079    26227816    18927236    + More
24845553    30249741    18362917    19820115    17994087    25474469    26108605    26823975    25315136    17550304    24495485    25830018    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    16453806    3149249    15020426    12537569    3107986    10935637    2128477    15829515    15760269    18327897    28004739    15632085    25401762    12364791    18563158    24438588    20966253    24308783    25244985    17507394    23537049    21292972   

EMBL

AB474576    BAH83639.1    AGBW02009838    OWR49781.1    RSAL01000013    RVE53364.1    + More
BABH01011359    NWSH01000584    PCG75503.1    GAIX01003539    JAA89021.1    ODYU01006765    SOQ48911.1    KQ460075    KPJ17903.1    JTDY01007331    KOB65290.1    FJ222590    ACI32657.1    HF969256    CCX34985.1    KK853368    KDR08088.1    GECU01017215    JAS90491.1    GECU01016852    JAS90854.1    GEDC01012037    JAS25261.1    GANO01002376    JAB57495.1    QOIP01000008    RLU19164.1    KQ971307    EFA10954.1    KQ414652    KOC66123.1    GFDL01001782    JAV33263.1    LC373547    BBD17790.1    KQ434792    KZC05463.1    CH933806    EDW14841.2    KQ982353    KYQ57199.1    KQ980989    KYN10606.1    GBBI01003518    JAC15194.1    KQ978220    KYM96309.1    KQ981264    KYN44033.1    CH940650    EDW68121.2    CH916378    EDV98622.1    KQ976519    KYM82148.1    JRES01000342    KNC32082.1    GDHC01009099    GDHC01002259    JAQ09530.1    JAQ16370.1    CM000160    EDW96016.1    CH954181    EDV48504.1    GAMC01008702    JAB97853.1    KRK02841.1    GDHF01010723    JAI41591.1    GBXI01014931    JAC99360.1    CH480840    EDW49483.1    AE014297    AAN13798.1    X06289    Y00222    AY437145    AY437140    AY437141    AY437142    AY437143    AY437144    AY437151    AY437146    AY437147    AY437148    AY437149    AY437150    AY437157    AY437152    AY437153    AY437154    AY437155    AY437156    AY437163    AY437158    AY437159    AY437160    AY437161    AY437162    AY437169    AY437164    AY437165    AY437166    AY437167    AY437168    AY437175    AY437170    AY437171    AY437172    AY437173    AY437174    AY437181    AY437176    AY437177    AY437178    AY437179    AY437180    AY437187    AY437182    AY437183    AY437184    AY437185    AY437186    AY437193    AY437188    AY437189    AY437190    AY437191    AY437192    AY437199    AY437194    AY437195    AY437196    AY437197    AY437198    AY437205    AY437200    AY437201    AY437202    AY437203    AY437204    AY437211    AY437206    AY437207    AY437208    AY437209    AY437210    AY437217    AY437212    AY437213    AY437214    AY437215    AY437216    AY437223    AY437218    AY437219    AY437220    AY437221    AY437222    AY437229    AY437224    AY437225    AY437226    AY437227    AY437228    AY437235    AY437230    AY437231    AY437232    AY437233    AY437234    AY438104    AY438105    AY438106    AY438107    AY438108    AY438109    AY438110    AY438111    AY438112    AY438113    AY438114    AY438115    AY438116    AY438117    AY438118    AY438119    AY438120    AY438121    AY438122    AY438123    AY438124    AY438125    AY438126    AY438127    AY438128    AY438129    AY438130    AY438131    AY438132    AY438133    AY438134    AY438135    AY438136    AY438137    AY438138    AY438139    AY438140    AY438141    AY438147    AY438148    AY438149    AY438150    AY438151    AY438152    AY438153    AY438154    AY438155    AY438156    AY438157    AY438158    AY438159    AY438160    AY438161    AY438162    AY438163    AY438164    AY438165    AY438166    AY438167    AY438168    AY438169    AY438170    AY438171    AY438172    AY438173    AY438174    AY438175    AY438176    AY438177    AY438178    AY438179    AY438180    AY438181    AY438182    AY438183    AY438184    AY438185    AY438186    AY438187    AY438188    AY438189    AY438190    AY438191    AY438192    AY438193    AY438194    AY438195    AY438196    AY438197    AY438198    AY438199    AY438200    AY438201    AY438202    BK004004    BT003267    AY061269    X05140    CH902617    EDV43393.1    GEZM01087813    JAV58461.1    GBYB01006036    JAG75803.1    LJIG01001192    KRT85748.1    CM000364    EDX12350.1    CM000070    EAL29174.3    CH964272    EDW83808.1    OUUW01000008    SPP83770.1    CP012526    ALC46983.1    GGFL01000270    MBW64448.1    GBHO01013075    JAG30529.1    GGFL01000955    MBW65133.1    AAAB01008980    GGFM01006283    MBW27034.1    GGFK01007058    MBW40379.1    GG666648    EEN46082.1    ATLV01020672    ATLV01020673    KE525304    KFB45503.1    GFTR01006815    JAW09611.1    GGFK01007967    MBW41288.1    JH431265    CVRI01000047    CRK98527.1    KF322113    AGT57826.1    GGFK01007307    MBW40628.1    LN881710    CUK27654.1    AB287420    BAF42029.1    KK114777    KFM63294.1    KK856841    PTY26471.1    APGK01039092    KB740967    ENN76807.1    GDIP01033188    JAM70527.1    AXCN02001866    GDIP01165819    JAJ57583.1    GL732653    EFX68540.1    GDIQ01133211    JAL18515.1    GDIP01215910    JAJ07492.1    GDIQ01136076    JAL15650.1    GDIQ01057093    JAN37644.1    EAA14361.4    GDIQ01136078    JAL15648.1    GDIQ01057091    JAN37646.1    GDIQ01171500    JAK80225.1    GDIQ01170107    JAK81618.1    GDIQ01091129    JAL60597.1    GDIQ01136077    JAL15649.1    GDIQ01211743    JAK39982.1   

Proteomes

UP000007151    UP000283053    UP000005204    UP000218220    UP000053240    UP000037510    + More
UP000027135    UP000279307    UP000007266    UP000053825    UP000076502    UP000009192    UP000075809    UP000078492    UP000078542    UP000078541    UP000008792    UP000001070    UP000078540    UP000037069    UP000005203    UP000192223    UP000095301    UP000002282    UP000092445    UP000091820    UP000092443    UP000008711    UP000095300    UP000001292    UP000000803    UP000192221    UP000007801    UP000000304    UP000001819    UP000007798    UP000268350    UP000092553    UP000001554    UP000030765    UP000069272    UP000076407    UP000183832    UP000075882    UP000076408    UP000054359    UP000019118    UP000075886    UP000000305    UP000007062   

PRIDE

C5NS65    H9JKZ4    A4V346    P10041   

Pfam

PF12661   hEGF        + More
PF07657   MNNL
PF00008   EGF
PF01414   DSL
PF07645   EGF_CA
PF04815   Sec23_helical
PF04810   zf-Sec23_Sec24
PF00626   Gelsolin
PF04811   Sec23_trunk
PF08033   Sec23_BS
PF12336   SOXp
PF00505   HMG_box

Interpro

IPR001774   DSL        + More
IPR009030   Growth_fac_rcpt_cys_sf       
IPR011651   Notch_ligand_N       
IPR001881   EGF-like_Ca-bd_dom       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR000742   EGF-like_dom       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR001190   SRCR       
IPR033108   Jag2       
IPR007123   Gelsolin-like_dom       
IPR036174   Znf_Sec23_Sec24_sf       
IPR029006   ADF-H/Gelsolin-like_dom_sf       
IPR036180   Gelsolin-like_dom_sf       
IPR006900   Sec23/24_helical_dom       
IPR012990   Sec23_24_beta_S       
IPR006896   Sec23/24_trunk_dom       
IPR041742   Sec24-like_trunk_dom       
IPR036465   vWFA_dom_sf       
IPR036175   Sec23/24_helical_dom_sf       
IPR006895   Znf_Sec23_Sec24       
IPR009071   HMG_box_dom       
IPR022097   SOX_fam       
IPR036910   HMG_box_dom_sf       

SUPFAM

SSF57184   SSF57184        + More
SSF82754   SSF82754       
SSF53300   SSF53300       
SSF81811   SSF81811       
SSF82919   SSF82919       
SSF47095   SSF47095       

Gene 3D

3.40.20.10     3.40.50.410     1.10.30.10    

CDD

cd01479  Sec24-like

ProteinModelPortal

C5NS65   A0A212F7S7   A0A3S2TRS3   H9JKZ4   A0A2A4JVJ9   S4P9W0   + More
A0A2H1W753   A0A194RJ98   A0A0L7KQA8   B6EBG2   X5J6H3   A0A067QK07   A0A1B6IU85   A0A1B6IV84   A0A1B6DHS9   U5EUD2   A0A3L8DFJ2   D6W6S0   A0A0L7R5K2   A0A1Q3G0E2   A0A2Z6BDU2   A0A154P0V1   B4KD59   A0A151XA34   A0A195DCJ0   A0A023F2F3   A0A195C622   A0A195FUA0   B4LZ18   B4JZ07   A0A195BC72   A0A0L0CIP5   A0A146LSY1   A0A088A1A9   A0A1W4XDD9   A0A1I8NEK0   B4PMU6   A0A1A9ZXT9   A0A1A9X1K6   A0A1A9XZ44   B3P352   W8BLF4   A0A0R1E101   A0A1I8P4M6   A0A0K8VRR9   A0A0A1WL33   B4IHW6   A4V346   P10041   A0A1W4W8A8   B3M2E0   A0A1Y1KDN6   A0A0C9RG58   A0A0T6BEM2   B4QTE8   Q293P0   B4NIU4   A0A3B0K6S8   A0A0M3QY36   A0A2M4CHQ4   A0A0A9YEE2   A0A2M4CIK6   A0A1S4H3H3   A0A2M3ZEQ0   A0A2M4AHW4   C3ZMU2   A0A084W5K9   A0A182F488   A0A224XNL1   A0A3F2Z217   A0A2M4AKZ5   T1IPW5   A0A1J1IE25   A0A182KJW8   V9P4G1   A0A2M4AJ44   A0A0U5JEA9   A0A182YN00   A0ZVQ7   A0A087TDV5   A0A2R7X495   N6UDS0   A0A0P6B6P4   A0A182QLK7   A0A0P5D3T0   E9HI96   A0A0N8BY81   A0A0P4ZAQ6   A0A0P5PDR8   A0A0P6EZF7   Q7Q0M5   A0A0P5P9B1   A0A0P6FMW7   A0A0P5MZA8   A0A0N8BK19   A0A0P5SIL6   A0A0P5NYC9   A0A0P5ILE6  

PDB

4XBM     E-value=7.99421e-123,     Score=1130

KEGG

100188969    K06051 delta | (RefSeq) Dl; delta

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0007275   GO:0016021   GO:0005509   GO:0007219   GO:0007154   GO:0005044   GO:0045746   GO:0005112   GO:0005886   GO:0030139   GO:0045179   GO:0048863   GO:0007298   GO:0005769   GO:0048665   GO:0007422   GO:0007015   GO:0008284   GO:0043208   GO:0008347   GO:0030720   GO:0035003   GO:0030713   GO:0005912   GO:0046331   GO:0048018   GO:0016330   GO:0045931   GO:0030718   GO:0048190   GO:0007498   GO:0036011   GO:0050768   GO:0008407   GO:0048100   GO:0009986   GO:0007475   GO:0048800   GO:0031410   GO:0007398   GO:0008356   GO:0008587   GO:0005768   GO:0007451   GO:0042676   GO:0001708   GO:0046667   GO:0007480   GO:0048477   GO:0042067   GO:0030707   GO:0007423   GO:0007476   GO:0030127   GO:0006886   GO:0006888   GO:0008270   GO:0005634   GO:0006355   GO:0003677   GO:0016020   GO:0005515   GO:0004672   GO:0048384  

PANTHER

PTHR24049:SF18  

Subcellular location

Membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.995347

 

 

Length:

727

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

36.27985

Exp number, first 60 AAs:

13.64732

Total prob of N-in:

0.64597

POSSIBLE N-term signal

sequence

outside

1  -  587

TMhelix

588  -  610

inside

611  -  727

 

 

Pi

203.545415

Theta

192.974734

Tajima's D

0.271633

CLR

1.162782

CSRT

0.447827608619569

Interpretation

Possibly Positive selection