Gene

KWMTBOMO03850

Pre Gene Modal

BGIBMGA010185

Annotation

PREDICTED:_protein_trachealess_isoform_X1_[Amyelois_transitella]

Location

Bomo_Chr7(-):4241058-4319525      View in EpiBrowser

Full name

Protein trachealess      

Transcription factor

bHLH

Location in the cell

Nuclear   Reliability : 3.843

CDS

ATGTTGCCGTATCAAGCGGTAGCGATGGACTACGCGGTGGCATCCGCTGGTTTTCATCACCACCAGCGGCCCGGTGGTTTGCCCGGAGTGATGGGGCTGCCCGGGCCAGGATCCGGTTTGAATCCAGGCCTGAACCCGGCCTTCACCCATTCCTGGTTCGTACAGACAAGCCCGGATATCTGTCGGCAGCAACAAGCATCCAACCAATCGCATCTCGAACCTGGTATCCTCGAGCTCCGAAAAGAGAAGAGTCGTGACGCAGCCCGCTCGAGGAGAGGAAAGGAAAACTACGAGTTCTATGAGCTGGCCAAGATGTTGCCACTACCGGCGGCCATCACCAGTCAACTGGACAAAGCGTCGATCATAAGGCTGACAATAAGCTACCTCAAGTTAAGGGACTTCTCCGGACACGGGGACCCGCCGTGGAGCCGGGATCCACCTCCGTCCAGTAAAGCTTTGAAAGGGGCACAGAATCGTCGAACAGCGGCTGGTCTGGCGATGGAATTGTTCGAGCAGCATCAGGGTACACACATATTACAGTCGCTGGATGGGTTCGCGTTGTCAGTGGCAGCCGATGGCAGATTCTTGTACATATCCGAAACTGTCTCTATATATTTAGGATTATCACAAGTAGAAATGACCGGTAGCAGTATATTCGACTATGTTCACCAAGCTGATCATGCTGAGATTGCTGAGCAGTTAGGGTTATCATTGGCCGGGAGATCGGGAGGTGCGGGACTTAACAGTCCCGCGTCCGGGAGCGAAGAAGGAAGTCAACATGGCACAAACAACCCTGATGTGTCATCGCAAATGAGCCTCGCAGCTAGTGGCTCTCTATATCGGGGAATGGATCGGGCTTTCTGTGTCCGCATGAAGAGCACCCTCACAAAACGCGGATGCCATTTCAAATCATCAGGATACAGGGTGGTTCTCATGCTGTGTAGACTCCGGCCTCAGTACTCATTCTCGCACAGTCGGAAGTCACCGACAGTCCTACTGGGAATGGTGGCGCTCGCCATAGCACTGCCACCGCCCTCCGTCCACGAGATACGACTAGAATCCGACATGTTTGTGACCAGAATCAACTTTGACTTCCGAATAGCTCATTGCGAACCAAGTAGGGTATCCGAGCTGCTTGGTTACACGGCAGAGGAGTTGACCGGAAAGAACCTCTACACGCTATGTCACGGAGAAGACGCCAACAAACTTAGGAAATGTCACTTAGATTTAATGAACAAAGGCCAAGTACTGACGCACTACTATAGGATAATGAACAAACTTGGCGGCTACACGTGGATGCAGACCTGCGCTACCGTTGTGTGTTCCTCTAAGAATGCTGAAGAGCAAAATATAATTTGCGTCAACTATGTCATTAGCGGCAGAGAGTACCCCAACACAGTAATGGACTGCTGCCAACTGGAAGAAAGCGTGCAAGGTGTGAAACGAGAGGAAACGACCGGAGATCCCGAAAACGGACCCCCAGACACCGACAACACGGGCGGTCCGCCGCCCACATCCAGGCATCCGGCAGAGAGAACCGAACCTCCAACGAACAGCGAGGCAGCTTCCTCTGCACCGGTCAACGCGTCCGACGTAACGCACCTGACGAGGCTAAACGACGCCCAGCCTCTACCGTTACACACGACCCCGGAGAGAACTTCCCCAATGCCCGCTAGAAGACTGAAAAAACGAAAACAAACAACCGACTGCGACGAGGACGAGGACGAGAGACGGAAATCCGCCTCCAATCCAGCAGCTACAATTTCACCAGCAGACCGCGACATGACCAAAACAGCCAACTTAACCATACCTGAAGCAGGAAACGACGCCACCTCGGTCAGAGATCTAGAGAACGCGATGTCGAAGCATCTACCGGCTCTCGACGGAAAAGAAATAGCTCATCGACCGACCGACTTCTCTACGGATGCGTTACTGAAACAGCAGCAGCAGAAGTCGACCATACAATGGATAGGGACCCAAAACCATCATTTGATGAACCGTCAGATACCTACCAACCATCCGTCTTCGACGCCAGCGTCCGCGTTACTGAGGCAACTCTACGCAAACAGAGAGAGCGTTATAAGAAGCAATTTCCTTGGTGACGGCAGAACTGGAGGCTACTACTCGAATGACGGCCAGTCAGGACCGCTGCCAACGCCGCCAGGAAGCGAGGGATCCGGTTATAGCGAACAGTTAGGTCACAAAGGAACGGACATAGGTTCGCTGGCGTACGGAGGATATGCGGAGTACCATTCAGCAATGACGCCGCCCGGTTCAGTTTCGCCGAGAGACAAACAACAATACGCTTTGTCGTACGACAATAGCGCTTATTCGGAAGCGTTAAGGCACTCGTATTTGGGCGAAGCGCCTCTACCGTTGAAGCCTCAAGCGTATTCGGCGGTACCGGGCGCGTTAGATTACGCGTCTCCATTGGACCAATCCCAGTTCTTCCATCCGCCTTCGTCGTTCCATCTGTACCATCCCCAGGCGCACGCGGCCCACCCGACCCACTCCCACCAGCCCGTAGACAAGACAGCGCCCCCTAACACGAACTGGTACTCGACGGGGTCATAG

Protein

MLPYQAVAMDYAVASAGFHHHQRPGGLPGVMGLPGPGSGLNPGLNPAFTHSWFVQTSPDICRQQQASNQSHLEPGILELRKEKSRDAARSRRGKENYEFYELAKMLPLPAAITSQLDKASIIRLTISYLKLRDFSGHGDPPWSRDPPPSSKALKGAQNRRTAAGLAMELFEQHQGTHILQSLDGFALSVAADGRFLYISETVSIYLGLSQVEMTGSSIFDYVHQADHAEIAEQLGLSLAGRSGGAGLNSPASGSEEGSQHGTNNPDVSSQMSLAASGSLYRGMDRAFCVRMKSTLTKRGCHFKSSGYRVVLMLCRLRPQYSFSHSRKSPTVLLGMVALAIALPPPSVHEIRLESDMFVTRINFDFRIAHCEPSRVSELLGYTAEELTGKNLYTLCHGEDANKLRKCHLDLMNKGQVLTHYYRIMNKLGGYTWMQTCATVVCSSKNAEEQNIICVNYVISGREYPNTVMDCCQLEESVQGVKREETTGDPENGPPDTDNTGGPPPTSRHPAERTEPPTNSEAASSAPVNASDVTHLTRLNDAQPLPLHTTPERTSPMPARRLKKRKQTTDCDEDEDERRKSASNPAATISPADRDMTKTANLTIPEAGNDATSVRDLENAMSKHLPALDGKEIAHRPTDFSTDALLKQQQQKSTIQWIGTQNHHLMNRQIPTNHPSSTPASALLRQLYANRESVIRSNFLGDGRTGGYYSNDGQSGPLPTPPGSEGSGYSEQLGHKGTDIGSLAYGGYAEYHSAMTPPGSVSPRDKQQYALSYDNSAYSEALRHSYLGEAPLPLKPQAYSAVPGALDYASPLDQSQFFHPPSSFHLYHPQAHAAHPTHSHQPVDKTAPPNTNWYSTGS

Description

Transcription factor, master regulator of tracheal cell fates in the embryo, necessary for the development of the salivary gland duct and the posterior spiracles. It may induce a general fate of branched tubular structures of epithelial origin. Heterodimers of tgo/trh are involved in the control of breathless expression.

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with tgo.

Miscellaneous

Readthrough of the terminator UGA may occur between the codons for 958-Ser and 960-Val.

Keywords

Alternative splicing   Complete proteome   Developmental protein   DNA-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Transcription   Transcription regulation  

Feature

chain  Protein trachealess
splice variant  In isoform C.

Uniprot

O15984   A0A2A4JWM2   A0A212F7R6   H9JKY4   A0A2H1WPH0   A0A194Q5V6   + More
A0A194R8D7   A0A0L7LM30   A0A1W4W9F0   A0A1Y1KHH7   A0A139WNU4   A0A1W4WJI4   E0W3Y7   A0A1Y1KMM7   A0A1W4WKR1   D7EII8   A0A139WPC2   A0A1Y1KHQ9   A0A310SEZ3   U4UWX9   A0A088AKM3   E2BRP8   A0A158NIX6   A0A224XJF8   A0A0F7IIN2   A0A023F318   A0A195BX49   A0A154P0E7   A0A2A3ECN2   E2A9Q2   A0A195C9N9   A0A0P8Y7X1   A0A0M9AAZ1   Q24119-3   H9TV77   F9W343   A0A0N8P0M4   B3NEQ2   A0A026WM86   A0A0P8YF36   A0A0R1DUF5   A0A195FRX0   A0A0J9UBH6   B4QF02   Q24119-1   M9PBG9   Q24119   B3M6K4   A0A1B0CWZ1   A0A1W4VZP7   A0A3B0JRR6   M9PDQ7   A0A151J7A3   A0A0Q5U2U0   Q24119-6   A0A0Q5U1V7   A0A0P9C1L1   N6TIQ2   A0A0R1DU69   A0A0R1E0I5   A0A1W4W0J5   A0A3B0JUT5   A0A0P8ZSR0   A0A2H8TJE5   A0A0R1DU24   A0A0A9XD20   A0A336LCQ0   B4MXG7   B4HVG2   A0A336LA71   A0A336L9I2   A0A146L9K6   X1WIC9   A0A2R7W6M4   A0A1J1IAN6   A0A1J1IAM3   A0A1Y1KHG7   A0A2S2R9V8  

Pubmed

10502107    22118469    19121390    26354079    26227816    28004739    + More
18362917    19820115    20566863    23537049    20798317    21347285    25474469    17994087    8557198    8557189    10731132    12537572    12537569    11740943    21994247    24508170    17550304    22936249    12537568    12537573    12537574    16110336    17569856    17569867    25401762    26823975   

EMBL

AB007832    BAA22946.1    NWSH01000494    PCG76034.1    AGBW02009838    OWR49771.1    + More
BABH01011308    BABH01011309    ODYU01010104    SOQ54971.1    KQ459582    KPI98785.1    KQ460597    KPJ13907.1    JTDY01000607    KOB76485.1    GEZM01083942    JAV60923.1    KQ971307    KYB29670.1    DS235885    EEB20343.1    GEZM01083940    JAV60925.1    EFA12054.2    KYB29671.1    GEZM01083941    JAV60924.1    KQ760551    OAD59854.1    KB632399    ERL94785.1    GL449978    EFN81642.1    ADTU01017069    ADTU01017070    ADTU01017071    ADTU01017072    ADTU01017073    ADTU01017074    ADTU01017075    ADTU01017076    ADTU01017077    GFTR01008265    JAW08161.1    KP147944    AKG92781.1    GBBI01003084    JAC15628.1    KQ976394    KYM93214.1    KQ434787    KZC05321.1    KZ288285    PBC29450.1    GL437918    EFN69854.1    KQ978068    KYM97579.1    CH902618    KPU77531.1    KQ435707    KOX80116.1    U33427    U42699    AE014296    BT031114    AY094911    BT133348    AFG26510.1    BT128786    AEL30808.1    KPU77532.1    CH954178    EDV50047.2    KK107152    EZA57068.1    KPU77528.1    CM000159    KRK00693.1    KQ981285    KYN43176.1    CM002912    KMY96670.1    CM000362    EDX07029.1    AGB93902.1    EDV38654.2    AJWK01033003    AJWK01033004    AJWK01033005    AJWK01033006    AJWK01033007    OUUW01000009    SPP84824.1    AGB93905.1    KQ979695    KYN19703.1    KQS43033.1    KQS43032.1    KPU77529.1    APGK01024805    KB740562    ENN80314.1    KRK00696.1    KRK00695.1    SPP84823.1    KPU77530.1    GFXV01001603    MBW13408.1    KRK00694.1    GBHO01026911    JAG16693.1    UFQS01002593    UFQT01002593    SSX14325.1    SSX33736.1    CH963876    EDW76736.2    CH480817    EDW49927.1    SSX14324.1    SSX33735.1    UFQS01002454    UFQT01002454    SSX14089.1    SSX33506.1    GDHC01015309    JAQ03320.1    ABLF02036334    ABLF02036340    ABLF02036350    ABLF02036352    ABLF02036363    ABLF02036364    ABLF02036366    KK854364    PTY15088.1    CVRI01000047    CRK97357.1    CRK97341.1    GEZM01083943    JAV60922.1    GGMS01017550    MBY86753.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000053268    UP000053240    UP000037510    + More
UP000192223    UP000007266    UP000009046    UP000030742    UP000005203    UP000008237    UP000005205    UP000078540    UP000076502    UP000242457    UP000000311    UP000078542    UP000007801    UP000053105    UP000000803    UP000008711    UP000053097    UP000002282    UP000078541    UP000000304    UP000092461    UP000192221    UP000268350    UP000078492    UP000019118    UP000007798    UP000001292    UP000007819    UP000183832   

PRIDE

O15984    H9JKY4    Q24119   

Pfam

PF08447   PAS_3        + More
PF00989   PAS
PF00046   Homeodomain
PF00096   zf-C2H2

Interpro

IPR000014   PAS        + More
IPR013655   PAS_fold_3       
IPR011598   bHLH_dom       
IPR036638   HLH_DNA-bd_sf       
IPR013767   PAS_fold       
IPR035965   PAS-like_dom_sf       
IPR001610   PAC       
IPR009057   Homeobox-like_sf       
IPR001356   Homeobox_dom       
IPR036236   Znf_C2H2_sf       
IPR013087   Znf_C2H2_type       
IPR000253   FHA_dom       

SUPFAM

SSF55785   SSF55785        + More
SSF47459   SSF47459       
SSF46689   SSF46689       
SSF57667   SSF57667       

Gene 3D

4.10.280.10    

CDD

cd00130  PAS
cd00083  HLH
cd00086  homeodomain

ProteinModelPortal

O15984   A0A2A4JWM2   A0A212F7R6   H9JKY4   A0A2H1WPH0   A0A194Q5V6   + More
A0A194R8D7   A0A0L7LM30   A0A1W4W9F0   A0A1Y1KHH7   A0A139WNU4   A0A1W4WJI4   E0W3Y7   A0A1Y1KMM7   A0A1W4WKR1   D7EII8   A0A139WPC2   A0A1Y1KHQ9   A0A310SEZ3   U4UWX9   A0A088AKM3   E2BRP8   A0A158NIX6   A0A224XJF8   A0A0F7IIN2   A0A023F318   A0A195BX49   A0A154P0E7   A0A2A3ECN2   E2A9Q2   A0A195C9N9   A0A0P8Y7X1   A0A0M9AAZ1   Q24119-3   H9TV77   F9W343   A0A0N8P0M4   B3NEQ2   A0A026WM86   A0A0P8YF36   A0A0R1DUF5   A0A195FRX0   A0A0J9UBH6   B4QF02   Q24119-1   M9PBG9   Q24119   B3M6K4   A0A1B0CWZ1   A0A1W4VZP7   A0A3B0JRR6   M9PDQ7   A0A151J7A3   A0A0Q5U2U0   Q24119-6   A0A0Q5U1V7   A0A0P9C1L1   N6TIQ2   A0A0R1DU69   A0A0R1E0I5   A0A1W4W0J5   A0A3B0JUT5   A0A0P8ZSR0   A0A2H8TJE5   A0A0R1DU24   A0A0A9XD20   A0A336LCQ0   B4MXG7   B4HVG2   A0A336LA71   A0A336L9I2   A0A146L9K6   X1WIC9   A0A2R7W6M4   A0A1J1IAN6   A0A1J1IAM3   A0A1Y1KHG7   A0A2S2R9V8  

PDB

5SY7     E-value=1.18773e-111,     Score=1034

KEGG

692366    K09098 neuronal PAS domain-containing protein 1/3 | (RefSeq) trh; trachealess

GO

GO:0005634   GO:0003677   GO:0006355   GO:0046983   GO:0045944   GO:0006357   GO:0000981   GO:0043565   GO:0007425   GO:0007424   GO:0007435   GO:0007431   GO:0007443   GO:0046982   GO:0060173   GO:0035202   GO:0072175   GO:0003700   GO:0035277   GO:0001228   GO:0005515   GO:0005007   GO:0005524   GO:0008284   GO:0008543   GO:0016021   GO:0004672   GO:0048384  

Subcellular location

Nucleus  

Length:

857

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03122

Exp number, first 60 AAs:

0.00145

Total prob of N-in:

0.00153

outside

1  -  857

 

 

Pi

258.414391

Theta

173.388543

Tajima's D

1.676836

CLR

0.274332

CSRT

0.828808559572021

Interpretation

Uncertain