Gene

KWMTBOMO03842

Annotation

Transposase_domain_containing_protein_[Haemonchus_contortus]

Location

Bomo_Chr7(+):3990830-3991989      View in EpiBrowser

Full name

Transposable element Tc1 transposase       + More
Transposable element Tcb1 transposase      
Transposable element Tcb2 transposase      
Mitogen-activated protein kinase      

Alternative Name

Transposable element Barney transposase

Location in the cell

Mitochondrial   Reliability : 3.405

CDS

ATGGCATGCAATGCAGTGCAACATTTCAAGCGCTATAACACAGCTTTAAATGTGTCCAGAACAAAAAGATCGAGAAAAACGACTCCGCAAGAAGATAGAATGATAACCAGGTTAGCTAAGAAAGATCCGTTTCTAGCCTCTATTTTAATTAAACACGAAGTGTTTGGGGCAAACGAAAGAGCCGGTGTATCTGCGAGGACCATTCGACGACGTTTGGTAGAAGCAGGGTTGTTCGGAAGAGTGGCTCGCAAAGTACCGTTGTTGAAGAAAGAACATAGAAATGCTCGTTTGCCATTTGCACGTAAATATGGACATTGGACCTTCGCCCAATGGCAACATGTACTTTTTTCTGACGAGACCAAGGTTAATTTGATTTCTTCAGATGGAAGGCAATATGTACGGCGTCCTGTAAAAGCGGAAATGAATCCAAGATTCACAAAAAAACAGGTGAAACATGGCGGTGGAAACATTAAAATATGGGGTTCATTTTCTGGACGTGGAGTGGGACCTGTGAGGAAAGTTCAGGGTAACTTAGACCAACATCAATACAAGGCAATATTGGAAGAAACTATGCTTCCCTATGCTGAGGAGCATCTCCCTATTATATGGGCGTTTCAGCAGGATAACGACCCGAAACATACCGCTCATTCAGTCAAGTCGTTTCTTACCAGTCAGTTTGTATCGGTGCTAGAGTGGCCAGCAAATAGCCCGGACCTCAACCCAATTGAGCACCTTTGGCACGAAATCAAGAAAAAAGTTGCCACTTATCGTAATACAAATTTGGATGAACTTCATGAAGCTTTTTGTGAGGCATGGGCAAACATTCCTGTCGAAACATGTCAGAAATTGATAATGTCTATGCCACATCGGAGTCAAGCGGTAATCACTAACAAAGGTTTTGCTACTGGGTACTGA

Protein

MACNAVQHFKRYNTALNVSRTKRSRKTTPQEDRMITRLAKKDPFLASILIKHEVFGANERAGVSARTIRRRLVEAGLFGRVARKVPLLKKEHRNARLPFARKYGHWTFAQWQHVLFSDETKVNLISSDGRQYVRRPVKAEMNPRFTKKQVKHGGGNIKIWGSFSGRGVGPVRKVQGNLDQHQYKAILEETMLPYAEEHLPIIWAFQQDNDPKHTAHSVKSFLTSQFVSVLEWPANSPDLNPIEHLWHEIKKKVATYRNTNLDELHEAFCEAWANIPVETCQKLIMSMPHRSQAVITNKGFATGY

Description

Probably essential for transposable element Tc1 transposition. The insertion of Tc1 is the main cause of spontaneous mutations. It is an endonuclease which can produce a single strand nick at the 5'-end of the transposon.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Miscellaneous

The N-terminal region of Tc1 transposase has strong affinity for double and single-stranded DNA.

Similarity

Belongs to the transposase 5 family.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

Keywords

Complete proteome   DNA integration   DNA recombination   DNA-binding   Endonuclease   Hydrolase   Nuclease   Nucleus   Reference proteome   Transposable element  

Feature

chain  Transposable element Tc1 transposase

Uniprot

A0A0K8TZE2   A0A3Q3QA83   A0A3B5QR67   A0A146TLD3   A0A146S9D2   A0A3Q2E5D4   + More
A0A3Q3IFX8   A0A3B5PVC4   A0A3B5R9W2   A0A3B5Q218   A0A3Q3JAF4   A0A3B5QL49   A0A3Q3QHH7   A0A3B5QJT0   A0A3Q3K8P4   A0A3B5QLW9   A0A3B5RDB4   A0A3Q3WMY7   A0A3B5QMJ0   A0A3B5R5Q2   A0A146RA31   A0A3Q3VT94   A0A3Q3LKR5   A0A3Q2Q7R2   W6NXN7   A0A3Q3WWM2   A0A336MYQ3   A0A0D6M518   A0A3Q4BZJ5   A0A1I8CQ10   A0A3Q3M0T2   A0A3Q3IS73   A0A0K8VQ61   A0A1I7XBJ4   A0A3Q3ITI9   A0A3Q3IC76   A0A0K8VY49   A0A3Q3IJA4   A0A3Q3XI36   A0A2G9US57   A0A034WQG6   A0A2G5TUY7   A0A2G5TUW4   A0A1I7XK39   E3NVH1   A0A016W5Y7   A0A2G5SD33   A0A2G5TAP7   A0A2H2IE84   P03934   A0A2G5TAG8   A0A2H2I0L3   A0A2Q4SIH5   A0A2H2JJL7   P35072   A0A034VMG2   A0A2M4CJW5   A0A2H2IGW1   Q04202   A0A2M4CJU9   A0A2G5UEF3   A0A0C2DLX3   A0A2H2IP28   A8XMV3   A0A2G5UEP8   A0A2H2I7P7   A0A2H2JM06   K7H1S5   A0A2H2IT91   A0A2H2IX08   K7H1S6   A0A2H2I434   A0A2G5TAZ4   A8X7C2   A0A2H2J5F5   A0A226EH80   A8XD01   A0A2H2IP06   A0A226DTR0   A0A2H2JFR1   A0A226DWZ3   A0A2H2HZZ4   A0A2H2IVU4   O96918   A0A3P8QWP4   A0A2H2I565   T2MD75   A0A3P8Q977   A0A3P8NT34   A0A3P8R5J4   A0A3P8Q3H8   A0A3P9BR28   A0A1V2MEG2   A0A2H2J2H1   A0A3P8NPP6   A0A3P8QD08   T1E3R7   A0A0F7Z1V0   A0A3Q3CKP9   A0A3P8NXC4  

EC Number

2.7.11.24

Pubmed

23542700    26829753    23874975    25348373    25730766    6306578    + More
9851916    2156234    7813449    2161057    2840637    1851119    14624247    24065732    25186727    23758969   

EMBL

GDHF01032864    GDHF01020721    JAI19450.1    JAI31593.1    GCES01092637    JAQ93685.1    + More
GCES01109049    JAQ77273.1    GCES01121356    JAQ64966.1    CAVP010060968    CDL96622.1    UFQS01002917    UFQT01002917    SSX14892.1    SSX34279.1    KE124836    EPB77486.1    GDHF01011290    JAI41024.1    GDHF01009391    GDHF01008532    JAI42923.1    JAI43782.1    KZ345517    PIO73111.1    GAKP01002517    JAC56435.1    PDUG01000005    PIC31120.1    PIC31119.1    DS270970    EFO98340.1    JARK01001337    EYC34438.1    PDUG01000018    PIC12806.1    PIC24259.1    X01005    FO081675    PIC24260.1    X07827    X54218    GAKP01016264    JAC42688.1    GGFL01001415    MBW65593.1    M64308    GGFL01001416    MBW65594.1    PDUG01000003    PIC37922.1    KN728553    KIH63612.1    HE600911    CAP33978.2    PIC37923.1    PIC24261.1    HE601187    CAP28533.2    LNIX01000004    OXA56016.1    HE600908    CAP30519.2    LNIX01000012    OXA48087.1    LNIX01000010    OXA49580.1    U89803    AAD03794.1    HAAD01003991    CDG70223.1    LJHF01000002    ONI46962.1    GAAZ01002710    JAA95233.1    GBEX01003690    JAI10870.1   

Proteomes

UP000261600    UP000002852    UP000265020    UP000261620    UP000261640    UP000265000    + More
UP000025227    UP000095286    UP000095283    UP000230233    UP000008281    UP000024635    UP000005237    UP000001940    UP000008549    UP000198287    UP000265100    UP000265160    UP000264840   

PRIDE

P03934    P35072   

Pfam

PF01498   HTH_Tnp_Tc3_2        + More
PF13358   DDE_3
PF00046   Homeodomain
PF00135   COesterase
PF03761   DUF316
PF00098   zf-CCHC
PF00067   p450
PF00069   Pkinase

Interpro

IPR038717   Tc1-like_DDE_dom        + More
IPR002492   Transposase_Tc1-like       
IPR009057   Homeobox-like_sf       
IPR001356   Homeobox_dom       
IPR036388   WH-like_DNA-bd_sf       
IPR002018   CarbesteraseB       
IPR029058   AB_hydrolase       
IPR036875   Znf_CCHC_sf       
IPR001878   Znf_CCHC       
IPR009003   Peptidase_S1_PA       
IPR005514   DUF316       
IPR001523   Paired_dom       
IPR017972   Cyt_P450_CS       
IPR001128   Cyt_P450       
IPR002401   Cyt_P450_E_grp-I       
IPR036396   Cyt_P450_sf       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR003527   MAP_kinase_CS       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF46689   SSF46689        + More
SSF53474   SSF53474       
SSF50494   SSF50494       
SSF57756   SSF57756       
SSF48264   SSF48264       
SSF56112   SSF56112       

Gene 3D

1.10.10.10     3.40.50.1820     1.10.630.10    

CDD

cd00086  homeodomain

ProteinModelPortal

A0A0K8TZE2   A0A3Q3QA83   A0A3B5QR67   A0A146TLD3   A0A146S9D2   A0A3Q2E5D4   + More
A0A3Q3IFX8   A0A3B5PVC4   A0A3B5R9W2   A0A3B5Q218   A0A3Q3JAF4   A0A3B5QL49   A0A3Q3QHH7   A0A3B5QJT0   A0A3Q3K8P4   A0A3B5QLW9   A0A3B5RDB4   A0A3Q3WMY7   A0A3B5QMJ0   A0A3B5R5Q2   A0A146RA31   A0A3Q3VT94   A0A3Q3LKR5   A0A3Q2Q7R2   W6NXN7   A0A3Q3WWM2   A0A336MYQ3   A0A0D6M518   A0A3Q4BZJ5   A0A1I8CQ10   A0A3Q3M0T2   A0A3Q3IS73   A0A0K8VQ61   A0A1I7XBJ4   A0A3Q3ITI9   A0A3Q3IC76   A0A0K8VY49   A0A3Q3IJA4   A0A3Q3XI36   A0A2G9US57   A0A034WQG6   A0A2G5TUY7   A0A2G5TUW4   A0A1I7XK39   E3NVH1   A0A016W5Y7   A0A2G5SD33   A0A2G5TAP7   A0A2H2IE84   P03934   A0A2G5TAG8   A0A2H2I0L3   A0A2Q4SIH5   A0A2H2JJL7   P35072   A0A034VMG2   A0A2M4CJW5   A0A2H2IGW1   Q04202   A0A2M4CJU9   A0A2G5UEF3   A0A0C2DLX3   A0A2H2IP28   A8XMV3   A0A2G5UEP8   A0A2H2I7P7   A0A2H2JM06   K7H1S5   A0A2H2IT91   A0A2H2IX08   K7H1S6   A0A2H2I434   A0A2G5TAZ4   A8X7C2   A0A2H2J5F5   A0A226EH80   A8XD01   A0A2H2IP06   A0A226DTR0   A0A2H2JFR1   A0A226DWZ3   A0A2H2HZZ4   A0A2H2IVU4   O96918   A0A3P8QWP4   A0A2H2I565   T2MD75   A0A3P8Q977   A0A3P8NT34   A0A3P8R5J4   A0A3P8Q3H8   A0A3P9BR28   A0A1V2MEG2   A0A2H2J2H1   A0A3P8NPP6   A0A3P8QD08   T1E3R7   A0A0F7Z1V0   A0A3Q3CKP9   A0A3P8NXC4  

PDB

5CR4     E-value=8.64155e-45,     Score=453

KEGG

NA   

GO

GO:0015074   GO:0003677   GO:0006313   GO:0005634   GO:0004519   GO:0016021   GO:0008270   GO:0006355   GO:0055114   GO:0008395   GO:0043231   GO:0016712   GO:0042738   GO:0006805   GO:0020037   GO:0005506   GO:0005737   GO:0006082   GO:0004707   GO:0005524   GO:0005007   GO:0008284   GO:0008543   GO:0004672   GO:0048384  

Subcellular location

Nucleus  

Length:

304

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00215

Exp number, first 60 AAs:

0.00155

Total prob of N-in:

0.06303

outside

1  -  304

 

 

Pi

21.386441

Theta

25.401423

Tajima's D

0.275712

CLR

0.098523

CSRT

0.453177341132943

Interpretation

Uncertain