Gene

KWMTBOMO03835

Pre Gene Modal

BGIBMGA010003

Annotation

PREDICTED:_putative_glutathione-specific_gamma-glutamylcyclotransferase_2_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr7(-):3628326-3655519      View in EpiBrowser

Full name

Gamma-glutamylcyclotransferase      

Location in the cell

Cytoplasmic   Reliability : 1.925

CDS

ATGGATAAGTTAAGAAACGAAACGAGCAGTTCCGAATCAAAAACAGAATCTAACAAGGAACCTTTCTGGGTATTTGGTTATGGTTCCCTCTGCTGGAATCCAGGGTTCGAATACCAGCAATCCTTGACTGGTTATGTAAAAGGTTTCTCAAGGAGATTCTGGCAAGGGAACACCACTCATCGTGGAACAGAAGATAAGCCGGGTCGCGTCGCCACTCTAATAGAGGACAAGGAAGGAATAACTTGGGGTAAAGCGTTTTTGGTGGCCGCAGAAAACAGCGTAGCACTGCCTTATCTCACCAAAAGAGAATGCAAATTAGGTGGCTACAAGACCTGCGTTGTGAACTTCCATCCAACACCTTTTTTACCGGCCACTAGGGCAGATAAAAAGGATGCCTTGCTGTACATAGCCCTTCCAGAGAATAAACATTGGCTTGGATCGGCGCCTTTGCCAGATATAGCGAAACAAATACTGGAATGCCGTGGTCCATCTGGCTCAAACGTTGAGTATCTCCTAAGGCTGGCAGACTTCATGAGAGAAGAAATTCCTGAGGCGTTAGACGATCACCTTTTCTCCTTAGAAAGGTTAGTCAGGAAGTTCGCTGCCGATTTCAAGATATGCTTAAGGTCTTTAGTTGGGGAACAAGAAAGAGAAGAAAGAGAGGTCAAAGTGGCCGTTCCTAGCAATCAATTCGCCTCTAGAATACCCGAGAAAAAGCTGCGTTGCGTAAACATGTGA

Protein

MDKLRNETSSSESKTESNKEPFWVFGYGSLCWNPGFEYQQSLTGYVKGFSRRFWQGNTTHRGTEDKPGRVATLIEDKEGITWGKAFLVAAENSVALPYLTKRECKLGGYKTCVVNFHPTPFLPATRADKKDALLYIALPENKHWLGSAPLPDIAKQILECRGPSGSNVEYLLRLADFMREEIPEALDDHLFSLERLVRKFAADFKICLRSLVGEQEREEREVKVAVPSNQFASRIPEKKLRCVNM

Description

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Catalytic Activity

glutathione = 5-oxo-L-proline + L-cysteinylglycine

Similarity

Belongs to the gamma-glutamylcyclotransferase family.

Uniprot

S4PEQ4   A0A2A4IT05   A0A3S2NRZ2   A0A194QZL2   A0A194QDH2   A0A2H1WDQ9   + More
A0A1B6LUB3   A0A026WXR8   A0A2P8YS70   A0A023EL93   A0A182GPM6   A0A1B6GY91   A0A0A1WPT5   W8AMT6   A0A3B0JFN5   B4NG72   A0A0L7L8Q1   B4LYA4   A0A0A1X779   W8AG64   A0A1Q3FDN8   A0A182RZA2   A0A182VZF6   B0WDK4   A0A0L0CBY2   A0A182MIV8   A0A0K8W6N4   A0A182NS07   Q7PXY0   A0A182HLG3   A0A182WSL2   A0A182VJQ9   Q29BN6   T1PGK5   E1ZYB4   A0A034VLT4   A0A034VMJ8   B3LY59   E2C8V6   A0A1L8EIN5   A0A1L8EJ14   A0A2A3EMP0   A0A1L8EIV8   A0A182JN12   A0A1A9X2C8   B4GP79   B4JTP0   E9J2L0   A0A0L7R5N5   A0A1B0FQX2   D6W6R9   A0A154P0W2   A0A0K8V0K2   A0A1A9ZM98   A0A1W4XC28   A0A034VJU6   A0A034VKX3   A0A1A9XKT9   A0A1B0AVD4   A0A195C842   A0A1I8NRY9   A0A0M9ABI0   A0A1A9VS57   A0A2M4CVD1   A0A151XA07   A0A195FUR8   A0A2M3ZC80   A0A195DCG8   A0A2M4AHD1   A0A1W4UJY8   B4HFX6   A0A195BD85   A0A158P446   A0A2M4CVP8   B4PNW8   A0A1J1HK31   A0A2M4BY52   T1E7X3   A0A2M4BY48   B3P8F1   Q9VCI9   A0A1L8DF69   A0A1L8DFG2   A0A0M4F4D2   E0VLN1   A0A0N7ZDI9   A0A087SYH3   A0A088A1Q4   B4K881   A0A1S3DAA5   A0A336KG26   A0A023F1X4   A0A1L8EAF8   A0A2P2I4M7   A0A1Y1MUZ1   A0A182YB54   A0A2L2Y5X1   A0A182PGK2   J3JVI9   A0A2S2QLE0  

EC Number

4.3.2.-

Pubmed

23622113    26354079    24508170    30249741    29403074    24945155    + More
26483478    25830018    24495485    17994087    26227816    18057021    26108605    12364791    14747013    17210077    15632085    23185243    25315136    20798317    25348373    21282665    18362917    19820115    21347285    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20566863    25474469    28004739    25244985    26561354    22516182   

EMBL

GAIX01006950    JAA85610.1    NWSH01008271    PCG62626.1    RSAL01000112    RVE47024.1    + More
KQ460930    KPJ10724.1    KQ459167    KPJ03507.1    ODYU01007976    SOQ51199.1    GEBQ01012716    JAT27261.1    KK107064    QOIP01000008    EZA60832.1    RLU19170.1    PYGN01000393    PSN47099.1    GAPW01003610    JAC09988.1    JXUM01078779    KQ563087    KXJ74506.1    GECZ01002373    JAS67396.1    GBXI01013864    JAD00428.1    GAMC01019244    GAMC01019243    JAB87312.1    OUUW01000005    SPP81204.1    CH964251    EDW83289.1    JTDY01002307    KOB71694.1    CH940650    EDW67992.1    KRF83601.1    GBXI01009769    GBXI01007561    JAD04523.1    JAD06731.1    GAMC01019245    GAMC01019240    JAB87310.1    GFDL01009372    JAV25673.1    DS231898    EDS44613.1    JRES01000634    KNC29747.1    AXCM01002120    GDHF01005461    JAI46853.1    AAAB01008987    EAA00932.3    APCN01000897    CM000070    EAL26961.1    KA646988    AFP61617.1    GL435204    EFN73813.1    GAKP01016212    JAC42740.1    GAKP01016214    JAC42738.1    CH902617    EDV43963.1    KPU80563.1    GL453713    EFN75629.1    GFDG01000217    JAV18582.1    GFDG01000216    JAV18583.1    KZ288215    PBC32754.1    GFDG01000215    JAV18584.1    CH479186    EDW38962.1    CH916374    EDV91469.1    GL767895    EFZ12942.1    KQ414652    KOC66124.1    CCAG010009277    CCAG010009278    KQ971307    EFA10955.1    KQ434792    KZC05462.1    GDHF01020194    JAI32120.1    GAKP01016213    JAC42739.1    GAKP01016215    JAC42737.1    JXJN01004182    JXJN01004183    JXJN01004184    KQ978220    KYM96308.1    KQ435710    KOX79873.1    GGFL01005102    MBW69280.1    KQ982353    KYQ57201.1    KQ981264    KYN44032.1    GGFM01005360    MBW26111.1    KQ980989    KYN10605.1    GGFK01006863    MBW40184.1    CH480815    EDW43369.1    KQ976519    KYM82150.1    ADTU01001346    GGFL01005103    MBW69281.1    CM000160    EDW98178.1    CVRI01000006    CRK87906.1    GGFJ01008849    MBW57990.1    GAMD01003273    JAA98317.1    GGFJ01008793    MBW57934.1    CH954182    EDV53975.1    AE014297    BT031190    AAF56170.1    AAF56171.1    ABY20431.1    GFDF01008985    JAV05099.1    GFDF01008984    JAV05100.1    CP012526    ALC46562.1    DS235277    EEB14287.1    GDRN01035976    JAI67376.1    KK112540    KFM57912.1    CH933806    EDW15435.1    KRG01549.1    UFQS01000235    UFQT01000235    SSX01803.1    SSX22180.1    GBBI01003676    JAC15036.1    GFDG01003214    JAV15585.1    IACF01003196    LAB68820.1    GEZM01023629    JAV88255.1    IAAA01014590    IAAA01014591    LAA03559.1    BT127257    AEE62219.1    GGMS01008789    MBY77992.1   

Proteomes

UP000218220    UP000283053    UP000053240    UP000053268    UP000053097    UP000279307    + More
UP000245037    UP000069940    UP000249989    UP000268350    UP000007798    UP000037510    UP000008792    UP000075900    UP000075920    UP000002320    UP000037069    UP000075883    UP000075884    UP000007062    UP000075840    UP000076407    UP000075903    UP000001819    UP000095301    UP000000311    UP000007801    UP000008237    UP000242457    UP000075880    UP000091820    UP000008744    UP000001070    UP000053825    UP000092444    UP000007266    UP000076502    UP000092445    UP000192223    UP000092443    UP000092460    UP000078542    UP000095300    UP000053105    UP000078200    UP000075809    UP000078541    UP000078492    UP000192221    UP000001292    UP000078540    UP000005205    UP000002282    UP000183832    UP000008711    UP000000803    UP000092553    UP000009046    UP000054359    UP000005203    UP000009192    UP000079169    UP000076408    UP000075885   

PRIDE

Q9VCI9   

Pfam

PF04752   ChaC

Interpro

IPR013024   GGCT-like        + More
IPR036568   GGCT-like_sf       
IPR006840   ChaC       

SUPFAM

SSF110857   SSF110857       

CDD

cd06661  GGCT_like

ProteinModelPortal

S4PEQ4   A0A2A4IT05   A0A3S2NRZ2   A0A194QZL2   A0A194QDH2   A0A2H1WDQ9   + More
A0A1B6LUB3   A0A026WXR8   A0A2P8YS70   A0A023EL93   A0A182GPM6   A0A1B6GY91   A0A0A1WPT5   W8AMT6   A0A3B0JFN5   B4NG72   A0A0L7L8Q1   B4LYA4   A0A0A1X779   W8AG64   A0A1Q3FDN8   A0A182RZA2   A0A182VZF6   B0WDK4   A0A0L0CBY2   A0A182MIV8   A0A0K8W6N4   A0A182NS07   Q7PXY0   A0A182HLG3   A0A182WSL2   A0A182VJQ9   Q29BN6   T1PGK5   E1ZYB4   A0A034VLT4   A0A034VMJ8   B3LY59   E2C8V6   A0A1L8EIN5   A0A1L8EJ14   A0A2A3EMP0   A0A1L8EIV8   A0A182JN12   A0A1A9X2C8   B4GP79   B4JTP0   E9J2L0   A0A0L7R5N5   A0A1B0FQX2   D6W6R9   A0A154P0W2   A0A0K8V0K2   A0A1A9ZM98   A0A1W4XC28   A0A034VJU6   A0A034VKX3   A0A1A9XKT9   A0A1B0AVD4   A0A195C842   A0A1I8NRY9   A0A0M9ABI0   A0A1A9VS57   A0A2M4CVD1   A0A151XA07   A0A195FUR8   A0A2M3ZC80   A0A195DCG8   A0A2M4AHD1   A0A1W4UJY8   B4HFX6   A0A195BD85   A0A158P446   A0A2M4CVP8   B4PNW8   A0A1J1HK31   A0A2M4BY52   T1E7X3   A0A2M4BY48   B3P8F1   Q9VCI9   A0A1L8DF69   A0A1L8DFG2   A0A0M4F4D2   E0VLN1   A0A0N7ZDI9   A0A087SYH3   A0A088A1Q4   B4K881   A0A1S3DAA5   A0A336KG26   A0A023F1X4   A0A1L8EAF8   A0A2P2I4M7   A0A1Y1MUZ1   A0A182YB54   A0A2L2Y5X1   A0A182PGK2   J3JVI9   A0A2S2QLE0  

PDB

5HWK     E-value=1.67238e-16,     Score=208

KEGG

101746090    K07232 glutathione-specific gamma-glutamylcyclotransferase [EC:4.3.2.7] | (RefSeq) putative glutathi

PATHWAY

00480    Glutathione metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006751   GO:0003839   GO:0061928   GO:0005737   GO:0016740   GO:0022008   GO:0005802   GO:0005112   GO:0006468   GO:0005007   GO:0005524   GO:0008284   GO:0008543   GO:0016021   GO:0004672   GO:0048384  

PANTHER

PTHR12192  

Length:

245

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1065

Exp number, first 60 AAs:

0.09474

Total prob of N-in:

0.16562

outside

1  -  245

 

 

Pi

247.812381

Theta

162.89103

Tajima's D

1.574258

CLR

0.112456

CSRT

0.800209989500525

Interpretation

Uncertain