Gene

KWMTBOMO03831

Pre Gene Modal

BGIBMGA010089

Annotation

PREDICTED:_general_transcription_factor_IIH_subunit_1_[Bombyx_mori]

Location

Bomo_Chr7(+):3419470-3428921      View in EpiBrowser

Full name

General transcription factor IIH subunit 1      

Alternative Name

TFIIH basal transcription factor complex subunit 1

Location in the cell

Nuclear   Reliability : 3.831

CDS

ATGACAACATCATCCGAAGATGTTTTGCTCAGCGTGAATTGCGTACGCTATAAGAAGGGAGACGGGACACTGTATGTAATGAATCAAAGATTAGCATGGATGTTGGAACACAGAGACACAGTCGCAGTATCTCATAAATATGCTGATATCAAAACACAAAAAATTTCACCAGCTGGCAAGGCTAAAATACAGCTTCAAGTGGTTTTACATGATGGCACATGTTCTACATTTCACTTTGTTAACCCGGGTGGCCCAGAGGCTCAGGCCAAAGACAGAGATCAAGTGATGGTATTACTACAAAACCTTTTACCAAAGTTCAAAAGACAGATTGATGGTGAACTAGAAATGAAATCTAAATTGTTGTCATTGCATCCAACATTAAAACATTTGTACGAGGATTTAGTTATATCTAAAGTTATTAATAGTGAGGAATACTGGAATACTCCTACTTTGAAACAGTATACAGAATCTAGTAACATTAAACAGGAAGCTGGTGTGTCAGGTGCATTCCTTGCTGATATTCAACCACAGACAGACGGTTGCAATGGTTTGAAATACAATCTAACTCAAGATATCATAGATGCTATATTCAAAACATATCCAGCAGTCAGAAAGAAACATATTGATTATGTACCCAATAAAATGACGGAAGCTGAATTCTGGACGAAATTCTTTCAATCACATTATTTTCACAGAGATCGAATAGCTTCGTCATCGAGCAAGGATTTATTTGGAGAATGTGCTAAATTAGATGACCACGCTATTGCTTCAGCAATGAGACACACAACACTAGATCTTACGGTTGATTTGAATAAGTTCATAGAGCACGTTCCACTGTTACCGACTGAAGAAGAAGCTAGCAATGAGAAGGATCGATCTGATAATAATTCTATACACAGAAATATGATTAAACGTTTCAACCAACACTCTATTATGGTGCTCAAAGCTAGTCAAAAATCAAATTCTAGTAATAATAGTAATAGCAGTAGTAGTAAAACATCGAATAACAACAATAAAGTTATCGAAAACGGTGTCAAAGATACAAATGGTGTCTCAAAGAGACCGGCCGAACACAGTACAGAACCGATAGAAAAGAAAAAACGAATATTAGAGCAGATACACTACGAGGATCTAGTTGCAGACCAGGGAAATGATGATGTACAGGAATTAAAATTGTCTAAGGTAGAAAGATATTTATTAGGACCGTCGTATCAGATAAGTCAGACGAGTGTTCAGACGAGCCACCCGCCGCCGCTGTCGGCCTTGGCGTCCGTATGTCAGGCGTGGTCGAGCGGCCAACAGTGCCAGCGGCCGGCGCGGGTGAGCGCGGGCGCGGCTGTGGGCGCGCTGGGGGAGCTCAGTCCGGGCGGCGCGCTCATGCGGCACCACCACGCCGCCTCTATGGCACAACTAATACCGGCGGACGTGAAGGCGGAGCTTCAGAGGCTGTACGCGTCGTGCGGCGAGCTGGCGAGGGAGCTTTGGCGCAGCTTCCCGCAGCCGGGCGCGCCGCCAGCCAACGAGCAGGACGCGGCGCCGCGGGCGACCATGTTCTACGACGCGCTGTTGCGGTTTAGGAATTTGAAACTGAGGCCCTTCGAGGAGAAGATGCTCCGTGACCTGACGCCCCTGGCGACGACTCTAACGAAACATTTGAACCAAATAATAGACACGGCCTGCGCTAAGTACGTGCTCTGGCAACAGAGGCAAGCGAAGATACGGTAG

Protein

MTTSSEDVLLSVNCVRYKKGDGTLYVMNQRLAWMLEHRDTVAVSHKYADIKTQKISPAGKAKIQLQVVLHDGTCSTFHFVNPGGPEAQAKDRDQVMVLLQNLLPKFKRQIDGELEMKSKLLSLHPTLKHLYEDLVISKVINSEEYWNTPTLKQYTESSNIKQEAGVSGAFLADIQPQTDGCNGLKYNLTQDIIDAIFKTYPAVRKKHIDYVPNKMTEAEFWTKFFQSHYFHRDRIASSSSKDLFGECAKLDDHAIASAMRHTTLDLTVDLNKFIEHVPLLPTEEEASNEKDRSDNNSIHRNMIKRFNQHSIMVLKASQKSNSSNNSNSSSSKTSNNNNKVIENGVKDTNGVSKRPAEHSTEPIEKKKRILEQIHYEDLVADQGNDDVQELKLSKVERYLLGPSYQISQTSVQTSHPPPLSALASVCQAWSSGQQCQRPARVSAGAAVGALGELSPGGALMRHHHAASMAQLIPADVKAELQRLYASCGELARELWRSFPQPGAPPANEQDAAPRATMFYDALLRFRNLKLRPFEEKMLRDLTPLATTLTKHLNQIIDTACAKYVLWQQRQAKIR

Description

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

Subunit

Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.

Similarity

Belongs to the TFB1 family.

Keywords

Complete proteome   DNA damage   DNA repair   Nucleus   Reference proteome   Repeat   Transcription   Transcription regulation  

Feature

chain  General transcription factor IIH subunit 1

Uniprot

H9JKN8   A0A2A4JLH2   A0A2H1WVG4   A0A194QDG7   A0A212EJ66   A0A437B9F2   + More
A0A067RJ16   A0A026W810   A0A2J7QES5   A0A195BTT7   A0A1W4VZG8   A0A195CED4   A0A034W020   F4WXP5   E2A1N1   A0A0K8WCI6   A0A151JUN4   A0A158N948   A0A0L0CK24   A0A151J7N8   W8C0P6   A0A2A3ERR8   B3NR56   A0A1A9VQA3   A0A1I8MTB2   B4P746   A0A1A9ZWZ4   A0A1B0G4A4   A0A0A1WS92   A0A1W4XGD9   A0A1L8DH93   A0A1A9YLR7   B4QFG2   A0A1A9WF35   A0A151WUY2   A0A1B6FGW6   A0A336M7N3   A0A3B0J1F4   B4HRB5   A0A0C9QVC9   A0A1B6CCQ5   A0A1I8NR24   E2C9K0   A0A0B4K726   Q960E8   A0A023EUH3   B4GAL8   Q291K0   A0A088AUQ9   A0A1B0C799   A0A0L7QL10   B3MDZ8   A0A1Y1M0H5   Q16L69   E0VCF0   B4J482   D2A3F8   A0A1S4FWY9   A0A1Q3F827   T1GW76   A0A232FLB0   B4LQ94   A0A0A9W7P0   A0A182JP18   A0A0J7L207   B4KNX5   A0A182MM03   A0A182T338   B4MQ83   A0A224XA42   A0A023F188   A0A0K8TRP6   U5EYR7   A0A1B0CWD0   A0A182WDP2   T1JKT1   A0A0A9WG22   A0A1B6LDR1   A0A1Y1M5I6   A0A1J1IN71   A0A087UJM6   A0A2R5LCA9   A0A2P6KCA8   R7VIH6   A0A0L8H913   A0A210R191   K1RJ65   A0A0K8SF12   F7BVJ4   A0A444UXK3   A0A2I0UT29   H3ASK4   V8P5L9   W5UJ23   A0A1W7RCQ6   A0A2Y9GUR5   A0A099ZK61   A0A2I0MHP1  

Pubmed

19121390    26354079    22118469    24845553    24508170    30249741    + More
25348373    21719571    20798317    21347285    26108605    24495485    17994087    18057021    25315136    17550304    25830018    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    24945155    26483478    15632085    23185243    28004739    17510324    20566863    18362917    19820115    28648823    25401762    26823975    25474469    26369729    23254933    28812685    22992520    17495919    9215903    24297900    23127152    26358130    23371554   

EMBL

BABH01024909    BABH01024910    NWSH01001172    PCG72260.1    ODYU01011304    SOQ56956.1    + More
KQ459167    KPJ03502.1    AGBW02014515    OWR41542.1    RSAL01000112    RVE47021.1    KK852655    KDR19295.1    KK107372    QOIP01000004    EZA51786.1    RLU24191.1    NEVH01015305    PNF27094.1    KQ976405    KYM91849.1    KQ977935    KYM98591.1    GAKP01011816    GAKP01011815    GAKP01011814    JAC47138.1    GL888426    EGI61045.1    GL435766    EFN72704.1    GDHF01022889    GDHF01019946    GDHF01003448    JAI29425.1    JAI32368.1    JAI48866.1    KQ981738    KYN36523.1    ADTU01009102    JRES01000378    KNC31824.1    KQ979662    KYN19889.1    GAMC01003902    JAC02654.1    KZ288192    PBC34204.1    CH954179    EDV56045.1    KQS62623.1    CM000158    EDW91011.1    KRJ99569.1    CCAG010004889    GBXI01017288    GBXI01012353    GBXI01007734    JAC97003.1    JAD01939.1    JAD06558.1    GFDF01008329    JAV05755.1    CM000362    CM002911    EDX07072.1    KMY93749.1    KQ982730    KYQ51511.1    GECZ01020328    JAS49441.1    UFQT01000226    SSX22048.1    OUUW01000001    SPP74735.1    CH480816    EDW47844.1    GBYB01007681    GBYB01007684    JAG77448.1    JAG77451.1    GEDC01026051    JAS11247.1    GL453868    EFN75339.1    AE013599    AFH08075.1    AY052097    JXUM01047993    JXUM01047994    GAPW01000543    KQ561542    JAC13055.1    KXJ78206.1    CH479181    EDW31970.1    CM000071    EAL25112.1    KRT01850.1    KRT01851.1    KRT01852.1    JXJN01027938    KQ414934    KOC59280.1    CH902619    EDV37543.1    GEZM01044079    JAV78518.1    CH477919    EAT35058.1    DS235053    EEB11056.1    CH916367    EDW02688.1    KQ971338    EFA02310.1    GFDL01011358    JAV23687.1    CAQQ02153970    CAQQ02153971    NNAY01000051    OXU31531.1    CH940648    EDW61379.1    KRF79969.1    GBHO01039796    GBHO01039795    GDHC01015637    GDHC01007245    GDHC01007205    GDHC01002562    JAG03808.1    JAG03809.1    JAQ02992.1    JAQ11384.1    JAQ11424.1    JAQ16067.1    LBMM01001258    KMQ96628.1    CH933808    EDW09020.1    AXCM01001638    CH963849    EDW74272.1    GFTR01007210    JAW09216.1    GBBI01003669    JAC15043.1    GDAI01000782    JAI16821.1    GANO01000118    JAB59753.1    AJWK01032239    JH431663    GBHO01039794    JAG03810.1    GEBQ01018146    JAT21831.1    GEZM01044080    JAV78517.1    CVRI01000056    CRL01679.1    KK120124    KFM77565.1    GGLE01003024    MBY07150.1    MWRG01016209    PRD23968.1    AMQN01016314    KB291938    ELU18424.1    KQ418812    KOF85771.1    NEDP02000890    OWF54756.1    JH817736    EKC34301.1    GBRD01014137    GBRD01014136    JAG51689.1    SCEB01005433    RXM92923.1    KZ505641    PKU49180.1    AFYH01025600    AFYH01025601    AZIM01000731    ETE69615.1    JT415436    AHH41690.1    GDAY02002551    JAV48916.1    KL895608    KGL82809.1    AKCR02000011    PKK29192.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000283053    UP000027135    + More
UP000053097    UP000279307    UP000235965    UP000078540    UP000192221    UP000078542    UP000007755    UP000000311    UP000078541    UP000005205    UP000037069    UP000078492    UP000242457    UP000008711    UP000078200    UP000095301    UP000002282    UP000092445    UP000092444    UP000192223    UP000092443    UP000000304    UP000091820    UP000075809    UP000268350    UP000001292    UP000095300    UP000008237    UP000000803    UP000069940    UP000249989    UP000008744    UP000001819    UP000005203    UP000092460    UP000053825    UP000007801    UP000008820    UP000009046    UP000001070    UP000007266    UP000015102    UP000215335    UP000008792    UP000075881    UP000036403    UP000009192    UP000075883    UP000075901    UP000007798    UP000092461    UP000075920    UP000183832    UP000054359    UP000014760    UP000053454    UP000242188    UP000005408    UP000002280    UP000008672    UP000221080    UP000248481    UP000053641    UP000053872   

PRIDE

H9JKN8    Q960E8   

Pfam

PF08567   PH_TFIIH        + More
PF03909   BSD
PF00179   UQ_con

Interpro

IPR005607   BSD_dom        + More
IPR011993   PH-like_dom_sf       
IPR027079   Tfb1/GTF2H1       
IPR013876   TFIIH_BTF_p62_N       
IPR016135   UBQ-conjugating_enzyme/RWD       
IPR000608   UBQ-conjugat_E2       

SUPFAM

SSF54495   SSF54495       

Gene 3D

2.30.29.30     3.10.110.10    

ProteinModelPortal

H9JKN8   A0A2A4JLH2   A0A2H1WVG4   A0A194QDG7   A0A212EJ66   A0A437B9F2   + More
A0A067RJ16   A0A026W810   A0A2J7QES5   A0A195BTT7   A0A1W4VZG8   A0A195CED4   A0A034W020   F4WXP5   E2A1N1   A0A0K8WCI6   A0A151JUN4   A0A158N948   A0A0L0CK24   A0A151J7N8   W8C0P6   A0A2A3ERR8   B3NR56   A0A1A9VQA3   A0A1I8MTB2   B4P746   A0A1A9ZWZ4   A0A1B0G4A4   A0A0A1WS92   A0A1W4XGD9   A0A1L8DH93   A0A1A9YLR7   B4QFG2   A0A1A9WF35   A0A151WUY2   A0A1B6FGW6   A0A336M7N3   A0A3B0J1F4   B4HRB5   A0A0C9QVC9   A0A1B6CCQ5   A0A1I8NR24   E2C9K0   A0A0B4K726   Q960E8   A0A023EUH3   B4GAL8   Q291K0   A0A088AUQ9   A0A1B0C799   A0A0L7QL10   B3MDZ8   A0A1Y1M0H5   Q16L69   E0VCF0   B4J482   D2A3F8   A0A1S4FWY9   A0A1Q3F827   T1GW76   A0A232FLB0   B4LQ94   A0A0A9W7P0   A0A182JP18   A0A0J7L207   B4KNX5   A0A182MM03   A0A182T338   B4MQ83   A0A224XA42   A0A023F188   A0A0K8TRP6   U5EYR7   A0A1B0CWD0   A0A182WDP2   T1JKT1   A0A0A9WG22   A0A1B6LDR1   A0A1Y1M5I6   A0A1J1IN71   A0A087UJM6   A0A2R5LCA9   A0A2P6KCA8   R7VIH6   A0A0L8H913   A0A210R191   K1RJ65   A0A0K8SF12   F7BVJ4   A0A444UXK3   A0A2I0UT29   H3ASK4   V8P5L9   W5UJ23   A0A1W7RCQ6   A0A2Y9GUR5   A0A099ZK61   A0A2I0MHP1  

PDB

6O9M     E-value=2.20066e-104,     Score=970

KEGG

101745944    K03141 transcription initiation factor TFIIH subunit 1 | (RefSeq) general transcription factor IIH s

PATHWAY

03022    Basal transcription factors - Bombyx mori (domestic silkworm)
03420    Nucleotide excision repair - Bombyx mori (domestic silkworm)

GO

GO:0000439   GO:0006289   GO:0006351   GO:0009411   GO:0005675   GO:0016887   GO:0008353   GO:0005634   GO:0001111   GO:0001113   GO:0006367   GO:0006366   GO:0070816   GO:0006360   GO:0045944   GO:0008094  

PANTHER

PTHR12856  

Subcellular location

Nucleus  

Length:

574

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00868

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00080

outside

1  -  574

 

 

Pi

151.846498

Theta

136.687346

Tajima's D

0.345441

CLR

2.000372

CSRT

0.474476276186191

Interpretation

Uncertain