Gene

KWMTBOMO03792

Pre Gene Modal

BGIBMGA010017

Annotation

COMM_domain_containing_4_[Bombyx_mori]

Location

Bomo_Chr7(-):1806868-1819207      View in EpiBrowser

Full name

COMM domain-containing protein 4      

Location in the cell

Cytoplasmic   Reliability : 1.99 Extracellular   Reliability : 1.5

CDS

ATGAAGTTCAAATTCTGTTCGGACGGTGATTGTCCGCTGTGGGCGTTAGCAGCCCTTCACGCCCTCAGCAGTCTACCGGCTTCGATATTCAGGGAACTCGTGCAAAAAGTACAAGAGGATAATTCTGATGACAGCATCATGGAAGTCTTGAAAGATACTAATTATTCGTCACGCGACGAATGCGCCAGGGCTGCGGCAGTCATCCGCTGGGTACTAAAACAGGCGTGGTCTTGTTCTTGCGGGGGCGCTCAGCTCACGCGAGATCTACTGGTGCTGGGAGTGCCTCGCGCCCACGCAACTGCCCTAGCGGACGTAGTCGACGAGGGAGCACAAGATTATAAAGAAAATGTCAAGAATAACGGCTTTATGGTGAACAAAGTGACAGATATTTCAATAGCAGAAGGTCCCAAAGGTTCAGTGGACACATATAAACTTACAATACACACAGATAACGTGTTTATAGCCGAACAAAATCGGAAGGAGCTTCTTATAGACAAGATTCAAGCTAAAGTTATGCTTGAGGAACTGAAGAAGGCGTACAAGAAAATGGAGGAAATTGGAAACGAAACTGGAAATAAATCATAA

Protein

MKFKFCSDGDCPLWALAALHALSSLPASIFRELVQKVQEDNSDDSIMEVLKDTNYSSRDECARAAAVIRWVLKQAWSCSCGGAQLTRDLLVLGVPRAHATALADVVDEGAQDYKENVKNNGFMVNKVTDISIAEGPKGSVDTYKLTIHTDNVFIAEQNRKELLIDKIQAKVMLEELKKAYKKMEEIGNETGNKS

Description

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B.

Subunit

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL2, CUL3, CUL4A, CUL5, CUL7.

Keywords

Complete proteome   Cytoplasm   Nucleus   Reference proteome   Transcription   Transcription regulation   Ubl conjugation pathway  

Feature

chain  COMM domain-containing protein 4

Uniprot

H9JKG6   Q2F615   A0A2H1VQ71   A0A437B5H2   A0A2A4IXW1   S4P3S3   + More
A0A194QD59   A0A0N1IE29   A0A212F7T9   A0A0N1I696   A0A0N1IBX4   A0A0L7LH38   A0A0L7KQ63   A0A0L0C571   A0A1J1I8P0   A0A1J1I6X6   B3M3F7   J9K1W9   A8E6W0   A0A1I8N895   B3DNC6   A0A0J9RUZ8   A0A2Y9FDY4   A0A341CRR1   A0A2U4CJS8   A0A2Y9P0Z5   A0A0P8XTA3   A0A340WIC0   A0A2H8TYK0   A0A1I8PAZ2   B4QK05   A0A384BEN9   A0A2F0B011   A0A1B0B1C4   A0A1L8DBX0   A0A1U7QYB5   B4HHR0   A0A2Y9FEB7   A0A2U4CJJ7   A0A2Y9NS79   A0A340WI20   A0A1L8DC73   A0A2U3YL91   A0A1A9W8F2   A0A2Y9KED8   A0A0P5VH94   A0A0P5UVR0   D6W6Z5   A0A0P5IR67   A0A0P6FGT3   A0A0P5Y876   A0A3Q7R9H7   A0A1B0CQS9   A0A2S2NHG8   A0A2I2UKZ2   A0A1A9VHP2   A0A0G2K6N9   A0A1U7TZJ7   A0A0N8AP35   A0A2S2NLL6   J9P188   A0A336KWJ0   A0A1A9XC74   A0A3Q7QCF7   A0A2U3WGJ8   A0A287B641   A0A452S8P1   B4PIE6   A0A3Q7UDU6   A0A0P6JXD9   A0A1W4U7D1   A0A2Y9HJ14   A0A3L7HNJ5   I3M6M5   A0A2K6L5K8   A0A2K6P6P7   A0A0M5JBP4   H0WKH2   A0A182X9B4   A0A182HKA2   B3ND37   A0A067RHZ0   A0A2K5QJ35   A0A0K8TQ82   Q9CQ02   A0A2K6BF95   A0A2K5V5H7   A0A2K5XBS8   A0A096N3R9   A0A2K5LJZ5   A0A2K5K703   H9Z1R0   A0A182L8I9   A0A2K6F3C8   U3FGD1   A0A023EJE9   M3Z0U8   A0A1S3EUA4  

Pubmed

19121390    23622113    26354079    22118469    26227816    26108605    + More
17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25315136    22936249    18362917    19820115    17975172    15057822    15632090    16341006    17550304    29704459    25362486    24845553    26369729    16141072    15489334    21183079    17431167    25319552    20966253    25243066    24945155   

EMBL

BABH01024775    BABH01024776    BABH01024777    DQ311257    ABD36202.1    ODYU01003770    + More
SOQ42947.1    RSAL01000151    RVE45746.1    NWSH01005605    PCG64104.1    GAIX01011485    JAA81075.1    KQ459167    KPJ03478.1    KQ458791    KPJ05091.1    AGBW02009831    OWR49791.1    KQ460869    KPJ11796.1    LADI01015387    KPJ20797.1    JTDY01001097    KOB74888.1    JTDY01007100    KOB65458.1    JRES01000903    KNC27382.1    CVRI01000043    CRK95940.1    CRK95939.1    CH902618    EDV39218.2    ABLF02038358    AE014296    BT030902    BT030946    ABC66146.2    ABV82284.1    ABV82328.1    BT032914    ACD99478.1    CM002912    KMY99586.1    KPU77946.1    GFXV01006423    MBW18228.1    CM000363    EDX10443.1    NTJE010036113    MBV96345.1    JXJN01007050    GFDF01010118    JAV03966.1    CH480815    EDW41475.1    GFDF01010117    JAV03967.1    GDIP01099963    JAM03752.1    GDIP01108010    LRGB01003146    JAL95704.1    KZS04019.1    KQ971307    EFA11486.2    GDIQ01210015    JAK41710.1    GDIQ01047586    JAN47151.1    GDIP01061518    JAM42197.1    AJWK01024023    GGMR01004015    MBY16634.1    AANG04001761    AC106191    CH473975    EDL95610.1    GDIQ01256779    JAJ94945.1    GGMR01005057    MBY17676.1    AAEX03016326    UFQS01001092    UFQT01001092    SSX08968.1    SSX28879.1    AEMK02000056    CM000159    EDW94503.2    GEBF01001863    JAO01770.1    RAZU01000166    RLQ67524.1    AGTP01003576    CP012525    ALC45044.1    AAQR03026499    APCN01000824    CH954178    EDV51759.2    KK852669    KDR18862.1    GDAI01001056    JAI16547.1    AK009802    AK004174    BC033438    BC049222    AQIA01063301    AQIA01063302    AQIA01063303    AQIA01063304    JSUE03038745    JU473072    JV635502    AFH29876.1    AFJ70842.1    GAMQ01001351    GAMQ01001350    GAMP01001924    JAB40501.1    JAB50831.1    GAPW01004491    JAC09107.1    AEYP01046627   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000007151    UP000053240    + More
UP000037510    UP000037069    UP000183832    UP000007801    UP000007819    UP000000803    UP000095301    UP000248484    UP000252040    UP000245320    UP000248483    UP000265300    UP000095300    UP000000304    UP000261681    UP000092460    UP000189706    UP000001292    UP000245341    UP000091820    UP000248482    UP000076858    UP000007266    UP000286640    UP000092461    UP000011712    UP000078200    UP000002494    UP000189704    UP000002254    UP000092443    UP000286641    UP000245340    UP000008227    UP000291022    UP000002282    UP000286642    UP000192221    UP000248481    UP000273346    UP000005215    UP000233180    UP000233200    UP000092553    UP000005225    UP000076407    UP000075840    UP000008711    UP000027135    UP000233040    UP000000589    UP000233120    UP000233100    UP000233140    UP000028761    UP000233060    UP000233080    UP000006718    UP000075882    UP000233160    UP000000715    UP000081671   

PRIDE

H9JKG6    Q2F615    A8E6W0    B3DNC6    Q9CQ02   

Pfam

PF13639   zf-RING_2        + More
PF04377   ATE_C
PF04376   ATE_N
PF07258   COMM_domain

Interpro

IPR013083   Znf_RING/FYVE/PHD        + More
IPR001841   Znf_RING       
IPR017920   COMM       
IPR007472   N-end_Aminoacyl_Trfase_C       
IPR007471   N-end_Aminoacyl_Trfase_N       
IPR017137   Arg-tRNA-P_Trfase_1_euk       
IPR030700   N-end_Aminoacyl_Trfase       
IPR016181   Acyl_CoA_acyltransferase       
IPR037356   Commd4       
IPR020848   AP_endonuclease_F1_CS       

SUPFAM

SSF55729   SSF55729       

Gene 3D

3.30.40.10    

CDD

cd04752  Commd4

ProteinModelPortal

H9JKG6   Q2F615   A0A2H1VQ71   A0A437B5H2   A0A2A4IXW1   S4P3S3   + More
A0A194QD59   A0A0N1IE29   A0A212F7T9   A0A0N1I696   A0A0N1IBX4   A0A0L7LH38   A0A0L7KQ63   A0A0L0C571   A0A1J1I8P0   A0A1J1I6X6   B3M3F7   J9K1W9   A8E6W0   A0A1I8N895   B3DNC6   A0A0J9RUZ8   A0A2Y9FDY4   A0A341CRR1   A0A2U4CJS8   A0A2Y9P0Z5   A0A0P8XTA3   A0A340WIC0   A0A2H8TYK0   A0A1I8PAZ2   B4QK05   A0A384BEN9   A0A2F0B011   A0A1B0B1C4   A0A1L8DBX0   A0A1U7QYB5   B4HHR0   A0A2Y9FEB7   A0A2U4CJJ7   A0A2Y9NS79   A0A340WI20   A0A1L8DC73   A0A2U3YL91   A0A1A9W8F2   A0A2Y9KED8   A0A0P5VH94   A0A0P5UVR0   D6W6Z5   A0A0P5IR67   A0A0P6FGT3   A0A0P5Y876   A0A3Q7R9H7   A0A1B0CQS9   A0A2S2NHG8   A0A2I2UKZ2   A0A1A9VHP2   A0A0G2K6N9   A0A1U7TZJ7   A0A0N8AP35   A0A2S2NLL6   J9P188   A0A336KWJ0   A0A1A9XC74   A0A3Q7QCF7   A0A2U3WGJ8   A0A287B641   A0A452S8P1   B4PIE6   A0A3Q7UDU6   A0A0P6JXD9   A0A1W4U7D1   A0A2Y9HJ14   A0A3L7HNJ5   I3M6M5   A0A2K6L5K8   A0A2K6P6P7   A0A0M5JBP4   H0WKH2   A0A182X9B4   A0A182HKA2   B3ND37   A0A067RHZ0   A0A2K5QJ35   A0A0K8TQ82   Q9CQ02   A0A2K6BF95   A0A2K5V5H7   A0A2K5XBS8   A0A096N3R9   A0A2K5LJZ5   A0A2K5K703   H9Z1R0   A0A182L8I9   A0A2K6F3C8   U3FGD1   A0A023EJE9   M3Z0U8   A0A1S3EUA4  

KEGG

692870    K22560 COMM domain containing 4 | (RefSeq) COMMD4; COMM domain containing 4

GO

GO:0016021   GO:0004057   GO:0003677   GO:0004519   GO:0006281   GO:0005737   GO:0005634  

PANTHER

PTHR21367  

Subcellular location

Cytoplasm  
Nucleus  

Length:

194

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.70771

Exp number, first 60 AAs:

0.70681

Total prob of N-in:

0.11153

outside

1  -  194

 

 

Pi

225.582977

Theta

160.578433

Tajima's D

1.813221

CLR

0.190185

CSRT

0.852307384630768

Interpretation

Uncertain