Gene

KWMTBOMO03771  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA010024

Annotation

trypsin-like_protease_precursor_[Bombyx_mori]

Location

Bomo_Chr7(-):1389154-1391617      View in EpiBrowser

Full name

Trypsin, alkaline A      

Location in the cell

Extracellular   Reliability : 3.766

CDS

ATGGTTTCCGTTCTCACCTTAGCCGTAGCTGTGCTCGCTGCCGTCTGCAGCTGCACTGCTAGCGATCTCGGTAGACCTGTGTCTATTGGCGAGCATCCCAGCCTGGTCCAAATTGAAGTATTCCTACCCATCTTGAATCAATGGTTCCAACAGTGCGCTGGTATTGTTCTCACCAACTACCACTACCTTTCAACTGCTACCTGTTTCCATGGAGAATTCTACGATCCTGCATACCGTCGCATTATCGCTGGATCTTCCCGTCGCAGTGAGCCCGGTGAAATATCTTATGTTCACTTTGCTGTTAACCATCCCGAATTCTCTGAGGAGAATTACGACAAGGATGTGAGCATCGTACGAGTAACACATGCCATCCACTTCGGCCCAAACATCCAGCAGGGTGCTATTATCCAACAAGGTGTCGTAATACCCCAGGGTATTTTTGTTGATCTGCTCGGATGGGGAACTACCGTTCAAGGCGGCAGTGTATCTGACGGCAACCTCCACAAGCTCGAACTCATTGTGACCAACAAAGAAAACTGCAGGGAACAGTACAAGGGTCATGATCGCGTCGTGACTGATAACAAATTCTGCGCCGGTTTGGTCCGGGCTGGTGGCCGCGACTACGACAATACTGACTTGGGTGCCCCTGCCTTCTTCCAAAATGCGCTAGTAGGCATCGTATCTTTTGGAAAGAGCAATGCCAATGACATCTACCCCGTAGTACTCACCAGCATCAGTTCTTTCACTGAATGGATCCTACAAAACGTTCACTAA

Protein

MVSVLTLAVAVLAAVCSCTASDLGRPVSIGEHPSLVQIEVFLPILNQWFQQCAGIVLTNYHYLSTATCFHGEFYDPAYRRIIAGSSRRSEPGEISYVHFAVNHPEFSEENYDKDVSIVRVTHAIHFGPNIQQGAIIQQGVVIPQGIFVDLLGWGTTVQGGSVSDGNLHKLELIVTNKENCREQYKGHDRVVTDNKFCAGLVRAGGRDYDNTDLGAPAFFQNALVGIVSFGKSNANDIYPVVLTSISSFTEWILQNVH

Catalytic Activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Similarity

Belongs to the peptidase S1 family.

Keywords

Disulfide bond   Hydrolase   Protease   Secreted   Serine protease   Signal   Zymogen  

Feature

propeptide  Activation peptide
chain  Trypsin, alkaline A

Uniprot

Q1HPT9   H9JKH3   H9JKL1   G8GBC4   H9JKL2   A0A2H1VGN5   + More
A0A2H1W3R1   A0A2W1BN83   A0A1B1LTR2   A0A2A4JTK1   E0W9N5   A0A2H1VGP3   A5CG75   A0A0L7L5I1   A0A194QET8   A0A437BTC7   A0A2A4JTX8   A0A2H1W3L1   B4X9A2   C9W8J1   A0A194QD40   B1NLD8   A0A0M4M544   A0A3S2N5V1   A0A194QJ28   C9W8I5   A0A212EW56   A0A1E1WB94   A0A2H1VGQ2   Q9U4I4   Q9U4I5   A0A2W1BJP2   I6TEW4   A0A2A4JSY0   Q6R560   A0A2H1VGQ8   A0A0M4MT18   A0A2H1W591   I7C7Q2   C9W8I6   Q56IB0   A0A2A4JTP3   A0A437BSH3   Q56IB2   B1NLE4   A0A0L7L163   A0A0L7KYH0   A0A1E1W498   A0A2W1BTM0   B6D1Q8   A0A2W1BP62   Q56IB1   A0A1B0RHN8   O18439   A0A2A4JUT0   A0A2W1BN80   I7DEJ5   Q4L1L0   A0A0N1PGP3   A0A0N1I8C7   A0A2H1WEE4   A9P3S4   A0A2H1VGM7   Q9NB81   A0A1E1WML3   A0A089RSX5   A0A194QD45   A0A194QDG3   B6CME9   A0A0L7L171   A0A2A4JUR5   B4X9A3   A0A2H1VIA8   B4X9A4   Q9NB89   A0A223AIS8   A0A2W1BKF9   A0A194QDC5   A0A194PZV2   O62598   Q4L1L3   B6D1Q7   A0A2W1BF78   Q4L1K4   Q4L1L8   Q9TXE6   Q4L1L9   P35045   A0A2H1VIX1   A0A194R252   Q4L1K8   Q4L1L1   Q4L1M0   A0A2H1VSQ4   Q4L1K6   A0A2A4K6W3   A0A2W1BJK7   Q9NB80   A0A194PQQ5   A0A2A4K5I4  

EC Number

3.4.21.4

Pubmed

19121390    28756777    20824821    18634789    26227816    26354079    + More
18314941    22118469    10989289    15944081    22824002    16469064    19133073    9404008    15979001    19146482    11267903    18760362    10672067    8462672    8205142   

EMBL

DQ443313    KM027249    ABF51402.1    AIU94618.1    BABH01024730    BABH01024727    + More
BABH01024734    JN120256    AER70119.1    BABH01024728    BABH01024729    ODYU01002467    SOQ39995.1    ODYU01006115    SOQ47673.1    KZ150010    PZC75085.1    KX380991    ANS56507.1    NWSH01000631    PCG75149.1    FJ205419    ADM35106.1    SOQ39998.1    AM690450    CAM84320.1    JTDY01002795    KOB70712.1    KQ459167    KPJ03460.1    RSAL01000013    RVE53439.1    PCG75148.1    SOQ47675.1    EF531638    ABR88249.1    FJ205440    ACR16004.1    KPJ03458.1    EF600053    ABU98618.1    PZC75086.1    KR024672    ALE15214.1    RSAL01000347    RVE42309.1    KPJ03461.1    FJ205431    ACR15998.2    AGBW02012089    OWR45697.1    GDQN01006776    JAT84278.1    SOQ39997.1    AF173498    AAF24228.1    AF173497    AAF24227.1    PZC75088.1    JQ904129    AFM77759.1    PCG75147.1    AY513650    AAR98919.1    SOQ39996.1    KR024671    ALE15213.1    SOQ47674.1    JN793548    AFO68328.1    FJ205433    ACR15999.2    AY953064    AY953068    AAX62037.1    AAX63384.1    PCG75146.1    RVE53438.1    AY953065    AAX62038.1    EF600059    ABU98624.1    JTDY01003642    KOB69233.1    JTDY01004416    KOB68185.1    GDQN01009270    JAT81784.1    PZC75083.1    EU673451    ACI45414.1    PZC75087.1    AY953066    AAX62039.1    KM360185    AKH49601.1    Y12274    CAA72953.1    PCG75152.1    PZC75084.1    JN793549    AFO68329.1    AY587155    AAT95347.1    KQ460409    KPJ14943.1    KPJ14944.1    ODYU01007983    SOQ51222.1    EF104913    ABP96915.1    SOQ39999.1    AF261981    AAF74743.1    GDQN01011173    GDQN01002795    JAT79881.1    JAT88259.1    KM083776    AIR09757.1    KPJ03463.1    KPJ03459.1    EU325549    ACB54939.1    KOB69232.1    PCG75150.1    EF531639    EF531641    ABR88250.1    ABR88252.1    SOQ39994.1    EF531640    ABR88251.1    AF261973    AAF74735.1    KX951432    KY684226    ARR75600.1    ASS33865.1    KZ149992    PZC75529.1    KPJ03462.1    KQ459582    KPI98851.1    AF064525    AF064526    AAC36247.1    AAC36248.1    AY587152    AAT95344.1    EU673450    ACI45413.1    KZ150104    PZC73448.1    AY587161    AAT95353.1    AY587147    AAT95362.1    AY587146    AAT95361.1    L16805    ODYU01002820    SOQ40778.1    KQ460878    KPJ11594.1    AY587157    AAT95349.1    AY587154    AAT95346.1    AY587145    AAT95360.1    ODYU01004217    SOQ43865.1    AY587159    AAT95351.1    NWSH01000106    PCG79493.1    PZC73447.1    AF261982    AAF74744.1    KQ459597    KPI95074.1    PCG79487.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053268    UP000283053    UP000007151    + More
UP000053240   

PRIDE

Q1HPT9    H9JKH3    H9JKL1    G8GBC4    H9JKL2    Q9TXE6    + More
P35045   

Pfam

PF00089   Trypsin        + More
PF07743   HSCB_C
PF00226   DnaJ

Interpro

IPR001254   Trypsin_dom        + More
IPR009003   Peptidase_S1_PA       
IPR018114   TRYPSIN_HIS       
IPR001314   Peptidase_S1A       
IPR033116   TRYPSIN_SER       
IPR012224   Pept_S1A_FX       
IPR036869   J_dom_sf       
IPR009073   HscB_oligo_C       
IPR036386   HscB_C_sf       
IPR004640   HscB       
IPR001623   DnaJ_domain       

SUPFAM

SSF50494   SSF50494        + More
SSF47144   SSF47144       
SSF46565   SSF46565       

Gene 3D

1.10.287.110     1.20.1280.20    

CDD

cd00190  Tryp_SPc
cd06257  DnaJ

ProteinModelPortal

Q1HPT9   H9JKH3   H9JKL1   G8GBC4   H9JKL2   A0A2H1VGN5   + More
A0A2H1W3R1   A0A2W1BN83   A0A1B1LTR2   A0A2A4JTK1   E0W9N5   A0A2H1VGP3   A5CG75   A0A0L7L5I1   A0A194QET8   A0A437BTC7   A0A2A4JTX8   A0A2H1W3L1   B4X9A2   C9W8J1   A0A194QD40   B1NLD8   A0A0M4M544   A0A3S2N5V1   A0A194QJ28   C9W8I5   A0A212EW56   A0A1E1WB94   A0A2H1VGQ2   Q9U4I4   Q9U4I5   A0A2W1BJP2   I6TEW4   A0A2A4JSY0   Q6R560   A0A2H1VGQ8   A0A0M4MT18   A0A2H1W591   I7C7Q2   C9W8I6   Q56IB0   A0A2A4JTP3   A0A437BSH3   Q56IB2   B1NLE4   A0A0L7L163   A0A0L7KYH0   A0A1E1W498   A0A2W1BTM0   B6D1Q8   A0A2W1BP62   Q56IB1   A0A1B0RHN8   O18439   A0A2A4JUT0   A0A2W1BN80   I7DEJ5   Q4L1L0   A0A0N1PGP3   A0A0N1I8C7   A0A2H1WEE4   A9P3S4   A0A2H1VGM7   Q9NB81   A0A1E1WML3   A0A089RSX5   A0A194QD45   A0A194QDG3   B6CME9   A0A0L7L171   A0A2A4JUR5   B4X9A3   A0A2H1VIA8   B4X9A4   Q9NB89   A0A223AIS8   A0A2W1BKF9   A0A194QDC5   A0A194PZV2   O62598   Q4L1L3   B6D1Q7   A0A2W1BF78   Q4L1K4   Q4L1L8   Q9TXE6   Q4L1L9   P35045   A0A2H1VIX1   A0A194R252   Q4L1K8   Q4L1L1   Q4L1M0   A0A2H1VSQ4   Q4L1K6   A0A2A4K6W3   A0A2W1BJK7   Q9NB80   A0A194PQQ5   A0A2A4K5I4  

PDB

1FXY     E-value=3.43538e-15,     Score=197

KEGG

100101175    no KO assigned | (RefSeq) trypsin-like protease

GO

GO:0004252   GO:0005509   GO:0007596   GO:0051087   GO:0051259   GO:0097428   GO:0001671   GO:0005615   GO:0016021   GO:0006508   GO:0006811   GO:0016020   GO:0007155   GO:0000049   GO:0004812   GO:0043039   GO:0042555   GO:0048384  

PANTHER

PTHR14021  

Subcellular location

  

SignalP

Position:   1 - 20,         Likelihood:  0.987274

 

 

Length:

257

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.78634

Exp number, first 60 AAs:

1.71351

Total prob of N-in:

0.09083

outside

1  -  257

 

 

Pi

242.209396

Theta

205.072329

Tajima's D

0.874967

CLR

0.203819

CSRT

0.619369031548423

Interpretation

Uncertain