Gene

KWMTBOMO03698  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002750

Annotation

PREDICTED:_pyruvate_dehydrogenase_E1_component_beta_subunit_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr6(-):15788185-15793993      View in EpiBrowser

Full name

Pyruvate dehydrogenase E1 component subunit beta      

Location in the cell

Cytoplasmic   Reliability : 1.322 Mitochondrial   Reliability : 1.93

CDS

ATGGCATTAAAATCATCGCCGGCTGTTCTCGGGATGCTCACTCGATTATCCCGTCGCAGTTTTGCCACATCGAAAGCTCTGGCTTCTAAGCCGGTGACTGTAAGAGATGCTTTAAATCAAGCGATCGACGAGGAGATGGAGAGAGACGAGAAAGTCTTCGTTTTGGGAGAGGAAGTCGCTCAATACGATGGTGCCTACAAAGTTACAAGGGGTCTATGGAAGAAATATGGTGATAAAAGAGTTATCGACACACCCATCACAGAGGCAGGATTCGCCGGTATAGCTGTTGGAGCTGCTTTTGCAGGGCTCAAGCCTATTTGTGAATTCATGACCTTTAACTTCTCTATGCAAGCTATTGATCATATAATAAACTCAGCCGCCAAGACCTTCTATATGTCAGCTGGCACAGTACCAGTGCCAATAGTATTCCGAGGACCTAATGGAGCTGCCTCCGGTGTTGCCGCACAACATTCCCAGTGCTTTGGTGCCTGGTACAGCCACTGTCCAGGCCTTAAAGTTCTAATGCCTTATTCAGCAGAGGATGCTAAAGGTCTCCTGAAAGCTGCCATCAGGGATCCCGACCCAGTTGTTATGTTGGAAGATGAAATTATGTATGGTATACCATTCCCAATGTCAGATGAAGCCCAGTCCAAAGACTTTGTACTTCCTATTGGCAAAGCTAAGGTAGAAAGGGAGGGTCGGCATATCACGCTAGTGTGCGCTGGACGAGGCACCGACACCGCGCTCAAGGCCGCTGAACAACTGGCTGGAAGCAAGGGTATAGAATGTGAAGTAGTAAATCTAAGAACAATAAGGCCAATGGATTTCGACACGATCGCTCGGTCCATTGCCAAAACACATCATCTCATTACTGTAGAACAAGGATGGCCGCAATCTGGAATCGGCGCAGAGATCTGCGCCCGCGTCATGGAGTCGCCGTCGTTCTTCGAGCTAGATGCGCCGGTGTGGCGAGTGTGCGGCGCCGACGTGCCCATGCCCTACGCCAGGACGCTCGAGGCGCACGCGGTGCCCGGACCCGCCGACGTGGTGGACGCCGTCACCAACGTGCTCGGCAACAAAATCAGTGCAGTGCAAGCCCAGTAG

Protein

MALKSSPAVLGMLTRLSRRSFATSKALASKPVTVRDALNQAIDEEMERDEKVFVLGEEVAQYDGAYKVTRGLWKKYGDKRVIDTPITEAGFAGIAVGAAFAGLKPICEFMTFNFSMQAIDHIINSAAKTFYMSAGTVPVPIVFRGPNGAASGVAAQHSQCFGAWYSHCPGLKVLMPYSAEDAKGLLKAAIRDPDPVVMLEDEIMYGIPFPMSDEAQSKDFVLPIGKAKVEREGRHITLVCAGRGTDTALKAAEQLAGSKGIECEVVNLRTIRPMDFDTIARSIAKTHHLITVEQGWPQSGIGAEICARVMESPSFFELDAPVWRVCGADVPMPYARTLEAHAVPGPADVVDAVTNVLGNKISAVQAQ

Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

Catalytic Activity

[dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) + pyruvate = [dihydrolipoyllysine-residue acetyltransferase]-(R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Uniprot

H9IZR5   A0A194R8S3   A0A2H1V0P1   S4PDP5   A0A194PX57   A0A3S2NM84   + More
A0A212FA10   A0A182QQ36   A0A1S4H3X9   Q7QDU3   A0A336MXN1   A0A182UX13   A0A336MZK5   W5J7J0   A0A182XB08   A0A182HX81   A0A182LN80   A0A182NDJ7   A0A2M3Z685   A0A182K007   A0A182W3R4   A0A2M4AEX7   A0A2M4BSD4   B0XA87   A0A182LUG9   A0A182RBE4   A0A182YLY1   T1E2S0   Q17D51   A0A084VUL4   A0A182PEU7   A0A1S4F7M2   A0A1Q3FG45   A0A023ERL5   A0A182JDB8   A0A336MUR1   A0A1B6L2R2   A0A2P8XMD5   U5ESA2   V9IHF4   A0A2A3E2G8   A0A182FM08   Q1HPJ1   A0A1B6GEQ8   A0A1B6EG39   A0A195F310   A0A195DCA7   A0A158NE37   A0A067RJD6   A0A151WFB4   A0A195BBX2   A0A0A9Y541   E2C3B2   K7IXW5   A0A1B0EZK0   A0A1Y1LZ82   A0A2J7PL96   A0A1L8E0L6   A0A226DAT4   A0A182U880   A0A1D2N7U1   E9J7R1   U4TT33   A0A1I8Q9Y7   E2AI43   A0A1L8ECM4   A0A2Z5RE12   T1PC65   A0A1L8ED34   A0A151IGB1   A0A0V0GB25   A0A1I8MP09   Q8IGJ4   Q7K5K3   A0A1W4U638   A0A0K8TSX5   B4HZ58   B4NBF7   D6X401   A0A023FCH4   B4PQ74   A0A0L7QL62   T1IFK5   B3P5L5   A0A0N8E2A6   R4WDA4   A0A026W2Y6   A0A0K8VLY4   A0A034WCB5   A0A0K8UPM2   A0A1B0DP56   A0A154PL96   B4K754   E9HA87   A0A224XF23   W8B9P1   A0A2H8TQV1   A0A0M9A1W7   A0A2T7NTB3   A0A310SVU9  

EC Number

1.2.4.1

Pubmed

19121390    26354079    23622113    22118469    12364791    20920257    + More
23761445    20966253    25244985    24330624    17510324    24438588    24945155    29403074    21347285    24845553    25401762    26823975    20798317    20075255    28004739    30926861    27289101    21282665    23537049    26760975    25315136    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26369729    17994087    18362917    19820115    25474469    17550304    23691247    24508170    30249741    25348373    21292972    24495485   

EMBL

BABH01038020    BABH01038021    KQ460500    KPJ14238.1    ODYU01000144    SOQ34415.1    + More
GAIX01003581    JAA88979.1    KQ459589    KPI97598.1    RSAL01000004    RVE54562.1    AGBW02009536    OWR50563.1    AXCN02001759    AAAB01008849    EAA07168.2    UFQT01002647    SSX33849.1    SSX33847.1    ADMH02002024    ETN59931.1    APCN01005148    GGFM01003207    MBW23958.1    GGFK01005867    MBW39188.1    GGFJ01006855    MBW55996.1    DS232572    EDS43584.1    AXCM01004341    GALA01001045    JAA93807.1    CH477300    EAT44269.1    ATLV01016963    KE525139    KFB41658.1    GFDL01008534    JAV26511.1    GAPW01002274    JAC11324.1    UFQT01002648    SSX33850.1    GEBQ01022037    JAT17940.1    PYGN01001729    PSN33167.1    GANO01002449    JAB57422.1    JR047731    AEY60490.1    KZ288455    PBC25522.1    DQ443411    ABF51500.1    GECZ01031345    GECZ01018906    GECZ01016442    GECZ01016074    GECZ01008852    JAS38424.1    JAS50863.1    JAS53327.1    JAS53695.1    JAS60917.1    GEDC01000400    JAS36898.1    KQ981855    KYN34771.1    KQ980989    KYN10545.1    ADTU01001291    KK852597    KDR20584.1    KQ983219    KYQ46521.1    KQ976522    KYM82066.1    GBHO01015438    GBHO01015437    GBRD01002408    GBRD01002407    GDHC01008432    GDHC01003715    JAG28166.1    JAG28167.1    JAG63413.1    JAQ10197.1    JAQ14914.1    GL452318    EFN77558.1    AJWK01022514    GEZM01048918    GEZM01048917    JAV76287.1    NEVH01024426    PNF17106.1    GFDF01001816    JAV12268.1    LNIX01000025    MH799926    OXA42665.1    QBH74085.1    LJIJ01000160    ODN01322.1    GL768602    EFZ11142.1    KB631615    ERL84684.1    GL439639    EFN66894.1    GFDG01002309    JAV16490.1    FX983733    BAX07232.1    KA645715    AFP60344.1    GFDG01002310    JAV16489.1    KQ977726    KYN00275.1    GECL01001072    JAP05052.1    BT001756    AAN71511.1    AE014297    AY047573    AAF56855.2    AAK77305.1    GDAI01000141    JAI17462.1    CH480819    EDW53315.1    CH964232    EDW81121.2    KQ971379    EEZ97343.1    GBBI01000234    JAC18478.1    CM000160    EDW98343.1    KQ414934    KOC59353.1    ACPB03005784    CH954182    EDV53265.1    GDIQ01102606    GDIP01043210    GDIQ01068820    LRGB01002127    JAM60505.1    JAN25917.1    KZS08995.1    AK417369    BAN20584.1    KK107488    QOIP01000012    EZA49951.1    RLU16080.1    GDHF01012739    JAI39575.1    GAKP01006623    JAC52329.1    GDHF01023682    GDHF01022729    JAI28632.1    JAI29585.1    AJVK01007913    AJVK01007914    KQ434954    KZC12527.1    CH933806    EDW16367.1    GL732610    EFX71388.1    GFTR01005350    JAW11076.1    GAMC01012792    GAMC01012790    JAB93763.1    GFXV01004761    MBW16566.1    KQ435794    KOX74119.1    PZQS01000009    PVD24420.1    KQ759866    OAD62493.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000283053    UP000007151    UP000075886    + More
UP000007062    UP000075903    UP000000673    UP000076407    UP000075840    UP000075882    UP000075884    UP000075881    UP000075920    UP000002320    UP000075883    UP000075900    UP000076408    UP000008820    UP000030765    UP000075885    UP000075880    UP000245037    UP000242457    UP000069272    UP000078541    UP000078492    UP000005205    UP000027135    UP000075809    UP000078540    UP000008237    UP000002358    UP000092461    UP000235965    UP000198287    UP000075902    UP000094527    UP000030742    UP000095300    UP000000311    UP000078542    UP000095301    UP000000803    UP000192221    UP000001292    UP000007798    UP000007266    UP000002282    UP000053825    UP000015103    UP000008711    UP000076858    UP000053097    UP000279307    UP000092462    UP000076502    UP000009192    UP000000305    UP000053105    UP000245119   

PRIDE

H9IZR5    B0XA87    Q1HPJ1    Q8IGJ4    Q7K5K3    B4HZ58    + More
B4NBF7    D6X401    B4PQ74    B3P5L5    E9HA87   

Pfam

PF02780   Transketolase_C        + More
PF02779   Transket_pyr

Interpro

IPR027110   PDHB        + More
IPR029061   THDP-binding       
IPR033248   Transketolase_C       
IPR005475   Transketolase-like_Pyr-bd       
IPR009014   Transketo_C/PFOR_II       
IPR020683   Ankyrin_rpt-contain_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR002110   Ankyrin_rpt       

SUPFAM

SSF52518   SSF52518        + More
SSF52922   SSF52922       
SSF48403   SSF48403       

Gene 3D

3.40.50.920     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

H9IZR5   A0A194R8S3   A0A2H1V0P1   S4PDP5   A0A194PX57   A0A3S2NM84   + More
A0A212FA10   A0A182QQ36   A0A1S4H3X9   Q7QDU3   A0A336MXN1   A0A182UX13   A0A336MZK5   W5J7J0   A0A182XB08   A0A182HX81   A0A182LN80   A0A182NDJ7   A0A2M3Z685   A0A182K007   A0A182W3R4   A0A2M4AEX7   A0A2M4BSD4   B0XA87   A0A182LUG9   A0A182RBE4   A0A182YLY1   T1E2S0   Q17D51   A0A084VUL4   A0A182PEU7   A0A1S4F7M2   A0A1Q3FG45   A0A023ERL5   A0A182JDB8   A0A336MUR1   A0A1B6L2R2   A0A2P8XMD5   U5ESA2   V9IHF4   A0A2A3E2G8   A0A182FM08   Q1HPJ1   A0A1B6GEQ8   A0A1B6EG39   A0A195F310   A0A195DCA7   A0A158NE37   A0A067RJD6   A0A151WFB4   A0A195BBX2   A0A0A9Y541   E2C3B2   K7IXW5   A0A1B0EZK0   A0A1Y1LZ82   A0A2J7PL96   A0A1L8E0L6   A0A226DAT4   A0A182U880   A0A1D2N7U1   E9J7R1   U4TT33   A0A1I8Q9Y7   E2AI43   A0A1L8ECM4   A0A2Z5RE12   T1PC65   A0A1L8ED34   A0A151IGB1   A0A0V0GB25   A0A1I8MP09   Q8IGJ4   Q7K5K3   A0A1W4U638   A0A0K8TSX5   B4HZ58   B4NBF7   D6X401   A0A023FCH4   B4PQ74   A0A0L7QL62   T1IFK5   B3P5L5   A0A0N8E2A6   R4WDA4   A0A026W2Y6   A0A0K8VLY4   A0A034WCB5   A0A0K8UPM2   A0A1B0DP56   A0A154PL96   B4K754   E9HA87   A0A224XF23   W8B9P1   A0A2H8TQV1   A0A0M9A1W7   A0A2T7NTB3   A0A310SVU9  

PDB

3EXI     E-value=1.32108e-128,     Score=1177

KEGG

733134    K00162 pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1] | (RefSeq) pyruvate dehydrogena

PATHWAY

00010    Glycolysis / Gluconeogenesis - Bombyx mori (domestic silkworm)
00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00620    Pyruvate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0004739   GO:0016021   GO:0006086   GO:0045254   GO:0006090   GO:0005739   GO:0003824   GO:0008152   GO:0043565   GO:0005737   GO:0006432   GO:0000049   GO:0004812   GO:0043039   GO:0042555   GO:0048384  

PANTHER

PTHR11624  

Length:

367

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.5572

Exp number, first 60 AAs:

0.00018

Total prob of N-in:

0.05191

outside

1  -  367

 

 

Pi

4.080359

Theta

12.754612

Tajima's D

-2.00634

CLR

601.631141

CSRT

0.0124493775311234

Interpretation

Possibly Positive selection