Gene

KWMTBOMO03691  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA014337

Annotation

phenylalanyl-tRNA_synthetase_alpha_subunit_[Bombyx_mori]

Location

Bomo_Chr6(-):15619252-15628783      View in EpiBrowser

Full name

Phenylalanine--tRNA ligase alpha subunit       + More
Phenylalanine--tRNA ligase alpha subunit B      
Phenylalanine--tRNA ligase alpha subunit A      

Alternative Name

Phenylalanyl-tRNA synthetase alpha subunit
Phenylalanyl-tRNA synthetase alpha subunit B
Phenylalanyl-tRNA synthetase alpha subunit A

Location in the cell

Cytoplasmic   Reliability : 3.335

CDS

ATGGAATTGAACGAAAGAATTTTAAAGTATCTAGAAAACAGCGACAAAGCTGACACTTTAAAATTATGTGAAGAATTCAACGAAGAACATCAAAAAATAGTTGGTGCTGTAAAAAGTTTGGAAGCTCTTGAAATGGTTATTTCGGAAGCTGTTAAGATTACAAAATGGGAGTTAACTGAAGAAGGAGAACTCGTTGCTAATAATGGTAGCCACGAAGCCGTATTATACAGAAGTATACCAGACAGTGGTGTACCGCAATCTGAAGCTATGAAGATGGTACCAAATGCAAAGGTGGGATTCAGTAAAGCCATGTCATCTGGATGGATATACATAGATAAATCAAGTGGACCGCCCCTCGTCAAACGTAAAGTTGATTCAATTACAGACATTGTACAGGAGAACCTTAGTGAAATTAGAAAAGGTATAGATAATTTATCAGAAAATGTAAGAAATGACTATAAAAAAAGGAAACTTCTACAAGAGGTGACCATTAAAAGCTTCTTGCTGTCGAAGGGCCCCCAATTTGCGATAACAATAAAGAAATTGGAAACAGATTTAACAAGTGACATGTTGTTGAGTGGCTCGTGGAAGACTCTAGAATTCAAACCATATAATTTTGATGCTTTAGGCCAACCACCAGAATGTGGTCACCTCCATCCCCTCTTGAAAGTAAGGTCGGAATTCCGTGAGATATTCTTGGAAATGGGTTTCACGGAGATGCCGACAAATAAATACGTTGAGAGTTCATTCTGGAACTTTGACGCACTGTTCCAACCTCAACAGCACCCAGCCAGGGATGCTCACGACACATTCTTCATGTCCTCGCCTGCTGCCACCACGGAGTTCCCCATGGAATACCTGGAGAGGGTGAAGAAGGTGCACAGTAAAGGTGGATATGGCTCCCAGGGTTACAGATACGATTGGAAGATAGAGGAGGCGCAGAAGAACCTGCTGCGGACGCACACGACGGCGGTCAGCGCCAGGATGCTGTACCGGCTGGCGCAGCAGACAGAGTTCACTCCGCAGAAGTACTTCAGCATCGATAAGGTGTTCCGCAACGAGACCCTGGACGCCACCCACCTGGCGGAGTTCCACCAGGTGGAGGGCGTGGTCGCGGACCGCGGGCTCGGGCTCGCCGACCTCATCACCGTGCTGGACGCCTTCTTCAAGAGGCTCGGCTTCGACCAGCTGCAGTTCAAGCCGGCGTACAACCCCTACACCGAACCCAGCATGGAAATATTCGCATACCACACCGGTCTCGCCAAATGGATAGAGATTGGTAATTCGGGGGTGTTCAGACCTGAGATGCTGCTGCCCATGGGCCTGCCTGAGGACGTGAACGTGATAGCGTGGGGCCTGTCCCTCGAGCGGCCCACCATGATCAAGTACGGGCTCAACAACATCCGGGACCTGGTCGGGCCCAAGGTCGACCTGCGCATGGTCTACAACAACCCTATATGCAGGCTCGATAAATGA

Protein

MELNERILKYLENSDKADTLKLCEEFNEEHQKIVGAVKSLEALEMVISEAVKITKWELTEEGELVANNGSHEAVLYRSIPDSGVPQSEAMKMVPNAKVGFSKAMSSGWIYIDKSSGPPLVKRKVDSITDIVQENLSEIRKGIDNLSENVRNDYKKRKLLQEVTIKSFLLSKGPQFAITIKKLETDLTSDMLLSGSWKTLEFKPYNFDALGQPPECGHLHPLLKVRSEFREIFLEMGFTEMPTNKYVESSFWNFDALFQPQQHPARDAHDTFFMSSPAATTEFPMEYLERVKKVHSKGGYGSQGYRYDWKIEEAQKNLLRTHTTAVSARMLYRLAQQTEFTPQKYFSIDKVFRNETLDATHLAEFHQVEGVVADRGLGLADLITVLDAFFKRLGFDQLQFKPAYNPYTEPSMEIFAYHTGLAKWIEIGNSGVFRPEMLLPMGLPEDVNVIAWGLSLERPTMIKYGLNNIRDLVGPKVDLRMVYNNPICRLDK

Catalytic Activity

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)

Subunit

Tetramer of two alpha and two beta subunits.
Heterotetramer; dimer of two heterodimers formed by alpha and beta subunits.

Similarity

Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.

Keywords

Aminoacyl-tRNA synthetase   ATP-binding   Complete proteome   Cytoplasm   Ligase   Nucleotide-binding   Protein biosynthesis   Reference proteome  

Feature

chain  Phenylalanine--tRNA ligase alpha subunit

Uniprot

E0D4V6   A0A2A4JJB0   A0A2H1WLT8   A0A194QLR4   A0A437BLU6   A0A194RAE4   + More
A0A212F868   S4PH52   A0A088AIQ1   A0A2A3E4D1   D3TMA3   A0A310S6D0   A0A154PT15   E0VRM2   A0A1B0GP45   A0A1L8DI45   A0A1L8DI01   A0A1I8PSY0   A0A411G7W0   A0A3L8DYE5   A0A034WV89   T1PEK3   U5EMI8   A0A1W4WER8   W8BRK3   A0A1B0CKY7   A0A195C1N8   A0A026WQG6   A0A1Y1M1Y0   A0A336MBU6   A0A1B6GIY3   A0A1S3JL40   A0A151JYP4   E9I8G4   A0A1S3JW17   A0A2P8YLR5   A0A3B0KQI8   E2BHC4   A0A210PGA1   A0A1B6L7A2   A0A1S3D383   Q29HD7   D6X495   A0A1W4VVZ7   A0A195B4J1   A0A158NE23   A0A1B6HP45   B4M1Z5   E2AL16   A0A087TR50   T1JMN7   A0A2R5LHQ2   Q9W3J5   B3NWZ8   Q17GX1   B4Q0M0   A0A3S1AQY2   B4IKX4   A0A2C9JH77   B4L8H4   A0A2J7Q0D3   A0A182GQ23   B3MRL3   B4JNQ5   A0A0K8TKU5   A0A0P6IZE0   A0A2L2YDJ4   F6R3C1   A0A3Q2T2V2   Q7SYV0   A0A3Q2QHZ0   A0A1A9VWS1   A0A147A3L2   V4BB96   Q6AZG6   A0A3P8TNE0   A0A0L8H4S8   N6TC13   A0A3Q1C9N3   A0A0S7H6L4   A0A3Q1FRC6   A0A0M3QZ20   A0A3P9LK34   A0A3S2P8B6   A0A3N0YJ69   A0A3B3YMN1   M4A322   H2MP85   A0A087X612   A0A3B3UM54   A0A3B3CCR0   A0A452GH79   A0A1Q3F7K2   B4MSE6   A0A3B3CDP9   A0A3B3RZA8   A0A3Q3ENB8   A0A452GH70   A0A3P9I2B1   A0A067QTY8  

EC Number

6.1.1.20

Pubmed

26354079    22118469    23622113    20353571    20566863    30249741    + More
25348373    25315136    24495485    24508170    28004739    21282665    29403074    20798317    28812685    15632085    17994087    18362917    19820115    21347285    10731132    12537572    12537569    25427601    17510324    17550304    15562597    26483478    26369729    26999592    26561354    20431018    23254933    23537049    17554307    23542700    29451363    28562605    29240929    24845553   

EMBL

AB546861    BAJ14786.1    NWSH01001373    PCG71490.1    ODYU01009540    SOQ54041.1    + More
KQ459011    KPJ04386.1    RSAL01000033    RVE51460.1    KQ460500    KPJ14245.1    AGBW02009779    OWR49936.1    GAIX01003392    JAA89168.1    KZ288408    PBC26116.1    EZ422555    ADD18831.1    KQ768090    OAD53197.1    KQ435207    KZC15056.1    DS235478    EEB16028.1    AJVK01033103    GFDF01008080    JAV06004.1    GFDF01008079    JAV06005.1    MH366179    QBB01988.1    QOIP01000002    RLU25312.1    GAKP01000827    JAC58125.1    KA647124    AFP61753.1    GANO01001009    JAB58862.1    GAMC01007067    JAB99488.1    AJWK01016789    AJWK01016790    KQ978379    KYM94525.1    KK107138    EZA57931.1    GEZM01046476    JAV77207.1    UFQT01000622    SSX25857.1    GECZ01007399    JAS62370.1    KQ981456    KYN41563.1    GL761538    EFZ23166.1    PYGN01000508    PSN45173.1    OUUW01000016    SPP88889.1    GL448287    EFN84893.1    NEDP02076722    OWF35523.1    GEBQ01020369    GEBQ01018824    GEBQ01012823    JAT19608.1    JAT21153.1    JAT27154.1    CH379064    EAL31825.2    KQ971410    EEZ97297.1    KQ976603    KYM79418.1    ADTU01013158    GECU01031341    JAS76365.1    CH940651    EDW65699.1    GL440429    EFN65869.1    KK116372    KFM67589.1    JH429682    GGLE01004925    MBY09051.1    AE014298    AY051694    CH954180    EDV46827.1    CH477255    EAT45883.1    CM000162    EDX02291.1    RQTK01001630    RUS69584.1    CH480859    EDW52745.1    CH933815    EDW07949.1    NEVH01019970    PNF22041.1    JXUM01079615    KQ563136    KXJ74423.1    CH902622    EDV34418.1    CH916371    EDV92348.1    GDAI01002847    JAI14756.1    GDUN01000739    JAN95180.1    IAAA01010200    LAA05275.1    AAMC01089013    BC054256    GCES01013234    JAR73089.1    KB200049    ESP03312.1    BC078035    KQ419376    KOF83785.1    APGK01043776    KB741017    KB631644    ENN75273.1    ERL84957.1    GBYX01444639    JAO36780.1    CP012528    ALC48663.1    CM012444    RVE69083.1    RJVU01040446    ROL46203.1    AYCK01017612    GFDL01011577    JAV23468.1    CH963851    EDW75035.1    KK853274    KDR09105.1   

Proteomes

UP000218220    UP000053268    UP000283053    UP000053240    UP000007151    UP000005203    + More
UP000242457    UP000076502    UP000009046    UP000092462    UP000095300    UP000279307    UP000095301    UP000192223    UP000092461    UP000078542    UP000053097    UP000085678    UP000078541    UP000245037    UP000268350    UP000008237    UP000242188    UP000079169    UP000001819    UP000007266    UP000192221    UP000078540    UP000005205    UP000008792    UP000000311    UP000054359    UP000000803    UP000008711    UP000008820    UP000002282    UP000271974    UP000001292    UP000076420    UP000009192    UP000235965    UP000069940    UP000249989    UP000007801    UP000001070    UP000008143    UP000265000    UP000078200    UP000030746    UP000265080    UP000053454    UP000019118    UP000030742    UP000257160    UP000257200    UP000092553    UP000265180    UP000261480    UP000002852    UP000001038    UP000028760    UP000261500    UP000261560    UP000291020    UP000007798    UP000261540    UP000261660    UP000265200    UP000027135   

PRIDE

E0D4V6    Q9W3J5    Q7SYV0    Q6AZG6   

Pfam

PF18552   PheRS_DBD1        + More
PF18553   PheRS_DBD3
PF18554   PheRS_DBD2
PF01409   tRNA-synt_2d
PF18569   Thioredoxin_16

Interpro

IPR004529   Phe-tRNA-synth_IIc_asu        + More
IPR040725   PheRS_DBD3       
IPR040586   PheRS_DBD2       
IPR006195   aa-tRNA-synth_II       
IPR002319   Phenylalanyl-tRNA_Synthase       
IPR040724   PheRS_DBD1       
IPR041503   AIMP2_thioredoxin       
IPR036390   WH_DNA-bd_sf       
IPR003903   UIM_dom       
IPR036282   Glutathione-S-Trfase_C_sf       

SUPFAM

SSF46785   SSF46785        + More
SSF47616   SSF47616       

ProteinModelPortal

E0D4V6   A0A2A4JJB0   A0A2H1WLT8   A0A194QLR4   A0A437BLU6   A0A194RAE4   + More
A0A212F868   S4PH52   A0A088AIQ1   A0A2A3E4D1   D3TMA3   A0A310S6D0   A0A154PT15   E0VRM2   A0A1B0GP45   A0A1L8DI45   A0A1L8DI01   A0A1I8PSY0   A0A411G7W0   A0A3L8DYE5   A0A034WV89   T1PEK3   U5EMI8   A0A1W4WER8   W8BRK3   A0A1B0CKY7   A0A195C1N8   A0A026WQG6   A0A1Y1M1Y0   A0A336MBU6   A0A1B6GIY3   A0A1S3JL40   A0A151JYP4   E9I8G4   A0A1S3JW17   A0A2P8YLR5   A0A3B0KQI8   E2BHC4   A0A210PGA1   A0A1B6L7A2   A0A1S3D383   Q29HD7   D6X495   A0A1W4VVZ7   A0A195B4J1   A0A158NE23   A0A1B6HP45   B4M1Z5   E2AL16   A0A087TR50   T1JMN7   A0A2R5LHQ2   Q9W3J5   B3NWZ8   Q17GX1   B4Q0M0   A0A3S1AQY2   B4IKX4   A0A2C9JH77   B4L8H4   A0A2J7Q0D3   A0A182GQ23   B3MRL3   B4JNQ5   A0A0K8TKU5   A0A0P6IZE0   A0A2L2YDJ4   F6R3C1   A0A3Q2T2V2   Q7SYV0   A0A3Q2QHZ0   A0A1A9VWS1   A0A147A3L2   V4BB96   Q6AZG6   A0A3P8TNE0   A0A0L8H4S8   N6TC13   A0A3Q1C9N3   A0A0S7H6L4   A0A3Q1FRC6   A0A0M3QZ20   A0A3P9LK34   A0A3S2P8B6   A0A3N0YJ69   A0A3B3YMN1   M4A322   H2MP85   A0A087X612   A0A3B3UM54   A0A3B3CCR0   A0A452GH79   A0A1Q3F7K2   B4MSE6   A0A3B3CDP9   A0A3B3RZA8   A0A3Q3ENB8   A0A452GH70   A0A3P9I2B1   A0A067QTY8  

PDB

3L4G     E-value=0,     Score=1690

KEGG

100500762    K01889 phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] | (RefSeq) FRSA; phenylalanyl-tRNA syn

PATHWAY

00970    Aminoacyl-tRNA biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0005737   GO:0004826   GO:0006432   GO:0005524   GO:0000049   GO:0002161   GO:0009328   GO:0005829   GO:0051290   GO:0016874   GO:0000166   GO:0004812   GO:0043039   GO:0042555   GO:0048384  

Subcellular location

Cytoplasm  

Length:

491

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00802

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00330

outside

1  -  491

 

 

Pi

2.29378

Theta

19.443305

Tajima's D

-1.417405

CLR

21.434312

CSRT

0.0709964501774911

Interpretation

Uncertain