Gene

KWMTBOMO03690

Pre Gene Modal

BGIBMGA014352

Annotation

PREDICTED:_glutamate_dehydrogenase?_mitochondrial-like_[Papilio_machaon]

Location

Bomo_Chr6(-):15614802-15616093      View in EpiBrowser

Full name

Glutamate dehydrogenase       + More
Glutamate dehydrogenase 2, mitochondrial      
Glutamate dehydrogenase, mitochondrial      
Glutamate dehydrogenase 1, mitochondrial      

Location in the cell

Mitochondrial   Reliability : 2.084

CDS

ATGAATATAGGTGTAGCGATAAATCCAAAACAATATACTATCGCTGAACTGCAGAGAATAACGAGAAGATATACTTTAGAACTTGCGAAGAAGAATTATATCGGTGCCGGCATCGACGTTCCAGCACCCGACGTGAACACGTCCGGTCGGGAGATGTCCTGGATCGTGGACACCTACATCAAGACGCTTGGTAAACTGTCACCATCGCTTCACCCAGCAAGAGCTACAAAGCCCTCGAGTTCCTTACAATTATTATTCATCGGCCATCAAATAACTTATATCATCTATCAATGTAGCCAATAA

Protein

MNIGVAINPKQYTIAELQRITRRYTLELAKKNYIGAGIDVPAPDVNTSGREMSWIVDTYIKTLGKLSPSLHPARATKPSSSLQLLFIGHQITYIIYQCSQ

Description

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).

Catalytic Activity

H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+)
H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+)

Subunit

Homohexamer.

Miscellaneous

ADP can occupy the NADH binding site and activate the enzyme.

Similarity

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Keywords

ADP-ribosylation   Mitochondrion   NADP   Oxidoreductase   Transit peptide   Alternative splicing   ATP-binding   Complete proteome   GTP-binding   NAD   Nucleotide-binding   Reference proteome   3D-structure   Acetylation   Direct protein sequencing   Disease mutation   Phosphoprotein  

Feature

chain  Glutamate dehydrogenase 2, mitochondrial
splice variant  In isoform C.
sequence variant  In HHF6; diminished sensitivity to GTP.

Uniprot

A0A1B6I3X7   A0A1B6MCH4   A0A0A0N1J8   A0A1B6H6A7   A0A1B6LL06   A0A1B0G229   + More
A0A0J7KNC5   A0A226DZK2   A0A1B6GVV3   A0A1B6EYJ5   I0IVB6   A0A1A9W5Q9   A0A2R7W1V0   A0A2H1V7P9   A0A0L7RDB5   A0A2P8ZB91   A0A3B0JPB7   A0A0U2U7H1   A0A0C4DHE7   R9QZD7   A0A0U2ICK1   A0A3P4NIB8   A0A0U2USC9   A0A0U2SKB2   A0A1A9VDQ7   A0A0U2SMK1   A0A0U2U3U9   A0A0U2UL37   D3TQR2   A0A1A9ZSU9   A0A232F5M0   K7IYA3   A0A1A9Y0I5   A0A1B0B2Z8   A0A0U2SWY2   A0A3B0JK98   Q8IMY1   A0A0K8UDM9   A0A1L8EA44   A0A3Q0E467   A0A171A2I5   A0A1L8EAH7   A0A2J7PVK0   H2PWN9   Q64I00   G1S9P7   Q64HZ9   A0A1I9WLI4   M1ERX9   A0A0K8SKG2   A0A1B6CCS9   A0A2S2PHU9   T1PBD9   A0A091KT94   Q59FQ4   B3M317   A0A1I8NSV1   A0A1L8EEM7   V9ICN1   A0A3B0JQU1   P54385-2   A0A1W4UJV6   I5ANX6   B4QSD4   Q298M7   B4G4C1   A0A3B0KCM3   T1P987   B4PL48   B3P8B7   E2C3C7   B4N9E8   B4HG10   A0A1S4FQT2   P54385   B4M0C5   A0A2U3YY02   A0A3Q0E0N0   A0A1L8EER7   A0A0Q9WUT7   A0A1I8NSU8   A0A2S2PUP3   P00367-3   B4K740   T1HLZ6  

EC Number

1.4.1.3

Pubmed

29403074    10731132    12537568    12537572    12537573    12537574    + More
16110336    17569856    17569867    24330026    20353571    28648823    20075255    26109357    26109356    15378063    27538518    23236062    26823975    25315136    17994087    10992165    12537569    6810872    15632085    17550304    20798317    17510324    3426581    3377777    3399399    3368458    8486350    14702039    15164054    15489334    429360    1286669    3585334    8314555    16023112    19608861    21269460    24275569    25944712    11254391    11903050    16959573    12054821    12653548    10338089    9571255    10636977    11214910    11297618   

EMBL

GECU01026111    JAS81595.1    GEBQ01006359    JAT33618.1    JQ861712    AGC92240.1    + More
GECU01037447    JAS70259.1    GEBQ01015586    JAT24391.1    CCAG010010758    LBMM01005184    KMQ91741.1    LNIX01000008    OXA50902.1    GECZ01003209    GECZ01000641    JAS66560.1    JAS69128.1    GECZ01026752    GECZ01010743    JAS43017.1    JAS59026.1    AB706394    BAM09215.1    KK854250    PTY13716.1    ODYU01001114    SOQ36873.1    KQ414615    KOC68746.1    PYGN01000117    PSN53762.1    OUUW01000007    SPP82763.1    KU234365    ALR85856.1    AE014297    AAN13963.3    JX125591    AGG09855.1    KU234369    ALR85860.1    CYRY02020334    VCW97027.1    KU234368    ALR85859.1    KU234367    ALR85858.1    KU234366    ALR85857.1    KU234364    ALR85855.1    KU234363    ALR85854.1    EZ423764    ADD20040.1    NNAY01000875    OXU26104.1    JXJN01007741    JXJN01007742    JXJN01007743    KU234370    ALR85861.1    SPP82764.1    BT128894    AAN13962.1    AEO46471.1    GDHF01027829    JAI24485.1    GFDG01003225    JAV15574.1    GEMB01001566    JAS01593.1    GFDG01003226    JAV15573.1    NEVH01020956    PNF20356.1    ABGA01245569    AY588268    ADFV01008835    AY588269    KU932368    APA34004.1    JP010539    AER99136.1    GBRD01012534    GDHC01009264    JAG53290.1    JAQ09365.1    GEDC01026153    JAS11145.1    GGMR01012767    GGMR01016376    MBY25386.1    MBY28995.1    KA645293    AFP59922.1    KK753902    KFP42693.1    AB209406    BAD92643.1    CH902617    EDV42417.1    GFDG01001617    JAV17182.1    JR038794    AEY58417.1    SPP82762.1    Y11314    Z29062    AY061323    BT001501    CM000070    EIM52661.1    CM000364    EDX14133.1    EAL27928.2    CH479179    EDW24469.1    SPP82761.1    KA645292    AFP59921.1    CM000160    EDW99033.1    CH954182    EDV53941.1    GL452320    EFN77465.1    CH964232    EDW80581.1    CH480815    EDW43403.1    CH940650    EDW67287.1    GFDG01001619    JAV17180.1    KRF99304.1    GGMS01000045    MBY69248.1    X07674    M20867    M37154    X07769    J03248    X66300    X66301    X66302    X66303    X66304    X66305    X66306    X66307    X66308    X66309    X66311    X66312    AK122685    AK294685    AL136982    CH471142    BC040132    BC112946    X67491    CH933806    EDW16353.1    ACPB03009469    ACPB03009470    ACPB03009471    ACPB03009472   

Proteomes

UP000092444    UP000036403    UP000198287    UP000091820    UP000053825    UP000245037    + More
UP000268350    UP000000803    UP000078200    UP000092445    UP000215335    UP000002358    UP000092443    UP000092460    UP000189704    UP000235965    UP000001595    UP000001073    UP000095301    UP000007801    UP000095300    UP000192221    UP000001819    UP000000304    UP000008744    UP000002282    UP000008711    UP000008237    UP000007798    UP000001292    UP000008792    UP000245341    UP000005640    UP000009192    UP000015103   

PRIDE

Q8IMY1    Q64I00    Q64HZ9    Q59FQ4    P54385    P00367    + More

Pfam

PF02812   ELFV_dehydrog_N        + More
PF00208   ELFV_dehydrog

Interpro

IPR006097   Glu/Leu/Phe/Val_DH_dimer_dom        + More
IPR006095   Glu/Leu/Phe/Val_DH       
IPR033524   Glu/Leu/Phe/Val_DH_AS       
IPR006096   Glu/Leu/Phe/Val_DH_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR014362   Glu_DH       
IPR033922   NAD_bind_Glu_DH       

SUPFAM

SSF51735   SSF51735       

CDD

cd01076  NAD_bind_1_Glu_DH

ProteinModelPortal

A0A1B6I3X7   A0A1B6MCH4   A0A0A0N1J8   A0A1B6H6A7   A0A1B6LL06   A0A1B0G229   + More
A0A0J7KNC5   A0A226DZK2   A0A1B6GVV3   A0A1B6EYJ5   I0IVB6   A0A1A9W5Q9   A0A2R7W1V0   A0A2H1V7P9   A0A0L7RDB5   A0A2P8ZB91   A0A3B0JPB7   A0A0U2U7H1   A0A0C4DHE7   R9QZD7   A0A0U2ICK1   A0A3P4NIB8   A0A0U2USC9   A0A0U2SKB2   A0A1A9VDQ7   A0A0U2SMK1   A0A0U2U3U9   A0A0U2UL37   D3TQR2   A0A1A9ZSU9   A0A232F5M0   K7IYA3   A0A1A9Y0I5   A0A1B0B2Z8   A0A0U2SWY2   A0A3B0JK98   Q8IMY1   A0A0K8UDM9   A0A1L8EA44   A0A3Q0E467   A0A171A2I5   A0A1L8EAH7   A0A2J7PVK0   H2PWN9   Q64I00   G1S9P7   Q64HZ9   A0A1I9WLI4   M1ERX9   A0A0K8SKG2   A0A1B6CCS9   A0A2S2PHU9   T1PBD9   A0A091KT94   Q59FQ4   B3M317   A0A1I8NSV1   A0A1L8EEM7   V9ICN1   A0A3B0JQU1   P54385-2   A0A1W4UJV6   I5ANX6   B4QSD4   Q298M7   B4G4C1   A0A3B0KCM3   T1P987   B4PL48   B3P8B7   E2C3C7   B4N9E8   B4HG10   A0A1S4FQT2   P54385   B4M0C5   A0A2U3YY02   A0A3Q0E0N0   A0A1L8EER7   A0A0Q9WUT7   A0A1I8NSU8   A0A2S2PUP3   P00367-3   B4K740   T1HLZ6  

PDB

6G2U     E-value=3.9998e-22,     Score=252

KEGG

101738956    K00261 glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] | (RefSeq) glutamate dehydrogenase, mitochondr

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
00471    D-Glutamine and D-glutamate metabolism - Bombyx mori (domestic silkworm)
00910    Nitrogen metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0006520   GO:0016639   GO:0000166   GO:0047952   GO:0004352   GO:0004367   GO:0070728   GO:0005739   GO:0006537   GO:0043531   GO:0005525   GO:0006538   GO:0005759   GO:0004353   GO:0006116   GO:0042802   GO:0006536   GO:0005524   GO:0005829   GO:0005737   GO:0019551   GO:0070403   GO:0032024   GO:0006541   GO:0008652   GO:0072350   GO:0021762   GO:0009226   GO:0005515   GO:0051103   GO:0008270   GO:0042555   GO:0048384   GO:0055114  

Subcellular location

Mitochondrion matrix  

Length:

100

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06553

Exp number, first 60 AAs:

0.00022

Total prob of N-in:

0.27703

outside

1  -  100

 

 

Pi

12.604882

Theta

12.973646

Tajima's D

-0.413063

CLR

0.66258

CSRT

0.266586670666467

Interpretation

Uncertain