Gene

KWMTBOMO03666  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA002208

Annotation

PREDICTED:_50S_ribosomal_protein_L1_[Papilio_xuthus]

Location

Bomo_Chr6(+):15219390-15227760      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase      

Location in the cell

Mitochondrial   Reliability : 2.156

CDS

ATGGCTGGGACTATTTTCCGTTTGCTTTTGACCAATACCACTTCAGCCCACAAAAATATTACAACTATTAGATCCATAAACACAGGAACGGTATCATATGCAGCCAGGAAAGGTACAAGAGCTAAGGCACGTGCAAAAAAAATTCAAGTTGAAGTCACAAAAGTTGGTTTCATTCCGCACAATCAAAGAGGAAGAAAGGTAGTTAAAACAGTGGTGAACAAGCATTTCAGCGATGAGCACAAAGCGATACCCATTGACGATGTGTATCCTATGAAGTATTACAAATGGGTGGTTTACACAGCTGAGGATGCAGTCAAAGCCCACCAGGAGACCCACCACCCGACCATGTTTAATGCACCTGATGCCTTCATCTTTGCAAAAATTGAATTTAACATGACTGGTATAAAGCAGACTCGATTCATGGATAGTTTCACTCGTTTGTCCTTGCTGCCTCATCCTTTCCCAAGAGAAGAAGAGCGCACTATTCTTGCCTTCTGTAAAGGAGCAGAGTTAATCAAGGAATTACAAGATGCAGGTGCTACAGTGGCTGGAGGCACAGATATTGTTAAGAAGATACAGGATGGTCAGATCAAATTATTTGAATATGATTACGTTGTAGCCCATCCAAACATATTGACGGATTTAGTGCCAATCCGTGGTCTCATGAAGAAGCGGTTCCCTAACGTGAGGTCTGGAACCCTGGACCCTAATCTGAAGGAGTTGGTGAAAAAGTTTGCTGGAGGTATCCAATATAAAGTAATAAAAGACGAAGCGCAACCGAGTTTTGGATCTGTAGAAGTACCAGTTGGCCGGTTAAATATGGAACCAAAGCAAGTGGCTGAAAATATTGGAAAATTGCTAAAAGACGTGCAGGCTGTCCGCCCCAAGAGAGATGGGCTCTTCGTAACAAGATGCCTGTTGGTAAGTCCTCCATCTACGGAGCAATTAATGATTGATCCGTTCGTGTTCGTAGATAGAACACTCTCGAAAGAGGTTCAAGATGATAGCGATGACGAAGACGAGCCCGTGGCGGCCACAGCGTAA

Protein

MAGTIFRLLLTNTTSAHKNITTIRSINTGTVSYAARKGTRAKARAKKIQVEVTKVGFIPHNQRGRKVVKTVVNKHFSDEHKAIPIDDVYPMKYYKWVVYTAEDAVKAHQETHHPTMFNAPDAFIFAKIEFNMTGIKQTRFMDSFTRLSLLPHPFPREEERTILAFCKGAELIKELQDAGATVAGGTDIVKKIQDGQIKLFEYDYVVAHPNILTDLVPIRGLMKKRFPNVRSGTLDPNLKELVKKFAGGIQYKVIKDEAQPSFGSVEVPVGRLNMEPKQVAENIGKLLKDVQAVRPKRDGLFVTRCLLVSPPSTEQLMIDPFVFVDRTLSKEVQDDSDDEDEPVAATA

Description

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Similarity

Belongs to the SINA (Seven in absentia) family.

Uniprot

H9IY75   A0A2A4JA26   A0A2H1WHT2   A0A194QHF4   A0A212EI69   A0A194REB1   + More
A0A0L7LMS5   A0A1J1HWF5   A0A0M4EPU9   B4K7W0   B4JH28   A0A0K8TSC8   A0A1I8MEP7   B3NZU8   A0A1I8PVL7   A0A3B0JP31   J3JVE1   B4HLM6   B4M5Q3   N6UMU6   Q9VHT5   B4NAF2   A0A1W4VVT4   B3M0D1   B4PT35   A0A1A9UZ15   Q298H4   B4G3S1   A0A1A9Z9M8   A0A1B0GAV3   A0A0L0CRW0   A0A1B0BQ35   A0A336MRE8   A0A182JW95   T1GK75   A0A182LA50   A0A182RSX3   A0A1Q3FDU6   A0A0A1X437   A0A034VD95   A0A1Y9IW17   A0A182HLQ4   Q7PY42   A0A023EQC2   A0A1A9XG75   B0W376   Q17CA4   W8BXJ3   A0A182UEC9   A0A182UQU6   A0A084VZE8   A0A182LV61   A0A182H1U7   A0A1Y9HAI6   A0A182Y3U9   A0A182IP59   A0A1S4F875   A0A0K8WCC9   A0A1A9WY60   U5ET83   A0A182FPX3   A0A336MSJ3   A0A182PSG9   A0A2M4BS39   A0A2M4BSC4   W5JF00   A0A2M3Z8T8   A0A2M4AM80   A0A182NSV5   A0A182WSV1   A0A1L8DRT3   A0A1Y1LFT1   A0A1L8DRJ6   A0A1B6LGQ7   A0A0A9VZT1   A0A2P8XFF2   A0A067RP01   A0A069DSQ3   A0A1B6IVC6   R4WPM2   A0A1B6FXW7   A0A158NMT4   A0A195EXW9   D6X497   A0A2J7RS27   A0A1W4WEA6   A0A1W4WDB1   F4WTC0   A0A195BBY1   A0A3L8D4G1   A0A195C7M0   A0A1B6CAE8   A0A0P4VMZ6   A0A151WUS3   A0A0T6BA46   A0A151JM45   A0A088AET5   A0A1B0D1M8   E2ALJ5  

EC Number

2.3.2.27

Pubmed

19121390    26354079    22118469    26227816    17994087    26369729    + More
25315136    22516182    23537049    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    15632085    26108605    20966253    25830018    25348373    12364791    14747013    17210077    24945155    17510324    24495485    24438588    26483478    25244985    20920257    23761445    28004739    25401762    29403074    24845553    26334808    23691247    21347285    18362917    19820115    21719571    30249741    27129103    20798317   

EMBL

BABH01038379    BABH01038380    BABH01038381    NWSH01002281    PCG68699.1    ODYU01008429    + More
SOQ52024.1    KQ459011    KPJ04365.1    AGBW02014704    OWR41160.1    KQ460500    KPJ14266.1    JTDY01000596    KOB76526.1    CVRI01000026    CRK92349.1    CP012526    ALC46210.1    CH933806    EDW14294.1    CH916369    EDV92719.1    GDAI01000555    JAI17048.1    CH954181    EDV49946.1    OUUW01000007    SPP82673.1    BT127208    KB632192    AEE62170.1    ERL89871.1    CH480815    EDW43053.1    CH940652    EDW58979.1    APGK01017031    KB739995    ENN82021.1    AE014297    AY051800    AAF54214.2    AAK93224.1    CH964232    EDW80766.1    CH902617    EDV43137.1    CM000160    EDW96496.1    CM000070    EAL27981.1    CH479179    EDW24392.1    CCAG010010901    JRES01000007    KNC34927.1    JXJN01018364    UFQS01002153    UFQT01002153    SSX13352.1    SSX32786.1    CAQQ02392881    GFDL01009305    JAV25740.1    GBXI01008864    JAD05428.1    GAKP01017691    JAC41261.1    APCN01000910    AAAB01008987    EAA00834.3    GAPW01002328    JAC11270.1    DS231831    EDS31219.1    CH477310    EAT43971.1    GAMC01002553    JAC04003.1    ATLV01018748    KE525248    KFB43342.1    AXCM01000028    JXUM01023254    KQ560656    KXJ81406.1    AXCN02001149    GDHF01003799    JAI48515.1    GANO01002895    JAB56976.1    UFQT01001768    SSX31733.1    GGFJ01006691    MBW55832.1    GGFJ01006690    MBW55831.1    ADMH02001345    ETN62937.1    GGFM01004161    MBW24912.1    GGFK01008521    MBW41842.1    GFDF01005024    JAV09060.1    GEZM01056990    JAV72522.1    GFDF01005025    JAV09059.1    GEBQ01017095    JAT22882.1    GBHO01045494    JAF98109.1    PYGN01002348    PSN30702.1    KK852553    KDR21469.1    GBGD01002128    JAC86761.1    GECU01016810    JAS90896.1    AK417611    BAN20826.1    GECZ01014876    JAS54893.1    ADTU01020803    KQ981940    KYN32742.1    KQ971410    EEZ97527.1    NEVH01000595    PNF43636.1    GL888334    EGI62583.1    KQ976529    KYM81727.1    QOIP01000014    RLU15021.1    KQ978231    KYM96161.1    GEDC01026979    GEDC01019601    GEDC01010631    JAS10319.1    JAS17697.1    JAS26667.1    GDKW01002884    JAI53711.1    KQ982729    KYQ51578.1    LJIG01002739    KRT84201.1    KQ978946    KYN27399.1    AJVK01022206    GL440609    EFN65697.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000007151    UP000053240    UP000037510    + More
UP000183832    UP000092553    UP000009192    UP000001070    UP000095301    UP000008711    UP000095300    UP000268350    UP000030742    UP000001292    UP000008792    UP000019118    UP000000803    UP000007798    UP000192221    UP000007801    UP000002282    UP000078200    UP000001819    UP000008744    UP000092445    UP000092444    UP000037069    UP000092460    UP000075881    UP000015102    UP000075882    UP000075900    UP000075920    UP000075840    UP000007062    UP000092443    UP000002320    UP000008820    UP000075902    UP000075903    UP000030765    UP000075883    UP000069940    UP000249989    UP000075886    UP000076408    UP000075880    UP000091820    UP000069272    UP000075885    UP000000673    UP000075884    UP000076407    UP000245037    UP000027135    UP000005205    UP000078541    UP000007266    UP000235965    UP000192223    UP000007755    UP000078540    UP000279307    UP000078542    UP000075809    UP000078492    UP000005203    UP000092462    UP000000311   

PRIDE

H9IY75    Q9VHT5   

Pfam

PF00687   Ribosomal_L1        + More
PF03145   Sina

Interpro

IPR023674   Ribosomal_L1-like        + More
IPR028364   Ribosomal_L1/biogenesis       
IPR016095   Ribosomal_L1_3-a/b-sand       
IPR005879   Ribosomal_L1_mit       
IPR008974   TRAF-like       
IPR018121   7-in-absentia-prot_TRAF-dom       
IPR004162   SINA-like       
IPR013010   Znf_SIAH       
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       

SUPFAM

SSF56808   SSF56808        + More
SSF49599   SSF49599       

Gene 3D

3.40.50.790     2.60.210.10     3.30.40.10    

CDD

cd00403  Ribosomal_L1

ProteinModelPortal

H9IY75   A0A2A4JA26   A0A2H1WHT2   A0A194QHF4   A0A212EI69   A0A194REB1   + More
A0A0L7LMS5   A0A1J1HWF5   A0A0M4EPU9   B4K7W0   B4JH28   A0A0K8TSC8   A0A1I8MEP7   B3NZU8   A0A1I8PVL7   A0A3B0JP31   J3JVE1   B4HLM6   B4M5Q3   N6UMU6   Q9VHT5   B4NAF2   A0A1W4VVT4   B3M0D1   B4PT35   A0A1A9UZ15   Q298H4   B4G3S1   A0A1A9Z9M8   A0A1B0GAV3   A0A0L0CRW0   A0A1B0BQ35   A0A336MRE8   A0A182JW95   T1GK75   A0A182LA50   A0A182RSX3   A0A1Q3FDU6   A0A0A1X437   A0A034VD95   A0A1Y9IW17   A0A182HLQ4   Q7PY42   A0A023EQC2   A0A1A9XG75   B0W376   Q17CA4   W8BXJ3   A0A182UEC9   A0A182UQU6   A0A084VZE8   A0A182LV61   A0A182H1U7   A0A1Y9HAI6   A0A182Y3U9   A0A182IP59   A0A1S4F875   A0A0K8WCC9   A0A1A9WY60   U5ET83   A0A182FPX3   A0A336MSJ3   A0A182PSG9   A0A2M4BS39   A0A2M4BSC4   W5JF00   A0A2M3Z8T8   A0A2M4AM80   A0A182NSV5   A0A182WSV1   A0A1L8DRT3   A0A1Y1LFT1   A0A1L8DRJ6   A0A1B6LGQ7   A0A0A9VZT1   A0A2P8XFF2   A0A067RP01   A0A069DSQ3   A0A1B6IVC6   R4WPM2   A0A1B6FXW7   A0A158NMT4   A0A195EXW9   D6X497   A0A2J7RS27   A0A1W4WEA6   A0A1W4WDB1   F4WTC0   A0A195BBY1   A0A3L8D4G1   A0A195C7M0   A0A1B6CAE8   A0A0P4VMZ6   A0A151WUS3   A0A0T6BA46   A0A151JM45   A0A088AET5   A0A1B0D1M8   E2ALJ5  

PDB

2FTC     E-value=2.81262e-15,     Score=199

KEGG

101736359    K02863 large subunit ribosomal protein L1 | (RefSeq) uncharacterized LOC101736359

GO

GO:0005840   GO:0016021   GO:0003735   GO:0006412   GO:0005739   GO:0003723   GO:0015934   GO:0032543   GO:0005762   GO:0022625   GO:0000470   GO:0008270   GO:0006511   GO:0016567   GO:0005634   GO:0007275   GO:0003676   GO:0005515   GO:0051103   GO:0005524   GO:0042555   GO:0048384  

PANTHER

PTHR45877  

Length:

347

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00365

Exp number, first 60 AAs:

0.00114

Total prob of N-in:

0.00265

outside

1  -  347

 

 

Pi

5.042268

Theta

17.3216

Tajima's D

-1.262076

CLR

17.920576

CSRT

0.0902454877256137

Interpretation

Uncertain