Gene

KWMTBOMO03656  Validated by peptides from experiments

Annotation

PREDICTED:_ras-related_protein_Rab-18-like_[Papilio_xuthus]

Location

Bomo_Chr6(+):14819319-14822086      View in EpiBrowser

Full name

Ras-related protein Rab-18      

Location in the cell

Cytoplasmic   Reliability : 3.015

CDS

ATGGATTGTGTGGCTAAATTGAAAATTCTGTTGCTTGGTGAGAGTGGCGTTGGTAAATCTAGTATTATATTAGCGTTCACAAAAGGCGACTACCAAGCACAGTTCCCTGCTACAATCGGAGTGGACTACAACCATAAGATTATGGATGTAAATGGACTAAAAGTTAAACTCGGAATTTGGGATACGGCAGGACAAGAACGATATAGAACTTTAACAACCAGTTTTTACAGAGAAGCGCACGGTGCTATATTAGTTTATGACGTATCTGAACCAAAAACCTTAGCAAAGTTAAACGAATGGGTTGAAGAGTTACAAGTTTACACTACGAATAAGAATATTGTCTGTTTGGTCGTTGGAAATAAAATTGATAAGGATAGAGCGGTACCCCGTGAACACGGTCAGGCCTTCGCTCAGAAACACAGAATGCTTTTCATCGAGAGCAGTGCTAAAACACAAGAAGGCATACATCTCGCCTTTGAGGAACTGACCCAAAAGATTATCGAAACTCCTGGATTATGGGAGAAAGACACATCGGCTTCAAACATTCGGGTTACAGAGGAAGAAGCGAGAGAACAAGGTGGATCGTGCTACGAAACAACTTGTTCCATAAAATAA

Protein

MDCVAKLKILLLGESGVGKSSIILAFTKGDYQAQFPATIGVDYNHKIMDVNGLKVKLGIWDTAGQERYRTLTTSFYREAHGAILVYDVSEPKTLAKLNEWVEELQVYTTNKNIVCLVVGNKIDKDRAVPREHGQAFAQKHRMLFIESSAKTQEGIHLAFEELTQKIIETPGLWEKDTSASNIRVTEEEAREQGGSCYETTCSIK

Description

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).

Similarity

Belongs to the small GTPase superfamily. Rab family.

Keywords

Acetylation   Cell membrane   Complete proteome   Developmental protein   GTP-binding   Lipoprotein   Membrane   Methylation   Nucleotide-binding   Palmitate   Phosphoprotein   Prenylation   Protein transport   Reference proteome   Transport  

Feature

chain  Ras-related protein Rab-18
propeptide  Removed in mature form

Uniprot

A0A194QFU9   S4NSQ9   A0A2H1W832   A0A2A4JCG2   H9IY70   A0A0P5TEN8   + More
A0A0P6I0E2   Q4SP01   A0A182U381   H3CR18   A0A182VI95   A0A182X412   Q7QGS6   A0A182I5I1   A0A2M3Z771   A0A1D2MLI6   A0A2M4AEF2   A0A2M4BZY9   W5JHW0   A0A182FKC3   E9HIT2   Q6P129   A0A2M4ADU3   T1L4D2   A0A067R6Y7   Q6UYC2   A0A182JCY5   A0A224XKC4   A0A069DQ33   Q0PD38   P35293   A0A3Q0DBU1   G3H3P1   A0A0V0G3Q6   A0A3Q3MIQ1   A0A182PJB0   A0A2Y9E3D5   A0A250YCA0   A0A2K5KNJ8   Q5EB77   A0A1B6I787   A0A1B6FI41   A0A1S3F0L0   I3MN66   A0A286XYW4   A0A0A9XZW7   S4RKZ6   G1TFB5   W5ML35   A0A084VSJ3   G3PVK7   A0A3Q0RKF1   Q28D30   A0A1S2ZX50   A0A182YKM2   A0A182KCB3   A0A1S3Q7V2   A0A182NC92   F6ZX76   A0A1B6KBP7   V9LD26   G3W037   A0A182MC58   A0A061I5P2   A0A3Q3IQ05   A0A060X2Z0   A0A1Q3FHQ6   A0A3B4EXZ0   A0A3Q3CI90   A0A3P8Q0A4   A0A3P9BM22   A0A182QMF7   A0A3Q3FZ10   A0A3Q4MHH7   I3KQW0   A0A3B5BJQ7   A0A0P6IVG1   A0A1D5R5M1   A0A3P8U173   A0A3Q1BJA5   A0A182HB16   H3AT07   A0A226EPC4   Q6GM52   A0A3B3SCQ0   H2SHQ6   T1HYX3   A0A3Q3SBI4   G1KE45   A0A2I4CAC4   A0A3Q1GN16   B0WBF2   E6ZI64   A0A3B3WV80   A0A087Y666   A0A3B3UQZ0   A0A182H3F1   Q7ZY33   A0A315V1Y0  

Pubmed

26354079    23622113    19121390    15496914    12364791    14747013    + More
17210077    27289101    20920257    23761445    21292972    23594743    24845553    26334808    11773082    11856727    12040188    12578829    16923123    21183079    7706395    7916717    16141072    15489334    1555775    26319212    21804562    29704459    28087693    21993624    25401762    26823975    24438588    20431018    25244985    17495919    24402279    21709235    23929341    24755649    25186727    26999592    17431167    26483478    9215903    27762356    29240929    21551351    29703783   

EMBL

KQ459011    KPJ04362.1    GAIX01013967    JAA78593.1    ODYU01006877    SOQ49116.1    + More
NWSH01002073    PCG69244.1    BABH01038450    GDIP01128964    LRGB01002901    JAL74750.1    KZS05563.1    GDIQ01011390    JAN83347.1    CAAE01014542    CAF97631.1    AAAB01008823    EAA05523.4    APCN01003445    GGFM01003600    MBW24351.1    LJIJ01000902    ODM93857.1    GGFK01005667    MBW38988.1    GGFJ01009494    MBW58635.1    ADMH02001144    ETN63947.1    GL732657    EFX68330.1    BX465854    BC065318    BC153660    AAH65318.1    AAI53661.1    GGFK01005635    MBW38956.1    CAEY01001080    KK852902    KDR14057.1    AY357728    AAQ56773.1    GFTR01003499    JAW12927.1    GBGD01002939    JAC85950.1    AB232612    CH466592    BAF02874.1    EDL23028.1    X80333    L04966    AK045514    AK140901    AK143673    AK146177    AK146397    AK154920    BC056351    M79308    JH000129    RAZU01000120    EGW05179.1    RLQ71808.1    GECL01003439    JAP02685.1    GFFW01003598    JAV41190.1    BC089957    GECU01031637    GECU01029152    GECU01024939    GECU01006274    GECU01001746    JAS76069.1    JAS78554.1    JAS82767.1    JAT01433.1    JAT05961.1    GECZ01019898    JAS49871.1    AGTP01076469    AGTP01076470    AAKN02037547    GBHO01018150    GBRD01006772    GDHC01009809    JAG25454.1    JAG59049.1    JAQ08820.1    AAGW02059558    AAGW02059559    AAGW02059560    AHAT01027019    ATLV01016042    KE525054    KFB40937.1    AAMC01019722    BC135986    CR855736    AAI35987.1    CAJ81541.1    GEBQ01031115    JAT08862.1    JW877730    AFP10247.1    AEFK01200006    AEFK01200007    AEFK01200008    AXCM01005795    KE673613    ERE77110.1    FR904783    CDQ71684.1    GFDL01008002    JAV27043.1    AXCN02001762    AERX01030759    GDUN01000772    JAN95147.1    JSUE03043110    JXUM01123892    KQ566767    KXJ69840.1    AFYH01115001    AFYH01115002    AFYH01115003    AFYH01115004    AFYH01115005    LNIX01000002    OXA59369.1    BC074233    CM004477    AAH74233.1    OCT73930.1    ACPB03021331    DS231879    EDS42391.1    FQ310508    CBN81748.1    AYCK01006041    JXUM01107366    KQ565135    KXJ71298.1    BC043996    AAH43996.1    NHOQ01002364    PWA17503.1   

Proteomes

UP000053268    UP000218220    UP000005204    UP000076858    UP000075902    UP000007303    + More
UP000075903    UP000076407    UP000007062    UP000075840    UP000094527    UP000000673    UP000069272    UP000000305    UP000000437    UP000015104    UP000027135    UP000075880    UP000000589    UP000189706    UP000001075    UP000273346    UP000261640    UP000075885    UP000248480    UP000233060    UP000002494    UP000081671    UP000005215    UP000005447    UP000245300    UP000001811    UP000018468    UP000030765    UP000007635    UP000261340    UP000008143    UP000079721    UP000076408    UP000075881    UP000087266    UP000075884    UP000002280    UP000007648    UP000075883    UP000030759    UP000261600    UP000193380    UP000261460    UP000264840    UP000265100    UP000265160    UP000075886    UP000261660    UP000261580    UP000005207    UP000261400    UP000006718    UP000265080    UP000257160    UP000069940    UP000249989    UP000008672    UP000198287    UP000186698    UP000261540    UP000005226    UP000015103    UP000001646    UP000192220    UP000257200    UP000002320    UP000261480    UP000028760    UP000261500   

PRIDE

H9IY70    Q4SP01    E9HIT2    Q6UYC2    P35293    G3H3P1    + More
Q5EB77    I3MN66    G1TFB5    G3PVK7    F6ZX76    G3W037    I3KQW0    Q6GM52    H2SHQ6    G1KE45    B0WBF2    E6ZI64   

Pfam

PF00071   Ras

Interpro

IPR005225   Small_GTP-bd_dom        + More
IPR001806   Small_GTPase       
IPR027417   P-loop_NTPase       
IPR025662   Sigma_54_int_dom_ATP-bd_1       

SUPFAM

SSF52540   SSF52540       

ProteinModelPortal

A0A194QFU9   S4NSQ9   A0A2H1W832   A0A2A4JCG2   H9IY70   A0A0P5TEN8   + More
A0A0P6I0E2   Q4SP01   A0A182U381   H3CR18   A0A182VI95   A0A182X412   Q7QGS6   A0A182I5I1   A0A2M3Z771   A0A1D2MLI6   A0A2M4AEF2   A0A2M4BZY9   W5JHW0   A0A182FKC3   E9HIT2   Q6P129   A0A2M4ADU3   T1L4D2   A0A067R6Y7   Q6UYC2   A0A182JCY5   A0A224XKC4   A0A069DQ33   Q0PD38   P35293   A0A3Q0DBU1   G3H3P1   A0A0V0G3Q6   A0A3Q3MIQ1   A0A182PJB0   A0A2Y9E3D5   A0A250YCA0   A0A2K5KNJ8   Q5EB77   A0A1B6I787   A0A1B6FI41   A0A1S3F0L0   I3MN66   A0A286XYW4   A0A0A9XZW7   S4RKZ6   G1TFB5   W5ML35   A0A084VSJ3   G3PVK7   A0A3Q0RKF1   Q28D30   A0A1S2ZX50   A0A182YKM2   A0A182KCB3   A0A1S3Q7V2   A0A182NC92   F6ZX76   A0A1B6KBP7   V9LD26   G3W037   A0A182MC58   A0A061I5P2   A0A3Q3IQ05   A0A060X2Z0   A0A1Q3FHQ6   A0A3B4EXZ0   A0A3Q3CI90   A0A3P8Q0A4   A0A3P9BM22   A0A182QMF7   A0A3Q3FZ10   A0A3Q4MHH7   I3KQW0   A0A3B5BJQ7   A0A0P6IVG1   A0A1D5R5M1   A0A3P8U173   A0A3Q1BJA5   A0A182HB16   H3AT07   A0A226EPC4   Q6GM52   A0A3B3SCQ0   H2SHQ6   T1HYX3   A0A3Q3SBI4   G1KE45   A0A2I4CAC4   A0A3Q1GN16   B0WBF2   E6ZI64   A0A3B3WV80   A0A087Y666   A0A3B3UQZ0   A0A182H3F1   Q7ZY33   A0A315V1Y0  

PDB

1X3S     E-value=9.49917e-54,     Score=528

KEGG

101737062    K07910 Ras-related protein Rab-18 | (RefSeq) ras-related protein Rab-18

GO

GO:0005525   GO:0003924   GO:0007420   GO:0043009   GO:0001654   GO:0034389   GO:0006886   GO:0032482   GO:0005794   GO:0019003   GO:0045202   GO:0071786   GO:0071782   GO:0051170   GO:0016324   GO:0009925   GO:0007264   GO:0007165   GO:0016020   GO:0005515   GO:0051103   GO:0005524   GO:0008270   GO:0042555   GO:0048384  

Subcellular location

Apical cell membrane  
Basal cell membrane  

Length:

204

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0907500000000001

Exp number, first 60 AAs:

0.0907500000000001

Total prob of N-in:

0.10156

outside

1  -  204

 

 

Pi

27.049317

Theta

25.491437

Tajima's D

0.213207

CLR

0.915186

CSRT

0.436678166091695

Interpretation

Uncertain