Gene

KWMTBOMO03644

Pre Gene Modal

BGIBMGA006340

Annotation

Tfpi_protein_[Danaus_plexippus]

Location

Bomo_Chr6(+):14307945-14316290      View in EpiBrowser

Full name

Tissue factor pathway inhibitor      

Alternative Name

Extrinsic pathway inhibitor
Lipoprotein-associated coagulation inhibitor

Location in the cell

Extracellular   Reliability : 2.15 PlasmaMembrane   Reliability : 1.87

CDS

ATGAAAACAGATTTATTGTTTTTCGTGCATTGTTTTTGTTCGGTGCTCATTTTAGAAGTAAACTGCAAAATTCAATATGAAACAATACCATCCGAAGATATCAGAGCTACCACTTATTCTCCTAAAATCGTATCCAAGACTTGTACGCTGATACCAGATGATGGACCCTGCAGAGGGAACATTCGAATGTACTACTTCGACCCGGCGTCATTGAAGTGTAATATATTCTTGTGGGGTGGTTGCCAGGGCAATGGAAACAGGTTCAAGACCGAGGAAGAATGCATAGGCAAATGTCTTAGTAAGCCTAATGCTGGACCGCACCGTCCGCGTTGGTGCAGCCTGTCATTTGACTATGGTTTCTGCTTCGGGAACGAGGAAAGATGGTACTACGATCATCTCTGGAGAGTTTGCAAGAAGACCCTTTATTCGGGTTGTGGAGGCAACAAAAATAACTTCTATAATCGAGAGCAGGTATCTTTGAAATTGAAAAATTCTACTCAATTCTCATTCTCCTTTTTAGTAGCTTCATTTCTCTGA

Protein

MKTDLLFFVHCFCSVLILEVNCKIQYETIPSEDIRATTYSPKIVSKTCTLIPDDGPCRGNIRMYYFDPASLKCNIFLWGGCQGNGNRFKTEEECIGKCLSKPNAGPHRPRWCSLSFDYGFCFGNEERWYYDHLWRVCKKTLYSGCGGNKNNFYNREQVSLKLKNSTQFSFSFLVASFL

Description

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity).

Similarity

Belongs to the peptidase S1 family.

Keywords

Alternative splicing   Blood coagulation   Complete proteome   Disulfide bond   Glycoprotein   Hemostasis   Protease inhibitor   Reference proteome   Repeat   Secreted   Serine protease inhibitor   Signal  

Feature

chain  Tissue factor pathway inhibitor
splice variant  In isoform Beta.

Uniprot

A0A2W1BVA6   A0A2H1W4A7   A0A0N0PDX3   A0A3P4MWC7   G9KT31   A0A1W5B883   + More
Q8CI80   Q8BSB7   A0A1W5BES8   A2ARA3   A0A2Y9J753   O54819-2   A2ARA4   M3YLF3   A0A1L8FVT1   Q7T0Z5   A0A340YD16   G1KNH2   A2ARA0   O54819   A0A2G9S1P5   A0A384B960   A0A218V109   A0A384B937   A0A068WVY0   E0W094   A0A1E1X1Z0   E7D1N7   A0A341BGB2   A0A2Y9EX92   A0A0C9SDN8   A0A0R3TLW2   A0A1E1XVA6   A0A0P5SZU0   A0A0P5CWR6   A0A0P5DD37   A0A0P5ME81   A0A0P5ERM0   A0A0N8D684   A0A0P5CUJ5   A0A0P5R1C6   A0A0P5CQW6   A0A0N8AY61   A0A0P5XTQ8   A0A0P5WQW6   A0A0P6ENJ5   A0A0N8BVG3  

Pubmed

28756777    26354079    23236062    15489334    10349636    11042159    + More
11076861    11217851    12466851    16141073    19468303    9493581    9974373    16141072    27762356    23485966    20566863    28503490    26131772    29209593   

EMBL

KZ149893    PZC78909.1    ODYU01006255    SOQ47929.1    KQ460170    KPJ17225.1    + More
CYRY02014350    VCW84470.1    JP019462    AES08060.1    BC036146    AAH36146.1    AL845305    AK034752    BAC28821.1    AF004833    AF016313    AK028356    AEYP01057875    AEYP01057876    AEYP01057877    CM004476    OCT75684.1    BC055972    AAH55972.1    KV928804    PIO34069.1    MUZQ01000073    OWK59697.1    LK028587    CDS22657.1    DS235857    EEB19050.1    GFAC01005899    JAT93289.1    HQ005987    ADV40281.1    GBZX01000563    JAG92177.1    UZAE01012241    VDO04155.1    GFAA01000291    JAU03144.1    GDIP01134115    JAL69599.1    GDIP01164359    JAJ59043.1    GDIP01157914    JAJ65488.1    GDIQ01165095    JAK86630.1    GDIQ01266004    JAJ85720.1    GDIP01064775    JAM38940.1    GDIP01166458    JAJ56944.1    GDIQ01127010    JAL24716.1    GDIP01168058    JAJ55344.1    GDIQ01231371    JAK20354.1    GDIP01069377    JAM34338.1    GDIP01082872    JAM20843.1    GDIQ01061381    JAN33356.1    GDIQ01140955    JAL10771.1   

Proteomes

UP000053240    UP000000589    UP000248482    UP000000715    UP000186698    UP000265300    + More
UP000001646    UP000261681    UP000197619    UP000009046    UP000252040    UP000248484    UP000046398    UP000278807   

PRIDE

A2ARA3    O54819    A2ARA4    A2ARA0   

Pfam

PF00014   Kunitz_BPTI        + More
PF00089   Trypsin
PF02822   Antistasin
PF00086   Thyroglobulin_1
PF00090   TSP_1
PF05986   ADAM_spacer1
PF00095   WAP
PF07679   I-set
PF08686   PLAC
PF01826   TIL

Interpro

IPR002223   Kunitz_BPTI        + More
IPR036880   Kunitz_BPTI_sf       
IPR020901   Prtase_inh_Kunz-CS       
IPR033116   TRYPSIN_SER       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR008296   TFPI-like       
IPR011061   Hirudin/antistatin       
IPR004094   Antistasin-like       
IPR000716   Thyroglobulin_1       
IPR036857   Thyroglobulin_1_sf       
IPR003582   ShKT_dom       
IPR010909   PLAC       
IPR036179   Ig-like_dom_sf       
IPR010294   ADAM_spacer1       
IPR003598   Ig_sub2       
IPR036383   TSP1_rpt_sf       
IPR000884   TSP1_rpt       
IPR013273   ADAMTS/ADAMTS-like       
IPR008197   WAP_dom       
IPR013098   Ig_I-set       
IPR036645   Elafin-like_sf       
IPR013783   Ig-like_fold       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR002919   TIL_dom       
IPR036084   Ser_inhib-like_sf       

SUPFAM

SSF57362   SSF57362        + More
SSF50494   SSF50494       
SSF57262   SSF57262       
SSF57610   SSF57610       
SSF57256   SSF57256       
SSF82895   SSF82895       
SSF48726   SSF48726       
SSF57567   SSF57567       

Gene 3D

4.10.410.10     4.10.800.10     2.20.100.10     2.60.40.10    

CDD

cd00109  KU
cd00191  TY

ProteinModelPortal

A0A2W1BVA6   A0A2H1W4A7   A0A0N0PDX3   A0A3P4MWC7   G9KT31   A0A1W5B883   + More
Q8CI80   Q8BSB7   A0A1W5BES8   A2ARA3   A0A2Y9J753   O54819-2   A2ARA4   M3YLF3   A0A1L8FVT1   Q7T0Z5   A0A340YD16   G1KNH2   A2ARA0   O54819   A0A2G9S1P5   A0A384B960   A0A218V109   A0A384B937   A0A068WVY0   E0W094   A0A1E1X1Z0   E7D1N7   A0A341BGB2   A0A2Y9EX92   A0A0C9SDN8   A0A0R3TLW2   A0A1E1XVA6   A0A0P5SZU0   A0A0P5CWR6   A0A0P5DD37   A0A0P5ME81   A0A0P5ERM0   A0A0N8D684   A0A0P5CUJ5   A0A0P5R1C6   A0A0P5CQW6   A0A0N8AY61   A0A0P5XTQ8   A0A0P5WQW6   A0A0P6ENJ5   A0A0N8BVG3  

PDB

4BD9     E-value=1.23418e-16,     Score=207

KEGG

NA   

GO

GO:0004867   GO:0004252   GO:0005576   GO:0007596   GO:0009986   GO:0030195   GO:0005901   GO:0005615   GO:0071383   GO:0016021   GO:0008233   GO:0008270   GO:0007165   GO:0016020   GO:0005515   GO:0051103   GO:0005524   GO:0042555   GO:0048384  

Subcellular location

Secreted  

SignalP

Position:   1 - 22,         Likelihood:  0.984865

 

 

Length:

178

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.25248

Exp number, first 60 AAs:

0.2473

Total prob of N-in:

0.03628

outside

1  -  178

 

 

Pi

0

Theta

0

Tajima's D

0

CLR

25.680051

CSRT

0

Interpretation

Uncertain