Gene

KWMTBOMO03618

Annotation

PREDICTED:_E3_ubiquitin-protein_ligase_RNF19B-like_[Bombyx_mori]

Location

Bomo_Chr6(+):13649758-13685325      View in EpiBrowser

Full name

RBR-type E3 ubiquitin transferase      

Location in the cell

Extracellular   Reliability : 2.908

CDS

ATGGCAAAGTCCAGGGAGGTTTATGATTTTAGCGTGTTGGATCAAGGCGAAGCTAGGCCAGTTAAAGTGAGCGGCGTCGAACAATCACACAGCAGGCAGCAAACAACAATAGAATACATACCCGAAGATGAAGAGGGTGACTTGCTCGAGTGTCCGCTGTGCTTGTCGACGTTGAACGCGAGCGCGACGGTACGGCTGGCGTGGTGCTCCCACCGCTGCTGCGAGCCGTGTCTGCGGCAATACCTGAATATCGAGATATATGAAGCCAGGGTGCCGGTCAGCTGTCCCGTCTGCCACGAGAGTATACACCCTTCAGATGTACGTCACATCGTGGACAATCCAGTTTTATTTGAAAAATATGAAGAATTCTCAGTGAGGCGCGCTCTGGCGGCCGACCCAGACACGCGATGGTGTCCAGCACCCGATTGCAGTTTCGCTGTAGTGGCAACAGGTTGCGCTTCGTGTCCGAAGCTGACCTGCCTGGCGCCCGGCTGCGGGGCGTCCTTCTGTTACCACTGCAAGGCGGCGTGGCATCCTACCCAGACCTGCGACGCGGCTAGACGCAGTCGGCAGCCTCCCCCCAGAGCGCCGCCGCCGACACACCCCGATATTGACCAGGGAGAAGTGAAGCCGTGTCCCCGTTGCTCGGTGCTGATCGTGAAGGTGGAGGACGGCTCTTGCAACCACATGGTCTGCTGCGTGTGCGGCGCCGAGTTCTGTTGGCTCTGCATGAAGGAGGTCTCGGACTTGCATTATCTCAGTCCGAGCGGCTGCACGTTTTGGGGCAAAAAACCGTGGTCCCGGAAGAAGAAGTTGCTGTGGCAGCTCGGGACGCTGGCGGGCGCGCCGCTCGGCATCGCGGTGGTGGCGGGCGTGGCGCTCCCCGCGCTGCTGGTGGGGCTCCCGCTGTGGGCCGGCCGCCGCGCGCACCGCCGCCTGCGCCGCGCCTCCGTCATCAAGAGGCGCGCCGCCGTCGCCGCCGCAGTTGCCGCCGCGGTCAGTGCCACTCGATGTACCCAGTCTAACTGTATTGTATAA

Protein

MAKSREVYDFSVLDQGEARPVKVSGVEQSHSRQQTTIEYIPEDEEGDLLECPLCLSTLNASATVRLAWCSHRCCEPCLRQYLNIEIYEARVPVSCPVCHESIHPSDVRHIVDNPVLFEKYEEFSVRRALAADPDTRWCPAPDCSFAVVATGCASCPKLTCLAPGCGASFCYHCKAAWHPTQTCDAARRSRQPPPRAPPPTHPDIDQGEVKPCPRCSVLIVKVEDGSCNHMVCCVCGAEFCWLCMKEVSDLHYLSPSGCTFWGKKPWSRKKKLLWQLGTLAGAPLGIAVVAGVALPALLVGLPLWAGRRAHRRLRRASVIKRRAAVAAAVAAAVSATRCTQSNCIV

Catalytic Activity

[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.

Similarity

Belongs to the RBR family.

Uniprot

A0A194QFZ2   A0A2A4J604   A0A139WAM3   A0A0P5YLA8   E9IG06   A0A0P4ZKA1   + More
A0A0N7ZT21   A0A164S5X3   A0A0P5BZM6   A0A0P6ARW8   A0A0P5SWV9   A0A0P5ZVK4   A0A0P5C0I7   A0A0P4ZSM0   A0A0P5C0D9   A0A0P4YU75   A0A0P5BDK2   A0A0P4Z151   A0A026VYY4   A0A0P5SBD9   A0A0P4ZRC1   A0A0P5C0Q0   A0A1W4WXC5   A0A0P5VQ11   A0A0P5KHG1   A0A0P5S8U4   A0A0P5CN64   A0A3L8E0C3   A0A0P5CI07   A0A0P5DBZ7   A0A0P6A550   A0A0P5GBC4   A0A0P4Z651   A0A0P4ZRV4   A0A0P4XH97   A0A0N1IU34   E2AD35   A0A0P5T5P7   A0A0N8DR78   A0A195FGW7   F4X5R1   A0A151WH87   A0A151JLR6   A0A0P6IKT8   A0A158NY24   A0A195BRN8   A0A088AFL1   A0A151I8Q0   I3JBR8   A0A2B4SFQ0   A0A3M6UMD2   G3NBB1   A0A3B4U0T6   A0A0L7QZE2   A0A2U9CXK5   I3JBR9   A0A3B4Y7M7   A0A3B5BN42   A0A3B4FPB6   A0A3P9DKX1   H2RQV6   K7INE0   H2RQV4  

EC Number

2.3.2.31

Pubmed

26354079    18362917    19820115    21282665    24508170    30249741    + More
20798317    21719571    21347285    25186727    30382153    21551351    20075255   

EMBL

KQ459011    KPJ04334.1    NWSH01003141    PCG66870.1    KQ971381    KYB24955.1    + More
GDIP01070235    JAM33480.1    GL762905    EFZ20509.1    GDIP01215370    JAJ08032.1    GDIP01215369    JAJ08033.1    LRGB01002078    KZS09288.1    GDIP01177690    JAJ45712.1    GDIP01039241    JAM64474.1    GDIP01134128    GDIP01134127    JAL69586.1    GDIP01037946    JAM65769.1    GDIP01177341    JAJ46061.1    GDIP01209328    GDIP01177689    JAJ14074.1    GDIP01177342    JAJ46060.1    GDIP01222224    JAJ01178.1    GDIP01185926    JAJ37476.1    GDIP01219869    JAJ03533.1    KK107555    EZA49013.1    GDIP01141877    JAL61837.1    GDIP01213416    JAJ09986.1    GDIP01177343    JAJ46059.1    GDIP01097041    GDIP01097040    GDIP01097039    JAM06674.1    GDIQ01189400    JAK62325.1    GDIP01142926    GDIP01142925    JAL60788.1    GDIP01169021    GDIP01041038    JAJ54381.1    QOIP01000002    RLU26171.1    GDIP01185925    JAJ37477.1    GDIP01252866    GDIP01237425    GDIP01235720    GDIP01211627    GDIP01210524    GDIP01177688    GDIP01168074    GDIP01165674    GDIP01165227    GDIP01161121    GDIP01159625    GDIP01158429    GDIP01154976    GDIP01153784    GDIP01153084    GDIP01152085    GDIP01149077    GDIP01149076    GDIP01139731    GDIP01139730    GDIP01139729    GDIP01138630    GDIP01138629    GDIP01138628    GDIP01131637    GDIP01121378    GDIP01121377    GDIP01089741    GDIP01089740    GDIP01089739    GDIP01088644    GDIP01088643    GDIP01088642    GDIP01045807    GDIP01045806    GDIP01045805    JAJ64973.1    GDIP01039240    JAM64475.1    GDIQ01244079    JAK07646.1    GDIP01231524    GDIP01231523    GDIP01231522    GDIP01219868    GDIP01177340    GDIP01147718    GDIP01147717    GDIP01147716    GDIP01137435    GDIP01137434    GDIP01137433    GDIP01114235    GDIP01114234    GDIP01114233    GDIP01110181    GDIP01095175    GDIP01095174    GDIP01095173    GDIP01094790    GDIP01087741    GDIP01072930    GDIP01072929    GDIP01071788    GDIP01037945    GDIQ01047846    JAJ03534.1    JAN46891.1    GDIP01222223    GDIP01222222    JAJ01180.1    GDIP01241168    JAI82233.1    KQ435710    KOX79782.1    GL438658    EFN68671.1    GDIP01132932    JAL70782.1    GDIP01008823    JAM94892.1    KQ981606    KYN39482.1    GL888740    EGI58212.1    KQ983128    KYQ47219.1    KQ978986    KYN26730.1    GDIQ01009421    JAN85316.1    ADTU01000549    ADTU01000550    KQ976423    KYM88884.1    KQ978339    KYM95015.1    AERX01034044    LSMT01000088    PFX28196.1    RCHS01001186    RMX54792.1    KQ414681    KOC63990.1    CP026264    AWP21287.1   

Proteomes

UP000053268    UP000218220    UP000007266    UP000076858    UP000053097    UP000192223    + More
UP000279307    UP000053105    UP000000311    UP000078541    UP000007755    UP000075809    UP000078492    UP000005205    UP000078540    UP000005203    UP000078542    UP000005207    UP000225706    UP000275408    UP000007635    UP000261420    UP000053825    UP000246464    UP000261360    UP000261400    UP000261460    UP000265160    UP000005226    UP000002358   

Pfam

PF00097   zf-C3HC4        + More
PF01485   IBR

Interpro

IPR018957   Znf_C3HC4_RING-type        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR002867   IBR_dom       
IPR001841   Znf_RING       
IPR031127   E3_UB_ligase_RBR       
IPR020846   MFS_dom       

Gene 3D

3.30.40.10    

CDD

cd06174  MFS

ProteinModelPortal

A0A194QFZ2   A0A2A4J604   A0A139WAM3   A0A0P5YLA8   E9IG06   A0A0P4ZKA1   + More
A0A0N7ZT21   A0A164S5X3   A0A0P5BZM6   A0A0P6ARW8   A0A0P5SWV9   A0A0P5ZVK4   A0A0P5C0I7   A0A0P4ZSM0   A0A0P5C0D9   A0A0P4YU75   A0A0P5BDK2   A0A0P4Z151   A0A026VYY4   A0A0P5SBD9   A0A0P4ZRC1   A0A0P5C0Q0   A0A1W4WXC5   A0A0P5VQ11   A0A0P5KHG1   A0A0P5S8U4   A0A0P5CN64   A0A3L8E0C3   A0A0P5CI07   A0A0P5DBZ7   A0A0P6A550   A0A0P5GBC4   A0A0P4Z651   A0A0P4ZRV4   A0A0P4XH97   A0A0N1IU34   E2AD35   A0A0P5T5P7   A0A0N8DR78   A0A195FGW7   F4X5R1   A0A151WH87   A0A151JLR6   A0A0P6IKT8   A0A158NY24   A0A195BRN8   A0A088AFL1   A0A151I8Q0   I3JBR8   A0A2B4SFQ0   A0A3M6UMD2   G3NBB1   A0A3B4U0T6   A0A0L7QZE2   A0A2U9CXK5   I3JBR9   A0A3B4Y7M7   A0A3B5BN42   A0A3B4FPB6   A0A3P9DKX1   H2RQV6   K7INE0   H2RQV4  

PDB

4KC9     E-value=3.03167e-15,     Score=199

KEGG

101746977    K11972 E3 ubiquitin-protein ligase RNF19A [EC:2.3.2.31] | (RefSeq) E3 ubiquitin-protein ligase RNF19

GO

GO:0046872   GO:0004842   GO:0016021   GO:0016874   GO:0005737   GO:0000209   GO:0000151   GO:0031624   GO:0032436   GO:0061630   GO:0006511   GO:0016740   GO:0005515   GO:0008270   GO:0022857   GO:0005215   GO:0051103   GO:0005524   GO:0042555   GO:0048384  

PANTHER

PTHR11685  

Length:

345

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.19841

Exp number, first 60 AAs:

8e-05

Total prob of N-in:

0.04558

outside

1  -  283

TMhelix

284  -  306

inside

307  -  345

 

 

Pi

24.424649

Theta

24.386589

Tajima's D

0.19989

CLR

0.744768

CSRT

0.424478776061197

Interpretation

Uncertain