Gene

KWMTBOMO03610

Pre Gene Modal

BGIBMGA006325

Annotation

extra_sex_combs_[Bombyx_mori]

Location

Bomo_Chr6(+):13495301-13500561      View in EpiBrowser

Full name

Polycomb protein EED      

Location in the cell

Cytoplasmic   Reliability : 1.271 Nuclear   Reliability : 1.959

CDS

ATGAATTTTTCTGAAAATGAAGCTGATGACACTTCAAGTGTTGATAGTACTTCAAACACAGACAATACGTCCCGTAGTGAGACTCCTACCAACTCAAGAGTGAAAAAACGTCGTCGCGGCAAAAAGAAAACCACTAAGCCAGTTAAACCTCCATACAAGTTCAATTGCAGTGCTAAAGAAGATCATGGTCAACCACTATTTGGATGCCAGTTCAATCATCATCTCGGTGAAGGAGAACCATCAGTATTTGCAGTAGTCGGTAGTAACAGAGTCTCAATATATGAGTGCCCTGAATCTGGAGGCTTCAAATTCTTGCAGTGCTATGCTGATCCTGATGTTGATGAAACATTTTACACATGCGCTTGGTCTTACGAAGAAGACACGATGCTTCCGCTCCTAGCCGTCGCCGGGTCACGCGGTATCATCCGTATCTTCCACCCCGCCACGCAGACGTGCATCAAACACTACGTGGGGCACGGACACGCCATCAACGAGGTTAAGTTCCATCCTCGAGACCCGAATCTACTTCTGTCGGCCAGCAAGGACCACGCTCTGCGGCTTTGGAACATTATGACTGACGTTTGCATAGCCATCTTCGGCGGGGTCGAGGGCCACAGAGACGAAGTGCTCAGCGCTGACTTCGATCTAAAAGGAGAAAGGATAATGTCCTGCGGGATGGACCACTCCCTGAAACTGTGGAGGTTGGACAAGCCCTCGATGAATGAGGCCATCAAACAGAGCTATAATTTCAATCCGCACAGAGCGCTACGTCCCTTCAATTCCTTGAAGGAACATTTTCCTGATTTTTCAACTAGAGATATACATAGGAATTACGTTGACTGCGTCAGGTGGATGGGAGATCTAATTCTTTCTAAATCGTGTGAAAACGCTATAATCTGCTGGAAGCCGGGCCGACTTGAGGACACGGAGCTGCGGCCCGGGGACAACTCCGTCACCATGGTGCATCGCTTCGACTACAAAGAGTGTGAAATATGGTTTATACGATTCGCTGTTGACTATAGTCAAAGGGTGATAGCTCTAGGTAATCAGTGCGGTAAGACCATGGTGTGGGAACTGGGGAACGTGGCTGGAGGCTCCCGAGTCTCGCAGCTCGTGCATCCGAGATGCGTTGCTGCGGTCAGACAGGTAACTCTCTCACGCAACGGCAAGATCCTACTGACGTGTTGCGACGACGGCACCATCTGGCGGTGGGACCGGGTCTCCGCCAGCAACTGA

Protein

MNFSENEADDTSSVDSTSNTDNTSRSETPTNSRVKKRRRGKKKTTKPVKPPYKFNCSAKEDHGQPLFGCQFNHHLGEGEPSVFAVVGSNRVSIYECPESGGFKFLQCYADPDVDETFYTCAWSYEEDTMLPLLAVAGSRGIIRIFHPATQTCIKHYVGHGHAINEVKFHPRDPNLLLSASKDHALRLWNIMTDVCIAIFGGVEGHRDEVLSADFDLKGERIMSCGMDHSLKLWRLDKPSMNEAIKQSYNFNPHRALRPFNSLKEHFPDFSTRDIHRNYVDCVRWMGDLILSKSCENAIICWKPGRLEDTELRPGDNSVTMVHRFDYKECEIWFIRFAVDYSQRVIALGNQCGKTMVWELGNVAGGSRVSQLVHPRCVAAVRQVTLSRNGKILLTCCDDGTIWRWDRVSASN

Description

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity).

Subunit

Component of the PRC2/EED-EZH2 complex.

Similarity

Belongs to the WD repeat ESC family.

Keywords

Chromatin regulator   Complete proteome   Nucleus   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   WD repeat  

Feature

chain  Polycomb protein EED

Uniprot

E5RWX8   H9J9Y0   O16021   A0A2A4JTR0   A0A2W1BV52   A0A212F587   + More
R4IT83   A0A194R7G9   A0A194QA22   A0A2H1WSP0   O16022   A0A2J7PDJ4   A0A067QSB7   A0A347ZJF6   A0A2P8ZKJ7   A0A347ZJF7   A0A1B6LV29   A0A1B6EUS2   U4UG71   N6U559   A0A139WM98   D6WCC2   A0A1W4WS66   J3JV55   A0A1W4WHA9   A0A1Y1LJT0   A0A1L7N283   E9ISN8   A0A0L7QWH6   A0A023F4K4   T1HXR8   A0A224XQR9   A0A069DT80   E0VN79   A0A154P6U4   A0A151WMC0   A0A0M8ZYT7   A0A026WPI2   A0A232FEF1   K7IRS7   A0A0J7P319   E2ADP6   A0A195E5K6   A0A195EVB7   A0A151IH66   F4WP90   A0A2A3ES72   A0A195B0U1   A0A158NR18   A0A1B0GKP6   E2BUS5   A0A0L7LE57   A0A0C9R285   T1J4Y1   A0A1B6EG92   E9H4Z8   A0A164R077   A0A0N8ATL3   A0A0P5J3H1   Q16G31   A0A182H2R0   A0A1Q3EWC0   A0A0P5JC02   H0ZRX6   A0A218UJ00   A0A151NM02   A0A1L1RP86   A0A2I0M127   A0A091FR44   A0A091FET9   A0A093C3F1   A0A091GTF5   A0A099ZGR5   A0A093SQ30   A0A091IU09   A0A091WN24   A0A091LWQ3   A0A091W017   A0A093GD39   A0A091NIQ8   A0A091J1R3   A0A0A0A822   A0A093DKT2   A0A093NXK1   A0A093F8D1   A0A091KNS1   A0A093JMQ8   A0A091QCZ8   Q5ZKH3   R0L1L4   G1NQR4   A0A1V4JR49   A0A0Q3PM19   U3JZ14   U3IZS5   F6TW64   J9K6S7   G3WKF2   A0A3Q0HLW3   G1KAU8  

Pubmed

22485166    19121390    9343430    28756777    22118469    23814061    + More
26354079    24845553    29403074    23537049    18362917    19820115    22516182    28004739    27956627    21282665    25474469    26334808    20566863    24508170    30249741    28648823    20075255    20798317    21719571    21347285    26227816    21292972    17510324    26483478    20360741    22293439    23371554    15642098    20838655    23749191    17495919    21709235   

EMBL

AB607838    BAJ54072.1    BABH01026037    AF003603    AAC05331.1    NWSH01000685    + More
PCG74790.1    KZ149893    PZC78938.1    AGBW02010219    OWR48902.1    JQ744271    AGC39037.1    KQ460647    KPJ13185.1    KQ459249    KPJ02373.1    ODYU01010734    SOQ56027.1    AF003604    AAC05332.1    NEVH01026386    PNF14398.1    KK853353    KDR08216.1    FX985724    BBA84462.1    PYGN01000028    PSN57027.1    FX985725    BBA84463.1    GEBQ01012439    JAT27538.1    GECZ01028024    JAS41745.1    KB632309    ERL92032.1    APGK01042227    KB741002    ENN75776.1    KQ971316    KYB29013.1    EEZ98792.2    BT127121    AEE62083.1    GEZM01053849    JAV73922.1    LC100105    BAW19570.1    GL765434    EFZ16293.1    KQ414713    KOC62955.1    GBBI01002510    JAC16202.1    ACPB03021030    GFTR01006085    JAW10341.1    GBGD01001591    JAC87298.1    DS235335    EEB14835.1    KQ434827    KZC07597.1    KQ982944    KYQ49014.1    KQ435794    KOX73880.1    KK107139    QOIP01000003    EZA57883.1    RLU24378.1    NNAY01000331    OXU29164.1    LBMM01000241    KMR03299.1    GL438820    EFN68408.1    KQ979608    KYN20475.1    KQ981965    KYN31834.1    KQ977637    KYN01135.1    GL888243    EGI64071.1    KZ288189    PBC34643.1    KQ976691    KYM77912.1    ADTU01023744    AJWK01030843    GL450746    EFN80548.1    JTDY01001482    KOB73767.1    GBYB01010209    JAG79976.1    JH431850    GEDC01000332    JAS36966.1    GL732592    EFX73235.1    LRGB01002285    KZS08223.1    GDIQ01244155    JAK07570.1    GDIQ01203666    JAK48059.1    CH478339    EAT33200.1    JXUM01003383    KQ560157    KXJ84133.1    GFDL01015444    JAV19601.1    GDIQ01227207    JAK24518.1    ABQF01027776    MUZQ01000270    OWK53704.1    AKHW03002570    KYO37818.1    AKCR02000051    PKK23378.1    KL447262    KFO71436.1    KK718917    KFO60070.1    KL452576    KFV06797.1    KL508517    KFO85685.1    KL892873    KGL80238.1    KL672094    KFW84699.1    KL218233    KFP03141.1    KL411053    KFR02901.1    KK510031    KFP62787.1    KK734465    KFR08365.1    KL215889    KFV67113.1    KK834501    KFP79027.1    KK501377    KFP14522.1    KL871085    KGL90221.1    KN126888    KFU93312.1    KL225030    KFW66695.1    KK388299    KFV52770.1    KK748189    KFP40935.1    KL206225    KFV80029.1    KK695283    KFQ23948.1    AJ720111    KB744949    EOA94172.1    LSYS01006642    OPJ74678.1    LMAW01002014    KQK82075.1    AGTO01010903    ADON01136942    ADON01136943    ADON01136944    ADON01136945    ADON01136946    ABLF02034383    AEFK01118901    AEFK01118902   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000053268    UP000235965    + More
UP000027135    UP000245037    UP000030742    UP000019118    UP000007266    UP000192223    UP000053825    UP000015103    UP000009046    UP000076502    UP000075809    UP000053105    UP000053097    UP000279307    UP000215335    UP000002358    UP000036403    UP000000311    UP000078492    UP000078541    UP000078542    UP000007755    UP000242457    UP000078540    UP000005205    UP000092461    UP000008237    UP000037510    UP000000305    UP000076858    UP000008820    UP000069940    UP000249989    UP000007754    UP000197619    UP000050525    UP000053872    UP000053760    UP000052976    UP000053641    UP000053258    UP000054308    UP000053283    UP000053605    UP000053875    UP000053119    UP000053858    UP000054081    UP000053584    UP000000539    UP000001645    UP000190648    UP000051836    UP000016665    UP000016666    UP000002280    UP000007819    UP000007648    UP000189705    UP000001646   

PRIDE

E5RWX8    H9J9Y0   

Pfam

PF00400   WD40        + More
PF06047   Nkap_C
PF00089   Trypsin

Interpro

IPR015943   WD40/YVTN_repeat-like_dom_sf        + More
IPR037352   Polycomb_EED       
IPR019775   WD40_repeat_CS       
IPR017986   WD40_repeat_dom       
IPR036322   WD40_repeat_dom_sf       
IPR001680   WD40_repeat       
IPR009269   NKAP_C       
IPR018114   TRYPSIN_HIS       
IPR001254   Trypsin_dom       
IPR009003   Peptidase_S1_PA       

SUPFAM

SSF50978   SSF50978        + More
SSF50494   SSF50494       

Gene 3D

2.130.10.10    

ProteinModelPortal

E5RWX8   H9J9Y0   O16021   A0A2A4JTR0   A0A2W1BV52   A0A212F587   + More
R4IT83   A0A194R7G9   A0A194QA22   A0A2H1WSP0   O16022   A0A2J7PDJ4   A0A067QSB7   A0A347ZJF6   A0A2P8ZKJ7   A0A347ZJF7   A0A1B6LV29   A0A1B6EUS2   U4UG71   N6U559   A0A139WM98   D6WCC2   A0A1W4WS66   J3JV55   A0A1W4WHA9   A0A1Y1LJT0   A0A1L7N283   E9ISN8   A0A0L7QWH6   A0A023F4K4   T1HXR8   A0A224XQR9   A0A069DT80   E0VN79   A0A154P6U4   A0A151WMC0   A0A0M8ZYT7   A0A026WPI2   A0A232FEF1   K7IRS7   A0A0J7P319   E2ADP6   A0A195E5K6   A0A195EVB7   A0A151IH66   F4WP90   A0A2A3ES72   A0A195B0U1   A0A158NR18   A0A1B0GKP6   E2BUS5   A0A0L7LE57   A0A0C9R285   T1J4Y1   A0A1B6EG92   E9H4Z8   A0A164R077   A0A0N8ATL3   A0A0P5J3H1   Q16G31   A0A182H2R0   A0A1Q3EWC0   A0A0P5JC02   H0ZRX6   A0A218UJ00   A0A151NM02   A0A1L1RP86   A0A2I0M127   A0A091FR44   A0A091FET9   A0A093C3F1   A0A091GTF5   A0A099ZGR5   A0A093SQ30   A0A091IU09   A0A091WN24   A0A091LWQ3   A0A091W017   A0A093GD39   A0A091NIQ8   A0A091J1R3   A0A0A0A822   A0A093DKT2   A0A093NXK1   A0A093F8D1   A0A091KNS1   A0A093JMQ8   A0A091QCZ8   Q5ZKH3   R0L1L4   G1NQR4   A0A1V4JR49   A0A0Q3PM19   U3JZ14   U3IZS5   F6TW64   J9K6S7   G3WKF2   A0A3Q0HLW3   G1KAU8  

PDB

5H13     E-value=4.4319e-146,     Score=1328

KEGG

100529126    K11462 polycomb protein EED | (RefSeq) ESC; extra sex combs

GO

GO:0035098   GO:0016571   GO:0003682   GO:0000122   GO:0070734   GO:0006342   GO:0004252   GO:0000978   GO:0005829   GO:0045120   GO:2000011   GO:0042802   GO:0061087   GO:0006349   GO:0046976   GO:0001739   GO:1990830   GO:0005515   GO:0006508   GO:0016021   GO:0022857   GO:0005215   GO:0051103   GO:0005524   GO:0008270   GO:0042555   GO:0048384  

PANTHER

PTHR10253:SF5  

Subcellular location

Nucleus  

Length:

411

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00987999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00719

outside

1  -  411

 

 

Pi

32.082621

Theta

25.877984

Tajima's D

-0.61454

CLR

0.502427

CSRT

0.219189040547973

Interpretation

Uncertain