Gene

KWMTBOMO03585  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006311

Annotation

PREDICTED:_probable_2-oxoglutarate_dehydrogenase_E1_component_DHKTD1_homolog?_mitochondrial_[Papilio_polytes]

Location

Bomo_Chr6(+):13014522-13040727      View in EpiBrowser

Full name

Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial      

Location in the cell

Cytoplasmic   Reliability : 1.442 Nuclear   Reliability : 1.571

CDS

ATGCTGTGTTTTAGTAAAGTGCGAGTGAGTAGACTAAGGTGTAAGGTGGATCGTTTGTACGATCGTGTTCTGTACCATTCGGGCGCGGGAGTCTTCGGGCATCGACCGACGATTGCAGATGAATACGAGATTCCAGAGGACATAATATCAAAGAGATATAAGAACTGCCGAGCGCAACAGCTGGTCAACGCCTACCGTACGTACGGACATCTAAAGGCTACTATAGATAACGTAGACTACAGAAATGAAAGCAGGAATATCAAAGAGCTGCATTATTCGAGGTACGGTCTCGATCCCGAAGAAACAGTGGACACGGGTCTCCTGTATGGTTATAGCGGCAACAACTCAATCAAAAGCTTAGTAGATGAACTGGTTAAAATATATTGCGGGCATATATCGTATGAGTTCACGCATTTGGAGTCAGAAGCAGAAAGAGAATGGTTCGCTCAGCGCATCGAAAGCGGTGTAGATCCTGTGGAAAACGATCGAAGAATCGAAATTCTCAAAGAATTACTCCATTCTCAAGCCTGGGATAAATTCCTCTCAATCAAGTATCCCACTGTGAAAAGATATTGTGGCGAAGGGGCTGAATCATTATTGACCTTCTTTTCGACTTTATTTCGACTTACAACATCAGAAAGAATAGAACAGGTCATCTTAGGAATGGCCCATAGAGGGAAGTTGAACGTCCTCAGTGGGCTATTACAGTGTCCTCCGGTCAAGATCTTCCACAAGTTTACAGGAAGACCAGAATTTCCGGACGAAGCAAACGCAGCTTGTGATATTTCAACCCATCTCAGTGCATCAATAGACATAAAAGTGAATGATAGACATGTTCGATTTTCCTTACTAAATAATCCCTCACATTTAGAGGCCGTGAACCCTGTTTCAATGGGAAAGACAAGGTCAAAGCAACTGCATTTAAAAGAGGGACAGTACTCACTGGATGACTCTTCCAGAATGGGAGACAAGGTGCTGAATGTTCAGGTACACGGAGACGCAGCGTTTACCGGACAAGGAGTTAACCAGGAGACTCTGATGCTCTCTCAGGCTCCACACTTCAATGTGGGCGGGTCCTTGCACGTGGTCGTCAATAATCAGGTCGGCTTCACCCTGCCGGCGTATCGGGGTCGTTCTTGTCGCTACGTCACGGATTTAGCTAAGTGCATATCGGCTCCTGTTATTCATGTAAATGGTGATCATCCGGAGCTAGTGGTGAAAGCAACAAACATTGCGTTCGAGTATCAAAGGAAGTTCCGTAAGGACGTCTTCATAGACTACAATTGCTTCAGGAGATGGGGACACAACGAACTCGACGACCCGACCTTCACAAATCCACGTCTTTATAAACTAATACACAACAGGAAGTCGATTCCCGATGTTTACGTTGAAAGATTAATATCAGAAGGCGTTGTTAACGAAGAGGATGTGAATAACATCACTAGTGAATACACCAAGTATCTACAATCGCAATATGAAGCGGTGAACGCGTACCAACCAGAGGTATCATATTATCAAGAACAGTGGTCGTCGATGTCAACTGCTCCAAAAGCAATAGAGACATGGGATACTGGAGTAGACGAAAATCTTTTGAAGACCATAGGACAAGCATCTGTGAGAATTCCCAGTGAATTTAATATCCATCCACATTTAGCTAAAACGCACGTTAAGAATAGATTATCTAGAATATCCGAAGGGAAAGATCTGGACTGGGCGACAGCTGAGGCTCTGGCTTTTGGTTCTCTTCTAATGGAGGGGCGCAATGTGAGGCTTAGCGGCGAAGACGTCGGCCGCGGTACATTCTCGCACAGACACGCGATGCTTGTCGACCAGGAAACCGAAGCTATACACGTTCCGCTCAATCATATGCACGAGGACCAAAAAGGATTTTTGGAAGTGGCTAATTCAATACTATCCGAGGAAGCAGTGCTGGGCTTTGAGTACGGGATGGCCTACGACAGCCCCGACAATCTCTGTATATGGGAGGCGCAGTTTGGCGACTTCTACAACGGAGCTCAAATAATAGTGGACGCGTTTATAGCTTCCGGAGAATCCAAGTGGGTCCGCAGTAACGGGCTGGTGATGCTTCTCCCGCACGGCTACGACGGCGCCGCGTCAGAGCACTCCTCGTGCAGGCTCGAGCGATTCCTCCAGTTGACCGACAGTCCGGAGAGCGCGCCCGACTCGGAGGCTGCGTGTCTGCACGTCGCCAACCCGACGACCCCGGCCCAGTACTTCCACTTGTTGAGGAGACAGGTTGTCCGTAACTACAGGAAGCCATTGATAATTGTAGCTCCGAAATTGCTGCTCCGCTTAGCCGATGCCGTCTCGCCCCTGTCCGATTTCGCACCCCGCACTCATTTCCAGCCAGTAATCGGTGACGGTTTGGCTGATGCGTTGAAAGTGAAGCGGGTGATCTTTGTAAGCGGTAAGCATTACTACGAGTTGCATAAGGAGCGCGTGCGGGCGAGGCTGGAGGACGTGGCCATTGTGAGGGTGGAAGCACTCGCACCCTTCCCCCTCCCGGAGCTACAGATGCAACTCAGCAAATACAAAAACGCCACGAAGTTTATCTGGAGTCAAGAAGAGCATAGAAATATGGGAGCGTGGAGTTTCATGAAGCCTCGCTTCGAAAACCTTTGCGGGCGAAAGTTGGTGTACGCGGGAAGGTCTGAGGCGCCAACCCCCGCGGTGGGCGCTAGTTCACTTCATCGCGTCGAAGTTGAGCACGTGCTGAAAGAACCATTGTATAATTTAAAATAA

Protein

MLCFSKVRVSRLRCKVDRLYDRVLYHSGAGVFGHRPTIADEYEIPEDIISKRYKNCRAQQLVNAYRTYGHLKATIDNVDYRNESRNIKELHYSRYGLDPEETVDTGLLYGYSGNNSIKSLVDELVKIYCGHISYEFTHLESEAEREWFAQRIESGVDPVENDRRIEILKELLHSQAWDKFLSIKYPTVKRYCGEGAESLLTFFSTLFRLTTSERIEQVILGMAHRGKLNVLSGLLQCPPVKIFHKFTGRPEFPDEANAACDISTHLSASIDIKVNDRHVRFSLLNNPSHLEAVNPVSMGKTRSKQLHLKEGQYSLDDSSRMGDKVLNVQVHGDAAFTGQGVNQETLMLSQAPHFNVGGSLHVVVNNQVGFTLPAYRGRSCRYVTDLAKCISAPVIHVNGDHPELVVKATNIAFEYQRKFRKDVFIDYNCFRRWGHNELDDPTFTNPRLYKLIHNRKSIPDVYVERLISEGVVNEEDVNNITSEYTKYLQSQYEAVNAYQPEVSYYQEQWSSMSTAPKAIETWDTGVDENLLKTIGQASVRIPSEFNIHPHLAKTHVKNRLSRISEGKDLDWATAEALAFGSLLMEGRNVRLSGEDVGRGTFSHRHAMLVDQETEAIHVPLNHMHEDQKGFLEVANSILSEEAVLGFEYGMAYDSPDNLCIWEAQFGDFYNGAQIIVDAFIASGESKWVRSNGLVMLLPHGYDGAASEHSSCRLERFLQLTDSPESAPDSEAACLHVANPTTPAQYFHLLRRQVVRNYRKPLIIVAPKLLLRLADAVSPLSDFAPRTHFQPVIGDGLADALKVKRVIFVSGKHYYELHKERVRARLEDVAIVRVEALAPFPLPELQMQLSKYKNATKFIWSQEEHRNMGAWSFMKPRFENLCGRKLVYAGRSEAPTPAVGASSLHRVEVEHVLKEPLYNLK

Description

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).

Catalytic Activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Similarity

Belongs to the alpha-ketoglutarate dehydrogenase family.

Keywords

Complete proteome   Glycolysis   Mitochondrion   Oxidoreductase   Reference proteome   Thiamine pyrophosphate   Transit peptide  

Feature

chain  Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial

Uniprot

H9J9W6   A0A2A4JYZ4   A0A2W1C0B4   A0A194QA39   A0A194R6A8   A0A212EWL3   + More
A0A336KE13   A0A336KRN1   A0A1Q3F7Y8   A0A1L8E1X1   A0A1B0CNM7   Q17A22   A0A1S4FAH9   A0A1I8PJ39   A0A182RBH6   A0A067QU92   A0A182N116   K7IUV8   A0A2J7Q3A4   A0A182QNH5   A0A182W4P1   Q7QFL5   A0A1I8MMC7   A0A182TTI2   T1PCK3   A0A182JSU8   A0A182IA84   A0A182P7W8   A0A084VQJ9   A0A1Y1M1P4   A0A1J1HYE3   A0A0L0BYF1   A0A232FJI2   A0A0C9RMD5   B4K6G8   A0A182G1X9   A0A182ILV6   D6WSA2   B3M1K2   A0A182Y7J3   A0A182FIZ8   B4M5V2   A0A0L7RIC1   A0A0P8YN15   B4NFC0   T2FGC6   A0A2M4ACB9   A0A2M4AC86   Q9VA02   A0A1W4UJW9   A0A1A9UWW9   B4JYP6   A0A2M4BCS7   B4PNA9   B7S8K1   W5JCA4   B4HZZ8   A0A1B0CA28   A0A0N0BIW2   A0A1B0FP46   B4GN62   A0A0M4ET54   B3P7S2   A0A088ARH6   Q29CE4   A0A2J7Q3B8   A0A0R1EBU7   E0VMM6   W8AY39   E2BWB8   A0A195C017   A0A0R1EB63   A0A195F0P0   A0A1B0AJV8   A0A2A3EEG9   A0A151WHB9   A0A0P4W105   A0A034W3N6   F4X649   A0A1B6F3Q9   A0A026VZ21   A0A0K8VTR3   A0A151JSB7   A0A034W135   A0A2M4BDZ8   R7TK32   B4QSK0   A0A0A1WZ00   A0A3L8D834   C3XZI3   A0A182SGC9   A0A195BFV0   A0A226DC11   N6UA32   A0A0K8VEC9   A0A210QCZ1   A0A146LLC5   A0A3M6V5H9   A0A1D2N397   T1HJH1  

EC Number

1.2.4.2

Pubmed

19121390    28756777    26354079    22118469    17510324    24845553    + More
20075255    12364791    14747013    17210077    25315136    24438588    28004739    26108605    28648823    17994087    26483478    18362917    19820115    25244985    10731132    12537572    12537569    17550304    20920257    23761445    15632085    20566863    24495485    20798317    25348373    21719571    24508170    23254933    25830018    30249741    18563158    23537049    28812685    26823975    30382153    27289101   

EMBL

BABH01025994    BABH01025995    BABH01025996    BABH01025997    NWSH01000409    PCG76602.1    + More
KZ149893    PZC78957.1    KQ459249    KPJ02393.1    KQ460647    KPJ13202.1    AGBW02011968    OWR45857.1    UFQS01000248    UFQT01000248    SSX01988.1    SSX22365.1    UFQS01000674    UFQT01000674    SSX06055.1    SSX26411.1    GFDL01011406    JAV23639.1    GFDF01001376    JAV12708.1    AJWK01020537    CH477341    EAT43084.1    KK853256    KDR09266.1    AAZX01008132    NEVH01019069    PNF23063.1    AXCN02001386    AAAB01008846    EAA06290.5    KA646487    KA646488    AFP61116.1    APCN01001132    ATLV01015219    KE525003    KFB40243.1    GEZM01042459    JAV79842.1    CVRI01000020    CRK91153.1    JRES01001160    KNC25062.1    NNAY01000115    OXU30835.1    GBYB01009480    JAG79247.1    CH933806    EDW16268.1    JXUM01039555    JXUM01039556    KQ561209    KXJ79339.1    KQ971354    EFA05916.2    CH902617    EDV43293.1    CH940652    EDW59028.1    KQ414584    KOC70615.1    KPU80189.1    CH964251    EDW82987.1    BT150263    AGV77165.1    GGFK01005079    MBW38400.1    GGFK01005072    MBW38393.1    AE014297    AY118301    BT001573    CH916377    EDV90808.1    GGFJ01001650    MBW50791.1    CM000160    EDW99191.1    EF710647    ACE75226.1    ADMH02001918    ETN60520.1    CH480819    EDW53605.1    AJWK01003181    KQ435726    KOX78238.1    CCAG010007645    CH479186    EDW39188.1    CP012526    ALC48035.1    CH954182    EDV52980.1    CM000070    EAL26702.3    PNF23060.1    KRK04722.1    DS235317    EEB14632.1    GAMC01015563    JAB90992.1    GL451103    EFN80022.1    KQ978501    KYM93516.1    KRK04721.1    KQ981866    KYN34043.1    KZ288282    PBC29566.1    KQ983120    KYQ47233.1    GDRN01096692    JAI59289.1    GAKP01010559    JAC48393.1    GL888769    EGI58082.1    GECZ01024919    JAS44850.1    KK107565    EZA48920.1    GDHF01010042    JAI42272.1    KQ978530    KYN30278.1    GAKP01010558    JAC48394.1    GGFJ01002138    MBW51279.1    AMQN01000298    KB309537    ELT94079.1    CM000364    EDX15097.1    GBXI01010557    JAD03735.1    QOIP01000012    RLU16243.1    GG666475    EEN66504.1    KQ976488    KYM83485.1    LNIX01000025    OXA42749.1    APGK01036958    KB740945    ENN77496.1    GDHF01015102    JAI37212.1    NEDP02004132    OWF46585.1    GDHC01010400    JAQ08229.1    RCHS01000076    RMX61139.1    LJIJ01000257    ODM99756.1    ACPB03006493   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000092461    + More
UP000008820    UP000095300    UP000075900    UP000027135    UP000075884    UP000002358    UP000235965    UP000075886    UP000075920    UP000007062    UP000095301    UP000075902    UP000075881    UP000075840    UP000075885    UP000030765    UP000183832    UP000037069    UP000215335    UP000009192    UP000069940    UP000249989    UP000075880    UP000007266    UP000007801    UP000076408    UP000069272    UP000008792    UP000053825    UP000007798    UP000000803    UP000192221    UP000078200    UP000001070    UP000002282    UP000000673    UP000001292    UP000053105    UP000092444    UP000008744    UP000092553    UP000008711    UP000005203    UP000001819    UP000009046    UP000008237    UP000078542    UP000078541    UP000092445    UP000242457    UP000075809    UP000007755    UP000053097    UP000078492    UP000014760    UP000000304    UP000279307    UP000001554    UP000075901    UP000078540    UP000198287    UP000019118    UP000242188    UP000275408    UP000094527    UP000015103   

PRIDE

H9J9W6    T2FGC6    Q9VA02   

Pfam

PF00676   E1_dh        + More
PF02779   Transket_pyr
PF16870   OxoGdeHyase_C
PF10225   NEMP

Interpro

IPR011603   2oxoglutarate_DH_E1        + More
IPR042179   KGD_C_sf       
IPR029061   THDP-binding       
IPR005475   Transketolase-like_Pyr-bd       
IPR001017   DH_E1       
IPR031717   KGD_C       
IPR019358   NEMP_fam       
IPR020846   MFS_dom       

SUPFAM

SSF52518   SSF52518       

Gene 3D

3.40.50.11610    

CDD

cd06174  MFS

ProteinModelPortal

H9J9W6   A0A2A4JYZ4   A0A2W1C0B4   A0A194QA39   A0A194R6A8   A0A212EWL3   + More
A0A336KE13   A0A336KRN1   A0A1Q3F7Y8   A0A1L8E1X1   A0A1B0CNM7   Q17A22   A0A1S4FAH9   A0A1I8PJ39   A0A182RBH6   A0A067QU92   A0A182N116   K7IUV8   A0A2J7Q3A4   A0A182QNH5   A0A182W4P1   Q7QFL5   A0A1I8MMC7   A0A182TTI2   T1PCK3   A0A182JSU8   A0A182IA84   A0A182P7W8   A0A084VQJ9   A0A1Y1M1P4   A0A1J1HYE3   A0A0L0BYF1   A0A232FJI2   A0A0C9RMD5   B4K6G8   A0A182G1X9   A0A182ILV6   D6WSA2   B3M1K2   A0A182Y7J3   A0A182FIZ8   B4M5V2   A0A0L7RIC1   A0A0P8YN15   B4NFC0   T2FGC6   A0A2M4ACB9   A0A2M4AC86   Q9VA02   A0A1W4UJW9   A0A1A9UWW9   B4JYP6   A0A2M4BCS7   B4PNA9   B7S8K1   W5JCA4   B4HZZ8   A0A1B0CA28   A0A0N0BIW2   A0A1B0FP46   B4GN62   A0A0M4ET54   B3P7S2   A0A088ARH6   Q29CE4   A0A2J7Q3B8   A0A0R1EBU7   E0VMM6   W8AY39   E2BWB8   A0A195C017   A0A0R1EB63   A0A195F0P0   A0A1B0AJV8   A0A2A3EEG9   A0A151WHB9   A0A0P4W105   A0A034W3N6   F4X649   A0A1B6F3Q9   A0A026VZ21   A0A0K8VTR3   A0A151JSB7   A0A034W135   A0A2M4BDZ8   R7TK32   B4QSK0   A0A0A1WZ00   A0A3L8D834   C3XZI3   A0A182SGC9   A0A195BFV0   A0A226DC11   N6UA32   A0A0K8VEC9   A0A210QCZ1   A0A146LLC5   A0A3M6V5H9   A0A1D2N397   T1HJH1  

PDB

2JGD     E-value=1.30024e-167,     Score=1517

KEGG

101740126    K15791 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2] | (RefSeq) probable 2-

PATHWAY

00310    Lysine degradation - Bombyx mori (domestic silkworm)
00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004591   GO:0006099   GO:0030976   GO:0005829   GO:0045252   GO:0006091   GO:0006096   GO:0031966   GO:0016021   GO:0008152   GO:0016624   GO:0051103   GO:0005524   GO:0008270   GO:0042555   GO:0048384   GO:0055114  

PANTHER

PTHR23152  

Subcellular location

Mitochondrion  

Length:

920

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00324

Exp number, first 60 AAs:

0.00204

Total prob of N-in:

0.00019

outside

1  -  920

 

 

Pi

182.829388

Theta

160.984907

Tajima's D

0.836575

CLR

0.142698

CSRT

0.616569171541423

Interpretation

Uncertain