Gene

KWMTBOMO03565

Pre Gene Modal

BGIBMGA006299

Annotation

PREDICTED:_peripheral_plasma_membrane_protein_CASK-like_[Bombyx_mori]

Location

Bomo_Chr6(+):12262062-12267332      View in EpiBrowser

Full name

Peripheral plasma membrane protein CASK      

Alternative Name

Calcium/calmodulin-dependent protein kinase

Location in the cell

Mitochondrial   Reliability : 1.9

CDS

ATGCTTTTTTTTCAGATCATCAGCAAGGATGACTCTCACTGGTGGCAAGCTCGTAAAGACGCTTCTGGCGGCTCGGCTGGTCTCATACCCAGTCCTGAGTTGCAGGAATGGAGGGCTGCGTGTGCTGCCGCAGAAAAATCTAGCACCGACCAAGTCAACTGTTCTATATTCGGCCGCAAGAAGAAGCAGTCCAAGGACAAGTATCTCGCTAAGCACAACGCGGTGTTCGATCAACTGGACGTAGTCACATACGAGGAAGTCGTCAAACTGCCTTCGTTCCAAAGAAAAACGCTGGTTCTGCTTGGCGCCCACGGAGTCGGCAGACGTCACATCAAGAACACTTTAATCGCCCGACATCCTGATCTGTACGCCTATCCTATACCGCACACCACGAGACCGCCGCGTCCGGACGAGGAGAGCAACAGACAGTATTACTTCATCAGCCACGATGAGATGATGGCTGATATCGCGGCCAACGAATATTTGGAATACGGCACGCACGAGGACGCGATGTACGGCACGAAGATCGAGACGATCCGGCGGATCCACGCCGAGCGCCGCGTCGCCATACTGGACGTCGAGCCGCAGGCCCTCAAGATCCTGCGCACCGCCGAGTTCGCGCCCTTCGTCGTGCTCGTCGCCTCGCCGGAGCCGCACACTGTCAGCGAGCAAGTCCGCGCCATGTACGACGGCACCACGCTAGAGCTTCTGGGCCGCGAGACGGAACAGCTGCGGCGGAACTACGGCCACTACGTTGACTTCACGGTCGTGAACCACGACATAGACGACACCATCGCGCAACTAGAGGCGGCGATCGCGCGCGTGCGCTCCAACCCGCAGTGGGTGCCCGTCTCGTGGGTCTACTGA

Protein

MLFFQIISKDDSHWWQARKDASGGSAGLIPSPELQEWRAACAAAEKSSTDQVNCSIFGRKKKQSKDKYLAKHNAVFDQLDVVTYEEVVKLPSFQRKTLVLLGAHGVGRRHIKNTLIARHPDLYAYPIPHTTRPPRPDEESNRQYYFISHDEMMADIAANEYLEYGTHEDAMYGTKIETIRRIHAERRVAILDVEPQALKILRTAEFAPFVVLVASPEPHTVSEQVRAMYDGTTLELLGRETEQLRRNYGHYVDFTVVNHDIDDTIAQLEAAIARVRSNPQWVPVSWVY

Description

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with eag. Interacts with CaMKII.

Similarity

Belongs to the MAGUK family.
In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Keywords

Alternative splicing   ATP-binding   Calmodulin-binding   Cell membrane   Complete proteome   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   SH3 domain   Transferase  

Feature

chain  Peripheral plasma membrane protein CASK
splice variant  In isoform A and isoform G.

Uniprot

A0A194QAE5   A0A2A4K1W7   A0A2A4K2J0   H9J9V4   A0A194R7K0   E9IHT7   + More
A0A0K8T4P3   A0A1B6CCQ1   E2ASJ6   A0A0C9R1A7   A0A2J7QG51   A0A067R6U6   T1I9P2   A0A1B6CHW8   A0A195BW99   A0A1A9UNN0   A0A151J6Y0   A0A026X3H3   A0A182WSP6   A0A182TRY6   A0A182Y3P6   A0A182HLJ8   D6WEC4   B3NZY8   A0A151WZP0   A0A1B6C8D9   A0A336KGN3   A0A336M3P7   A0A182JTV1   A0A0P4W5Y5   A0A023F4C5   Q17E54   A0A158P3G5   A0A034VRZ6   A0A034VNJ5   A0A182PSM5   B4G609   A0A084VVT4   A0A2J7QG19   A0A0A1WK85   K7J2A6   A0A1B6C0X7   A8JR72   A0A1W4XGY7   K7J2A7   A0A1B6ILM6   A0A0A9WK55   A0A0Q9W844   A0A0Q9X044   A0A0A9WSE7   A0A1Y1M581   A0A0Q9W019   A0A232F5Q3   W8BA69   A0A1B6KHE7   A0A0Q9W086   A0A182L9Z8   T1PN67   A0A1B6KHC7   Q24210-2   A8JR71   T1PCF3   B4HM46   A0A0Q9VZV4   B4NHN8   B4K703   A0A182RAM2   A0A1W4VQH4   A0A2C9GKK1   A0A034VSU1   A0A0P8YLP4   A0A0K8WM54   A0A034VQY7   A0A0K8WLW8   A0A1I8NGQ3   U5ENN4   N6UTD1   A0A182VZI6   B4JGQ3   A0A1I8P1R0   W8B0H9   A0A2M4CSE2   A0A3B0JPX6   A0A0L7RF88   Q29AR4   B4QZ93   A0A0A1X353   A0A0A1WKB1   A0A1W4W1R1   Q24210   A0A1B6DHA6   A0A154PDC4   A0A1W4W1R6   A0A0B4KH39   A0A1W4VQ70   B4MC57   B3LVH5   A0A1B6GYS9   A0A0R1E448   A0A0Q9XAF3  

EC Number

2.7.11.17

Pubmed

26354079    19121390    21282665    20798317    24845553    24508170    + More
25244985    18362917    19820115    17994087    25474469    17510324    21347285    25348373    24438588    25830018    20075255    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    25401762    28004739    28648823    24495485    20966253    9178262    8617233    12537569    14687552    15901771    16880127    26109357    26109356    25315136    23537049    15632085    17550304   

EMBL

KQ459249    KPJ02404.1    NWSH01000224    PCG78237.1    PCG78236.1    BABH01025923    + More
BABH01025924    KQ460647    KPJ13215.1    GL763294    EFZ19865.1    GBRD01005332    JAG60489.1    GEDC01026100    JAS11198.1    GL442313    EFN63593.1    GBYB01001740    JAG71507.1    NEVH01014836    PNF27523.1    KK852659    KDR19138.1    ACPB03020482    ACPB03020483    ACPB03020484    ACPB03020485    ACPB03020486    GEDC01024307    JAS12991.1    KQ976403    KYM92241.1    KQ979796    KYN19083.1    KK107037    EZA61949.1    APCN01000909    KQ971326    EEZ99889.2    CH954181    EDV49986.1    KQ982649    KYQ53145.1    GEDC01027719    JAS09579.1    UFQS01000396    UFQT01000396    SSX03597.1    SSX23962.1    SSX03596.1    SSX23961.1    GDRN01089491    JAI60647.1    GBBI01002351    JAC16361.1    CH477285    EAT44764.1    ADTU01007864    ADTU01007865    ADTU01007866    GAKP01014060    JAC44892.1    GAKP01014061    JAC44891.1    CH479179    EDW23776.1    ATLV01017277    KE525161    KFB42078.1    PNF27522.1    GBXI01015040    JAC99251.1    AAZX01001591    AAZX01006227    AAZX01008245    GEDC01030126    JAS07172.1    AE014297    ABW08724.1    GECU01019894    JAS87812.1    GBHO01035803    JAG07801.1    CH940656    KRF78391.1    CH933806    KRG01504.1    GBHO01032900    JAG10704.1    GEZM01042960    JAV79445.1    KRF78392.1    NNAY01000914    OXU25942.1    GAMC01019821    JAB86734.1    GEBQ01029101    JAT10876.1    KRF78397.1    KA649495    AFP64124.1    GEBQ01029121    JAT10856.1    U53190    X94264    AY094916    BT003532    BT003550    BT046172    BT044550    ABW08723.1    ACI12875.1    KA646369    AFP60998.1    CH480815    EDW43094.1    KRF78396.1    CH964272    EDW84648.1    EDW15290.1    GAKP01014062    JAC44890.1    CH902617    KPU79786.1    GDHF01000170    JAI52144.1    GAKP01014063    JAC44889.1    GDHF01000156    JAI52158.1    GANO01000524    JAB59347.1    APGK01017005    APGK01017006    APGK01017007    KB739995    KB631244    KB631245    KB631613    ENN82017.1    ERL84187.1    ERL84188.1    ERL84668.1    CH916369    EDV92657.1    GAMC01019824    JAB86731.1    GGFL01004072    MBW68250.1    OUUW01000007    SPP82953.1    KQ414607    KOC69493.1    CM000070    EAL27285.3    CM000364    EDX13829.1    GBXI01010360    GBXI01008548    JAD03932.1    JAD05744.1    GBXI01015015    JAC99276.1    GEDC01012231    JAS25067.1    KQ434869    KZC09384.1    AGB96191.1    EDW58678.2    EDV42545.2    GECZ01002211    JAS67558.1    CM000160    KRK04027.1    KRG01505.1   

Proteomes

UP000053268    UP000218220    UP000005204    UP000053240    UP000000311    UP000235965    + More
UP000027135    UP000015103    UP000078540    UP000078200    UP000078492    UP000053097    UP000076407    UP000075902    UP000076408    UP000075840    UP000007266    UP000008711    UP000075809    UP000075881    UP000008820    UP000005205    UP000075885    UP000008744    UP000030765    UP000002358    UP000000803    UP000192223    UP000008792    UP000009192    UP000215335    UP000075882    UP000001292    UP000007798    UP000075900    UP000192221    UP000007801    UP000095301    UP000019118    UP000030742    UP000075920    UP000001070    UP000095300    UP000268350    UP000053825    UP000001819    UP000000304    UP000076502    UP000002282   

PRIDE

H9J9V4    A8JR72    Q24210    A8JR71   

Pfam

PF00595   PDZ        + More
PF07653   SH3_2
PF00625   Guanylate_kin
PF02828   L27
PF00069   Pkinase
PF00018   SH3_1
PF01569   PAP2

Interpro

IPR036028   SH3-like_dom_sf        + More
IPR027417   P-loop_NTPase       
IPR020590   Guanylate_kinase_CS       
IPR036034   PDZ_sf       
IPR001478   PDZ       
IPR008145   GK/Ca_channel_bsu       
IPR008144   Guanylate_kin-like_dom       
IPR001452   SH3_domain       
IPR004172   L27_dom       
IPR014775   L27_C       
IPR036892   L27_dom_sf       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR035473   CASK_SH3       
IPR036938   P_Acid_Pase_2/haloperoxi_sf       
IPR000326   P_Acid_Pase_2/haloperoxidase       

SUPFAM

SSF50044   SSF50044        + More
SSF52540   SSF52540       
SSF50156   SSF50156       
SSF101288   SSF101288       
SSF56112   SSF56112       
SSF48317   SSF48317       

CDD

cd12081  SH3_CASK

ProteinModelPortal

A0A194QAE5   A0A2A4K1W7   A0A2A4K2J0   H9J9V4   A0A194R7K0   E9IHT7   + More
A0A0K8T4P3   A0A1B6CCQ1   E2ASJ6   A0A0C9R1A7   A0A2J7QG51   A0A067R6U6   T1I9P2   A0A1B6CHW8   A0A195BW99   A0A1A9UNN0   A0A151J6Y0   A0A026X3H3   A0A182WSP6   A0A182TRY6   A0A182Y3P6   A0A182HLJ8   D6WEC4   B3NZY8   A0A151WZP0   A0A1B6C8D9   A0A336KGN3   A0A336M3P7   A0A182JTV1   A0A0P4W5Y5   A0A023F4C5   Q17E54   A0A158P3G5   A0A034VRZ6   A0A034VNJ5   A0A182PSM5   B4G609   A0A084VVT4   A0A2J7QG19   A0A0A1WK85   K7J2A6   A0A1B6C0X7   A8JR72   A0A1W4XGY7   K7J2A7   A0A1B6ILM6   A0A0A9WK55   A0A0Q9W844   A0A0Q9X044   A0A0A9WSE7   A0A1Y1M581   A0A0Q9W019   A0A232F5Q3   W8BA69   A0A1B6KHE7   A0A0Q9W086   A0A182L9Z8   T1PN67   A0A1B6KHC7   Q24210-2   A8JR71   T1PCF3   B4HM46   A0A0Q9VZV4   B4NHN8   B4K703   A0A182RAM2   A0A1W4VQH4   A0A2C9GKK1   A0A034VSU1   A0A0P8YLP4   A0A0K8WM54   A0A034VQY7   A0A0K8WLW8   A0A1I8NGQ3   U5ENN4   N6UTD1   A0A182VZI6   B4JGQ3   A0A1I8P1R0   W8B0H9   A0A2M4CSE2   A0A3B0JPX6   A0A0L7RF88   Q29AR4   B4QZ93   A0A0A1X353   A0A0A1WKB1   A0A1W4W1R1   Q24210   A0A1B6DHA6   A0A154PDC4   A0A1W4W1R6   A0A0B4KH39   A0A1W4VQ70   B4MC57   B3LVH5   A0A1B6GYS9   A0A0R1E448   A0A0Q9XAF3  

PDB

1KGD     E-value=2.63451e-64,     Score=621

KEGG

101744976    K06103 calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1] | (RefSeq) peripheral plasma

GO

GO:0016301   GO:0016021   GO:0005524   GO:0004672   GO:0004674   GO:0007615   GO:0004683   GO:0031594   GO:0042043   GO:0008582   GO:0007616   GO:0008049   GO:0040011   GO:0005886   GO:0040012   GO:2000331   GO:0007269   GO:0048149   GO:0007163   GO:0061174   GO:0005516   GO:0072375   GO:0016080   GO:0008344   GO:0007298   GO:0007274   GO:0048488   GO:0007628   GO:0046928   GO:1900073   GO:0016081   GO:1900244   GO:0005515   GO:0003676   GO:0015074   GO:0006468   GO:0016020   GO:0051103   GO:0008270   GO:0042555   GO:0048384  

Subcellular location

Cell membrane  

Length:

288

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00023

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01014

outside

1  -  288

 

 

Pi

162.060468

Theta

177.632979

Tajima's D

-0.449475

CLR

20.54559

CSRT

0.253787310634468

Interpretation

Uncertain