Gene

KWMTBOMO03560

Pre Gene Modal

BGIBMGA006298

Annotation

PREDICTED:_peripheral_plasma_membrane_protein_CASK_[Bombyx_mori]

Location

Bomo_Chr6(+):12037450-12054126      View in EpiBrowser

Full name

Peripheral plasma membrane protein CASK      

Alternative Name

Calcium/calmodulin-dependent protein kinase

Location in the cell

Cytoplasmic   Reliability : 2.08

CDS

ATGGCCGAAGACGAAGTGTTATTCGACGATGTGTACGAATTGTGCGAAATCATCGGAAAGGGTCCATTCAGTTTGGTTCGTCGCTGTGTGCACCGGCAAACAGCACAACAGTTTGCAGTGAAAATTGTGGATGTGGCCCGCTTCACTGCTAGTCCGGGACTTAGCACTGCAGATTTGAAAAGAGAAGCAACAATATGTCATATGTTGAAGCATCCTCATATAGTGGAACTGCTGGAAACCTACAGCTCCGAAGGCATGCTATATATGGTGTTTGAATATATGGATGGCTCTGACCTTTGCTTCGAAGTGGTTCGACGAGCTTCTGCCGGGTTCGTCTACAGCGAAGCGGTGGCATGTCATTACATGCGTCAGATTCTCGAAGCGCTCCGCTATTGTCACGAGAACGACATCGTGCACCGTGACGTCAGACCTCACTGCGTTCTGCTGGCCGGGAGGGACAACTGCGCGCCGGTGAAGCTCGGGGGATTCGGCGTGGCCGCCCAGTTGCCAACGCCCACGTCGCATCGAGCCCCACCAGAACTGGTGATGGACAATCGACCGCTAATGGGTCCGATGGGCCAAGCCTATCTCAAATCCGATGAGTACGGTCGTATCGGTACTCCTCACTATATGGCCCCGGAAGTTGTATCCAGCCAGTTGTACGGGAAGCCCGTCGATGTGTGGGCGGCGGGTATATTGTTGCACGTACTGCTTGTTGGATATCTACCCTTCGCCGGAACAAGGGAACGCCTGTTCGAGGCTATTTGCAGGGGGAGATTAAGGTTCGACGCTCCTCTCTGGGATGATGTAAGCGATGCTGCCAAAGATCTAGTGCAACGCATGCTCACCGTCGATCACACTCAGAGGATCAACATTCAAGACGTGCTCAATCATCGATGGATAAAAGATCGCGAAAAACAGAACCGCATCCACCTGGCCGGTACCGTCGAGGAGCTGAAGAAGTTTAATAGTCGTCGTCGATTGAGGGCTGCCACTCTCGGCGCCGCCGCGGCCGACGACGAGGAGGAGGAGGAACAGCAGCCGACTCGCAAACAGGCGATGCTCGAGGAGGCCAACGCTGCAGCTGTGAATATCGTCGTGGAGTCATTGGACGACGTGGCTGTCCTCCAGGACGGTCCGTTGTTCATAGACCCGGACCTCTTCCACAGCGTGCTCGACGATTTGCAACTGAGAGCCCTACTAGAGGTGTACGACCGCATAGCGTGCACTGTGGTGGTGACGAGCGGGCGAGCCCCCGCGGCGGAGGGTCGCGCCCGCGCCCGCCACGCGCTGGAGGCCACCACGCGCCTGCGCCACGCCGCCGCCCCCGCCGCGCCCCCCGCCGCGCCCGCCGCCGCCGCGCCCGCCGCCGCCGCGCCCGCCACCGCCGCCGCCGTGCACGACCTGCGCCGCCTGCTCGCTCTGCCGCACGTTAAGAAAATCTAA

Protein

MAEDEVLFDDVYELCEIIGKGPFSLVRRCVHRQTAQQFAVKIVDVARFTASPGLSTADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEYMDGSDLCFEVVRRASAGFVYSEAVACHYMRQILEALRYCHENDIVHRDVRPHCVLLAGRDNCAPVKLGGFGVAAQLPTPTSHRAPPELVMDNRPLMGPMGQAYLKSDEYGRIGTPHYMAPEVVSSQLYGKPVDVWAAGILLHVLLVGYLPFAGTRERLFEAICRGRLRFDAPLWDDVSDAAKDLVQRMLTVDHTQRINIQDVLNHRWIKDREKQNRIHLAGTVEELKKFNSRRRLRAATLGAAAADDEEEEEQQPTRKQAMLEEANAAAVNIVVESLDDVAVLQDGPLFIDPDLFHSVLDDLQLRALLEVYDRIACTVVVTSGRAPAAEGRARARHALEATTRLRHAAAPAAPPAAPAAAAPAAAAPATAAAVHDLRRLLALPHVKKI

Description

May regulate transmembrane proteins that bind calcium, calmodulin, or nucleotides. Functionally modulates eag potassium channels; increases eag current and whole-cell conductance. Also regulates autophosphorylation of CaMKII.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Interacts with eag. Interacts with CaMKII.

Similarity

Belongs to the MAGUK family.
In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Keywords

Alternative splicing   ATP-binding   Calmodulin-binding   Cell membrane   Complete proteome   Kinase   Membrane   Nucleotide-binding   Phosphoprotein   Reference proteome   Repeat   SH3 domain   Transferase  

Feature

chain  Peripheral plasma membrane protein CASK
splice variant  In isoform A and isoform G.

Uniprot

A0A0N0PD55   A0A212F0U0   H9J9V3   A0A194QG32   A0A2A4JFP8   A0A2A4JGK0   + More
A0A1B6C0X7   A0A1B6DHA6   A0A224XLD3   A0A0K8SEW2   A0A1B6DER4   A0A232F5Q3   A0A1B6G1C8   A0A0N1IT67   A0A0A9WSH7   A0A023F4C5   A0A067RCY7   A0A0A9WSE7   A0A0K8SEV3   A0A0A9WH75   A0A1S4ENM9   A0A2A3EEW1   K7J2A6   K7J2A7   E2ASJ0   A0A2S2Q3F2   E2BZU4   A0A2H8TJY2   A0A0A9WK55   A0A026X1H1   A0A2M4AVN7   A0A0L7RF97   B3P8S1   F5HMI9   B4G619   J9JVX3   B4QZ94   A0A139WKH6   D6WEC4   A0A0Q9VZW4   A0A1A9YUC0   B4JGQ4   A0A0K8U4D6   A0A0K8USR1   A0A0Q9WC59   A0A0Q9VZV6   B4HM48   W8BF57   A0A1A9W5Y9   A0A2C9GQA3   A0A084VVT9   A0A2M4CSE2   A0NGZ6   B3LVH5   A0A0Q9XA77   A0A1W4W1R1   A0A0Q9X046   Q24210   A0A1W4VQ70   Q29AR4   A0A0P8XYE7   A0A3B0JPX6   A0A0P9C8I4   E1JIS7   B4MC57   A0A0R1E448   A0A1W4W370   A0A1W4VQG9   A0A1I8NGR6   A0A0B4KH39   A0A034VQY7   A0A0K8WM54   A0A1I8NGR2   A0A0K8WLW8   A0A0A1X353   A0A0K8VA90   A0A1Y1M581   A0A0K8WKD8   A0A0Q9X7H2   A0A0Q9WXB7   A0A0Q9X5S6   A0A1I8NGQ2   U5ENN4   A0A1B6KHC7   A0A1S3JFV7   A0A1J1J4A6   A0A1J1J8K3   A0A2I4DAX8   A0A146V7X9   A0A1I8NGQ8   A0A1I8P1T1   A0A1I8NGR3   A0A1I8P1L9  

EC Number

2.7.11.17

Pubmed

26354079    22118469    19121390    28648823    25401762    25474469    + More
24845553    20075255    20798317    24508170    17994087    12364791    18362917    19820115    24495485    24438588    9178262    8617233    10731132    12537572    12537569    14687552    15901771    16880127    15632085    12537568    12537573    12537574    16110336    17569856    17569867    17550304    25315136    25348373    25830018    28004739   

EMBL

KQ460324    KPJ15842.1    AGBW02011024    OWR47350.1    BABH01025906    KQ459249    + More
KPJ02406.1    NWSH01001543    PCG70905.1    PCG70906.1    GEDC01030126    JAS07172.1    GEDC01012231    JAS25067.1    GFTR01007585    JAW08841.1    GBRD01014003    JAG51823.1    GEDC01013168    JAS24130.1    NNAY01000914    OXU25942.1    GECZ01013521    JAS56248.1    KQ435859    KOX70502.1    GBHO01035804    JAG07800.1    GBBI01002351    JAC16361.1    KK852547    KDR21602.1    GBHO01032900    JAG10704.1    GBRD01014004    JAG51822.1    GBHO01035802    JAG07802.1    KZ288272    PBC29739.1    AAZX01001591    AAZX01006227    AAZX01008245    GL442313    EFN63587.1    GGMS01002948    MBY72151.1    GL451689    EFN78780.1    GFXV01002177    MBW13982.1    GBHO01035803    JAG07801.1    KK107037    EZA61943.1    GGFK01011532    MBW44853.1    KQ414607    KOC69489.1    CH954182    EDV54235.1    AAAB01008987    EGK97511.1    CH479179    EDW23778.1    ABLF02026617    CM000364    EDX13830.1    KQ971326    KYB28489.1    EEZ99889.2    CH940656    KRF78394.1    CCAG010002878    CH916369    EDV92658.1    GDHF01030891    JAI21423.1    GDHF01022756    JAI29558.1    KRF78395.1    KRF78393.1    CH480815    EDW43096.1    GAMC01009233    JAB97322.1    APCN01000909    ATLV01017289    ATLV01017290    ATLV01017291    ATLV01017292    ATLV01017293    ATLV01017294    ATLV01017295    KE525161    KFB42083.1    GGFL01004072    MBW68250.1    EAU75645.3    CH902617    EDV42545.2    CH933806    KRG01502.1    KRG01500.1    U53190    X94264    AE014297    AY094916    BT003532    BT003550    BT046172    CM000070    EAL27285.3    KPU79785.1    OUUW01000007    SPP82953.1    KPU79787.1    ACZ94977.1    EDW58678.2    CM000160    KRK04027.1    AGB96191.1    GAKP01014063    JAC44889.1    GDHF01000170    JAI52144.1    GDHF01000156    JAI52158.1    GBXI01010360    GBXI01008548    JAD03932.1    JAD05744.1    GDHF01016503    JAI35811.1    GEZM01042960    JAV79445.1    GDHF01000790    JAI51524.1    CH964272    KRG00088.1    KRG00089.1    KRG00087.1    GANO01000524    JAB59347.1    GEBQ01029121    JAT10856.1    CVRI01000070    CRL07232.1    CRL07233.1    GCES01072810    JAR13513.1   

Proteomes

UP000053240    UP000007151    UP000005204    UP000053268    UP000218220    UP000215335    + More
UP000053105    UP000027135    UP000079169    UP000242457    UP000002358    UP000000311    UP000008237    UP000053097    UP000053825    UP000008711    UP000007062    UP000008744    UP000007819    UP000000304    UP000007266    UP000008792    UP000092444    UP000001070    UP000001292    UP000091820    UP000075840    UP000030765    UP000007801    UP000009192    UP000192221    UP000000803    UP000001819    UP000268350    UP000002282    UP000095301    UP000007798    UP000085678    UP000183832    UP000192220    UP000095300   

PRIDE

H9J9V3    Q24210    E1JIS7   

Pfam

PF00069   Pkinase        + More
PF02828   L27
PF07653   SH3_2
PF00595   PDZ
PF00625   Guanylate_kin
PF00018   SH3_1

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR036892   L27_dom_sf       
IPR014775   L27_C       
IPR000719   Prot_kinase_dom       
IPR004172   L27_dom       
IPR008145   GK/Ca_channel_bsu       
IPR001452   SH3_domain       
IPR008144   Guanylate_kin-like_dom       
IPR036028   SH3-like_dom_sf       
IPR027417   P-loop_NTPase       
IPR001478   PDZ       
IPR036034   PDZ_sf       
IPR020590   Guanylate_kinase_CS       
IPR035473   CASK_SH3       

SUPFAM

SSF56112   SSF56112        + More
SSF101288   SSF101288       
SSF50156   SSF50156       
SSF52540   SSF52540       
SSF50044   SSF50044       

CDD

cd12081  SH3_CASK

ProteinModelPortal

A0A0N0PD55   A0A212F0U0   H9J9V3   A0A194QG32   A0A2A4JFP8   A0A2A4JGK0   + More
A0A1B6C0X7   A0A1B6DHA6   A0A224XLD3   A0A0K8SEW2   A0A1B6DER4   A0A232F5Q3   A0A1B6G1C8   A0A0N1IT67   A0A0A9WSH7   A0A023F4C5   A0A067RCY7   A0A0A9WSE7   A0A0K8SEV3   A0A0A9WH75   A0A1S4ENM9   A0A2A3EEW1   K7J2A6   K7J2A7   E2ASJ0   A0A2S2Q3F2   E2BZU4   A0A2H8TJY2   A0A0A9WK55   A0A026X1H1   A0A2M4AVN7   A0A0L7RF97   B3P8S1   F5HMI9   B4G619   J9JVX3   B4QZ94   A0A139WKH6   D6WEC4   A0A0Q9VZW4   A0A1A9YUC0   B4JGQ4   A0A0K8U4D6   A0A0K8USR1   A0A0Q9WC59   A0A0Q9VZV6   B4HM48   W8BF57   A0A1A9W5Y9   A0A2C9GQA3   A0A084VVT9   A0A2M4CSE2   A0NGZ6   B3LVH5   A0A0Q9XA77   A0A1W4W1R1   A0A0Q9X046   Q24210   A0A1W4VQ70   Q29AR4   A0A0P8XYE7   A0A3B0JPX6   A0A0P9C8I4   E1JIS7   B4MC57   A0A0R1E448   A0A1W4W370   A0A1W4VQG9   A0A1I8NGR6   A0A0B4KH39   A0A034VQY7   A0A0K8WM54   A0A1I8NGR2   A0A0K8WLW8   A0A0A1X353   A0A0K8VA90   A0A1Y1M581   A0A0K8WKD8   A0A0Q9X7H2   A0A0Q9WXB7   A0A0Q9X5S6   A0A1I8NGQ2   U5ENN4   A0A1B6KHC7   A0A1S3JFV7   A0A1J1J4A6   A0A1J1J8K3   A0A2I4DAX8   A0A146V7X9   A0A1I8NGQ8   A0A1I8P1T1   A0A1I8NGR3   A0A1I8P1L9  

PDB

3TAC     E-value=2.65704e-125,     Score=1149

KEGG

101744547    K06103 calcium/calmodulin-dependent serine protein kinase [EC:2.7.11.1] | (RefSeq) peripheral plasma

GO

GO:0005524   GO:0004683   GO:0004672   GO:0004674   GO:0007615   GO:0008049   GO:0042043   GO:0008582   GO:0031594   GO:0007616   GO:0040011   GO:0005886   GO:2000331   GO:0040012   GO:0005516   GO:0072375   GO:0007269   GO:0061174   GO:0007163   GO:0048149   GO:0007274   GO:0048488   GO:0008344   GO:0007298   GO:0016080   GO:0007628   GO:0046928   GO:0016081   GO:1900244   GO:1900073   GO:0005515   GO:0006468   GO:0016020   GO:0051103   GO:0008270   GO:0042555   GO:0048384  

Subcellular location

Cell membrane  

Length:

481

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.65539

Exp number, first 60 AAs:

0.000990000000000001

Total prob of N-in:

0.03474

outside

1  -  481

 

 

Pi

220.230935

Theta

155.853641

Tajima's D

1.028479

CLR

0.294078

CSRT

0.665416729163542

Interpretation

Uncertain