Gene

KWMTBOMO03533  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006250

Annotation

PREDICTED:_protocadherin-15_[Bombyx_mori]

Location

Bomo_Chr6(+):10940445-10981344      View in EpiBrowser

Full name

Cadherin-99C       + More
Tetraspanin      

Location in the cell

Nuclear   Reliability : 1.623

CDS

ATGGCCATAAACATTCTTATTGAGATGCCGCGGTGGAGTGCGCTGATCCGGCATGGACAAACATCGATATGGCTTTTCCTATGCCTGGTTTATCTGGTCATCGCCACTCCCGGTCCATGCGAAGTGGAAACGGGTCAATCGAGTATTATAGTCGATATCGAAGAAAGCAGAGGAGATCAAGTTAACCAAAGCACGGTGCCAGCAATCTTGCCAGTAGTGGGGGAGCCAGATGTGGATGTAGTATTATCGACAGTGTTCCCTAAGGGGCCAACGCTGTTTCAGCTCGATGGAAAACGCTTACAACTACTCCAGCCCCTCGATAGAGACGCGGACAACCTCTCACATATGGTCTTTCAGTTGGTGTGCCAAGTGAAAGCTACGAAGAAGCGTCGGACCATACCTGTGATAGTGAGAGTGTCGGATATCAATGATAATGCGCCCGTGTTTCAGGGGACTCCGTATGAAACTAGCGTCTCTGAGTTGGCTCCGATTGGCACGACGATATTCGAAGGGATTCGAGCAGTTGACATCGACGCTGGAGTTAATGGCTTGTCAGAATACTTCATAATACAGGGAGATAACCAGACATTGGATTCAATGAACGCCGCTGACGGGTACAGCCATTTCGCCATTCCGATACCTCATGTTGGACACGTCACAGTTAACAAGAGTTTGGATTACGAACGAACACAGAAGTATCTAGTCACTATTGTTGCTTCTGATCGTGCCCGTGATAACAAAAGACGGTTGTCAAGTACAACGACGCTAACAGTGAACGTTCAAGATGATGATGATCAAGATCCTTCATTCATATACAAAGGCTGCACCCTACACGAAGGAGCTTGTTTCAACCCCGAATATGCCAGTTACGTGAACAGCGGTATGCTAGCAGGAATCCTCTCATTAGAACCGGAAAAGATTCAAGCCGTCGACATGGATACATTGAACGCGAGGATACGTTACAGCATCGAGAGCGGAGAACCAGAGTCTTGGCCGGATTATTTCACTATCGACACGAACACCGGCGCTGTAAGGCAACTGGTGCCGGTCGATACAAGTATTGCGAAAAAGTTTCAATTGGTCATTAAGGCCGAAGAAGTATCAGAAGCGAAACGTTATACCACAGCCAAGTTGACCATCACAGTGCGGCCGGTAGACGCTAGTCCACCAGTCGTGAAAGCTTCTTCAGATTTAGGGGAAGTCGAGGAAAACTCACCGAAAGGAACTAAAGTCTTGGACTTAAACGGTCAGCCGATTGAGCTAGCTGTTTCTGATCCCGATCTGGGACCAGGAGATCCAATTCCGAACTACACGTTTGAACTAACCACTAATTTCTTCGACATCAAGGACGGATATTTGGTTGTTGGTGACGAGACACTTGACAGAGATCCACCGAATCCAGGGAAATATAGAATTCAGGTCGTAGCCCGCGAAGCGAACGGTGGAGCCGCCTCAGCTCCATATACCATCACCGTACAGTTGCTAGACCAGAACGATAACGCACCAACCATACCTAAAACCCAACCAATAGTTGTACCGGCCACTTTAGAACCCACCGCAGTGCATAAGGTCGAAGCTGTTGACATCGACGAGGGTGAGAACGCACGTGTGACCTATAATTTATATCACGTGTCTAATAATGGTGGCAACAAATTCACTATAGACCCTAACACGGGAGTTATATCAAGCACGGGGCGTCTCCAAGCCGGCGAACAATACAGCGTTACAGTTCGAGCCACCGACGCTAAGGGCCTCAGTTCCCAGGGCATTGTGGAGTTATCCGTGGCCCCCGGCCCTAACACGAGCCCGCCGCAGTTCTCGTCCAGAGACTACTACGCGCCCGTCTCGGAGGGCGCCGCCATTAACTCGACCGTCACCACGGTCACTGCAAAAGATCCCGAGAACGAGCCTGTGACATACAGCATATTATCTGGAAACGATCTGAGACAGTTCGCAATCGGCTCTAATACTGGCGTCATAACGGTCATTAGGAGTCTAGACCGAGAAGTTTTGACGAGATATCAATTGGAGGTGAAAGCAGAAGATCCAGGGAAATTAGTGAGCACTGCGACCGTCAATATTAAAGTTACCGACATAAACGATAATAATCCGAAATTTGATGAGGAATTCTATACGTTTCATGTTAAAGAAGGGATGTCCGATGAATTCGTTGGGTACGTGCACGCGACGGACGCGGACGAAGGCGTCAACGCGATCATAAGCTACAGCATCCCGAACAATTTGCCTTTCAACATCGACAACAACACCGGGATGATCAGCACCAAGACCAAACTCGACTATGAGAAGACGAAGGAATATTCTTTCGTGGTAACAGCGACAGATGGCGCTATAGACAAACGTCTGGGAACAGCGTCGGTCGCTGTACAAGTACAAGACATACCCGATGAAGCGCCAATATTTCCTTTGCCGCTGTATTCGGTTCATGTACCGGAAAACGTGCCCAATTACCCAGTCGTTAAAGTTCAGGCAGAAGATCCCGATACATCTCCGGAGATAACGTACACGATAATGAAAGGCGATATGGATCTGTTTTCGATCGACCGCAAGTCGGGTCTGGTAAGGACTCTGCAGGCCTTAGATAGAGAAACATCGGCCCGACACGAACTCATTGTTGGCACCGAAGAGAACAGCGAAGAAGGACCGGGCGCGACCACAACTATAGAGATTGTCGTTGATGACAAGAACGATAACTCGCCCATATTCACGTCAGTGGTCCGACCGGTCACGGTGGAGGACTCATCGTCTATAGGGAGTCTCGTGCAGACGGTCGTCGCCAGTGACGCAGACGCGACGTCACCGAACAACAGAGTCCGGTACAAACTAGTGGGTCGGGGTAAAGCGTCCAAGTACTTCCACGTCGAACCCGACACCGGTGCGTTGAGGGTTCGCGATGATCTGAAGAAGGAAACGGATAGCGAGTATACGGTGGACGTACAAGCTTACGACCAAGGCGATCCGGTCATGTCATCGGTGACCAGTCTAACGGTGTACGTGAGCCATTCGGCAACCGTTCCACCTGACGTCGGCTTAGGTTTCGCTGATACAGTGTATACGGAACACGTTGCCGAGAACTCGCCCAACGGTACCCTAGTTAGAGTGTTGCCATTACTCAATAAAAGGGAACATTCCCCAGACACGCCTCTAAAATGCTTACTCACAGAATCTTCGCAAAAAGGGATATTCTACGTGAAGCTGACAGAAGACCGCGACTGCGCGATATACCTTAACACGAGTTCGCTAGACTACGAGACACTATCGGAGTATTCTCTGGAAGTACAACTGGAGTCCATACAGGGTCTGATCAACCCCGACAGTAGTAGAGCGCTCGTCAAAGTTCATGTGACCGACGTCAATGACAACCACCCCGTGTTTGTGTTCAACGAACAGTCCACTGTGGCCGCCGCGAAAGGGAAATACTTCGCTATTGTCAATAAAGAGATGCTTCTGGGCACCAACGTTCTTCAAGTAAAGGCGAAAGATCGGGACAGCGGCGCTTACGGCAAGTTAGAATACCACAAGAACTCGTGGACCGAAGCGGCCGAAGAGTACTTCGGTCTGGACGCGGACACGGGGATCATAAGCAATATAAAATCGTTCGAGAACGTTCCAAAGGACATTCTGCCGTTCAAGTTCAGCGTGACCGCGAGAGACAACCCTGATTCGCCACAGGACTATAATATAGCCAGAGCGTCGGTTGTGATAAACTTATTACAAAAAGAGAATCAACTGGTATTGGAAATAGCGGATTTGAATCCGGATGCGATGCGCCGGAGAGCCAGAAGTCTTCTATCGGTCATAGAAGAGAAGAGCGGTTTGGTCGCCGGCCTAGAAAAGTTAACGTCGAGACATTATCTAGGAGAGAATGGTACATTGGAGAGCGACAGCCGTGGGACCGACGTTTGGCTCTACCTAATCGAACCTAGTACTGGCGAAATATTGACTAGAGAATCTATGCCTGTGCAGAAGGCCATAGAGACTGGGGTCCACAAAGCGGTGGCTGCTCGGCTTCAGTCTCCAGTCAGTGAAGTTCGAGCTCCTTTATTAGCGGCCGAATTGCCGAAGAAGCCTCACATAGCAGCCGCGCCGCTCGCCACGGCCCTACCCGCCGCCCTGATAGGCCTGGCCGCCGTCGTACTGGTCGCCGCACTGGTCGCCACCATCTACATCTGCGCCTCATGGAACAGGTATAAGAAACACAAAGAGCAAGCGGTTCAACAGTACGGAACTCTGAGTATGAGCATGCCGCCTCCTCGTCCTCCGTCTGGCTACGAGTCCAGTGAAGATGACCCCGCACCGAGATATGAAACACAGGTACTCAATATGGCGGTCGATGACGCGGATCTGCAATTAGACTTCAGTCCAAACAATCACGCGTTCAATATACACAACGTTCAATATTTATCCAAAGATAATGGTGAGAGAAGTCCAACGTTATCGGAAACAGCGACGACAGCTCGAGCCTCGAGCGTCAATGAAAACGGGGGTACTCTGAACAAACTCCACAACAGCCACTACGATCCTATCGCGAACAACGCGTCCATAGCGCGCAACACACAGACATTGAACCGAAGGATGCCGAACTCGCAAGCGTTGAACAACGCTCTCGGGACATTGCCCCGTGCCAACAATAACAATGTCGGTGGTGGATTATTAGCCGCCACATTAGGTAGGAAGATCAACGGGAATAATCACAAGAAGAAAACTCAACCCATAATGGCGTACGACGATATACCCGGAATGCAGAAAGCCTCTGACAACGACAACGTGACATTTGGCAAAAGAAACTTCTCTGGGTACCCATACGATCAATCGACTGTCGAAACTACGACAGAGTTATAG

Protein

MAINILIEMPRWSALIRHGQTSIWLFLCLVYLVIATPGPCEVETGQSSIIVDIEESRGDQVNQSTVPAILPVVGEPDVDVVLSTVFPKGPTLFQLDGKRLQLLQPLDRDADNLSHMVFQLVCQVKATKKRRTIPVIVRVSDINDNAPVFQGTPYETSVSELAPIGTTIFEGIRAVDIDAGVNGLSEYFIIQGDNQTLDSMNAADGYSHFAIPIPHVGHVTVNKSLDYERTQKYLVTIVASDRARDNKRRLSSTTTLTVNVQDDDDQDPSFIYKGCTLHEGACFNPEYASYVNSGMLAGILSLEPEKIQAVDMDTLNARIRYSIESGEPESWPDYFTIDTNTGAVRQLVPVDTSIAKKFQLVIKAEEVSEAKRYTTAKLTITVRPVDASPPVVKASSDLGEVEENSPKGTKVLDLNGQPIELAVSDPDLGPGDPIPNYTFELTTNFFDIKDGYLVVGDETLDRDPPNPGKYRIQVVAREANGGAASAPYTITVQLLDQNDNAPTIPKTQPIVVPATLEPTAVHKVEAVDIDEGENARVTYNLYHVSNNGGNKFTIDPNTGVISSTGRLQAGEQYSVTVRATDAKGLSSQGIVELSVAPGPNTSPPQFSSRDYYAPVSEGAAINSTVTTVTAKDPENEPVTYSILSGNDLRQFAIGSNTGVITVIRSLDREVLTRYQLEVKAEDPGKLVSTATVNIKVTDINDNNPKFDEEFYTFHVKEGMSDEFVGYVHATDADEGVNAIISYSIPNNLPFNIDNNTGMISTKTKLDYEKTKEYSFVVTATDGAIDKRLGTASVAVQVQDIPDEAPIFPLPLYSVHVPENVPNYPVVKVQAEDPDTSPEITYTIMKGDMDLFSIDRKSGLVRTLQALDRETSARHELIVGTEENSEEGPGATTTIEIVVDDKNDNSPIFTSVVRPVTVEDSSSIGSLVQTVVASDADATSPNNRVRYKLVGRGKASKYFHVEPDTGALRVRDDLKKETDSEYTVDVQAYDQGDPVMSSVTSLTVYVSHSATVPPDVGLGFADTVYTEHVAENSPNGTLVRVLPLLNKREHSPDTPLKCLLTESSQKGIFYVKLTEDRDCAIYLNTSSLDYETLSEYSLEVQLESIQGLINPDSSRALVKVHVTDVNDNHPVFVFNEQSTVAAAKGKYFAIVNKEMLLGTNVLQVKAKDRDSGAYGKLEYHKNSWTEAAEEYFGLDADTGIISNIKSFENVPKDILPFKFSVTARDNPDSPQDYNIARASVVINLLQKENQLVLEIADLNPDAMRRRARSLLSVIEEKSGLVAGLEKLTSRHYLGENGTLESDSRGTDVWLYLIEPSTGEILTRESMPVQKAIETGVHKAVAARLQSPVSEVRAPLLAAELPKKPHIAAAPLATALPAALIGLAAVVLVAALVATIYICASWNRYKKHKEQAVQQYGTLSMSMPPPRPPSGYESSEDDPAPRYETQVLNMAVDDADLQLDFSPNNHAFNIHNVQYLSKDNGERSPTLSETATTARASSVNENGGTLNKLHNSHYDPIANNASIARNTQTLNRRMPNSQALNNALGTLPRANNNNVGGGLLAATLGRKINGNNHKKKTQPIMAYDDIPGMQKASDNDNVTFGKRNFSGYPYDQSTVETTTEL

Description

Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25639794). Essential for female fertility (PubMed:16260500, PubMed:16507588). Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands (PubMed:16260500, PubMed:16507588, PubMed:24718992, PubMed:25236597). Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane (PubMed:16260500, PubMed:16507588, PubMed:25236597). Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli (PubMed:25236597). Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation (PubMed:24718992). May also function in cellular adhesion during the development of other tubular epithelia such as the trachea (PubMed:24718992). Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation (PubMed:24718992). In salivary gland development, this function is independent of the other apical membrane determinants crb and sas (PubMed:24718992). Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794).

Subunit

Interacts (via the cytoplasmic domain) with ck (PubMed:25236597, PubMed:27331610). Interacts (via the cytoplasmic domain) with Cul1 and Ubr3 (PubMed:27331610).

Similarity

Belongs to the tetraspanin (TM4SF) family.

Keywords

Calcium   Cell membrane   Cell projection   Complete proteome   Endosome   Glycoprotein   Immunity   Membrane   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Cadherin-99C

Uniprot

H9J9Q7   A0A2A4J1J8   A0A2W1BHM6   A0A2A4J1V5   A0A2A4J1X9   A0A194QQ78   + More
D6X4A8   A0A2J7PRK0   A0A2L1IQ93   A0A195EWU0   A0A158NMT2   A0A088AET7   E0W1X2   A0A151WUR1   A0A067R0I3   A0A195BC01   A0A0C9Q5P1   A0A1Y1JXU7   A0A0M9A2C8   A0A0L7R4B4   A0A310SGK3   A0A1W4W376   A0A151JMK0   A0A1B6M4B4   A0A0K8SAM5   U4U7L3   A0A0K8VNC9   A0A0K8UJD9   B4JSG4   B4NA24   A0A2S2QWG8   A0A0L0CIS9   A0A336LX47   A0A034V2D8   B4K7A9   A0A0Q9X4W4   A0A1I8M293   A0A1I8P7B9   W4VRE0   B4LXA2   W8ACW7   A0A3B0KBK7   A0A3B0JF44   N6TVF1   D0QWQ5   B3LWY5   Q29C64   Q16YV5   A0A1W4UD82   X1XJY8   B3P5B9   Q9VAF5   B4PPI8   A0A0M3QXW1   A0A2Y9D0T4   Q7PR41   A0A1J1HSA3   A0A026WEH6   E2C9P0   E2ALJ1   A0A195C6A6   A0A0A9Z1U2   A0A0C9Q5N7   A0A3L8D355   A0A232FKT7   A0A034V1C5   T1HRM9   A0A226ETJ8   A0A1B0G844   A0A0J7L7N9   A0A0A9Y656   A0A1A9XI52   A0A1A9VR31   A0A1A9X183   A0A182J082   A0A182R763   A0A182W2N0   A0A182PEL2   A0A1B0ACL6   A0A182FQ11   A0A182S8E0   A0A182MHU7   A0A182QAB1   A0A182XVF3   A0A182NGA1   A0A182G7C3   A0A2S2PQ60   A0A182JZB2   W5JDX0   A0A147BEC3   B0WCX8   A0A182UR09   A0A1J1HN32   A0A182UGJ2   A0A182XM02   T1KBH0   A0A1B0BWJ3  

Pubmed

19121390    28756777    26354079    18362917    19820115    29415259    + More
21347285    20566863    24845553    28004739    23537049    17994087    26108605    25348373    25315136    24495485    19859648    18057021    15632085    17510324    15708564    10731132    12537572    16260500    16507588    24718992    25236597    25639794    27331610    17550304    12364791    24508170    20798317    25401762    30249741    28648823    25244985    26483478    20920257    23761445    29652888   

EMBL

BABH01034055    BABH01034056    NWSH01004181    PCG65394.1    KZ150198    PZC72300.1    + More
PCG65392.1    PCG65393.1    KQ461181    KPJ07647.1    KQ971410    EEZ97736.2    NEVH01021956    PNF18968.1    MF741661    AVD96944.1    KQ981940    KYN32745.1    ADTU01020795    ADTU01020796    ADTU01020797    ADTU01020798    ADTU01020799    DS235873    EEB19566.1    KQ982729    KYQ51576.1    KK852827    KDR15408.1    KQ976529    KYM81724.1    GBYB01009413    JAG79180.1    GEZM01100050    JAV53048.1    KQ435788    KOX74523.1    KQ414657    KOC65725.1    KQ764182    OAD54580.1    KQ978946    KYN27402.1    GEBQ01009217    JAT30760.1    GBRD01016021    JAG49805.1    KB632192    ERL89874.1    GDHF01011961    JAI40353.1    GDHF01025530    JAI26784.1    CH916373    EDV94704.1    CH964232    EDW80667.1    GGMS01012893    MBY82096.1    JRES01000321    KNC32313.1    UFQS01000188    UFQT01000188    SSX00969.1    SSX21349.1    GAKP01022655    JAC36297.1    CH933806    EDW14233.2    KRG00938.1    GANO01003660    JAB56211.1    CH940650    EDW66754.1    GAMC01020780    GAMC01020778    JAB85775.1    OUUW01000005    SPP80958.1    SPP80957.1    APGK01017058    APGK01017059    KB739995    ENN82023.1    FJ821034    ACN94758.1    CH902617    EDV43824.1    KPU80491.1    CM000070    EAL26782.1    CH477508    EAT39806.1    ABLF02032681    ABLF02032682    ABLF02032685    CH954182    EDV53169.1    AY853687    AY853686    AE014297    BT016059    AAV36944.1    AAX12107.1    CM000160    EDW98238.2    CP012526    ALC46613.1    APCN01000528    AAAB01008859    EAA07876.6    CVRI01000017    CRK90268.1    KK107245    EZA54500.1    GL453868    EFN75379.1    GL440609    EFN65693.1    KQ978231    KYM96165.1    GBHO01015953    GBHO01015952    GBHO01013854    GBHO01004382    JAG27651.1    JAG27652.1    JAG29750.1    JAG39222.1    GBYB01009408    JAG79175.1    QOIP01000014    RLU14820.1    NNAY01000071    OXU31282.1    GAKP01022654    GAKP01022653    JAC36299.1    ACPB03016317    LNIX01000002    OXA59926.1    CCAG010000177    CCAG010000178    CCAG010000179    CCAG010000180    CCAG010000181    CCAG010000182    CCAG010000183    CCAG010000184    CCAG010000185    CCAG010000186    LBMM01000264    KMR02409.1    GBHO01015955    GBHO01015951    GBHO01015949    GBHO01015948    JAG27649.1    JAG27653.1    JAG27655.1    JAG27656.1    AXCM01000235    AXCN02001627    JXUM01150034    KQ570914    KXJ68278.1    GGMR01018916    MBY31535.1    ADMH02001428    ETN62562.1    GEGO01006729    JAR88675.1    DS231891    EDS43938.1    CVRI01000012    CRK89363.1    CAEY01001950    JXJN01021835   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007266    UP000235965    UP000078541    + More
UP000005205    UP000005203    UP000009046    UP000075809    UP000027135    UP000078540    UP000053105    UP000053825    UP000192223    UP000078492    UP000030742    UP000001070    UP000007798    UP000037069    UP000009192    UP000095301    UP000095300    UP000008792    UP000268350    UP000019118    UP000007801    UP000001819    UP000008820    UP000192221    UP000007819    UP000008711    UP000000803    UP000002282    UP000092553    UP000075840    UP000007062    UP000183832    UP000053097    UP000008237    UP000000311    UP000078542    UP000279307    UP000215335    UP000015103    UP000198287    UP000092444    UP000036403    UP000092443    UP000078200    UP000091820    UP000075880    UP000075900    UP000075920    UP000075885    UP000092445    UP000069272    UP000075901    UP000075883    UP000075886    UP000076408    UP000075884    UP000069940    UP000249989    UP000075881    UP000000673    UP000002320    UP000075903    UP000075902    UP000076407    UP000015104    UP000092460   

PRIDE

H9J9Q7    Q9VAF5   

Pfam

PF00028   Cadherin        + More
PF00335   Tetraspanin

Interpro

IPR015919   Cadherin-like_sf        + More
IPR020894   Cadherin_CS       
IPR002126   Cadherin-like_dom       
IPR018499   Tetraspanin/Peripherin       
IPR018503   Tetraspanin_CS       
IPR000301   Tetraspanin       
IPR008952   Tetraspanin_EC2_sf       

SUPFAM

SSF49313   SSF49313        + More
SSF48652   SSF48652       

ProteinModelPortal

H9J9Q7   A0A2A4J1J8   A0A2W1BHM6   A0A2A4J1V5   A0A2A4J1X9   A0A194QQ78   + More
D6X4A8   A0A2J7PRK0   A0A2L1IQ93   A0A195EWU0   A0A158NMT2   A0A088AET7   E0W1X2   A0A151WUR1   A0A067R0I3   A0A195BC01   A0A0C9Q5P1   A0A1Y1JXU7   A0A0M9A2C8   A0A0L7R4B4   A0A310SGK3   A0A1W4W376   A0A151JMK0   A0A1B6M4B4   A0A0K8SAM5   U4U7L3   A0A0K8VNC9   A0A0K8UJD9   B4JSG4   B4NA24   A0A2S2QWG8   A0A0L0CIS9   A0A336LX47   A0A034V2D8   B4K7A9   A0A0Q9X4W4   A0A1I8M293   A0A1I8P7B9   W4VRE0   B4LXA2   W8ACW7   A0A3B0KBK7   A0A3B0JF44   N6TVF1   D0QWQ5   B3LWY5   Q29C64   Q16YV5   A0A1W4UD82   X1XJY8   B3P5B9   Q9VAF5   B4PPI8   A0A0M3QXW1   A0A2Y9D0T4   Q7PR41   A0A1J1HSA3   A0A026WEH6   E2C9P0   E2ALJ1   A0A195C6A6   A0A0A9Z1U2   A0A0C9Q5N7   A0A3L8D355   A0A232FKT7   A0A034V1C5   T1HRM9   A0A226ETJ8   A0A1B0G844   A0A0J7L7N9   A0A0A9Y656   A0A1A9XI52   A0A1A9VR31   A0A1A9X183   A0A182J082   A0A182R763   A0A182W2N0   A0A182PEL2   A0A1B0ACL6   A0A182FQ11   A0A182S8E0   A0A182MHU7   A0A182QAB1   A0A182XVF3   A0A182NGA1   A0A182G7C3   A0A2S2PQ60   A0A182JZB2   W5JDX0   A0A147BEC3   B0WCX8   A0A182UR09   A0A1J1HN32   A0A182UGJ2   A0A182XM02   T1KBH0   A0A1B0BWJ3  

PDB

5W1D     E-value=8.24998e-42,     Score=434

KEGG

101741348    K16500 protocadherin-15 | (RefSeq) protocadherin-15

GO

GO:0007156   GO:0005886   GO:0005509   GO:0016021   GO:0017022   GO:0098609   GO:0005913   GO:0004022   GO:2000370   GO:0031526   GO:0032529   GO:0032533   GO:0002385   GO:0045176   GO:0019722   GO:0016324   GO:0035239   GO:0005768   GO:0005902   GO:0007305   GO:0031528   GO:0005887   GO:0007304   GO:0010008   GO:0016339   GO:0044331   GO:0007155   GO:0016020   GO:0051103   GO:0005524   GO:0008270   GO:0042555   GO:0048384  

Subcellular location

Apical cell membrane   Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil.   With evidence from 10 publications.
Endosome membrane   Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil.   With evidence from 10 publications.
Cell projection   Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil.   With evidence from 10 publications.
Microvillus membrane   Dispersed throughout the enterocyte membrane, but becomes clustered in the brush border membrane in response to uracil.   With evidence from 10 publications.
Membrane  

Length:

1619

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

33.27463

Exp number, first 60 AAs:

9.85694

Total prob of N-in:

0.48106

outside

1  -  1375

TMhelix

1376  -  1398

inside

1399  -  1619

 

 

Pi

213.323609

Theta

174.269052

Tajima's D

0.49832

CLR

0.33067

CSRT

0.510474476276186

Interpretation

Uncertain