Gene

KWMTBOMO03531  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006237

Annotation

DNA_ligase_3_[Papilio_xuthus]

Location

Bomo_Chr6(-):10802391-10807454      View in EpiBrowser

Full name

DNA ligase      

Location in the cell

Nuclear   Reliability : 4.228

CDS

ATGTCCGATTCAACACCGTTTTACGTAGATCGAGCCAAAGGTGGTAGGGCAGCATGTAAATTATGTAAAGGCAACTGTCCTAGTGGTGAACTACGTATGGCCAAACTTGTACCGAGCCCGTATGGCGATAATCAATCCATGAAATCTTGGTATCATGTTCATTGTTTTACTGACGTATTGTTAAAGCAACGCCCTAATACTAAACGAGTTGAATCCATCAACGACATTGGTAACTGGGACAATATTAGTAAGGAAGATCAAGAATTGATACTAAAAAAATTAAACGAAACTGAAAAATTGTACGCAGAAAAACACAGTGGGAAATACACAGCGAAACTAATTGAAAACAAATCTTTAGGCTCCATAAAGAAAAATAGTGTTAAAAGTGAGCCAGACACTACTGATAGTGGTAACATTGTAGAAGATAATAAATTTAGTACTTTTATTGAATTATGTAAAAGAATTGCAAAAGTCGATGCATATACTGAAAAGACTGCTGCTGTTAATTCTTTTTTTACGAAAGGAATAGAGAAAGATAATTTTAAAGGAGATCTTGGTTTGTGGTGTAAATTACTATTACCTCAAGTAACCAAAAGAGTTTATAATTTAAAGAGCAAACAATTAGTTAAGCTCTTCTCAAAAATATTCAATATTGATCACGATGATATGTTAACGGATCTAGAACAGGGAGATGTGGCAAATACGATACAGAGATTTTTCTCAACATCAAAGGTAGTGCAACCTGCTTCCTTTAGTTCACTTACGATCCACAACATAGAAGATTTCCTAGAAAACTTATCTACATTAACAAAAGAAGAAGAACAAATTTACCACTTCAAAAAAATTGTGAAAAAATGTACATTAGATGATATGAAAATGTTGATACGGTTAATAAAAGGAGATCTAAGAATTAATGCTGGACCAAAGCATATCTTGGAAGGAGTGCATCCCGATTCATATAATGTTTTTCAGACGTCAAGAGACCTTAATATGGTTCTTGATCGGGTTTTGTCAAAGAATAATAGTTCAAATGACAAGGGTGTGAGCCACAAAGCTGTTTCAGCAAAACTGACATTAATGACTCCAGTTTTGCCTATGTTAGCTGAAGCATGCAAATCAATTGAAATGGCGATGAAAAAATGTCCAAACGGTATGTACTCTGAAATTAAATATGATGGGGAGAGAGTTCAGATACATAAAAAAGGTACAGAATTTAAATACTTTTCTAGAGCATTAAAACCTGTGATGGCACATAAAGTAAGCTTATTTAAGGAACATTTGCCTAAAGCTTTTCCTAAAGGAGAAGATATGATATTAGATGCTGAAGTTTTGATGGTGGATGTGTGTACTGGGAAGCCCTTACCATTTGGTACATTGGGCGTACACAAACAATCTGAATTTAAAGATGCGGAAGTATGTTTGTTTATATTTGATTGTCTCTATTATAATGGAGAAGTATTGATGAATGAGCCAATTTGGAAAAGAAAGAAGTTTCTTGAGGAAAATATGATTGAAGTAAAAAATCATGTCATGTTATCTGAATTACAGTTTATTGAGAAGCCATCAGATTTAGCTAAGATGATTGCTGAGGTTCTACAACTGGGTCTGGAAGGACTGGTACTAAAAGACCGTGAATCTATATATGAGCCGGGAAAACGTCATTGGTTGAAAGTGAAGAAAGATTATCTCTTTGATGGAGCAATGGCTGACACTGCAGATCTTGTTGTACTTGGAGCTTGGTTTGGTACAGGTAAGAAAGGCGGAATGATGTCAGTATTCTTGATGGGCTGTTTGGATAAGTACAAAAATAAGTGGGTAACTGTAACCAAAGTGCATACGGGACATGATGATAGCACGCTCGAGAGACTTCAAAAGGAGTTAGGACCTTTAATGTTGAAGATTTCTCAAGACAGTAATAAAGTCCCGTCATGGTTAGACTGTAAAAAGGGTATGGTGCCGGATTTCGTCGCTTTAGATCCTAAGAAGCAACCAGTTTGGGAAATTACAGGTACCGAGTTAACAAAAGCAAACCAACACACAGCCGATGGGATATCAGTGAGGTTCCCAAGAGTCACAAGGATTCGAACAGACAAAGACTGGCAGTCCGCCACGAACTTGGATGAACTGAAACATTTATACAAAACTTCGAAAGAAACCAGTGACGTCTCATTATTAAACAAATTGGCTGCTTCAGCTTCTGGTATTGAAACAACGAACAAAAAAACGAAGGCTAGTCCGAAGAAACAAAATAAATTGGACAATTTCTTAAAGAAAGAACCAAAACAGAGTCCTTCAAAGAAATCTCCAGATAGTCCCCTAGTAAAGTTAGAAACAAAAGCGTCGAACAAAAATAAACTGAATGGTTCTAATTCGGATTTGAGTTACGATGAGACTGATTCTAAAAGGGAAATCAAAAGAAGGAAAAGACATTTAAATATTTCGGAAGGAACCCTCTCTGAATCTTATGAGGAAACGAATAAGAATAAGAAAAAGAACACCGAAGAAACAAAGAAGTCGGAGGAGACTGAAACGGATGTCAAAAGAGAAATGAAAAGAAAGAAAAGAGATTTAGACAGTTCTCAAGAAACTATTGCAGAGTTAAATGAGACGCCTGCAAAAGTAAAGAGAAAAGACAAAACAACAGTTAGTGGAAATAAATTATACCCCGACAACCCTTTGCCGGACGCGTTCAAAGATAAAATATTAAGTTTATATCCCGACTTAATATCTTTTTCGGAGGACGAAAGAAAACATTTTGTTAGGCATTGGATTGCGTACGGAGGTGTTCTTGTGAAATCGATGCGATCTGCGAACGTTGATTTTGTCGTACATAATAACAATTGTATTACATACAAGGAAATGCAAAGGTTAAAAGAAGAATTGCGTCAAGGCGTAAGGCATGTTACGAAAAATTGGTTAATTAGGTGTATAAATGAGGTTGCACTATGTGATACTACTAAATATGCGGTAACGGTTATACCTCAGAAATTATATTAA

Protein

MSDSTPFYVDRAKGGRAACKLCKGNCPSGELRMAKLVPSPYGDNQSMKSWYHVHCFTDVLLKQRPNTKRVESINDIGNWDNISKEDQELILKKLNETEKLYAEKHSGKYTAKLIENKSLGSIKKNSVKSEPDTTDSGNIVEDNKFSTFIELCKRIAKVDAYTEKTAAVNSFFTKGIEKDNFKGDLGLWCKLLLPQVTKRVYNLKSKQLVKLFSKIFNIDHDDMLTDLEQGDVANTIQRFFSTSKVVQPASFSSLTIHNIEDFLENLSTLTKEEEQIYHFKKIVKKCTLDDMKMLIRLIKGDLRINAGPKHILEGVHPDSYNVFQTSRDLNMVLDRVLSKNNSSNDKGVSHKAVSAKLTLMTPVLPMLAEACKSIEMAMKKCPNGMYSEIKYDGERVQIHKKGTEFKYFSRALKPVMAHKVSLFKEHLPKAFPKGEDMILDAEVLMVDVCTGKPLPFGTLGVHKQSEFKDAEVCLFIFDCLYYNGEVLMNEPIWKRKKFLEENMIEVKNHVMLSELQFIEKPSDLAKMIAEVLQLGLEGLVLKDRESIYEPGKRHWLKVKKDYLFDGAMADTADLVVLGAWFGTGKKGGMMSVFLMGCLDKYKNKWVTVTKVHTGHDDSTLERLQKELGPLMLKISQDSNKVPSWLDCKKGMVPDFVALDPKKQPVWEITGTELTKANQHTADGISVRFPRVTRIRTDKDWQSATNLDELKHLYKTSKETSDVSLLNKLAASASGIETTNKKTKASPKKQNKLDNFLKKEPKQSPSKKSPDSPLVKLETKASNKNKLNGSNSDLSYDETDSKREIKRRKRHLNISEGTLSESYEETNKNKKKNTEETKKSEETETDVKREMKRKKRDLDSSQETIAELNETPAKVKRKDKTTVSGNKLYPDNPLPDAFKDKILSLYPDLISFSEDERKHFVRHWIAYGGVLVKSMRSANVDFVVHNNNCITYKEMQRLKEELRQGVRHVTKNWLIRCINEVALCDTTKYAVTVIPQKLY

Catalytic Activity

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.

Similarity

Belongs to the ATP-dependent DNA ligase family.
Belongs to the peptidase S1 family.

Feature

chain  DNA ligase

Uniprot

H9J9P4   A0A2W1BB99   A0A2A4JXV3   A0A194QG46   A0A194QRN8   A0A212F753   + More
A0A0L7LWK8   A0A1W4WD65   A0A1B6G6F1   A0A1B6ENC4   A0A139WND0   A0A310S4Q1   A0A087ZW84   A0A3L8DJH7   E0VGK6   A0A2A3EL55   A0A0C9QZ00   E2A6Z4   A0A151WKM0   A0A1B6C8P5   A0A1B6CLD8   A0A151J5C6   A0A154PUH1   A0A0M9A8D8   E2B3R6   A0A2P2I0Z2   A0A1Y1KHU9   K7J0X3   A0A151IEJ9   A0A0A9WH49   A0A0A9WE47   A0A0K8S800   A0A0A9WE37   A0A0A9WG25   A0A023F1W7   A0A151JTG1   A0A0L7QVE8   C3XPG8   T1IZP4   A0A0K2V401   A0A0K2V4Z8   A0A3B3SG92   V9KA84   A0A0F7Z9Z8   W5M261   I3K6G0   W5M246   I3K6G1   A0A087UPX1   A0A3B4FZX7   A0A2K6GKJ1   U3K569   A0A2K5PBN6   A0A1W4Z1J9   A0A3B4TZZ6   H0X1G3   A0A2K6U819   A0A2D0QB60   A0A3P9BZI9   A0A2K5PBM8   A0A2K5PBL3   A0A2K6GKG3   A0A1S3I5L9   A0A3B4CGY2   Q5U2M4   A0A218V1M8   A0A3B4E3M9   A0A3P8R2C9   A0A096MKE9   B1AT03   A0A2K5DDA8   Q3UC82   A0A2K6U842   A0A3B4WGM2   A0A2K6NLW9   A0A2K5IFJ0   U3BYS5   Q80ZH7   A0A2K6KHU5   M3YTT8   F7F289   A0A2K6KHT8   A0A2K6NLY5   F1P394   A0A2K6DA19   A0A2K5XIQ3   A0A2K5IFF0   G3VV55   A0A0F8B978   H0Z3J4   F6S760   H0VMT6   A0A2K6DA10   A0A2K5XIP9   G3SNT4   A0A2Y9E242  

EC Number

6.5.1.1
3.4.21.-

Pubmed

19121390    28756777    26354079    22118469    26227816    18362917    + More
19820115    30249741    20566863    20798317    28004739    20075255    25401762    25474469    18563158    29240929    24402279    25186727    15489334    15057822    22673903    12040188    17242355    19144319    19468303    21183079    10349636    11042159    11076861    11217851    12466851    16141073    25362486    25243066    15592404    21709235    25835551    20360741    17431167    21993624   

EMBL

BABH01034042    KZ150198    PZC72298.1    NWSH01000431    PCG76464.1    KQ459249    + More
KPJ02421.1    KQ461181    KPJ07645.1    AGBW02009939    OWR49539.1    JTDY01000004    KOB79516.1    GECZ01011765    JAS58004.1    GECZ01030357    JAS39412.1    KQ971311    KYB29442.1    KQ776210    OAD52215.1    QOIP01000007    RLU20362.1    DS235148    EEB12512.1    KZ288215    PBC32495.1    GBYB01000950    JAG70717.1    GL437208    EFN70797.1    KQ983009    KYQ48394.1    GEDC01027432    JAS09866.1    GEDC01023009    JAS14289.1    KQ980039    KYN18131.1    KQ435127    KZC14850.1    KQ435713    KOX79317.1    GL445398    EFN89653.1    IACF01002037    LAB67707.1    GEZM01083754    JAV61033.1    KQ977890    KYM98997.1    GBHO01036878    JAG06726.1    GBHO01036872    JAG06732.1    GBRD01016414    JAG49412.1    GBHO01036882    JAG06722.1    GBHO01036880    JAG06724.1    GBBI01003180    JAC15532.1    KQ981960    KYN31908.1    KQ414727    KOC62534.1    GG666451    EEN69839.1    AFFK01020498    HACA01027674    CDW45035.1    HACA01027675    CDW45036.1    JW862115    AFO94632.1    GBEX01001803    JAI12757.1    AHAT01005635    AERX01031221    KK120932    KFM79410.1    AGTO01001464    AAQR03133402    AAQR03133403    AAQR03133404    AAQR03133405    AAQR03133406    AAQR03133407    AAQR03133408    AC095947    BC085959    AAH85959.1    MUZQ01000070    OWK59883.1    AL645594    CH466556    EDL15670.1    AK150644    BAE29732.1    GAMT01000827    GAMS01008539    GAMR01005266    GAMQ01003589    GAMP01008910    JAB11034.1    JAB14597.1    JAB28666.1    JAB38262.1    JAB43845.1    BC049240    AK143531    AAH49240.1    BAE25421.1    EDL15669.1    AEYP01021486    AADN05000057    AEFK01177040    AEFK01177041    AEFK01177042    KQ041273    KKF28555.1    ABQF01026224    ABQF01026225    ABQF01026226    JSUE03016470    AAKN02033121   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000037510    + More
UP000192223    UP000007266    UP000005203    UP000279307    UP000009046    UP000242457    UP000000311    UP000075809    UP000078492    UP000076502    UP000053105    UP000008237    UP000002358    UP000078542    UP000078541    UP000053825    UP000001554    UP000261540    UP000018468    UP000005207    UP000054359    UP000261460    UP000233160    UP000016665    UP000233040    UP000192224    UP000261420    UP000005225    UP000233220    UP000221080    UP000265160    UP000085678    UP000261440    UP000002494    UP000197619    UP000265100    UP000000589    UP000233020    UP000261360    UP000233200    UP000233080    UP000233180    UP000000715    UP000008225    UP000000539    UP000233120    UP000233140    UP000007648    UP000007754    UP000006718    UP000005447    UP000007646    UP000248480   

PRIDE

H9J9P4   

Pfam

PF01068   DNA_ligase_A_M        + More
PF04675   DNA_ligase_A_N
PF04679   DNA_ligase_A_C
PF00645   zf-PARP
PF16759   LIG3_BRCT
PF00089   Trypsin
PF00147   Fibrinogen_C
PF10283   zf-CCHH
PF01661   Macro

Interpro

IPR036957   Znf_PARP_sf        + More
IPR036599   DNA_ligase_N_sf       
IPR012309   DNA_ligase_ATP-dep_C       
IPR012308   DNA_ligase_ATP-dep_N       
IPR000977   DNA_ligase_ATP-dep       
IPR012340   NA-bd_OB-fold       
IPR016059   DNA_ligase_ATP-dep_CS       
IPR031916   LIG3_BRCT       
IPR001510   Znf_PARP       
IPR012310   DNA_ligase_ATP-dep_cent       
IPR036420   BRCT_dom_sf       
IPR001357   BRCT_dom       
IPR002181   Fibrinogen_a/b/g_C_dom       
IPR001254   Trypsin_dom       
IPR018114   TRYPSIN_HIS       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR036056   Fibrinogen-like_C       
IPR020837   Fibrinogen_CS       
IPR033116   TRYPSIN_SER       
IPR022700   CLIP       
IPR019406   APLF_PBZ       
IPR002589   Macro_dom       

SUPFAM

SSF117018   SSF117018        + More
SSF50249   SSF50249       
SSF52113   SSF52113       
SSF56496   SSF56496       
SSF50494   SSF50494       

Gene 3D

1.10.3260.10     3.30.1740.10     3.40.50.10190    

CDD

cd00087  FReD
cd00190  Tryp_SPc
cd00027  BRCT

ProteinModelPortal

H9J9P4   A0A2W1BB99   A0A2A4JXV3   A0A194QG46   A0A194QRN8   A0A212F753   + More
A0A0L7LWK8   A0A1W4WD65   A0A1B6G6F1   A0A1B6ENC4   A0A139WND0   A0A310S4Q1   A0A087ZW84   A0A3L8DJH7   E0VGK6   A0A2A3EL55   A0A0C9QZ00   E2A6Z4   A0A151WKM0   A0A1B6C8P5   A0A1B6CLD8   A0A151J5C6   A0A154PUH1   A0A0M9A8D8   E2B3R6   A0A2P2I0Z2   A0A1Y1KHU9   K7J0X3   A0A151IEJ9   A0A0A9WH49   A0A0A9WE47   A0A0K8S800   A0A0A9WE37   A0A0A9WG25   A0A023F1W7   A0A151JTG1   A0A0L7QVE8   C3XPG8   T1IZP4   A0A0K2V401   A0A0K2V4Z8   A0A3B3SG92   V9KA84   A0A0F7Z9Z8   W5M261   I3K6G0   W5M246   I3K6G1   A0A087UPX1   A0A3B4FZX7   A0A2K6GKJ1   U3K569   A0A2K5PBN6   A0A1W4Z1J9   A0A3B4TZZ6   H0X1G3   A0A2K6U819   A0A2D0QB60   A0A3P9BZI9   A0A2K5PBM8   A0A2K5PBL3   A0A2K6GKG3   A0A1S3I5L9   A0A3B4CGY2   Q5U2M4   A0A218V1M8   A0A3B4E3M9   A0A3P8R2C9   A0A096MKE9   B1AT03   A0A2K5DDA8   Q3UC82   A0A2K6U842   A0A3B4WGM2   A0A2K6NLW9   A0A2K5IFJ0   U3BYS5   Q80ZH7   A0A2K6KHU5   M3YTT8   F7F289   A0A2K6KHT8   A0A2K6NLY5   F1P394   A0A2K6DA19   A0A2K5XIQ3   A0A2K5IFF0   G3VV55   A0A0F8B978   H0Z3J4   F6S760   H0VMT6   A0A2K6DA10   A0A2K5XIP9   G3SNT4   A0A2Y9E242  

PDB

3L2P     E-value=0,     Score=1727

KEGG

101739679    K10776 DNA ligase 3 [EC:6.5.1.1] | (RefSeq) DNA ligase 3

PATHWAY

03410    Base excision repair - Bombyx mori (domestic silkworm)

GO

GO:0006260   GO:0003677   GO:0071897   GO:0006310   GO:0051103   GO:0008270   GO:0005524   GO:0003910   GO:0006288   GO:0043504   GO:0004252   GO:0005634   GO:0006273   GO:0005737   GO:0005739   GO:0097681   GO:0006281   GO:0005654   GO:0090298   GO:0006302   GO:0003909   GO:0042555   GO:0048384  

Length:

998

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02049

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00021

outside

1  -  998

 

 

Pi

266.131275

Theta

219.935524

Tajima's D

-2.479104

CLR

10.593555

CSRT

0.000899955002249887

Interpretation

Possibly Positive selection