Silkworm Genome Informatics Database

Gene

KWMTBOMO03503 Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006539

Annotation

PREDICTED:_angiotensin-converting_enzyme-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr6(+):9722520-9735084 View in EpiBrowser

Full name

Angiotensin-converting enzyme

Alternative Name

Dipeptidyl carboxypeptidase I
Kininase II

Location in the cell

Nuclear Reliability : 2.54

CDS

ATGATCGTCGCTAGGTTCATTTGCCTAGTTGGAATAATTTCAACGGCAGTGTCAGTTCAGTTCCAAACAAATCCTTCGTCAGATATGTCAGCAGACGAGACGAGCACACCGAAAAATAATAAAACTTTAGATGTCTCCGATGAAAGTGGACATGAATTAGAAGCGGACGTGGATGACATTAAAGAGAAAAAGTTCCTAGACGAAGCCATAAAAGCGATATTAGATCCTCATGCTTTTATTCCAAAAAACCAAGATGAACTCGAAAGTTACAAACTCCAATTAGATGAATTAAACAAATCTAATATAAGTTTAGATTCATTCTTAAGCGAAATGGATAATTTAAGTCTTGAAGTATGCAAAACATCCCAAAAAGCATTGTGGTCTTATGTATCTGATATCAACAATGAAACTAAAAAGAACAAAATGGTTAGAATAACTGCAGAGGAAGACGAAATTAAGAAACAGTACTGGAATATTTTGAAGACAAAATATTTAAGAGATGACACAGTTAAGAATGATCGTAATTACCAGCGTAAAATTAGAATTATAAAAGAACGTGGAACTAACGTACAGATGCCACAAAGCAAGCAAAGAGAAGAAATAGACTTAATGCAAAGAATATGGAGTCGCGTATCGTTATGTGCTTACAATACTTCATGTAACAATGAAGATTCCATTCGATCCATGAGCGATGTCATTGCAATATTCAAAACGAGCAATGATTCCAAAGAATTGGCATATTACTGGAAAGCTTTTCGCGACATGACAGGCCGAAAGATTCGTCCAATATTTAAAGACTACGTTACGAGAATGAACGCCGTAGCGAAATCGGAGAATTTCAGTGACGCAGGTGAAATGTGGCGGCTTTCTTACGATGACAATAATTTCGTTGAAACTGTGAAAACGATTTGGAATGAAATGAAACCGTTGTATAACCTCATACGCGACTATGTGAGATTAAAGCTGAAATCTTATTATCCTGAGGACATTAAAAGTGATACTAATTGTATACCGGCACATCTATTAGGAAACCTATGGGCACAAGAATGGCAGGCGATTTATCCAAAAGTCATAGCGTATCCGAAACACTATCGACACAAAACGTTCACTCAAGGTCTGAAATCGAAAGATTTGTTCGACGCCGTTGATTTATTTCATCAATCATTGGGCTTTGACTCCGCAAATGACTCTTATAAGGATATCAGTGATGGCGTTCCTTCAGCCAATTGCCTGCCTTCGAGTCACGACATGTGCGACGGTGTTAATTACAAGATTAAATGGTGCGGTGATAAAATCACAGATGTAGAGGTGGCCTTATCGCAAGCGGCAAGACTTCTGGGTCATGTTCAGTACTTTAAGCATTACAAGGATTTATCGCCTTTGTATAGAGACGGACCGAATCCAGCGTTTCACGATGCAATCTCGGACATCGTTGCGGTGCAGTTAACCTTGCCAGACCATCTAAAGACCTTGAACTTAGTGAAGGCATCAACTGGCCGAGAGGTTACAATAAACCATCTTCTCTGGCTGGCTCTAGAGAAAATACCTCTAATGGCGTACGCGTACGTTTTGGATACATGGAGATGGGATATATTCGGGAATAGTAGTTTGGAAAACTGGAATGCACACTGGTGGGATCTACGGACAAAAGAGACAGGCGTGTCACCTCCGGTGTTGAGGAACGAAAGCGATTTGGACCCTGCCGCCAAATATCACGTTGTGTCACATGTTCAATACATCACGTACCTAATATCTCACGTTCTGGAATTTCAAATTTTGTTCTCTCTCTGCAAAAAAGTTAACCACACGGGACCACTCCATGAATGCTCTTTGTACGGGCATAAGGAAGTAGGAAAATTGTTAAGCAATGGCATGGCACTGGGTGCAAGTGAAGATTGGAACACTGTGCTCGAAACAATGACCGGGGAAAGACAATTATCGACCGAAGGAATCCTAGAATACTTTTCGATTCTCGAAGATTTCTTAAGAAAAGAAAACTTACGTTTAGCTGCAGTAGTAGAAGATATGGATAAAAGTGCTCCGATAGTAGTGGGAGCTATAGTTGTGTTTCTAACAGTACTTATTATTGTATTGTACTGTGCTAAGAAACATGATCTTGGAAGAAAAATGCGTTCATTTTGTGGTCTAACTAAAAACGGCTCTCTTGATATAGTTACCAATGAGGTACCTCAAAGTAAAACAAACGATATCGAAGGTATTGTCGAAGATAAAGTTTGA

Protein

MIVARFICLVGIISTAVSVQFQTNPSSDMSADETSTPKNNKTLDVSDESGHELEADVDDIKEKKFLDEAIKAILDPHAFIPKNQDELESYKLQLDELNKSNISLDSFLSEMDNLSLEVCKTSQKALWSYVSDINNETKKNKMVRITAEEDEIKKQYWNILKTKYLRDDTVKNDRNYQRKIRIIKERGTNVQMPQSKQREEIDLMQRIWSRVSLCAYNTSCNNEDSIRSMSDVIAIFKTSNDSKELAYYWKAFRDMTGRKIRPIFKDYVTRMNAVAKSENFSDAGEMWRLSYDDNNFVETVKTIWNEMKPLYNLIRDYVRLKLKSYYPEDIKSDTNCIPAHLLGNLWAQEWQAIYPKVIAYPKHYRHKTFTQGLKSKDLFDAVDLFHQSLGFDSANDSYKDISDGVPSANCLPSSHDMCDGVNYKIKWCGDKITDVEVALSQAARLLGHVQYFKHYKDLSPLYRDGPNPAFHDAISDIVAVQLTLPDHLKTLNLVKASTGREVTINHLLWLALEKIPLMAYAYVLDTWRWDIFGNSSLENWNAHWWDLRTKETGVSPPVLRNESDLDPAAKYHVVSHVQYITYLISHVLEFQILFSLCKKVNHTGPLHECSLYGHKEVGKLLSNGMALGASEDWNTVLETMTGERQLSTEGILEYFSILEDFLRKENLRLAAVVEDMDKSAPIVVGAIVVFLTVLIIVLYCAKKHDLGRKMRSFCGLTKNGSLDIVTNEVPQSKTNDIEGIVEDKV

Description

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg-binding ability of the sperm.

Catalytic Activity

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactor

Zn(2+)
chloride

Similarity

Belongs to the peptidase M2 family.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Alternative splicing Carboxypeptidase Cell membrane Complete proteome Cytoplasm Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Phosphoprotein Protease Reference proteome Repeat Secreted Signal Transmembrane Transmembrane helix Zinc

Feature

chain  Angiotensin-converting enzyme
propeptide  Removed in secreted form
splice variant  In isoform Testis-specific.

Uniprot

H9JAJ4 A0A2A4JLZ3 A0A2W1C0X6 A0A194QTP2 A0A194QBS1 A0A0L7LPG8 + More
D2A533 Q16W80 A0A1Q3FMT2 A0A2J7PUA6 B0WAI2 A0A1S4G7T4 A0A182G4Y2 A0A182F8Z6 A0A023EWR5 A0A0P6AG22 A0A0P5MF77 A0A0P5P2U5 A0A067RGQ0 A0A182K2U1 A0A182LXS0 W5JI07 E9G1V9 A0A182JKB6 A0A1S5QMZ5 A0A0P5NXX2 A0A162QEW6 A0A1E1WWB8 P09470-2 A0A0P5DWJ9 A0A0P4W2J2 A0A0P4XKM2 A0A2C9H8S8 A0A0P5KP31 A0A182Y8L7 A0A0P5J1U9 A0A2Y9G4W0 A0A182RDY9 A0A1Y1NA19 V4AKT8 A0A0N8APF5 A0A182TCN2 A0A182HYU2 A0A2Y9KP47 A0A182KZE4 A0A1J1J340 A0A2U3YBR9 T1I107 A0A084WT83 A0A182TTS0 E9GU43 A0A182N9U1 A0A2U3WBV7 Q4ACT8 A0A182UTK5 A0A0P5NN17 A0A2J7QUE9 A0A2T7NPJ2 A0A383ZL24 A0A2J7QUF6 F1RRW4 A0A218QXF0 A0A2K6G9P9 Q7Q9W7 A0A0P4ZFQ8 A0A182R0V2 A0A0N7ZQD9 A0A0P5UHX7 A0A182W3L5 E2C0X3 A0A0P5W4G4 A0A0P5CWD0 A0A1B6GNU4 A0A0P5FWE4 A0A154PK20 E9GIV2 C8UZT5 A0A310SP14 A0A2Y9DH86 A0A3Q0CPJ2 A0A1S3WH64 A0A0P5NKM2 A0A0P5YQN8 A0A2L2Y254 Q8K233 F6QCP8 A0A1S3GIY4 A0A2Y9PD35 M3VXV0 A0A096P6D3 A0A182PQS5 A0A2S2QF02 T1KX65 A0A2U4C3T3 A0A0P6J8C8 A0A0N0BEI9 A0A158P0W6 A0A2Y9PPT2 A0A2K5I630

EC Number

3.4.-.-

Pubmed

19121390 28756777 26354079 26227816 18362917 19820115 + More
17510324 26483478 24945155 24845553 20920257 23761445 21292972 2545691 2164636 15489334 2841312 2835538 7753170 8642790 15665832 16944957 17114649 21183079 23535237 25244985 28004739 23254933 20966253 24438588 17145192 12364791 14747013 17210077 20798317 19656189 26561354 12040188 19468303 17975172 21347285

EMBL

BABH01009468 BABH01009469 NWSH01001141 PCG72420.1 KZ149899 PZC78616.1 + More
KQ461155 KPJ08370.1 KQ459249 KPJ02440.1 JTDY01000388 KOB77418.1 KQ971361 EFA05307.1 CH477573 EAT38830.1 GFDL01006170 JAV28875.1 NEVH01021203 PNF19925.1 DS231872 EDS41405.1 JXUM01144647 KQ569835 KXJ68504.1 GAPW01000035 JAC13563.1 GDIP01031200 JAM72515.1 GDIQ01180368 JAK71357.1 GDIQ01138775 JAL12951.1 KK852651 KDR19442.1 AXCM01000458 ADMH02001350 ETN62918.1 GL732529 EFX86561.1 KR068494 AMO02511.1 GDIQ01136230 JAL15496.1 LRGB01000340 KZS19632.1 GEMQ01000103 JAT91086.1 J04946 J04947 M55333 M61094 BC040404 J03940 GDIP01150573 JAJ72829.1 GDRN01078040 JAI62649.1 GDIP01240539 JAI82862.1 GDIQ01206910 JAK44815.1 GDIQ01208158 JAK43567.1 GEZM01008451 JAV94774.1 KB201847 ESO94196.1 GDIQ01255819 JAJ95905.1 APCN01005408 APCN01005409 CVRI01000064 CRL05281.1 ACPB03016228 ATLV01026865 ATLV01026866 KE525420 KFB53427.1 GL732565 EFX76973.1 AB231334 BAE16967.2 GDIQ01144124 JAL07602.1 NEVH01011186 PNF32208.1 PZQS01000010 PVD23094.1 PNF32210.1 AEMK02000080 GEUW01000012 JAW07033.1 AAAB01008898 EAA09164.3 GDIP01213973 JAJ09429.1 AXCN02001200 GDIP01222825 JAJ00577.1 GDIP01114950 JAL88764.1 GL451850 EFN78409.1 GDIP01091235 LRGB01001253 JAM12480.1 KZS13268.1 GDIP01164551 JAJ58851.1 GECZ01014580 GECZ01005674 JAS55189.1 JAS64095.1 GDIQ01254826 JAJ96898.1 KQ434943 KZC12209.1 GL732547 EFX80591.1 BN001299 CAX63316.1 KQ762196 OAD56126.1 GDIQ01140929 JAL10797.1 GDIP01055046 JAM48669.1 IAAA01001533 IAAA01001534 IAAA01001535 IAAA01001536 IAAA01001537 IAAA01001538 IAAA01001539 IAAA01001540 LAA02269.1 BC034367 CH466558 AAH34367.1 EDL34254.1 AL596246 AL731865 AANG04004184 AHZZ02010522 AHZZ02010523 GGMS01006897 MBY76100.1 CAEY01000676 GEBF01003132 JAO00501.1 KQ435827 KOX71968.1 ADTU01005878 ADTU01005879 ADTU01005880 ADTU01005881 ADTU01005882

Proteomes

UP000005204 UP000218220 UP000053240 UP000053268 UP000037510 UP000007266 + More
UP000008820 UP000235965 UP000002320 UP000069940 UP000249989 UP000069272 UP000027135 UP000075881 UP000075883 UP000000673 UP000000305 UP000075880 UP000076858 UP000000589 UP000076407 UP000076408 UP000248481 UP000075900 UP000030746 UP000075901 UP000075840 UP000248482 UP000075882 UP000183832 UP000245341 UP000015103 UP000030765 UP000075902 UP000075884 UP000245340 UP000075903 UP000245119 UP000261681 UP000008227 UP000233160 UP000007062 UP000075886 UP000075920 UP000008237 UP000076502 UP000248480 UP000189706 UP000079721 UP000081671 UP000248483 UP000011712 UP000028761 UP000075885 UP000015104 UP000245320 UP000053105 UP000005205 UP000233080

PRIDE

H9JAJ4 P09470 Q4ACT8 F1RRW4 F6QCP8

Pfam

PF01401   Peptidase_M2        + More
PF07690   MFS_1
PF07701   HNOBA
PF00211   Guanylate_cyc
PF07700   HNOB
PF05160   DSS1_SEM1

Interpro

IPR001548   Peptidase_M2        + More
IPR020846   MFS_dom
IPR011701   MFS
IPR036259   MFS_trans_sf
IPR013087   Znf_C2H2_type
IPR018297   A/G_cyclase_CS
IPR038158   H-NOX_domain_sf
IPR024096   NO_sig/Golgi_transp_ligand-bd
IPR011645   HNOB_dom_associated
IPR029787   Nucleotide_cyclase
IPR001054   A/G_cyclase
IPR011644   Heme_NO-bd
IPR007834   DSS1_SEM1

SUPFAM

SSF103473   SSF103473        + More
SSF55073   SSF55073
SSF111126   SSF111126

Gene 3D

3.30.70.1230 3.90.1520.10

CDD

cd06461 M2_ACE
cd06174 MFS

ProteinModelPortal

H9JAJ4 A0A2A4JLZ3 A0A2W1C0X6 A0A194QTP2 A0A194QBS1 A0A0L7LPG8 + More
D2A533 Q16W80 A0A1Q3FMT2 A0A2J7PUA6 B0WAI2 A0A1S4G7T4 A0A182G4Y2 A0A182F8Z6 A0A023EWR5 A0A0P6AG22 A0A0P5MF77 A0A0P5P2U5 A0A067RGQ0 A0A182K2U1 A0A182LXS0 W5JI07 E9G1V9 A0A182JKB6 A0A1S5QMZ5 A0A0P5NXX2 A0A162QEW6 A0A1E1WWB8 P09470-2 A0A0P5DWJ9 A0A0P4W2J2 A0A0P4XKM2 A0A2C9H8S8 A0A0P5KP31 A0A182Y8L7 A0A0P5J1U9 A0A2Y9G4W0 A0A182RDY9 A0A1Y1NA19 V4AKT8 A0A0N8APF5 A0A182TCN2 A0A182HYU2 A0A2Y9KP47 A0A182KZE4 A0A1J1J340 A0A2U3YBR9 T1I107 A0A084WT83 A0A182TTS0 E9GU43 A0A182N9U1 A0A2U3WBV7 Q4ACT8 A0A182UTK5 A0A0P5NN17 A0A2J7QUE9 A0A2T7NPJ2 A0A383ZL24 A0A2J7QUF6 F1RRW4 A0A218QXF0 A0A2K6G9P9 Q7Q9W7 A0A0P4ZFQ8 A0A182R0V2 A0A0N7ZQD9 A0A0P5UHX7 A0A182W3L5 E2C0X3 A0A0P5W4G4 A0A0P5CWD0 A0A1B6GNU4 A0A0P5FWE4 A0A154PK20 E9GIV2 C8UZT5 A0A310SP14 A0A2Y9DH86 A0A3Q0CPJ2 A0A1S3WH64 A0A0P5NKM2 A0A0P5YQN8 A0A2L2Y254 Q8K233 F6QCP8 A0A1S3GIY4 A0A2Y9PD35 M3VXV0 A0A096P6D3 A0A182PQS5 A0A2S2QF02 T1KX65 A0A2U4C3T3 A0A0P6J8C8 A0A0N0BEI9 A0A158P0W6 A0A2Y9PPT2 A0A2K5I630

PDB

2IUX E-value=2.18717e-89, Score=842

KEGG

101735566 K01283 peptidyl-dipeptidase A [EC:3.4.15.1] | (RefSeq) angiotensin-converting enzyme-like

GO

GO:0016021 GO:0008237 GO:0008241 GO:0004180 GO:0046872 GO:0005615 GO:0008238 GO:0008239 GO:0005886 GO:0016020 GO:0055085 GO:0003676 GO:1902033 GO:0048286 GO:0010815 GO:0031711 GO:0050729 GO:0035814 GO:0097225 GO:0031100 GO:0031526 GO:0008144 GO:0009925 GO:0010629 GO:0043065 GO:1900086 GO:0043171 GO:0070062 GO:0008217 GO:0031404 GO:0042310 GO:0045777 GO:0031982 GO:0004175 GO:0097756 GO:0003084 GO:0008270 GO:0070573 GO:0050769 GO:0050482 GO:0007283 GO:0042755 GO:0032092 GO:0060177 GO:0051019 GO:0010608 GO:0014910 GO:0032091 GO:0060047 GO:0002446 GO:0003081 GO:0042447 GO:0008233 GO:0005764 GO:0090281 GO:0005768 GO:0001822 GO:0050435 GO:0071838 GO:0019233 GO:0008240 GO:0009897 GO:0061098 GO:0032496 GO:0046325 GO:2000170 GO:0006518 GO:0060978 GO:0003779 GO:0009792 GO:0031434 GO:1903597 GO:0005737 GO:0020037 GO:0000166 GO:0035556 GO:0004383 GO:0006406 GO:0043248 GO:0008541 GO:0006508 GO:0004352 GO:0000287 GO:0003723 GO:0006270 GO:0042555 GO:0048384

PANTHER

PTHR10514

Subcellular location

Secreted
Cell membrane
Cytoplasm

SignalP

Position: 1 - 18, Likelihood: 0.767881

Length:

745

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

25.23096

Exp number, first 60 AAs:

3.14147

Total prob of N-in:

0.16021

outside

1 - 678

TMhelix

679 - 701

inside

702 - 745

Pi

232.151536

Theta

21.831343

Tajima's D

0.459286

CLR

162.993443

CSRT

0.509574521273936

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics