Gene

KWMTBOMO03485

Annotation

PREDICTED:_non-structural_maintenance_of_chromosomes_element_1_homolog_[Amyelois_transitella]

Location

Bomo_Chr6(+):9219907-9224685      View in EpiBrowser

Full name

4-hydroxybenzoate polyprenyltransferase, mitochondrial       + More
Non-structural maintenance of chromosomes element 1 homolog      

Alternative Name

Para-hydroxybenzoate--polyprenyltransferase

Location in the cell

Nuclear   Reliability : 3.506

CDS

ATGTCTTACAGTAAAGTTCACAGATATTTTTTAAGAACTATAGCCAGTAGCGGTGTTATGAGTGTTGATGAAGCTCATCGAGTCCTGACTAAATTTACAGGTGAGCCGATCTTGTTAAAGAACTGCATTCAAGAAATTAATGATGTTATCAGACCATATCAGCAGTCAATCAAAGTAACATACAATGAAAGTACAAATGAAGAAGTAGTTATATTCTTAACCCATGCTTGGGATTCAATATCTGAATCCCAAAAGATCTTCACAGCTAAGGAATTAGACTATTTCAGATTATTAATTGAAGAAATAATGAGTATAGATGTAAGAGAAATCACAGGCATTCATGCAATTAATTTGGTTAATAAAATGGGCCAGAAAATATCAATGCTCCAAGCTGAAAATTTATTGGCTAAATGGTGTAAAATGTACTACTTAGAGAAGATACAAAATAAATACCGCTTAGGTGTGAGAACCATAAATGAATTTGAAGATTATTTTGAGAAATACATGCCTGATGTAATGAAAGATTGTTACATTTGTAAGAAAAATGTTTTTTGGGGGGCTAACTGCATAGCATGTGAAAAAGCTATTCACACTAGGTGCCTTAATCAGTACTTAGAAAAAATAAAAAAATGGCCTTGTTGTAAACTCGACTTCAGTCCAGATCAACTGAAACAACTTAACGAAAGCCAGAGAATGACTCAGATAACTCAAACCTTTGAAGACACACAGTCAATTGAAGAAAGGTCGGAGAATTCAACAGCTTCCAATGTAGAAAATGATAATACAGAAGAAATGGAAAGAAGTCAAAATACAGATAACATACGACGTCTCTCTAGAAAGAGGAAGAGAGAATAA

Protein

MSYSKVHRYFLRTIASSGVMSVDEAHRVLTKFTGEPILLKNCIQEINDVIRPYQQSIKVTYNESTNEEVVIFLTHAWDSISESQKIFTAKELDYFRLLIEEIMSIDVREITGIHAINLVNKMGQKISMLQAENLLAKWCKMYYLEKIQNKYRLGVRTINEFEDYFEKYMPDVMKDCYICKKNVFWGANCIACEKAIHTRCLNQYLEKIKKWPCCKLDFSPDQLKQLNESQRMTQITQTFEDTQSIEERSENSTASNVENDNTEEMERSQNTDNIRRLSRKRKRE

Description

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair.

Catalytic Activity

4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Cofactor

Mg(2+)

Subunit

Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A or EID3 and NSMCE3 probably form a subcomplex that bridges the head domains of the SMC5-SMC6 heterodimer. Interacts with NSMCE3.

Similarity

Belongs to the calycin superfamily. Lipocalin family.
Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
Belongs to the UbiA prenyltransferase family.
Belongs to the NSE1 family.

Keywords

Chromosome   Complete proteome   DNA damage   DNA recombination   DNA repair   Metal-binding   Nucleus   Reference proteome   Telomere   Transferase   Ubl conjugation   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  Non-structural maintenance of chromosomes element 1 homolog

Uniprot

H9JAI5   A0A2W1BW85   A0A2A4JL89   A0A0L7LQM6   A0A2H1WNW9   A0A194PZC2   + More
A0A194RPM2   A0A1E1WP66   S4PRT9   A0A212EWM9   A0A084W2U7   A0A182NM98   A0A182IY62   W5JVK0   Q0IFZ1   A0A182FFD2   A0A1Y1MUU0   A0A023EMY4   A0A182GQK8   A0A0K8TLT2   A0A182V699   A0A182MTZ3   Q16PA4   A0A182QE16   B0WPT4   Q7PNL4   A0A182LJP5   A0A182HM54   A0A182Y0U5   A0A182PN97   A0A1S4FU51   A0A182WK80   A0A182RQ96   A0A182XCS8   A0A1Q3F251   A0A182K710   A0A139WF15   A0A182GPD4   A0A1B0D601   B0X5P6   A0A1J1I5W1   A0A182UIE1   A0A1W4WZ49   N6TT82   A0A1I8NHF5   J4G7D8   A0A3L8DA19   A0A226E201   A0A1D2MQ27   A0A195E5H4   K7IS45   A0A1I8PFM2   A0A232EW33   A0A384BLK0   A0A384BLI6   A0A369JNE1   A0A341BAW9   R7V2F2   B4KJU9   E2ADT0   A0A195B0G5   D2I208   A0A158NQZ2   A0A1S3ERR1   A0A151WMC6   A0A2Y9PN56   A0A195EVG1   G1LBK8   B4JPS2   E2RFI7   A0A0L7QQF7   I3MYE7   G1DFX6   B3MKT7   A0A2Y9PLL6   H0WQR7   A0A2U3VPV4   M3YNH9   A0A2Y9L8G0   Q3T0X7   A0A2Y9LKS2   A0A2Y9LAS1   A0A2U3ZCR9   A0A3Q0CVU7   A0A2K6BS10   L5KNB2   A0A2Y9HX60   G7NQF5   M3W893   G7Q0S6   B2RDU2   A0A1U7UIK6   A0A2K6GY88   A0A2A3ECE5   A0A340WYY9   A0A2K6P830   A0A2K5VW03   H9FQY0  

EC Number

2.5.1.39
2.3.2.27

Pubmed

19121390    28756777    26227816    26354079    23622113    22118469    + More
24438588    20920257    23761445    17510324    28004739    24945155    26483478    26369729    12364791    14747013    17210077    20966253    25244985    18362917    19820115    23537049    25315136    22247176    30249741    27289101    20075255    28648823    24813606    23254933    17994087    20798317    20010809    21347285    16341006    26319212    23258410    22002653    17975172    25362486    25319552   

EMBL

BABH01009435    BABH01009436    BABH01009437    KZ149899    PZC78601.1    NWSH01001063    + More
PCG72845.1    JTDY01000301    KOB77803.1    ODYU01009962    SOQ54728.1    KQ459583    KPI98671.1    KQ459896    KPJ19457.1    GDQN01002423    JAT88631.1    GAIX01000520    JAA92040.1    AGBW02011942    OWR45879.1    ATLV01019698    KE525278    KFB44541.1    ADMH02000355    ETN66854.1    CH477281    EAT44933.1    GEZM01020066    JAV89421.1    GAPW01003884    JAC09714.1    JXUM01015651    KQ560436    KXJ82427.1    GDAI01002271    JAI15332.1    AXCM01001822    CH477789    EAT36198.1    AXCN02000938    DS232029    EDS32499.1    AAAB01008960    EAA11970.5    APCN01004355    GFDL01013467    JAV21578.1    KQ971354    KYB26512.1    JXUM01078212    KQ563051    KXJ74565.1    AJVK01011901    AJVK01011902    DS232391    EDS40983.1    CVRI01000042    CRK95571.1    APGK01019841    APGK01053910    KB741239    KB740134    KB632275    ENN72114.1    ENN81278.1    ERL91088.1    HE797078    CCM02353.1    QOIP01000010    RLU17327.1    LNIX01000008    OXA51310.1    LJIJ01000697    ODM95209.1    KQ979608    KYN20440.1    NNAY01001922    OXU22562.1    LUEZ02000055    RDB21203.1    AMQN01005336    KB295744    ELU12684.1    CH933807    EDW12552.1    GL438820    EFN68442.1    KQ976691    KYM77951.1    GL194078    EFB28138.1    ADTU01023710    KQ982944    KYQ48980.1    KQ981965    KYN31874.1    ACTA01017866    CH916372    EDV98902.1    AAEX03004424    KQ414786    KOC60809.1    AGTP01031047    AGTP01031048    JI861692    AEJ84180.1    CH902620    EDV31618.1    AAQR03122989    AAQR03122990    AEYP01082357    AEYP01082358    AEYP01082359    BC102214    KB030664    ELK12078.1    CM001272    EHH31533.1    AANG04002788    CM001295    EHH60264.1    AK315674    BAG38039.1    KZ288295    PBC28962.1    AQIA01042469    JU333284    JU474598    JV046378    AFE77039.1    AFH31402.1    AFI36449.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053268    UP000053240    UP000007151    + More
UP000030765    UP000075884    UP000075880    UP000000673    UP000008820    UP000069272    UP000069940    UP000249989    UP000075903    UP000075883    UP000075886    UP000002320    UP000007062    UP000075882    UP000075840    UP000076408    UP000075885    UP000075920    UP000075900    UP000076407    UP000075881    UP000007266    UP000092462    UP000183832    UP000075902    UP000192223    UP000019118    UP000030742    UP000095301    UP000006352    UP000279307    UP000198287    UP000094527    UP000078492    UP000002358    UP000095300    UP000215335    UP000261680    UP000291021    UP000076154    UP000252040    UP000014760    UP000009192    UP000000311    UP000078540    UP000005205    UP000081671    UP000075809    UP000248483    UP000078541    UP000008912    UP000001070    UP000002254    UP000053825    UP000005215    UP000007801    UP000005225    UP000245340    UP000000715    UP000248482    UP000009136    UP000189706    UP000233120    UP000010552    UP000248481    UP000011712    UP000009130    UP000189704    UP000233160    UP000242457    UP000265300    UP000233200    UP000233100   

PRIDE

H9JAI5    Q3T0X7    B2RDU2   

Pfam

PF07574   SMC_Nse1        + More
PF08746   zf-RING-like
PF00061   Lipocalin
PF01066   CDP-OH_P_transf
PF01040   UbiA

Interpro

IPR011513   Nse1        + More
IPR036388   WH-like_DNA-bd_sf       
IPR002219   PE/DAG-bd       
IPR013083   Znf_RING/FYVE/PHD       
IPR014857   Znf_RING-like       
IPR001841   Znf_RING       
IPR019786   Zinc_finger_PHD-type_CS       
IPR022272   Lipocalin_CS       
IPR000566   Lipocln_cytosolic_FA-bd_dom       
IPR012674   Calycin       
IPR014472   CHOPT       
IPR000462   CDP-OH_P_trans       
IPR006370   HB_polyprenyltransferase-like       
IPR000537   UbiA_prenyltransferase       
IPR030470   UbiA_prenylTrfase_CS       
IPR011011   Znf_FYVE_PHD       

SUPFAM

SSF50814   SSF50814        + More
SSF57903   SSF57903       

Gene 3D

1.10.10.10     3.30.40.10     2.40.128.20    

CDD

cd16493  RING-CH-C4HC3_NSE1

ProteinModelPortal

H9JAI5   A0A2W1BW85   A0A2A4JL89   A0A0L7LQM6   A0A2H1WNW9   A0A194PZC2   + More
A0A194RPM2   A0A1E1WP66   S4PRT9   A0A212EWM9   A0A084W2U7   A0A182NM98   A0A182IY62   W5JVK0   Q0IFZ1   A0A182FFD2   A0A1Y1MUU0   A0A023EMY4   A0A182GQK8   A0A0K8TLT2   A0A182V699   A0A182MTZ3   Q16PA4   A0A182QE16   B0WPT4   Q7PNL4   A0A182LJP5   A0A182HM54   A0A182Y0U5   A0A182PN97   A0A1S4FU51   A0A182WK80   A0A182RQ96   A0A182XCS8   A0A1Q3F251   A0A182K710   A0A139WF15   A0A182GPD4   A0A1B0D601   B0X5P6   A0A1J1I5W1   A0A182UIE1   A0A1W4WZ49   N6TT82   A0A1I8NHF5   J4G7D8   A0A3L8DA19   A0A226E201   A0A1D2MQ27   A0A195E5H4   K7IS45   A0A1I8PFM2   A0A232EW33   A0A384BLK0   A0A384BLI6   A0A369JNE1   A0A341BAW9   R7V2F2   B4KJU9   E2ADT0   A0A195B0G5   D2I208   A0A158NQZ2   A0A1S3ERR1   A0A151WMC6   A0A2Y9PN56   A0A195EVG1   G1LBK8   B4JPS2   E2RFI7   A0A0L7QQF7   I3MYE7   G1DFX6   B3MKT7   A0A2Y9PLL6   H0WQR7   A0A2U3VPV4   M3YNH9   A0A2Y9L8G0   Q3T0X7   A0A2Y9LKS2   A0A2Y9LAS1   A0A2U3ZCR9   A0A3Q0CVU7   A0A2K6BS10   L5KNB2   A0A2Y9HX60   G7NQF5   M3W893   G7Q0S6   B2RDU2   A0A1U7UIK6   A0A2K6GY88   A0A2A3ECE5   A0A340WYY9   A0A2K6P830   A0A2K5VW03   H9FQY0  

PDB

5WY5     E-value=3.19343e-14,     Score=189

KEGG

101736332    K22817 non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] | (RefSeq) non-structural m

GO

GO:0006281   GO:0030915   GO:0035556   GO:0046872   GO:0005634   GO:0004842   GO:0006301   GO:0000724   GO:0016780   GO:0031305   GO:0047293   GO:0002083   GO:0006744   GO:0008299   GO:0008654   GO:2001022   GO:0046983   GO:0005654   GO:0000781   GO:0015074   GO:0003676   GO:0004352   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384  

PANTHER

PTHR20973   PTHR10414  

Subcellular location

Mitochondrion inner membrane  
Nucleus  
Chromosome  
Telomere  

Length:

284

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00563999999999999

Exp number, first 60 AAs:

0.00263

Total prob of N-in:

0.22188

outside

1  -  284

 

 

Pi

323.025637

Theta

200.746511

Tajima's D

0.610292

CLR

0.00042

CSRT

0.548422578871056

Interpretation

Uncertain