Gene

KWMTBOMO03476

Pre Gene Modal

BGIBMGA006526

Annotation

PREDICTED:_probable_ATP-dependent_RNA_helicase_pitchoune_[Bombyx_mori]

Location

Bomo_Chr6(+):8848393-8854323      View in EpiBrowser

Full name

RNA helicase       + More
Probable ATP-dependent RNA helicase pitchoune      

Location in the cell

Cytoplasmic   Reliability : 2.441

CDS

ATGGAATCTAAAAAACTTCCCAAATTTAAAGAACTTAAAGAGCAACTCTCTGCAGCTACTTTAAATGCAATCAGAGAGATGGGATTCAAAAGGATGACTGAAATACAGGCAGAGGTCCTACCATCAGCGCTGGATGGTAACGATATAGTGGCGACAGCAAAAACAGGCTCAGGAAAAACATTAGCATTTCTAATACCTGTAATCGAAGTGGTTGCTAAAAACATAGAAAAAGCTATGCACGGTACGTTTTCCATCATAATTGCACCAACAAGGGAACTGGCAATACAAACATATTCAGTCTTACAGGAGTTGATCAATCATCATAATAAAATCACATCAACTTTAGTGATTGGTGGAGAGAGCAGAAAAAAACAGAGCTCTGATCTTGTTCAAGGTATGCATATTGTTGTAGCCACACCAGGTAGATTATTTGATCACATGAGAACTAAAGAGTTTGATTACAAATGTGTCAAATGTCTTGTACTGGATGAAGCTGATAAAATATTTCAATATGGTTTTGAAGAAGATCTAAAACAGATAATTAATCGGTTACCAAAGGATAGGCAAACAATGCTTTTCAGCGCAACACTTTCTGAGAGAACTGATGCTCTAGTGGAGTCTGCCATGAAAAAAGACAAGATACAACATATCAATACTGATCAGGATGACCTGTGTGCTACAGTGGAAGGTTTAAAACAGGGATATGCTGTGTGTCAAACCCAGTATAGATTGTGGTGGTTACATAAGGTGCTGAAGAAAACAAAACAATTCAAAGTTATGGTATTTTTTTCGAGTTGTAAATCTGTTGTGTTCCATTACGAATTCTTTCAGAAATACTGTCAAATGAACGTTTTGTGTATCCATGGTAAAATGAACCAAACCGATAGAACAGCAACCATCAATATATTCTATGAAACAGAAAATATAGCGTTATTCTGTACAGATGTTGCGGCAAGAGGATTGGATATACCGGCTGTAGATTGGATAGTCCAGTTCGATCCACCTGGTGATGCAAATGAATACATTCACAGAGTGGGCAGAACGGCGAGAGGTTTGGGTGCTGATGGTAATGCAGTTTTACTTCTAAGACCTGAGGAAGTGGGTTTTGTGGATTACCTGAAGGAATCTAAAATATATGTAGATAAATACGAAAGCTGGGATTCTTATTATAATTTACAAAAAAAGTTGGATACGGCAATGTCTGATTCTAATTTCGTAAACTTAGCGATTGAAGCATTTGAGGGATATGTTAGAGCGCTGGAAGTCAGAAAGCTAAAACAGATATTTAATTTGTTGACAATGGATCTAGACGTTTTAGCAAGATCTTTTGGTTTAAAAGAAAAGCCTGATGTTGATATACGCATAGGGTTTAGTAAAAAACATCGACCAAGGAAAAGAATGGCAGCGATTTTAGCTTCCCAAAGTGACACAAAGAAAGCTAAATCATGA

Protein

MESKKLPKFKELKEQLSAATLNAIREMGFKRMTEIQAEVLPSALDGNDIVATAKTGSGKTLAFLIPVIEVVAKNIEKAMHGTFSIIIAPTRELAIQTYSVLQELINHHNKITSTLVIGGESRKKQSSDLVQGMHIVVATPGRLFDHMRTKEFDYKCVKCLVLDEADKIFQYGFEEDLKQIINRLPKDRQTMLFSATLSERTDALVESAMKKDKIQHINTDQDDLCATVEGLKQGYAVCQTQYRLWWLHKVLKKTKQFKVMVFFSSCKSVVFHYEFFQKYCQMNVLCIHGKMNQTDRTATINIFYETENIALFCTDVAARGLDIPAVDWIVQFDPPGDANEYIHRVGRTARGLGADGNAVLLLRPEEVGFVDYLKESKIYVDKYESWDSYYNLQKKLDTAMSDSNFVNLAIEAFEGYVRALEVRKLKQIFNLLTMDLDVLARSFGLKEKPDVDIRIGFSKKHRPRKRMAAILASQSDTKKAKS

Description

Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Miscellaneous

Mutation in the pit gene produce larvae that cannot grow beyond the first instar larval stage although they can live as long as 7-10 days. All the tissues are equally affected and the perfectly shaped larvae are indistinguishable from first instar wild-type animals.
'Pitchoune' means 'small' in Provence (Southern part of France).

Similarity

Belongs to the DEAD box helicase family.
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

Keywords

ATP-binding   Complete proteome   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Reference proteome   RNA-binding  

Feature

chain  Probable ATP-dependent RNA helicase pitchoune

Uniprot

A0A2W1BU37   A0A194RNN9   A0A2A4J8M1   A0A194PZB6   S4P7R6   A0A0L0CEK4   + More
A0A1B6E4Q7   A0A0Q9X1W3   A0A0Q9X2B0   B4K6L4   B4M0M9   A0A0Q9WRB4   A0A0M4EGD0   A0A1Y1LJF9   B5DW65   A0A3B0K2U9   A0A034V7T4   A0A0K8TZH5   A0A0T6BH44   B4NHR6   A0A131Y3V7   A0A0K8TNZ2   A0A0K8R9Y7   A0A195DXU2   B4JRL9   D6W8J8   A0A2J7RRR1   A0A131XJI9   B4HM85   L7MKE2   W8BRJ4   A0A1W4W1L2   L7M567   A0A131YVP3   B4PLK0   B3LVL5   A0A224YNN8   B3P7N7   A0A195FFG3   A0A1A9VGC8   A0A1B6GIA3   A0A0B4LHF7   Q9VD51   A0A1E1XF66   A0A1I8Q5V6   G3MGY5   A0A158NH79   E9HPU8   A0A1I8N0G9   A0A1B0G9E6   A0A0N8C7S8   A0A0P5R2X6   A0A1B0A332   A0A1J1J3T6   A0A0P5NRZ2   A0A0P5LW05   A0A0P5SDG0   A0A0P5IMI1   A0A0P5PQS6   A0A0P5PMA1   A0A146MF85   A0A026X1E9   A0A0N8AYX7   A0A0P5N1H9   A0A0P5S6M3   A0A0P5HRP9   A0A0P5I9A7   A0A0P5PEL9   A0A1L8DGK8   A0A0P6GGE3   A0A0P5NCH5   A0A0P6BBZ8   A0A0P5A3H4   A0A0P6D864   A0A151XD17   A0A0P5Q0N6   A0A0P6HAY4   A0A0P6FX70   A0A0P6DL16   A0A1B6KE89   A0A0P5D3X7   A0A0P5N0P0   A0A0P5MHR0   A0A0P5NWY0   A0A336LY65   A0A0N8EAF2   A0A0P5BTJ0   A0A0N8B4B4   A0A0P5B2M3   A0A0P5YTJ8   A0A0P5RD11   A0A0P5UPV5   A0A0P5L0N4   A0A195B6U5   A0A0P5SP59   A0A0P5LTM5   A0A0P5LB25   A0A0P5VBT1   A0A0N8EL32  

EC Number

3.6.4.13

Pubmed

28756777    26354079    23622113    26108605    17994087    28004739    + More
15632085    25348373    26369729    18362917    19820115    28049606    25576852    24495485    26830274    17550304    28797301    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    9716523    12537569    28503490    22216098    21347285    21292972    25315136    26823975    24508170   

EMBL

KZ150004    PZC75253.1    KQ459896    KPJ19453.1    NWSH01002631    PCG67800.1    + More
KQ459583    KPI98666.1    GAIX01004474    JAA88086.1    JRES01000501    KNC30690.1    GEDC01004386    JAS32912.1    CH933806    KRG02044.1    KRG02045.1    EDW16314.1    CH940650    EDW67321.1    KRF83246.1    CP012526    ALC47404.1    GEZM01055754    JAV72948.1    CM000070    EDY68110.1    OUUW01000005    SPP80279.1    GAKP01021350    GAKP01021349    JAC37603.1    GDHF01032633    JAI19681.1    LJIG01000276    KRT86664.1    CH964272    EDW84676.1    GEFM01003195    JAP72601.1    GDAI01001998    JAI15605.1    GADI01005826    JAA67982.1    KQ980107    KYN17693.1    CH916373    EDV94409.1    KQ971312    EEZ98368.1    NEVH01000599    PNF43502.1    GEFH01002880    JAP65701.1    CH480815    EDW43133.1    GACK01000742    JAA64292.1    GAMC01007082    JAB99473.1    GACK01006800    JAA58234.1    GEDV01005303    JAP83254.1    CM000160    EDW97949.1    CH902617    EDV42585.1    GFPF01006213    MAA17359.1    CH954182    EDV54198.1    KQ981625    KYN39123.1    GECZ01007597    JAS62172.1    AE014297    AHN57458.1    U84552    AY071402    AY119620    GFAC01001305    JAT97883.1    JO841136    AEO32753.1    ADTU01015209    GL732711    EFX66239.1    CCAG010017460    GDIQ01106435    JAL45291.1    GDIQ01106436    JAL45290.1    CVRI01000070    CRL07099.1    GDIQ01160108    JAK91617.1    GDIQ01174701    JAK77024.1    GDIQ01095090    JAL56636.1    GDIQ01211896    JAK39829.1    GDIQ01145826    JAL05900.1    GDIQ01136922    JAL14804.1    GDHC01000957    JAQ17672.1    KK107063    EZA61209.1    GDIQ01229243    JAK22482.1    GDIQ01148736    JAL02990.1    GDIQ01108734    JAL42992.1    GDIQ01229241    JAK22484.1    GDIQ01215846    GDIQ01215845    GDIQ01110641    JAK35880.1    GDIQ01129677    LRGB01000687    JAL22049.1    KZS17013.1    GFDF01008495    JAV05589.1    GDIQ01044008    JAN50729.1    GDIQ01147178    JAL04548.1    GDIP01016779    JAM86936.1    GDIP01208028    JAJ15374.1    GDIQ01081893    JAN12844.1    KQ982294    KYQ58210.1    GDIQ01120777    JAL30949.1    GDIQ01044007    JAN50730.1    GDIQ01041609    JAN53128.1    GDIQ01075947    JAN18790.1    GEBQ01030483    JAT09494.1    GDIP01161528    GDIQ01064054    JAJ61874.1    JAN30683.1    GDIQ01160109    JAK91616.1    GDIQ01158013    JAK93712.1    GDIQ01158014    JAK93711.1    UFQT01000292    SSX22905.1    GDIQ01046052    JAN48685.1    GDIP01180278    JAJ43124.1    GDIQ01214147    JAK37578.1    GDIP01195228    JAJ28174.1    GDIP01053657    JAM50058.1    GDIQ01108732    JAL42994.1    GDIP01110037    JAL93677.1    GDIQ01176846    JAK74879.1    KQ976574    KYM80238.1    GDIQ01092991    JAL58735.1    GDIQ01189996    JAK61729.1    GDIQ01176847    JAK74878.1    GDIP01102489    JAM01226.1    GDIQ01016212    JAN78525.1   

Proteomes

UP000053240    UP000218220    UP000053268    UP000037069    UP000009192    UP000008792    + More
UP000092553    UP000001819    UP000268350    UP000007798    UP000078492    UP000001070    UP000007266    UP000235965    UP000001292    UP000192221    UP000002282    UP000007801    UP000008711    UP000078541    UP000078200    UP000000803    UP000095300    UP000005205    UP000000305    UP000095301    UP000092444    UP000092445    UP000183832    UP000053097    UP000076858    UP000075809    UP000078540   

PRIDE

Q9VD51   

Pfam

PF13959   DUF4217        + More
PF00271   Helicase_C
PF00270   DEAD

Interpro

IPR025313   DUF4217        + More
IPR027417   P-loop_NTPase       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR014014   RNA_helicase_DEAD_Q_motif       

SUPFAM

SSF52540   SSF52540       

CDD

cd00079  HELICc

ProteinModelPortal

A0A2W1BU37   A0A194RNN9   A0A2A4J8M1   A0A194PZB6   S4P7R6   A0A0L0CEK4   + More
A0A1B6E4Q7   A0A0Q9X1W3   A0A0Q9X2B0   B4K6L4   B4M0M9   A0A0Q9WRB4   A0A0M4EGD0   A0A1Y1LJF9   B5DW65   A0A3B0K2U9   A0A034V7T4   A0A0K8TZH5   A0A0T6BH44   B4NHR6   A0A131Y3V7   A0A0K8TNZ2   A0A0K8R9Y7   A0A195DXU2   B4JRL9   D6W8J8   A0A2J7RRR1   A0A131XJI9   B4HM85   L7MKE2   W8BRJ4   A0A1W4W1L2   L7M567   A0A131YVP3   B4PLK0   B3LVL5   A0A224YNN8   B3P7N7   A0A195FFG3   A0A1A9VGC8   A0A1B6GIA3   A0A0B4LHF7   Q9VD51   A0A1E1XF66   A0A1I8Q5V6   G3MGY5   A0A158NH79   E9HPU8   A0A1I8N0G9   A0A1B0G9E6   A0A0N8C7S8   A0A0P5R2X6   A0A1B0A332   A0A1J1J3T6   A0A0P5NRZ2   A0A0P5LW05   A0A0P5SDG0   A0A0P5IMI1   A0A0P5PQS6   A0A0P5PMA1   A0A146MF85   A0A026X1E9   A0A0N8AYX7   A0A0P5N1H9   A0A0P5S6M3   A0A0P5HRP9   A0A0P5I9A7   A0A0P5PEL9   A0A1L8DGK8   A0A0P6GGE3   A0A0P5NCH5   A0A0P6BBZ8   A0A0P5A3H4   A0A0P6D864   A0A151XD17   A0A0P5Q0N6   A0A0P6HAY4   A0A0P6FX70   A0A0P6DL16   A0A1B6KE89   A0A0P5D3X7   A0A0P5N0P0   A0A0P5MHR0   A0A0P5NWY0   A0A336LY65   A0A0N8EAF2   A0A0P5BTJ0   A0A0N8B4B4   A0A0P5B2M3   A0A0P5YTJ8   A0A0P5RD11   A0A0P5UPV5   A0A0P5L0N4   A0A195B6U5   A0A0P5SP59   A0A0P5LTM5   A0A0P5LB25   A0A0P5VBT1   A0A0N8EL32  

PDB

6EM5     E-value=2.40567e-103,     Score=960

KEGG

101746537    K13179 ATP-dependent RNA helicase DDX18/HAS1 [EC:3.6.4.13] | (RefSeq) probable ATP-dependent RNA hel

GO

GO:0003723   GO:0005524   GO:0004386   GO:0008283   GO:0005730   GO:0016887   GO:0016779   GO:0003724   GO:0003676   GO:0008270   GO:0016491   GO:0004352   GO:0000287   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

  

Length:

482

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0549299999999999

Exp number, first 60 AAs:

0.00225

Total prob of N-in:

0.00623

outside

1  -  482

 

 

Pi

237.400096

Theta

176.331305

Tajima's D

0.977942

CLR

0.000562

CSRT

0.653017349132543

Interpretation

Uncertain