Gene

KWMTBOMO03475  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006357

Annotation

PREDICTED:_probable_ATP-dependent_RNA_helicase_pitchoune_[Papilio_polytes]

Location

Bomo_Chr6(-):8838771-8846252      View in EpiBrowser

Full name

RNA helicase       + More
Probable ATP-dependent RNA helicase pitchoune      

Location in the cell

Nuclear   Reliability : 3.608

CDS

ATGCCGACACCAGATAAAATACTTCTCAGAAAAATAAGAAAACGAGAAAAACGAAAACTGAAACTTACATCTCAAAAAACTGATTCAAATCCTGAACCAGAAAAAGATATTGAAGCATTAAATAATGAAAAAGAAGCTAAGAAGAGAGTTGTACAAGACGGTGACACAAATGGAAAAGTTCCCAAAAAAAAATTGAAAAAGGTTAAAGAAGAGTTAAAAGAAGAACCAGTTGAAGTAAAATCTGAGGAAGAATCTAGTGATGACTCTCAAGATGAGCAAGACACTAAAGAAGATGATTCGGAAAAAAAATCGAACAACGATTTACCTGGATCAAGCCTCTGCTTAGGTATACTATCAGATCAAAAATTCACTGCACTGGAAGGCACAGTGTGCGAACCAACTCTTTTAGGAATTAAAGATATGGGCTTTATAACGATGACAGAGATTCAAGCTAAAGCTATACCTCCTTTGTTGGAAGGCAGGGATCTTGTGGGTGCTGCCAAAACTGGCTCTGGAAAAACACTAGCATTCTTAATACCGGCTATAGACCTTATATACAAATTAAAATTTAAACCAAGAAATGGTACTGGAGTCATCATTTTGTCACCCACAAGAGAGTTATCAATGCAAACATTTGGCGTTCTCATGGAATTGATGAAATACCACCACCATACATATGGTCTGGTAATGGGTGGTGCAAACAGAAGTACTGAAGCTCAGAAACTCTCTAAAGGTATCAACATTTTAGTTGCTACTCCTGGACGTTTACTGGATCACTTGCAAAATACACCAGACTTCTTGTATAAGAACCTTCAGTGCTTAGTTATTGATGAGGCTGACAGGATATTGGAAATTGGATTTGAAGAAGAAGTTAAACAGATCATAAAATTGCTGCCAAAACGCCGGCAAACTATGTTATTCAGTGCTACACAAACAAAGAAGACTGAAGCACTAACTGCTTTGGCATTGAAGCATGAACCCGTGTATGTTGGGGTTGATGACCACAGAGAACAGGCAACTGTTGATAGTTTAGAACAGGGATATATCGTATGCCCATCAGAGAAACGTATGATGGTTTTATTCACATTCCTTAAGAAGAATAGAAAAAAGAAGGTTATGGTATTCTTTTCAACCTGTATGTCTGTCAAATACCACCATGAACTTTTCAATTATATTGACCTTCCTGTGATGTCCATACATGGAAAACAACAACAAACGAAGCGTACAACAACATTCTTCCAGTTTTGCAATGCTGAATCTGGTATACTACTTTGTACTGATGTCGCGGCGCGTGGTCTGGACATTCCGGCCGTTGATTGGATTGTACAGTATGATCCTCCAGATGATCCAAAGGAATACATCCATCGGGTTGGAAGAACTGCGAGGGGTCTAGGAACTAGTGGACACGCTTTGTTATTCTTACGTCCAGAAGAGCTTGGATTCTTACGATACTTAAAGCAGTCGAGAGTTACCCTAAACGAATTTGAATTCTCATGGAATAAAGTTGCAGATATACAACTACAGCTAGAAAAACTTATCTCTCGAAACTATTTCCTGAATCAATCTGCAAAAGAAGCCTTCAAAAGTTACCTGAGAGCCTATGATTCTCATCACTTGAAAACGATTTTTGACATTGATACAATCGATTTAGCTAAGGCATCGAAATCATTTGGTTTCAATGTACCGCCCGCTGTAGAACTAAAAGTCGCAAACAAAGGACCTCCACAGAAAAGAAAGGGAGGTGGTGGTTATGGATACTTCAAGTCCTTAAACGCTCCATCCGATTTCAAAAGGAAGACAGATAAAACGAAAATATACAGACAAAAGGGGAACAATAAGAAAACGATCAGTTGA

Protein

MPTPDKILLRKIRKREKRKLKLTSQKTDSNPEPEKDIEALNNEKEAKKRVVQDGDTNGKVPKKKLKKVKEELKEEPVEVKSEEESSDDSQDEQDTKEDDSEKKSNNDLPGSSLCLGILSDQKFTALEGTVCEPTLLGIKDMGFITMTEIQAKAIPPLLEGRDLVGAAKTGSGKTLAFLIPAIDLIYKLKFKPRNGTGVIILSPTRELSMQTFGVLMELMKYHHHTYGLVMGGANRSTEAQKLSKGINILVATPGRLLDHLQNTPDFLYKNLQCLVIDEADRILEIGFEEEVKQIIKLLPKRRQTMLFSATQTKKTEALTALALKHEPVYVGVDDHREQATVDSLEQGYIVCPSEKRMMVLFTFLKKNRKKKVMVFFSTCMSVKYHHELFNYIDLPVMSIHGKQQQTKRTTTFFQFCNAESGILLCTDVAARGLDIPAVDWIVQYDPPDDPKEYIHRVGRTARGLGTSGHALLFLRPEELGFLRYLKQSRVTLNEFEFSWNKVADIQLQLEKLISRNYFLNQSAKEAFKSYLRAYDSHHLKTIFDIDTIDLAKASKSFGFNVPPAVELKVANKGPPQKRKGGGGYGYFKSLNAPSDFKRKTDKTKIYRQKGNNKKTIS

Description

Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis.

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Miscellaneous

Mutation in the pit gene produce larvae that cannot grow beyond the first instar larval stage although they can live as long as 7-10 days. All the tissues are equally affected and the perfectly shaped larvae are indistinguishable from first instar wild-type animals.
'Pitchoune' means 'small' in Provence (Southern part of France).

Similarity

Belongs to the DEAD box helicase family.
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

Keywords

ATP-binding   Complete proteome   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Reference proteome   RNA-binding  

Feature

chain  Probable ATP-dependent RNA helicase pitchoune

Uniprot

A0A2W1BNP3   A0A2A4J767   A0A212F650   S4PLI4   H9JA12   A0A194PXI2   + More
A0A0L7LBX8   D6W8J8   A0A1W4XJB7   A0A0T6BH44   K7J159   A0A1Y1LJF9   A0A2J7RRR1   A0A1B6E4Q7   A0A0N0U4N8   A0A195FFG3   A0A158NH79   K7J154   A0A0C9R1I3   E9IJQ2   A0A0K8TNZ2   A0A195B6U5   A0A195DXU2   A0A154P607   E0VZA3   A0A1I8N0G9   A0A026X1E9   A0A146MF85   N6UM89   U4U8K9   W8BRJ4   A0A2S2ND42   A0A2H8TDD5   A0A1I8Q5V6   A0A336LY65   A0A2S2QMA8   A0A1B0G9E6   A0A0L0CEK4   A0A1B0A332   A0A3Q0IP60   B4HM85   A0A0B4LHF7   B3LVL5   B3P7N7   Q9VD51   B4K6L4   X1WV14   B4PLK0   A0A0K8TZH5   B5DW65   A0A034V7T4   A0A0Q9X2B0   A0A0Q9X1W3   B4M0M9   A0A3B0K2U9   A0A067QLN7   A0A0Q9WRB4   A0A0M4EGD0   A0A3L8DQJ5   A0A1W4W1L2   A0A1A9VGC8   B4JRL9   A0A0L7QJS7   A0A151XD17   B4NHR6   A0A1B6GIA3   T1PH19   A0A1J1J3T6   A0A0N8EL32   A0A0P5I9A7   A0A0P6GGE3   A0A0N8EAF2   A0A0P6HAY4   A0A0P5BTJ0   A0A0P5IMI1   A0A0P5N0P0   A0A0P5SDG0   A0A0P5PMA1   A0A0P5NRZ2   A0A0P5B2M3   A0A0P4ZEE9   A0A0P5D3X7   A0A0P5PEL9   A0A0P5A3H4   A0A0P5MHR0   A0A0P5NCH5   A0A0P5S6M3   A0A0N8B4B4   A0A0P6DL16   A0A0P5PQS6   A0A0P5UPV5   A0A0P5Q0N6   A0A0P5R2F2   A0A0P5HRP9   A0A0P5RD11   A0A0P5VBT1   A0A0P6D864   A0A023F4R2   A0A0P5YTJ8   A0A0P5LB25  

EC Number

3.6.4.13

Pubmed

28756777    22118469    23622113    19121390    26354079    26227816    + More
18362917    19820115    20075255    28004739    21347285    21282665    26369729    20566863    25315136    24508170    26823975    23537049    24495485    26108605    17994087    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    9716523    12537569    17550304    15632085    25348373    24845553    30249741    25474469   

EMBL

KZ150004    PZC75254.1    NWSH01002631    PCG67801.1    AGBW02010074    OWR49215.1    + More
GAIX01004010    JAA88550.1    BABH01009406    KQ459589    KPI97469.1    JTDY01001746    KOB73007.1    KQ971312    EEZ98368.1    LJIG01000276    KRT86664.1    GEZM01055754    JAV72948.1    NEVH01000599    PNF43502.1    GEDC01004386    JAS32912.1    KQ435824    KOX72228.1    KQ981625    KYN39123.1    ADTU01015209    GBYB01001815    JAG71582.1    GL763877    EFZ19207.1    GDAI01001998    JAI15605.1    KQ976574    KYM80238.1    KQ980107    KYN17693.1    KQ434813    KZC06784.1    DS235851    EEB18709.1    KK107063    EZA61209.1    GDHC01000957    JAQ17672.1    APGK01017820    KB740053    ENN81801.1    KB632093    ERL88693.1    GAMC01007082    JAB99473.1    GGMR01002494    MBY15113.1    GFXV01000294    MBW12099.1    UFQT01000292    SSX22905.1    GGMS01009625    MBY78828.1    CCAG010017460    JRES01000501    KNC30690.1    CH480815    EDW43133.1    AE014297    AHN57458.1    CH902617    EDV42585.1    CH954182    EDV54198.1    U84552    AY071402    AY119620    CH933806    EDW16314.1    ABLF02029216    CM000160    EDW97949.1    GDHF01032633    JAI19681.1    CM000070    EDY68110.1    GAKP01021350    GAKP01021349    JAC37603.1    KRG02045.1    KRG02044.1    CH940650    EDW67321.1    OUUW01000005    SPP80279.1    KK853180    KDR10194.1    KRF83246.1    CP012526    ALC47404.1    QOIP01000005    RLU22532.1    CH916373    EDV94409.1    KQ415041    KOC58877.1    KQ982294    KYQ58210.1    CH964272    EDW84676.1    GECZ01007597    JAS62172.1    KA648066    AFP62695.1    CVRI01000070    CRL07099.1    GDIQ01016212    JAN78525.1    GDIQ01215846    GDIQ01215845    GDIQ01110641    JAK35880.1    GDIQ01044008    JAN50729.1    GDIQ01046052    JAN48685.1    GDIQ01044007    JAN50730.1    GDIP01180278    JAJ43124.1    GDIQ01211896    JAK39829.1    GDIQ01160109    JAK91616.1    GDIQ01095090    JAL56636.1    GDIQ01136922    JAL14804.1    GDIQ01160108    JAK91617.1    GDIP01195228    JAJ28174.1    GDIP01218079    JAJ05323.1    GDIP01161528    GDIQ01064054    JAJ61874.1    JAN30683.1    GDIQ01129677    LRGB01000687    JAL22049.1    KZS17013.1    GDIP01208028    JAJ15374.1    GDIQ01158013    JAK93712.1    GDIQ01147178    JAL04548.1    GDIQ01108734    JAL42992.1    GDIQ01214147    JAK37578.1    GDIQ01075947    JAN18790.1    GDIQ01145826    JAL05900.1    GDIP01110037    JAL93677.1    GDIQ01120777    JAL30949.1    GDIQ01108733    JAL42993.1    GDIQ01229241    JAK22484.1    GDIQ01108732    JAL42994.1    GDIP01102489    JAM01226.1    GDIQ01081893    JAN12844.1    GBBI01002310    JAC16402.1    GDIP01053657    JAM50058.1    GDIQ01176847    JAK74878.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000053268    UP000037510    UP000007266    + More
UP000192223    UP000002358    UP000235965    UP000053105    UP000078541    UP000005205    UP000078540    UP000078492    UP000076502    UP000009046    UP000095301    UP000053097    UP000019118    UP000030742    UP000095300    UP000092444    UP000037069    UP000092445    UP000079169    UP000001292    UP000000803    UP000007801    UP000008711    UP000009192    UP000007819    UP000002282    UP000001819    UP000008792    UP000268350    UP000027135    UP000092553    UP000279307    UP000192221    UP000078200    UP000001070    UP000053825    UP000075809    UP000007798    UP000183832    UP000076858   

PRIDE

H9JA12    Q9VD51   

Pfam

PF13959   DUF4217        + More
PF00271   Helicase_C
PF00270   DEAD
PF09531   Ndc1_Nup
PF00013   KH_1
PF16544   STAR_dimer

Interpro

IPR000629   RNA-helicase_DEAD-box_CS        + More
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR025313   DUF4217       
IPR027417   P-loop_NTPase       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR019049   Nucleoporin_prot_Ndc1/Nup       
IPR036612   KH_dom_type_1_sf       
IPR004088   KH_dom_type_1       
IPR032377   STAR_dimer       
IPR004087   KH_dom       

SUPFAM

SSF52540   SSF52540        + More
SSF54791   SSF54791       

Gene 3D

3.30.1370.10    

CDD

cd00079  HELICc

ProteinModelPortal

A0A2W1BNP3   A0A2A4J767   A0A212F650   S4PLI4   H9JA12   A0A194PXI2   + More
A0A0L7LBX8   D6W8J8   A0A1W4XJB7   A0A0T6BH44   K7J159   A0A1Y1LJF9   A0A2J7RRR1   A0A1B6E4Q7   A0A0N0U4N8   A0A195FFG3   A0A158NH79   K7J154   A0A0C9R1I3   E9IJQ2   A0A0K8TNZ2   A0A195B6U5   A0A195DXU2   A0A154P607   E0VZA3   A0A1I8N0G9   A0A026X1E9   A0A146MF85   N6UM89   U4U8K9   W8BRJ4   A0A2S2ND42   A0A2H8TDD5   A0A1I8Q5V6   A0A336LY65   A0A2S2QMA8   A0A1B0G9E6   A0A0L0CEK4   A0A1B0A332   A0A3Q0IP60   B4HM85   A0A0B4LHF7   B3LVL5   B3P7N7   Q9VD51   B4K6L4   X1WV14   B4PLK0   A0A0K8TZH5   B5DW65   A0A034V7T4   A0A0Q9X2B0   A0A0Q9X1W3   B4M0M9   A0A3B0K2U9   A0A067QLN7   A0A0Q9WRB4   A0A0M4EGD0   A0A3L8DQJ5   A0A1W4W1L2   A0A1A9VGC8   B4JRL9   A0A0L7QJS7   A0A151XD17   B4NHR6   A0A1B6GIA3   T1PH19   A0A1J1J3T6   A0A0N8EL32   A0A0P5I9A7   A0A0P6GGE3   A0A0N8EAF2   A0A0P6HAY4   A0A0P5BTJ0   A0A0P5IMI1   A0A0P5N0P0   A0A0P5SDG0   A0A0P5PMA1   A0A0P5NRZ2   A0A0P5B2M3   A0A0P4ZEE9   A0A0P5D3X7   A0A0P5PEL9   A0A0P5A3H4   A0A0P5MHR0   A0A0P5NCH5   A0A0P5S6M3   A0A0N8B4B4   A0A0P6DL16   A0A0P5PQS6   A0A0P5UPV5   A0A0P5Q0N6   A0A0P5R2F2   A0A0P5HRP9   A0A0P5RD11   A0A0P5VBT1   A0A0P6D864   A0A023F4R2   A0A0P5YTJ8   A0A0P5LB25  

PDB

6EM5     E-value=1.09598e-169,     Score=1533

KEGG

101735809    K13179 ATP-dependent RNA helicase DDX18/HAS1 [EC:3.6.4.13] | (RefSeq) probable ATP-dependent RNA hel

GO

GO:0003723   GO:0004386   GO:0005524   GO:0016021   GO:0005730   GO:0008283   GO:0016887   GO:0016779   GO:0003724   GO:0003676   GO:0008270   GO:0016491   GO:0004352   GO:0000287   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

  

Length:

617

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00504999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00050

outside

1  -  617

 

 

Pi

234.21002

Theta

156.151962

Tajima's D

1.466759

CLR

0

CSRT

0.778361081945903

Interpretation

Uncertain