Gene

KWMTBOMO03474

Pre Gene Modal

BGIBMGA006524

Annotation

PREDICTED:_ATP-dependent_RNA_helicase_DDX18-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr6(+):8813543-8837864      View in EpiBrowser

Full name

RNA helicase       + More
ATP-dependent RNA helicase DDX18      

Alternative Name

DEAD box protein 18
Myc-regulated DEAD box protein

Location in the cell

Mitochondrial   Reliability : 2.065

CDS

ATGAGCGCTAACGATATTTATCCTAAGTGTACATTTTCCATGCTCAAAGGTGCAGCTAAAACAGGAAGTGGAAAAACATTAGCTTTCTTAATACCTGCTGTAGATCAACTTATTAAACTTGGATTTACACTAAAACATGGTACAGGTTGCATCATTCTATCTCCAACAAGAGAATTAGCTCTGCAGACATTTGAAGTACTAAAGAGACTCTTGACAGATATTGATATTTCACATTGCTTGATTGTTGGAGGTGAGAAAAAAAATAAGGATGTGTCCAAGCTACAAAAAGGCATGAATATTGTAGTGAGTACTCCTGGAAGACTTCTTGATCATTTACAAACCACAAACACATTTAATTGCAAAAATCTGAAATGTCTTATAATTGATGAAGCTGATAAACTGTTAGAATCTGGCTTTGAAAAGCATGTAAATGGAATACTGGAAAAACTTCCAAATGATAAACAAACCGTTCTTTTTAGTGCAACGATTGATGATAGAGTTAAGAATCTAGCTAGACTGGCGTTGAGGAGCGATCCGATCTGGATAACTGTTGATGATGACGCAAAGCGGTCCACTGTCTCTGGATTGCAACAGGGGTACTACATTTGCCCAGTAGAAAAAAGAATGGCTTGGTTGTACAAGATGTTGAAGAAGTGCAAGAAACTGAAAGTCATGGTGTTTTTCTCATCGTGTAAATCGGTCGATTTTCATTATGAATTCTTTAGAGTGAATTGTAAGGCAATCGTCTCTAGTATACACGGCAGACAAAGCCAGGCCAAAAGAAAAGAAGCCTATCACGGTTTCGTGGAAGCACAAAACGGTGCGTTGTTCTGTACCGATGTCGCCGCGAGAGGACTGGACATACCGAGCGTCGATTGGATTGTCCAATACGACCCTCCCACTGACCCTAAGGAGTACATACATAGAGTTGGACGTACCGCCCGAGGTATGAACAGCAAAGGCAATGCAGTGATATTACTTAGACCAGAGGAAGAGGAATTCGTGAAGTTCTTAGAGAACGAAAAAGTTTATTTAGATAAATACACTTTTGGCGATCCCCCGGCAGACATACAAGAATTTCTTCAAAAACTAATAAAAGAGAACGGAGTTATGAAAGTTTTGGCGAGAAAAGCTTTTCTTTCGTTTTTACGTTGTTATAAAAATCATCCACTGAAGAGTATTTTTAATATCAAAAATCTGAATCTACAGTTGGCATCAAAAGCCTTTGGATTTGATGAAACGCCTCATGTCGATTTCTTACGTTCTAAATGA

Protein

MSANDIYPKCTFSMLKGAAKTGSGKTLAFLIPAVDQLIKLGFTLKHGTGCIILSPTRELALQTFEVLKRLLTDIDISHCLIVGGEKKNKDVSKLQKGMNIVVSTPGRLLDHLQTTNTFNCKNLKCLIIDEADKLLESGFEKHVNGILEKLPNDKQTVLFSATIDDRVKNLARLALRSDPIWITVDDDAKRSTVSGLQQGYYICPVEKRMAWLYKMLKKCKKLKVMVFFSSCKSVDFHYEFFRVNCKAIVSSIHGRQSQAKRKEAYHGFVEAQNGALFCTDVAARGLDIPSVDWIVQYDPPTDPKEYIHRVGRTARGMNSKGNAVILLRPEEEEFVKFLENEKVYLDKYTFGDPPADIQEFLQKLIKENGVMKVLARKAFLSFLRCYKNHPLKSIFNIKNLNLQLASKAFGFDETPHVDFLRSK

Catalytic Activity

ATP + H2O = ADP + H(+) + phosphate

Subunit

Interacts with NOL8; the interaction is RNA-dependent.

Similarity

Belongs to the DEAD box helicase family.
Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.

Keywords

3D-structure   ATP-binding   Chromosome   Complete proteome   Direct protein sequencing   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Polymorphism   Reference proteome   RNA-binding  

Feature

chain  ATP-dependent RNA helicase DDX18
sequence variant  In a breast cancer sample; somatic mutation.

Uniprot

A0A2A4J8R3   A0A2W1BNS0   A0A2H1VSJ3   A0A194RTK6   A0A194Q235   S4P8N7   + More
A0A0L7LC99   F6ULQ6   A0A2U3Z4R5   A0A2Y9HI63   M1ELT2   A0A2U3X5D2   L8HPY2   F1N533   A0A2Y9HIL3   A0A1S3FHP6   A0A1U7TH24   F1MSX0   A0A384BQ06   A0A340XB62   D2HKQ4   Q4ZG72   W5PR38   A0A087T3K2   W5PR35   A0A2K5Q786   A0A2Y9J6B6   A0A250YKL0   M3XP52   H2P7D6   G1PX95   B0CMA2   L5JZ09   A0A2K6LMS3   M3VVC3   G3SEJ0   G1RM95   A0A2U4B2L2   A0A0B8S095   H2QIL6   A0A2R9AT87   A0A2K5Q755   A0A2K5F427   A0A2J8VMC2   B2KI24   A0A341AHR5   A0A2Y9PM70   I3MFP7   A0A024RAH8   Q9NVP1   F7I994   A0A2K6NC17   U3F396   A0A2Y9RWU0   H0WVW2   A0A077Z4U3   A0A3P9C624   A9RA86   I3L7B7   A0A2K6BY02   B3EX37   A0A2K5MNQ7   I2CTC7   T1PH19   A0A3P8N6S8   A0A1S3A3H6   A0A0D9RVB2   H9G1D5   A0A0K8TNZ2   A0A2K5VDJ7   A0A2K5ZIT8   B7NZ91   Q5XHY0   A0A0D9RVB5   A0A383Z2F9   A0A1S3WIA4   A0A3B3ZW52   B2RUM8   Q8K363   A0A3L7HMN3   F6XN35   G1U642   E2RFA3   A0A2K6F6M4   A0A3B4GJZ6   G1T3N1   C3PT29   U3IW62   A0A2K5HQD2   A0A084VFF1   G3UC65   A0A1A7YDM3   G7PN44   H0VAC0   I3JM49   A0A1Q3EXA6   B0WUQ7   A0A3B3CGB0   G3SZ42   A0A2M4AE22  

EC Number

3.6.4.13

Pubmed

28756777    26354079    23622113    26227816    19892987    23236062    + More
22751099    19393038    24813606    20010809    20809919    28087693    21993624    23258410    17975172    22398555    16136131    22722832    11181995    14702039    15489334    8861962    12665801    16963496    19608861    20813266    21269460    24275569    20941364    16959974    25362486    25243066    25186727    25319552    26369729    15057822    25463417    12040188    21183079    16141072    29704459    17495919    16341006    23749191    24438588    22002653    29451363   

EMBL

NWSH01002631    PCG67802.1    KZ150004    PZC75255.1    ODYU01004177    SOQ43768.1    + More
KQ459896    KPJ19451.1    KQ459589    KPI97470.1    GAIX01004109    JAA88451.1    JTDY01001746    KOB73010.1    JP008464    AER97061.1    JH883501    ELR46355.1    GL192967    EFB20498.1    AC009404    AAX88947.1    AMGL01054442    KK113246    KFM59691.1    GFFW01000630    JAV44158.1    AEYP01049577    ABGA01338421    ABGA01338422    ABGA01338423    AAPE02035807    AAPE02035808    DP000561    ABY74563.1    KB031068    ELK04560.1    AANG04001482    CABD030015109    ADFV01086491    ADFV01086492    ADFV01086493    GBZA01000170    JAG69598.1    AC172375    GABC01002832    GABF01005921    GABD01005231    GABE01007542    NBAG03000272    JAA08506.1    JAA16224.1    JAA27869.1    JAA37197.1    PNI53565.1    AJFE02065096    NDHI03003416    PNJ58661.1    DP000699    ACC62099.1    AGTP01000913    CH471103    EAW95194.1    AK001467    BC001238    BC003360    BC024739    X98743    CR457060    GAMT01000484    GAMS01004609    GAMR01004114    GAMP01003051    JAB11377.1    JAB18527.1    JAB29818.1    JAB49704.1    AAQR03093401    AAQR03093402    HG805960    CDW55517.1    AHZZ02003617    DP000513    ABX89268.1    AEMK02000098    DP000762    ACE73640.1    JV489178    AFJ70212.1    KA648066    AFP62695.1    AQIB01162610    JU336941    JU477673    AFE80694.1    AFH34477.1    GDAI01001998    JAI15605.1    AQIA01014040    DP001024    ACJ72832.1    AC128353    BC083919    AAH83919.1    BC141230    BC141231    CH466520    AAI41231.1    EDL39784.1    AK075864    AK019845    BC028246    BC103776    RAZU01000200    RLQ66352.1    AAGW02005285    AAEX03011884    DP001104    ACQ63054.1    ADON01077451    ATLV01012386    KE524787    KFB36695.1    HADX01006126    SBP28358.1    CM001288    EHH55889.1    AAKN02006738    AERX01027326    GFDL01015102    JAV19943.1    DS232108    EDS35043.1    GGFK01005708    MBW39029.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000037510    UP000002281    UP000245341    + More
UP000248481    UP000245340    UP000009136    UP000081671    UP000189704    UP000261680    UP000291021    UP000265300    UP000002356    UP000054359    UP000233040    UP000248482    UP000000715    UP000001595    UP000001074    UP000010552    UP000233180    UP000011712    UP000001519    UP000001073    UP000245320    UP000002277    UP000240080    UP000233020    UP000252040    UP000248483    UP000005215    UP000005640    UP000008225    UP000233200    UP000248484    UP000005225    UP000030665    UP000265160    UP000028761    UP000008227    UP000233120    UP000233060    UP000265100    UP000079721    UP000029965    UP000233100    UP000233140    UP000002494    UP000261681    UP000261520    UP000000589    UP000273346    UP000002280    UP000001811    UP000002254    UP000233160    UP000261460    UP000016666    UP000233080    UP000030765    UP000007646    UP000009130    UP000005447    UP000005207    UP000002320    UP000261560   

PRIDE

Q4ZG72    Q9NVP1    I3L7B7    Q8K363   

Pfam

PF00270   DEAD        + More
PF13959   DUF4217
PF00271   Helicase_C

Interpro

IPR027417   P-loop_NTPase        + More
IPR025313   DUF4217       
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR014001   Helicase_ATP-bd       
IPR001650   Helicase_C       

SUPFAM

SSF52540   SSF52540       

CDD

cd00079  HELICc

ProteinModelPortal

A0A2A4J8R3   A0A2W1BNS0   A0A2H1VSJ3   A0A194RTK6   A0A194Q235   S4P8N7   + More
A0A0L7LC99   F6ULQ6   A0A2U3Z4R5   A0A2Y9HI63   M1ELT2   A0A2U3X5D2   L8HPY2   F1N533   A0A2Y9HIL3   A0A1S3FHP6   A0A1U7TH24   F1MSX0   A0A384BQ06   A0A340XB62   D2HKQ4   Q4ZG72   W5PR38   A0A087T3K2   W5PR35   A0A2K5Q786   A0A2Y9J6B6   A0A250YKL0   M3XP52   H2P7D6   G1PX95   B0CMA2   L5JZ09   A0A2K6LMS3   M3VVC3   G3SEJ0   G1RM95   A0A2U4B2L2   A0A0B8S095   H2QIL6   A0A2R9AT87   A0A2K5Q755   A0A2K5F427   A0A2J8VMC2   B2KI24   A0A341AHR5   A0A2Y9PM70   I3MFP7   A0A024RAH8   Q9NVP1   F7I994   A0A2K6NC17   U3F396   A0A2Y9RWU0   H0WVW2   A0A077Z4U3   A0A3P9C624   A9RA86   I3L7B7   A0A2K6BY02   B3EX37   A0A2K5MNQ7   I2CTC7   T1PH19   A0A3P8N6S8   A0A1S3A3H6   A0A0D9RVB2   H9G1D5   A0A0K8TNZ2   A0A2K5VDJ7   A0A2K5ZIT8   B7NZ91   Q5XHY0   A0A0D9RVB5   A0A383Z2F9   A0A1S3WIA4   A0A3B3ZW52   B2RUM8   Q8K363   A0A3L7HMN3   F6XN35   G1U642   E2RFA3   A0A2K6F6M4   A0A3B4GJZ6   G1T3N1   C3PT29   U3IW62   A0A2K5HQD2   A0A084VFF1   G3UC65   A0A1A7YDM3   G7PN44   H0VAC0   I3JM49   A0A1Q3EXA6   B0WUQ7   A0A3B3CGB0   G3SZ42   A0A2M4AE22  

PDB

6EM5     E-value=3.21166e-97,     Score=907

KEGG

101746400    K13179 ATP-dependent RNA helicase DDX18/HAS1 [EC:3.6.4.13] | (RefSeq) ATP-dependent RNA helicase DDX

GO

GO:0004386   GO:0005524   GO:0003723   GO:0003676   GO:0005694   GO:0005730   GO:0071392   GO:0004004   GO:0016020   GO:0030099   GO:0008270   GO:0016491   GO:0004352   GO:0000287   GO:0006270   GO:0042555   GO:0048384  

Subcellular location

Nucleus  
Nucleolus  
Chromosome  

Length:

423

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.39514

Exp number, first 60 AAs:

0.39211

Total prob of N-in:

0.03194

outside

1  -  423

 

 

Pi

175.324825

Theta

17.496038

Tajima's D

0.355646

CLR

0.469895

CSRT

0.481825908704565

Interpretation

Uncertain