Gene

KWMTBOMO03452

Pre Gene Modal

BGIBMGA006362

Annotation

PREDICTED:_mediator_of_RNA_polymerase_II_transcription_subunit_4_[Papilio_machaon]

Location

Bomo_Chr6(-):8194763-8196872      View in EpiBrowser

Full name

Mediator of RNA polymerase II transcription subunit 4      

Alternative Name

Mediator complex subunit 4

Location in the cell

Nuclear   Reliability : 3.422

CDS

ATGGCGTCACATTTAAGTACTAAAGATCGCTTATTGGCACTAATAGATGATATCGAACTTATTGCTAAGGAAATAATAGAAGTTTCCATAGCACCAAAACCACAGAAAGTGTCCGCTGCAGATCATGCTCAGTTGACGGACCTACTTCTATCAAAACATGGAGAATTGAAAAAAACATTAGACCTAGCTGACGAACAAGCAAAGATCCAACAGAAAATGAATGAACTCAAAGCTGAAGTAGATAGTAAGGATCAAGATATATATCACCTTCAAAGACAATTGAAAGATGCAGAACAAATTCTGGCTACATCACTGTATCAAGCTCGACAGAAACTTGCATCAATAGTGAAGTCTAGAAAGAGACCTGTACCCTCTGAGGAGTTGATCAAATTTGCACACAGAATAAGTGCATCTAATGCTGTCAGCGCACCTTTGTCGTGGCAACCTGGTGATCCTCGTCGGCCTTATCCAACTGATTTAGAAATGAGATTAGGAATGCTCGGTCGCCTCTGTGATCTGCCATTGAATGGTCACACGCCTTCTACACTGAATGAACTTCATCGTATAACAACTGGTGGAGTACCAGCTTCAGCTTCAAGCCAATTCACTTGGCATCCATCAGGCGAGCTACACATGTCTGTTGGAGGCGGTAACTCTGTAGCTATTGATGGCCGAGGGAAGGATGCTCCCAACCAAGAAGATGTTGAAGTTATGTCCACAGACTCCAGTTCAAGTTCAAGTAGTGATTCACAATGA

Protein

MASHLSTKDRLLALIDDIELIAKEIIEVSIAPKPQKVSAADHAQLTDLLLSKHGELKKTLDLADEQAKIQQKMNELKAEVDSKDQDIYHLQRQLKDAEQILATSLYQARQKLASIVKSRKRPVPSEELIKFAHRISASNAVSAPLSWQPGDPRRPYPTDLEMRLGMLGRLCDLPLNGHTPSTLNELHRITTGGVPASASSQFTWHPSGELHMSVGGGNSVAIDGRGKDAPNQEDVEVMSTDSSSSSSSDSQ

Description

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Subunit

Component of the Mediator complex.

Similarity

Belongs to the Mediator complex subunit 4 family.

Keywords

Activator   Coiled coil   Complete proteome   Nucleus   Reference proteome   Transcription   Transcription regulation  

Feature

chain  Mediator of RNA polymerase II transcription subunit 4

Uniprot

H9JA17   A0A2A4JPG8   A0A194RPV8   S4NXY1   A0A2H1VEK9   A0A2Z5U7J5   + More
A0A212F948   A0A194PVX9   A0A1B0DM83   A0A1L8DGQ3   A0A182UIA6   A0A182XUK1   A0A182VD86   A0A084VES6   A0A182JVR9   A0A182SH62   A0A182J2R8   A0A182PNI9   A0A182M6M3   A0A182L7P8   A0A182I838   Q7QH62   A0A182YF32   A0A026WY17   A0A1Y1N1D5   A0A1L8DGL1   E2B3N6   E2AIG7   A0A1Q3EYG1   E9J3B9   E0VEA4   A0A151HZ25   A0A158NIE5   A0A2J7Q6J7   A0A023EMZ6   D6WBA5   F4WJI6   A0A067QFU4   A0A2M4ARX8   W5JGL5   A0A195D316   A0A2M4BWS5   A0A0L7RDW2   A0A0N1ITD8   A0A310SNS5   B0X235   Q177A7   A0A1Q3EYF5   A0A151XDS7   V5GJM1   A0A0A9Z0Z2   A0A151IUW1   A0A0T6ATC3   A0A154PB41   A0A0P4VYZ9   A0A088AN46   R4G4N5   A0A151K185   A0A2A3EGB3   A0A023FB78   A0A2M3ZAY5   A0A182QWV9   A0A224XRV5   A0A232FFT9   K7J751   A0A182R3R1   A0A0K8VL91   A0A182NG50   W8BFP2   A0A182VX28   A0A182F8G9   A0A1B6DGF2   U4UJW5   A0A1A9XU77   A0A1A9VIB1   A0A1A9ZM46   A0A1A9WHN6   N6U1A5   A0A336MKC0   U4UKF6   U5ETT4   N6U3Y4   A0A1B6LG16   A0A1B0CG95   A0A1B6F7P7   A0A1B6I1Q0   A0A0L0BNX5   A0A1I8M6Z8   A0A1I8P5P3   A0A1J1I6I4   A0A0J7JUE7   T1IG40   A0A2S2NDS7   C4WTS2   J9K6G7   A0A2H8TNC8   A0A182GRP4   K7J0B0  

Pubmed

19121390    26354079    23622113    22118469    24438588    20966253    + More
12364791    25244985    24508170    30249741    28004739    20798317    21282665    20566863    21347285    24945155    18362917    19820115    21719571    24845553    20920257    23761445    17510324    25401762    26823975    27129103    25474469    28648823    20075255    24495485    23537049    26108605    25315136    26483478   

EMBL

BABH01009332    NWSH01000938    PCG73474.1    KQ459896    KPJ19439.1    GAIX01011977    + More
JAA80583.1    ODYU01001883    SOQ38714.1    AP017538    BBB06936.1    AGBW02009653    OWR50229.1    KQ459589    KPI97482.1    AJVK01006897    GFDF01008448    JAV05636.1    ATLV01012290    KE524778    KFB36470.1    AXCM01002109    APCN01002617    AAAB01008817    KK107063    QOIP01000005    EZA60970.1    RLU22546.1    GEZM01020153    GEZM01020152    JAV89357.1    GFDF01008486    JAV05598.1    GL445365    EFN89692.1    GL439791    EFN66757.1    GFDL01014719    JAV20326.1    GL768061    EFZ12691.1    AAZO01001504    DS235088    EEB11710.1    KQ976704    KYM77083.1    ADTU01016738    NEVH01017470    PNF24198.1    GAPW01003353    JAC10245.1    KQ971312    EEZ98716.2    GL888183    EGI65642.1    KK853582    KDR06509.1    GGFK01010234    MBW43555.1    ADMH02001471    ETN62463.1    KQ976973    KYN06754.1    GGFJ01008368    MBW57509.1    KQ414613    KOC68921.1    KQ435824    KOX72224.1    KQ761768    OAD57128.1    DS232279    EDS38965.1    CH477379    GFDL01014710    JAV20335.1    KQ982294    KYQ58408.1    GALX01006649    JAB61817.1    GBHO01008119    GBRD01013700    GDHC01016036    JAG35485.1    JAG52126.1    JAQ02593.1    KQ980946    KYN11235.1    LJIG01022876    KRT78278.1    KQ434864    KZC09027.1    GDKW01001816    JAI54779.1    GAHY01000621    JAA76889.1    KQ981178    KYN45281.1    KZ288269    PBC30041.1    GBBI01000534    JAC18178.1    GGFM01004922    MBW25673.1    AXCN02001190    GFTR01003868    JAW12558.1    NNAY01000297    OXU29380.1    AAZX01008222    GDHF01013004    JAI39310.1    GAMC01014464    GAMC01014462    GAMC01014460    JAB92091.1    GEDC01012535    JAS24763.1    KB632237    ERL90481.1    APGK01043586    KB741015    ENN75330.1    UFQT01001195    SSX29429.1    ERL90480.1    GANO01002641    JAB57230.1    ENN75331.1    GEBQ01017377    JAT22600.1    AJWK01010865    AJWK01010866    GECZ01023491    JAS46278.1    GECU01026870    JAS80836.1    JRES01001582    KNC21757.1    CVRI01000039    CRK94550.1    LBMM01030588    KMQ81888.1    ACPB03002685    GGMR01002493    MBY15112.1    AK340745    BAH71292.1    ABLF02040145    ABLF02040154    GFXV01003868    MBW15673.1    JXUM01016808    KQ560466    KXJ82280.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000092462    + More
UP000075902    UP000076407    UP000075903    UP000030765    UP000075881    UP000075901    UP000075880    UP000075885    UP000075883    UP000075882    UP000075840    UP000007062    UP000076408    UP000053097    UP000279307    UP000008237    UP000000311    UP000009046    UP000078540    UP000005205    UP000235965    UP000007266    UP000007755    UP000027135    UP000000673    UP000078542    UP000053825    UP000053105    UP000002320    UP000008820    UP000075809    UP000078492    UP000076502    UP000005203    UP000078541    UP000242457    UP000075886    UP000215335    UP000002358    UP000075900    UP000075884    UP000075920    UP000069272    UP000030742    UP000092443    UP000078200    UP000092445    UP000091820    UP000019118    UP000092461    UP000037069    UP000095301    UP000095300    UP000183832    UP000036403    UP000015103    UP000007819    UP000069940    UP000249989   

PRIDE

H9JA17   

Pfam

PF10018   Med4        + More
PF14939   DCAF15_WD40
PF00400   WD40
PF04427   Brix
PF08662   eIF2A
PF03483   B3_4
PF03484   B5
PF18262   PhetRS_B1
PF07544   Med9
PF17759   tRNA_synthFbeta

Interpro

IPR019258   Mediator_Med4        + More
IPR038914   DCAF15       
IPR032734   DCAF15_WD40       
IPR001680   WD40_repeat       
IPR007109   Brix       
IPR017986   WD40_repeat_dom       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR013979   TIF_beta_prop-like       
IPR019775   WD40_repeat_CS       
IPR020472   G-protein_beta_WD-40_rep       
IPR011425   Med9       
IPR005146   B3/B4_tRNA-bd       
IPR004531   Phe-tRNA-synth_IIc_bsu_arc       
IPR040659   PhetRS_B1       
IPR005147   tRNA_synthase_B5-dom       
IPR020825   Phe-tRNA_synthase_B3/B4       
IPR009061   DNA-bd_dom_put_sf       
IPR041616   PheRS_beta_core       

SUPFAM

SSF50978   SSF50978        + More
SSF46955   SSF46955       

Gene 3D

2.130.10.10     3.50.40.10    

CDD

cd00769  PheRS_beta_core

ProteinModelPortal

H9JA17   A0A2A4JPG8   A0A194RPV8   S4NXY1   A0A2H1VEK9   A0A2Z5U7J5   + More
A0A212F948   A0A194PVX9   A0A1B0DM83   A0A1L8DGQ3   A0A182UIA6   A0A182XUK1   A0A182VD86   A0A084VES6   A0A182JVR9   A0A182SH62   A0A182J2R8   A0A182PNI9   A0A182M6M3   A0A182L7P8   A0A182I838   Q7QH62   A0A182YF32   A0A026WY17   A0A1Y1N1D5   A0A1L8DGL1   E2B3N6   E2AIG7   A0A1Q3EYG1   E9J3B9   E0VEA4   A0A151HZ25   A0A158NIE5   A0A2J7Q6J7   A0A023EMZ6   D6WBA5   F4WJI6   A0A067QFU4   A0A2M4ARX8   W5JGL5   A0A195D316   A0A2M4BWS5   A0A0L7RDW2   A0A0N1ITD8   A0A310SNS5   B0X235   Q177A7   A0A1Q3EYF5   A0A151XDS7   V5GJM1   A0A0A9Z0Z2   A0A151IUW1   A0A0T6ATC3   A0A154PB41   A0A0P4VYZ9   A0A088AN46   R4G4N5   A0A151K185   A0A2A3EGB3   A0A023FB78   A0A2M3ZAY5   A0A182QWV9   A0A224XRV5   A0A232FFT9   K7J751   A0A182R3R1   A0A0K8VL91   A0A182NG50   W8BFP2   A0A182VX28   A0A182F8G9   A0A1B6DGF2   U4UJW5   A0A1A9XU77   A0A1A9VIB1   A0A1A9ZM46   A0A1A9WHN6   N6U1A5   A0A336MKC0   U4UKF6   U5ETT4   N6U3Y4   A0A1B6LG16   A0A1B0CG95   A0A1B6F7P7   A0A1B6I1Q0   A0A0L0BNX5   A0A1I8M6Z8   A0A1I8P5P3   A0A1J1I6I4   A0A0J7JUE7   T1IG40   A0A2S2NDS7   C4WTS2   J9K6G7   A0A2H8TNC8   A0A182GRP4   K7J0B0  

KEGG

101746442    K15146 mediator of RNA polymerase II transcription subunit 4 | (RefSeq) mediator of RNA polymerase I

GO

GO:0003712   GO:0016592   GO:0006357   GO:0070847   GO:0016567   GO:0003723   GO:0005524   GO:0006432   GO:0000287   GO:0005737   GO:0004826   GO:0006520   GO:0016491   GO:0004352   GO:0006270   GO:0042555   GO:0048384  

PANTHER

PTHR13208   PTHR28541  

Subcellular location

Nucleus  

Length:

251

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00017

Exp number, first 60 AAs:

0

Total prob of N-in:

0.10083

outside

1  -  251

 

 

Pi

226.396934

Theta

212.225197

Tajima's D

0.485445

CLR

0.034161

CSRT

0.509424528773561

Interpretation

Uncertain