Gene

KWMTBOMO03448

Pre Gene Modal

BGIBMGA006364

Annotation

PREDICTED:_pyrroline-5-carboxylate_reductase_[Bombyx_mori]

Location

Bomo_Chr6(-):8095771-8100622      View in EpiBrowser

Full name

Pyrroline-5-carboxylate reductase      

Location in the cell

PlasmaMembrane   Reliability : 0.863

CDS

ATGAGTAATAATTTTAAGATCGGTTTTGTTGGAGGAGGGAATATGTCAACAGCAATTGTTCAAGGAATTTTAAAAAATGATGCTTATCCGGCTTCAAATATTTGGGTTTCTGGGCCACACTTGGAAAACCTACAGAAATGGTCACTTTTAAACACAAATGTTAGCATAAAAAACTCTGATGTTGTTAACAACTGTGAAATAATATTTCTAGGCATAAAGCCAAATAAATTAGAAACAGCTGTGCAACAATGTCTAAATGGCATAGAATCTCTTAGTAAGAAAAAATCAATATTGTTTGTTTCTATGTTGGCTGGAAGGAAAATAAATGATTTGCAGGAGGTGTTAAGTGTACTATCTCCTTATGCTGATATAAGAATAATAAGGATAATGCCAAATACACCTATGGCCGTAGGGGCTGGTATATGTCTTTACACAACGGATAACAATGTTTCACAAGATCAATGTAAATTTTTGGAAGATCTATTGAGTAGCACTGCACTATGTGAAAGAGTTGAAGAACCAACAATGGACACACTTGGAGTTTTGACTGCTTGTGGACCTGCTTTTATTTATATTGTGATAGAAGCCTTAGCCGATGGTGCTGTGAAGCAAGGTGTTCCTCGAGCAATGGCATTGCGTCACGCAGCACAGGTGGTAGTGGGTAGCGGTCAGATGGTCTTGCAAACCGGTAAACATCCTGGTCTATTGAAAGATGAAGTTTGTTCTCCTGCTGGTTCCACTATATGTGGTGTGACTGAGTTAGAAAATGGAAGATTGAGGTCTACATTCATAAATGCAATTGAAGCTGCAACAAATAGGACGAAAGATCTTGGAAAACGTTAA

Protein

MSNNFKIGFVGGGNMSTAIVQGILKNDAYPASNIWVSGPHLENLQKWSLLNTNVSIKNSDVVNNCEIIFLGIKPNKLETAVQQCLNGIESLSKKKSILFVSMLAGRKINDLQEVLSVLSPYADIRIIRIMPNTPMAVGAGICLYTTDNNVSQDQCKFLEDLLSSTALCERVEEPTMDTLGVLTACGPAFIYIVIEALADGAVKQGVPRAMALRHAAQVVVGSGQMVLQTGKHPGLLKDEVCSPAGSTICGVTELENGRLRSTFINAIEAATNRTKDLGKR

Catalytic Activity

L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH

Similarity

Belongs to the pyrroline-5-carboxylate reductase family.

Uniprot

A0A2H1W8R1   A0A194PVS3   A0A2A4JPD9   A0A194RQ37   A0A0N0PF62   V5SJ26   + More
T1GKW2   A0A0K8U594   A0A0K8WHL9   B4LXA3   A0A1W4UBH3   B4JSG3   A0A034VUN4   W8BLL8   B4K7A8   A0A2A3E4E4   A0A0B4J2M9   T1PI37   B4PMQ9   A0A154PDA8   A0A232EF11   A0A1I8MXR4   A0A1L8EDU4   Q9V3F8   A0A1L8EBN6   K7IZW8   O96643   A0A0L7QPP0   B4ILV5   Q6NP47   A0A3B0K3N1   A0A1I8PIP8   A0A0T6AU53   B3P380   Q29BT4   B4GPN9   A0A0J7KT06   A0A1A9XI54   A0A195CSA1   V5GFX0   B4NHY8   A0A195FSU1   F4WFL5   A0A3L8DWK8   A0A151WIA5   A0A151J4M5   A0A1A9VR32   D3TNW1   A0A151HZ37   Q0QHK4   D6W9S1   E2AAJ1   B3LVB6   A0A158NSH6   A0A0M4EN63   A0A1B0BWJ5   A0A1B0D902   A0A1B0ACL7   A0A1A9X186   W8CBR5   A0A2J7QRD1   A0A1L8E2P1   A0A1Z5L5M3   A0A336K9D3   A0A0K8SXU3   A0A1W4WUK0   A0A146KRB4   A0A182QY18   A0A026WNB1   E0VE13   A0A0K8SX01   A0A0P4VNQ5   A0A0K8TLB1   A0A1Y1M0D2   A0A182NG99   A0A023F1E3   A0A182GF55   A0A224XU55   N6TZQ5   A0A023ENV0   A0A293MXX1   A0A182IYG7   A0A0T6ATZ6   B0WCX9   Q2KQA2   A0A1Q3FCU0   A0A182JZB4   Q1HRH9   A0A0A9Z490   Q16YV4   A0A2M4BVP5   A0A2R5LJX3   A0A084VCD2   A0A0V0GAN1   W5JGW5   A0A182R762   A0A1B6IKB3   A0A1B6MFT9   A0A1J1I4U9  

EC Number

1.5.1.2

Pubmed

26354079    17994087    25348373    24495485    17550304    28648823    + More
25315136    10858562    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20075255    15632085    21719571    30249741    20353571    18362917    19820115    20798317    21347285    28528879    26823975    24508170    20566863    27129103    26369729    28004739    25474469    26483478    23537049    24945155    15804581    17204158    25401762    17510324    24438588    20920257    23761445   

EMBL

ODYU01006743    SOQ48874.1    KQ459589    KPI97486.1    NWSH01000938    PCG73454.1    + More
KQ459896    KPJ19435.1    LADJ01005682    KPJ20884.1    KF647644    AHB50506.1    CAQQ02390338    GDHF01030500    JAI21814.1    GDHF01001755    JAI50559.1    CH940650    EDW66755.1    CH916373    EDV94703.1    GAKP01013157    GAKP01013155    JAC45797.1    GAMC01004605    GAMC01004603    JAC01951.1    CH933806    EDW14232.1    KZ288416    PBC26029.1    KA647800    AFP62429.1    CM000160    EDW95979.1    KQ434878    KZC09896.1    NNAY01005138    OXU16959.1    GFDG01001937    JAV16862.1    AF170829    AE014297    AAD49740.1    AAF55626.1    GFDG01002773    JAV16026.1    AF098020    AAC70780.1    KQ414815    KOC60524.1    CH480892    EDW55431.1    BT011084    AAR82750.1    OUUW01000007    SPP82550.1    LJIG01022798    KRT78657.1    CH954181    EDV48532.1    CM000070    EAL26913.1    CH479186    EDW39122.1    LBMM01003504    KMQ93456.1    KQ977329    KYN03571.1    GALX01005592    JAB62874.1    CH964272    EDW83638.1    KQ981276    KYN43511.1    GL888120    EGI66992.1    QOIP01000003    RLU24831.1    KQ983089    KYQ47568.1    KQ980159    KYN17429.1    EZ423113    ADD19389.1    KQ976719    KYM76752.1    DQ374015    ABG77993.1    KQ971312    EEZ98115.1    GL438128    EFN69538.1    CH902617    EDV43648.1    ADTU01024930    ADTU01024931    CP012526    ALC46064.1    JXJN01021835    AJVK01027986    AJVK01027987    GAMC01004606    JAC01950.1    NEVH01011914    PNF31136.1    GFDF01001168    JAV12916.1    GFJQ02004679    JAW02291.1    UFQS01000141    UFQT01000141    SSX00412.1    SSX20792.1    GBRD01008086    JAG57735.1    GDHC01020703    GDHC01008850    JAP97925.1    JAQ09779.1    AXCN02001627    KK107161    EZA56589.1    DS235088    EEB11619.1    GBRD01008087    JAG57734.1    GDKW01000286    JAI56309.1    GDAI01002652    JAI14951.1    GEZM01047934    JAV76687.1    GBBI01003604    JAC15108.1    JXUM01059245    KQ562042    KXJ76834.1    GFTR01004793    JAW11633.1    APGK01054985    KB741257    KB631615    ENN71742.1    ERL84683.1    JXUM01039862    JXUM01039863    GAPW01002972    KQ561220    JAC10626.1    KXJ79312.1    GFWV01012305    GFWV01019472    MAA44200.1    KRT78656.1    DS231891    EDS43939.1    AY623401    AAV31910.1    GFDL01009685    JAV25360.1    DQ440115    ABF18148.1    GBHO01035610    GBHO01025400    GBHO01004290    GBHO01004288    GBHO01004287    GBHO01004286    GBHO01004285    GBHO01004282    GBHO01002798    GBHO01002796    GBHO01002795    GBHO01002794    GDHC01018697    GDHC01016435    GDHC01015029    GDHC01005258    JAG07994.1    JAG18204.1    JAG39314.1    JAG39316.1    JAG39317.1    JAG39318.1    JAG39319.1    JAG39322.1    JAG40806.1    JAG40808.1    JAG40809.1    JAG40810.1    JAP99931.1    JAQ02194.1    JAQ03600.1    JAQ13371.1    CH477508    EAT39807.1    GGFJ01008004    MBW57145.1    GGLE01005714    MBY09840.1    ATLV01010660    KE524596    KFB35626.1    GECL01001661    JAP04463.1    ADMH02001428    ETN62563.1    GECU01020346    GECU01010791    JAS87360.1    JAS96915.1    GEBQ01010665    GEBQ01005201    GEBQ01003774    JAT29312.1    JAT34776.1    JAT36203.1    CVRI01000039    CRK94620.1   

Proteomes

UP000053268    UP000218220    UP000053240    UP000015102    UP000008792    UP000192221    + More
UP000001070    UP000009192    UP000242457    UP000005203    UP000002282    UP000076502    UP000215335    UP000095301    UP000000803    UP000002358    UP000053825    UP000001292    UP000268350    UP000095300    UP000008711    UP000001819    UP000008744    UP000036403    UP000092443    UP000078542    UP000007798    UP000078541    UP000007755    UP000279307    UP000075809    UP000078492    UP000078200    UP000078540    UP000007266    UP000000311    UP000007801    UP000005205    UP000092553    UP000092460    UP000092462    UP000092445    UP000091820    UP000235965    UP000192223    UP000075886    UP000053097    UP000009046    UP000075884    UP000069940    UP000249989    UP000019118    UP000030742    UP000075880    UP000002320    UP000075881    UP000008820    UP000030765    UP000000673    UP000075900    UP000183832   

PRIDE

Q9V3F8    O96643    Q6NP47   

Pfam

PF03807   F420_oxidored        + More
PF14748   P5CR_dimer

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR008927   6-PGluconate_DH-like_C_sf       
IPR029036   P5CR_dimer       
IPR000304   Pyrroline-COOH_reductase       
IPR028939   P5C_Rdtase_cat_N       
IPR016181   Acyl_CoA_acyltransferase       

SUPFAM

SSF48179   SSF48179        + More
SSF51735   SSF51735       
SSF55729   SSF55729       

ProteinModelPortal

A0A2H1W8R1   A0A194PVS3   A0A2A4JPD9   A0A194RQ37   A0A0N0PF62   V5SJ26   + More
T1GKW2   A0A0K8U594   A0A0K8WHL9   B4LXA3   A0A1W4UBH3   B4JSG3   A0A034VUN4   W8BLL8   B4K7A8   A0A2A3E4E4   A0A0B4J2M9   T1PI37   B4PMQ9   A0A154PDA8   A0A232EF11   A0A1I8MXR4   A0A1L8EDU4   Q9V3F8   A0A1L8EBN6   K7IZW8   O96643   A0A0L7QPP0   B4ILV5   Q6NP47   A0A3B0K3N1   A0A1I8PIP8   A0A0T6AU53   B3P380   Q29BT4   B4GPN9   A0A0J7KT06   A0A1A9XI54   A0A195CSA1   V5GFX0   B4NHY8   A0A195FSU1   F4WFL5   A0A3L8DWK8   A0A151WIA5   A0A151J4M5   A0A1A9VR32   D3TNW1   A0A151HZ37   Q0QHK4   D6W9S1   E2AAJ1   B3LVB6   A0A158NSH6   A0A0M4EN63   A0A1B0BWJ5   A0A1B0D902   A0A1B0ACL7   A0A1A9X186   W8CBR5   A0A2J7QRD1   A0A1L8E2P1   A0A1Z5L5M3   A0A336K9D3   A0A0K8SXU3   A0A1W4WUK0   A0A146KRB4   A0A182QY18   A0A026WNB1   E0VE13   A0A0K8SX01   A0A0P4VNQ5   A0A0K8TLB1   A0A1Y1M0D2   A0A182NG99   A0A023F1E3   A0A182GF55   A0A224XU55   N6TZQ5   A0A023ENV0   A0A293MXX1   A0A182IYG7   A0A0T6ATZ6   B0WCX9   Q2KQA2   A0A1Q3FCU0   A0A182JZB4   Q1HRH9   A0A0A9Z490   Q16YV4   A0A2M4BVP5   A0A2R5LJX3   A0A084VCD2   A0A0V0GAN1   W5JGW5   A0A182R762   A0A1B6IKB3   A0A1B6MFT9   A0A1J1I4U9  

PDB

2GRA     E-value=5.10767e-42,     Score=428

KEGG

101745536    K00286 pyrroline-5-carboxylate reductase [EC:1.5.1.2] | (RefSeq) pyrroline-5-carboxylate reductase

PATHWAY

00330    Arginine and proline metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0055129   GO:0004735   GO:0006561   GO:0016021   GO:0006520   GO:0016491   GO:0004352   GO:0000287   GO:0003723   GO:0006270   GO:0042555   GO:0048384   GO:0055114  

Length:

280

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.73104

Exp number, first 60 AAs:

0.572

Total prob of N-in:

0.07548

outside

1  -  280

 

 

Pi

190.201095

Theta

172.370326

Tajima's D

0.667433

CLR

139.221713

CSRT

0.566571671416429

Interpretation

Uncertain