Gene

KWMTBOMO03442

Annotation

PREDICTED:_proton-coupled_folate_transporter-like_[Papilio_machaon]

Location

Bomo_Chr6(+):8000414-8017891      View in EpiBrowser

Full name

Angiotensin-converting enzyme      

Location in the cell

PlasmaMembrane   Reliability : 4.379

CDS

ATGAACATTTCATCTCTTCTGTACGTGCAATTCGTAATGCAAGATGTGAATGTTAACACCGAAAACCGAGTGTCGGTGTTTAATTGGAAGCTACCATTGAAGGCGTTCAAAAGCCTAATAAAGAGCCGGGAAGGACACAAAAGGAAAATAATATTACTCATGTTGCTTGTGTCTCTCGGAGATAGAGTTCTACTATCAGCTGAGGTGCTAATCGCCTACATGTACTATAGGTACAAATTTCATTGGGACGACATAATGTTTGGCTCGTTTTTGGCATATAAGAACATCATCAGCTTCTTTGGTACATTATTAATATTGAGTCTGCTGAAGCGACGCTTGAAACTGTCGGACGAGATGGTAGGAGTTTTCAGCTGCCTGTCAAACATATTATCTACATCTGGTCTCATTGCCACCACTTACACTTACTGCGTATTTGTGCTTCCTTTGCTCGGGATAATATCTCAAGGATCTCAGGTCGTCCAGAGGCCGCTACTGAATAAGCAAATTTTACCAACTGAACAAGGTAAAATATACAGCGTTATGGGAGCCCTCCAATCTGCAATACAGACATTGTCGTCGCCGCTATACTCCCTGTTATACAGCAGAACTGTCTCAACGTTTCCAGATGCTTGGCTTCTGCCGGGATTGGGACTCGCGTTAATACAATTAACAGCATACCTAATAGCAAGGAGGTTACGTCTGAAATCAAATGTCGCAGACAATGATAATATGAAAGTTAATACTGAAGATTGTTGTTTAGATATAGAAGACAAAGTGATTAAAAATGATCTCAACTCTGTCGAATTAGCGTCTGAAAAGTGTGCCGAAAAGTAA

Protein

MNISSLLYVQFVMQDVNVNTENRVSVFNWKLPLKAFKSLIKSREGHKRKIILLMLLVSLGDRVLLSAEVLIAYMYYRYKFHWDDIMFGSFLAYKNIISFFGTLLILSLLKRRLKLSDEMVGVFSCLSNILSTSGLIATTYTYCVFVLPLLGIISQGSQVVQRPLLNKQILPTEQGKIYSVMGALQSAIQTLSSPLYSLLYSRTVSTFPDAWLLPGLGLALIQLTAYLIARRLRLKSNVADNDNMKVNTEDCCLDIEDKVIKNDLNSVELASEKCAEK

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M2 family.
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Uniprot

A0A194RPU8   A0A1E1WVC4   A0A212F393   A0A194PVY9   A0A0L7KYA7   A0A1B6LLW9   + More
A0A1B6CE26   A0A194QS69   A0A194QAI0   A0A1E1W1C8   A0A146M6W4   A0A0A9W4N6   A0A182QCE8   A0A2H1W938   A0A182J2E5   A0A2W1BZD6   A0A182N9U1   A0A084WT83   Q16W79   A0A2M4BIV5   A0A2M4AAV7   A0A2M3Z330   A0A2M4BIX1   A0A182W3L5   A0A2M3Z363   A0A2M4CTY3   A0A182MSS2   A0A2M4CUE7   A0A2M4CSN5   A0A2M4CUE3   A0A182VHT3   Q5TSW5   A0A182PQS5   A0A2C9H8S5   A0A194RE89   A0A2S2NH79   A0A182RDY9   A0A182H1C2   A0A212FAM1   A0A194PXP8   A0A182K2U1   A0A1J1HPT6   A0A1Y1KH29   A0A1Q3FLB8   A0A1Q3FLC7   A0A2S2NX57   A0A2H1WT49   B0WAI1   A0A1Q3FKN7   A0A1Q3FL61  

EC Number

3.4.-.-

Pubmed

26354079    22118469    26227816    26823975    25401762    28756777    + More
24438588    17510324    12364791    14747013    17210077    26483478    28004739   

EMBL

KQ459896    KPJ19429.1    GDQN01000298    JAT90756.1    AGBW02010586    OWR48209.1    + More
KQ459589    KPI97492.1    JTDY01004458    KOB68135.1    GEBQ01015246    JAT24731.1    GEDC01025663    JAS11635.1    KQ461155    KPJ08368.1    KQ459249    KPJ02439.1    GDQN01010353    JAT80701.1    GDHC01003145    JAQ15484.1    GBHO01041233    GBRD01004096    JAG02371.1    JAG61725.1    AXCN02001200    ODYU01007104    SOQ49580.1    KZ149899    PZC78617.1    ATLV01026865    ATLV01026866    KE525420    KFB53427.1    CH477573    EAT38831.1    GGFJ01003793    MBW52934.1    GGFK01004578    MBW37899.1    GGFM01002176    MBW22927.1    GGFJ01003792    MBW52933.1    GGFM01002194    MBW22945.1    GGFL01004110    MBW68288.1    AXCM01000458    GGFL01004789    MBW68967.1    GGFL01004111    MBW68289.1    GGFL01004788    MBW68966.1    AAAB01008898    EAL40562.4    KQ460323    KPJ15907.1    GGMR01003934    MBY16553.1    JXUM01102960    KQ564767    KXJ71770.1    AGBW02009461    OWR50763.1    KQ459586    KPI98097.1    CVRI01000006    CRK88225.1    GEZM01088643    GEZM01088642    JAV58047.1    GFDL01006678    JAV28367.1    GFDL01006731    JAV28314.1    GGMR01009161    MBY21780.1    ODYU01010862    SOQ56231.1    DS231872    EDS41404.1    GFDL01006875    JAV28170.1    GFDL01006801    JAV28244.1   

Proteomes

UP000053240    UP000007151    UP000053268    UP000037510    UP000075886    UP000075880    + More
UP000075884    UP000030765    UP000008820    UP000075920    UP000075883    UP000075903    UP000007062    UP000075885    UP000076407    UP000075900    UP000069940    UP000249989    UP000075881    UP000183832    UP000002320   

Pfam

PF07690   MFS_1        + More
PF01401   Peptidase_M2
PF07701   HNOBA
PF00211   Guanylate_cyc
PF07700   HNOB

Interpro

IPR011701   MFS        + More
IPR036259   MFS_trans_sf       
IPR020846   MFS_dom       
IPR001548   Peptidase_M2       
IPR018297   A/G_cyclase_CS       
IPR038158   H-NOX_domain_sf       
IPR024096   NO_sig/Golgi_transp_ligand-bd       
IPR011645   HNOB_dom_associated       
IPR029787   Nucleotide_cyclase       
IPR001054   A/G_cyclase       
IPR011644   Heme_NO-bd       

SUPFAM

SSF103473   SSF103473        + More
SSF55073   SSF55073       
SSF111126   SSF111126       

Gene 3D

3.30.70.1230     3.90.1520.10    

CDD

cd06174  MFS
cd06461  M2_ACE

ProteinModelPortal

A0A194RPU8   A0A1E1WVC4   A0A212F393   A0A194PVY9   A0A0L7KYA7   A0A1B6LLW9   + More
A0A1B6CE26   A0A194QS69   A0A194QAI0   A0A1E1W1C8   A0A146M6W4   A0A0A9W4N6   A0A182QCE8   A0A2H1W938   A0A182J2E5   A0A2W1BZD6   A0A182N9U1   A0A084WT83   Q16W79   A0A2M4BIV5   A0A2M4AAV7   A0A2M3Z330   A0A2M4BIX1   A0A182W3L5   A0A2M3Z363   A0A2M4CTY3   A0A182MSS2   A0A2M4CUE7   A0A2M4CSN5   A0A2M4CUE3   A0A182VHT3   Q5TSW5   A0A182PQS5   A0A2C9H8S5   A0A194RE89   A0A2S2NH79   A0A182RDY9   A0A182H1C2   A0A212FAM1   A0A194PXP8   A0A182K2U1   A0A1J1HPT6   A0A1Y1KH29   A0A1Q3FLB8   A0A1Q3FLC7   A0A2S2NX57   A0A2H1WT49   B0WAI1   A0A1Q3FKN7   A0A1Q3FL61  

KEGG

101745252    K20840 MFS transporter, PCFT/HCP family, solute carrier family 46, member 3 | (RefSeq) proton-couple

GO

GO:0055085   GO:0016021   GO:0004180   GO:0008237   GO:0008241   GO:0046872   GO:0020037   GO:0000166   GO:0035556   GO:0004383  

PANTHER

PTHR10514  

Length:

277

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

91.00208

Exp number, first 60 AAs:

10.61674

Total prob of N-in:

0.99212

POSSIBLE N-term signal

sequence

inside

1  -  49

TMhelix

50  -  72

outside

73  -  86

TMhelix

87  -  109

inside

110  -  129

TMhelix

130  -  152

outside

153  -  209

TMhelix

210  -  229

inside

230  -  277

 

 

Pi

313.746828

Theta

169.425375

Tajima's D

2.314537

CLR

0.429145

CSRT

0.926103694815259

Interpretation

Uncertain